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Introduction About ZELIS 5MG TABLET
ZELIS 5MG TABLET contains Lisinopril which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) and heart failure. It also manages the onset of signs of symptoms of heart failure (such as difficulty in breathing, swollen ankles and feet or extreme tiredness even after a mild physical activity) and can reduce kidney damage in diabetic patients who have high blood pressure.
Before taking ZELIS 5MG TABLET inform your doctor if you have any liver, kidney or heart problems (other than hypertension and heart failure). You must also inform your doctor if you have severe hypotension (low blood pressure), diabetes or are severely dehydrated due to any recent sickness (such as vomiting or diarrhea).
ZELIS 5MG TABLET is not recommended for use in women who are pregnant or breastfeeding due to increased risk of side effects. Stop taking ZELIS 5MG TABLET and inform your doctor immediately if you become pregnant while undergoing therapy with ZELIS 5MG TABLET.
ZELIS 5MG TABLET may cause dizziness while standing up suddenly or while changing positions, especially during the initial days of the therapy. Therefore, do not drive or operate any heavy tools or machines as a precaution. Also, avoid consumption of alcohol as it could aggravate your dizziness.
Other most common side effects of taking ZELIS 5MG TABLET are dizziness, headache, nausea and diarrhea. Consult your doctor if any of these side effect worsens.
Uses Of ZELIS 5MG TABLET
- Manage hypertension (high blood pressure)
- Manage and manages heart failure
- Manage kidney problems in diabetic patients who have high blood pressure
How ZELIS 5MG TABLET Works
ZELIS 5MG TABLET is an ACE inhibitor. It works by blocking the actions of an enzyme called angiotensin-converting enzyme (ACE), that causes narrowing of blood vessels and increase in blood pressure. As a result, it relaxes the blood vessels and allows blood to flow more smoothly across the blood vessels with less pressure.
It also improves blood flow and oxygen supply to the heart and the kidneys. This reduces strain on the heart and kidneys, improves their functions and manages the risks of heart failure or kidney damage.
How to use ZELIS 5MG TABLET
Take ZELIS 5MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. ZELIS 5MG TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking ZELIS 5MG TABLET unless your doctor advises you to stop.
Side Effects Of ZELIS 5MG TABLET
Common
- dizziness, headache
- nausea, diarrhea
- cough
- kidney problems
Uncommon
- high blood urea levels
- feeling nervous, mood changes
- tingling or pricking sensation in the body
- feeling dizzy while standing up
- changes in taste
- problems in sleeping
- fast heartbeat
- pale skin due to low blood supply
- itchy or runny nose
- skin rash or itching
- stomach pain, indigestion
- inability to get or maintain an erection, impotence
- tiredness, weakness
- high potassium levels in blood
Rare
- enlargement of breasts in men
- swelling of glands in neck, underarms or groin
- confusion
- dry mouth
- hair loss
- low sodium levels in blood causing tiredness, weakness, confusion and muscle weakness
Stop taking ZELIS 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane with severe joint pain and fever)
- signs of heart attack (severe sudden chest pain that might spread to the neck, shoulders and arms with shortness of breath and sweating)
- signs of stroke (weakness or numbness in one side of the body along with confusion, difficulty in speaking or loss of coordination)
- signs of kidney failure (low urine output, cloudy urine or bloody urine along with lower back pain, nausea, vomiting or swelling in your legs, ankles or feet)
- signs of pancreatitis (severe abdominal pain radiating to the back with vomiting)
- signs of liver problems (yellowing of your skin or whites of the eyes (jaundice), dark urine, pale stools, tiredness, fever, nausea, stomach pain and weakness)
- signs of a low immunity (frequent incidence of infections resulting in fever, severe chills, sore throat or mouth ulcers)
- increased bleeding or bruising, pale skin and tiredness
How To Manage Side Effects
Nausea and vomiting:
Take ZELIS 5MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
ZELIS 5MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking ZELIS 5MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you accidentally become pregnant while undergoing therapy with ZELIS 5MG TABLET, stop taking this medicine and inform your doctor immediately.
Breastfeeding
ZELIS 5MG TABLET is not recommended for use in breast-feeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
ZELIS 5MG TABLET may make you feel tired or dizzy. Therefore, do not drive or handle any heavy tools or machines as a precaution.
Alcohol
Avoid consumption of alcohol while taking ZELIS 5MG TABLET as it may severely decrease your blood pressure and make you feel dizzier or faint
Kidney
ZELIS 5MG TABLET should be used with caution in patients with kidney problems (including narrowing or blood vessels supplying the kidneys, dialysis or kidney transplantation). Therefore, consult your doctor before taking it.
Liver
ZELIS 5MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take ZELIS 5MG TABLET if you are allergic to Lisinopril or to any other ACE inhibitors (such as captopril, enalapril, ramipril).
Heart Disease
ZELIS 5MG TABLET should be used with caution in patients with other heart problems apart from hypertension and heart failure (such as irregular heartbeat, heart valve disease or enlarged heart). Therefore, consult your doctor before taking it.
Others
ZELIS 5MG TABLET is not recommended for use if you:
- have diabetes with impaired kidney functions
Before taking ZELIS 5MG TABLET, inform your doctor if you:
- have hypotension (low blood pressure)
- have stroke or mini stroke
- are severely dehydrated due to any recent sickness such as vomiting or diarrhea
- have diabetes
- have any autoimmune disease that affects the skin or collagen (Ex. lupus erythematosus, rheumatoid arthritis, or scleroderma)
- are scheduled for any upcoming surgery (including minor dental surgery)
- are scheduled for LDL apheresis (a procedure used to remove cholesterol from the blood)
- have any desensitization management (used to reduce the effect of an allergy to bee or wasp stings)
- have high levels of potassium in the blood
Use in paediatrics:
ZELIS 5MG TABLET is not recommended for use in children and adolescents (aged below 18 years) unless prescribed by a physician. Therefore, consult your doctor before consumption.
Use in geriatrics:
ZELIS 5MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking ZELIS 5MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- racecadotril (a medicine used to manage diarrhea)
- medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
- trimethoprim containing antibiotics (used for infections)
- medicines used to manage organ transplant rejection (Ex. ciclosporin, temsirolimus, sirolimus, everolimus)
- heparin (used to manage blood clots)
- medicines used for heart conditions such as hypertension, chest pain, irregular heartbeats or heart failure (Ex. atenolol, propranolol, furosemide, bumetanide, nitroglycerin, valsartan, aliskiren, procainamide, sacubitril/valsartan)
- lithium (a medicine used in some types of mental illness)
- tricyclic antidepressants (used to manage depression) Ex. amitriptyline
- antipsychotics (used to manage serious mental illnesses) Ex. clozapine, risperidone
- anesthetics (used to manage pain during surgery) Ex. propofol, thiopental, lidocaine
- medicines used to relieve pain (Ex. morphine, aspirin, ibuprofen, celecoxib, valdecoxib)
- gold therapy (used to manage rheumatic conditions)
- medicines used to suppress cough (such as dextromethorphan, guaiphenesin, pseudoephedrine)
- anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagliptin, metformin, gliclazide
- allopurinol (a medicine used to reduce blood uric acid levels)
Overdosage:
If you or anyone else accidentally took more ZELIS 5MG TABLET, contact your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include severe dizziness or light-headedness with fainting, fast heartbeat, anxiety, cough and fast breathing.
Synopsis
| Drug | : | Lisinopril |
| Pharmacological Category | : | ACE (Angiotensin Converting Enzyme) inhibitors |
| Therapeutic Indication | : | Hypertension, Heart failure, kidney disease |
| Dosage Forms | : | Tablet |
More Information
- Keep ZELIS 5MG TABLET out of the sight and reach of children
- Store ZELIS 5MG TABLET at room temperature
FAQs About ZELIS 5MG TABLET
Is ZELIS 5MG TABLET safe to use in diabetic patients?
ZELIS 5MG TABLET may alter the blood sugar levels in your body. It can also hide the symptoms of low blood sugar. Therefore, it is necessary to inform your doctor if you have diabetes before taking ZELIS 5MG TABLET as a precaution. Your doctor will closely monitor your blood sugar levels to avoid the risk of side effects. Also, inform your doctor if you experience any unusual tiredness, hunger or thirst while undergoing therapy with ZELIS 5MG TABLET.
What precautions should be followed while taking ZELIS 5MG TABLET?
Before taking ZELIS 5MG TABLET inform your doctor if you have any liver, kidney or heart problems (other than hypertension and heart failure). You must also inform your doctor if you have low blood pressure, diabetes or are severely dehydrated. Regularly visit your doctor and take all the necessary tests which your doctor recommends to you without fail. If you are pregnant or become pregnant while taking ZELIS 5MG TABLET, stop taking the medicine and inform your doctor immediately.
Can I consume alcohol while taking ZELIS 5MG TABLET?
Avoid consumption of alcohol while taking ZELIS 5MG TABLET as it might severely decrease your blood pressure and make you feel dizzier and drowsier.
What happens if I accidentally take more ZELIS 5MG TABLET?
If you or anyone else accidentally took more ZELIS 5MG TABLET, contact your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include severe dizziness or light-headedness with fainting, fast heartbeat, anxiety, cough and fast breathing.
Can I take ZELIS 5MG TABLET daily?
Your doctor will evaluate your health condition and suggests whether can you take ZELIS 5MG TABLET every day or not.
Can I stop taking ZELIS 5MG TABLET if my blood pressure reduces?
Do not stop therapy with ZELIS 5MG TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take ZELIS 5MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
What are the uses of ZELIS 5MG TABLET?
ZELIS 5MG TABLET is used to manage hypertension and heart failure. It also helps to manage the signs of symptoms of heart failure and can manage kidney disease in diabetic patients with high blood pressure.
What type of a medicine is ZELIS 5MG TABLET?
ZELIS 5MG TABLET is an antihypertensive medicine. It is used to manage hypertension and heart failure. It can also protect your kidneys from getting damaged due to high blood pressure.
How ZELIS 5MG TABLET works?
ZELIS 5MG TABLET relaxes the blood vessels and allows blood to flow more smoothly across the blood vessels with less pressure. It also improves blood flow and oxygen supply to the heart and the kidneys. This reduces strain on the heart and kidneys, improves their functions and manages the risks of heart failure or kidney damage.
What are the side effects of ZELIS 5MG TABLET?
The most common side effects of taking ZELIS 5MG TABLET are dizziness, headache, nausea and diarrhea. Consult your doctor if any of these side effect worsens.
Can ZELIS 5MG TABLET be used during pregnancy?
ZELIS 5MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking ZELIS 5MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.
What is the best time to take ZELIS 5MG TABLET?
ZELIS 5MG TABLET can be taken with or without meals. Your doctor will decide the best time for you to take ZELIS 5MG TABLET based on your age, body weight and disease condition.
What to do if I forgot to take a dose of ZELIS 5MG TABLET?
If you have missed a dose of ZELIS 5MG TABLET, take it as soon as you remember. However, if it is time for the next dose of ZELIS 5MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of ZELIS 5MG TABLET to compensate the missed ones.
Can ZELIS 5MG TABLET cause erectile dysfunction?
ZELIS 5MG TABLET may cause difficulty in getting erection in few individuals. If you experience any such symptom, contact your doctor for advice.
How fast will ZELIS 5MG TABLET work?
ZELIS 5MG TABLET usually starts to act within an hour, and its effect may last up to 24 hours. However, some people may require several weeks of management until the optimum effect on their blood pressure is observed.
References
1. KD. Tripathi. Cardiovascular drugs. Drugs affecting Renin-angiotensin system. Essentials of medical pharmacology. 7th Edition. 2019. Page – 503.
2. L Rydén 1, P W Armstrong, J G Cleland, J D Horowitz, B M Massie, M Packer, P A Poole-Wilson. Efficacy and safety of high dose lisinopril in chronic heart failure patients at high cardiovascular risk, including those with diabetes mellitus. Results from the ATLAS trial. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. December 2000. [Accessed on 24th November 2022] https://pubmed.ncbi.nlm.nih.gov/11071803/
3. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 24th November 2022] https://www.medicines.org.uk/emc/files/pil.10114.pdf
Useful Diagnostic Tests
- Kidney function test
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