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Introduction About XYLOCAINE 2% INJECTION
XYLOCAINE 2% INJECTION contains Lignocaine, which belongs to the group of medicines called Local anaesthetic agents. It is used to cause numbness (loss of sensation) of body parts in the regions where it has been administered (local anesthesia). It is generally used prior to spinal anesthesia or before surgical procedures to cause a temporary loss of sensation. It also helps to control the heartbeat in patients with arrythmia (an irregular heartbeat).
XYLOCAINE 2% INJECTION will be given to you only by a trained anaesthesiologist around the areas (such as hands, legs, abdomen, pelvis, and spine) locally where loss of sensation (numbness) is required.
Before receiving XYLOCAINE 2% INJECTION, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any breathing disorders, blood problems, epilepsy, glaucoma, stroke, dehydration, low blood potassium levels, or muscle weakness.
XYLOCAINE 2% INJECTION should be used in pregnant or breastfeeding women only if considered necessary by the physician. The most common side effects of receiving XYLOCAINE 2% INJECTION are nausea, slow heart rate, dizziness, lower back pain, difficulty walking, and an inability to control urine or bowel movements. Inform your doctor if any of these side effects worsen.
Uses Of XYLOCAINE 2% INJECTION
- Causes numbness of body parts when used prior to spinal anesthesia or surgical procedures
- To manage arrythmia (an irregular heartbeat)
How XYLOCAINE 2% INJECTION Works
XYLOCAINE 2% INJECTION is an anaesthetic agent. It reduces pain sensation and causes numbness in body parts by blocking the flow of certain ions (sodium ions) through the nerves that cause pain sensation. As a result, it limits the transfer of pain signals from the peripheral parts of the body (i.e., the face, hands, legs, abdomen, and pelvis) to the brain, which leads to a loss of sensation. It also normalizes heart rate by blocking the generation of abnormal electrical signals in the heart.
How to use XYLOCAINE 2% INJECTION
XYLOCAINE 2% INJECTION will be given to you only by a doctor or by a trained anaesthesiologist. Your doctor or anaesthesiologist will decide the correct dose and site of administration for you depending upon your age, body weight, health condition, and the type of nerve block that is required to provide anesthesia or pain relief.
It can be administered locally to the region where loss of sensation (numbness) is required or can be administered in a vein, around the spinal cord, or a nerve to cause numbness during surgeries (caesarean section or other major surgeries) to stop pain sensation.
Side Effects Of XYLOCAINE 2% INJECTION
Common
- pain at the site of the injection
- low blood pressure causing dizziness, drowsiness, or light-headedness
- nausea, vomiting
- tingling or pricking sensation (pins and needles)
- slow heartbeat, feeling faint
- changes in vision, blurred vision
- difficulty in passing urine
- pain or numbness in the legs or back
- unable to walk properly
- problems in controlling the bowels and bladder
Consult your doctor immediately if you experience any of the following side effects after receiving XYLOCAINE 2% INJECTION:
- signs of severe allergic reactions (such as skin rash, severe itching of the skin with raised lumps, blisters in the skin, swelling of the face, lips, tongue, and/or throat with difficulty breathing or swallowing)
- blood problems (causing bluish discoloration of the skin, headache, tiredness, weakness, and shortness of breath)
- fits or convulsions
How To Manage Side Effects
Dizziness Or Drowsiness
Avoid standing or walking after surgery. Try to rest and relax. Get enough sleep. Consult your doctor if you continue to feel dizzy for a prolonged period of time.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
Warning & Precautions
Pregnancy
Consult your doctorXYLOCAINE 2% INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving XYLOCAINE 2% INJECTION.
Breastfeeding
Consult your doctorXYLOCAINE 2% INJECTION should be used for breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving XYLOCAINE 2% INJECTION if you are breastfeeding.
Driving and Using Machines
Use with CautionXYLOCAINE 2% INJECTION may make you feel dizzy or drowsy for some time after administration. Therefore, do not drive or operate any heavy tools or machines if your abilities are affected by XYLOCAINE 2% INJECTION.
Alcohol
Consult your doctorAvoid the consumption of alcohol before receiving XYLOCAINE 2% INJECTION.
Kidney
Use with CautionXYLOCAINE 2% INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
Use with CautionXYLOCAINE 2% INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedInform your doctor before receiving XYLOCAINE 2% INJECTION if you are allergic to lignocaine or to any other local anaesthetics (such as bupivacaine).
Lungs
Use with CautionXYLOCAINE 2% INJECTION should be used with caution in patients with breathing disorders (such as asthma or COPD). Therefore, consult your doctor before receiving it.
Heart Disease
Consult your doctorXYLOCAINE 2% INJECTION is not recommended for use in patients with heart diseases (such as heart block, an abnormal heartbeat, or a very slow heartbeat). It should be used with caution in patients with other heart disorders. Therefore, consult your doctor before receiving it.
Use In Pediatrics
Consult your doctorXYLOCAINE 2% INJECTION should be used in children and adolescents (aged below 18 years) only if it is considered necessary by the physician. It is not recommended for use in neonates aged less than 1 month. Therefore, consult your doctor for advice before administration.
Use In Geriatrics
Use with CautionXYLOCAINE 2% INJECTION should be used with caution with elderly patients. Therefore, consult your doctor for advice before receiving it.
Others
XYLOCAINE 2% INJECTION is not recommended for use if you:
- have low blood volume
- have porphyria (an inherited blood disorder)
Before receiving XYLOCAINE 2% INJECTION, inform your physician if you:
- are feeling sick or tired for no reason
- have epilepsy (fits)
- have glaucoma
- have low potassium levels in the blood, causing muscle cramps and constipation
- recently had vomiting, diarrhea, or excessive blood loss
- are not drinking enough amount of water
- have too much acidity in the blood
- have any skin infection (with pus) in and around the areas where the medicine is planned to be administered
- have problems thinking or reasoning
- have myasthenia gravis (severe muscle weakness or tenderness)
- have stroke
- have an imbalance in the constituents of the blood
- have a blood disorder
Interactions
A. Drug-Drug interactions:
Before receiving XYLOCAINE 2% INJECTION, inform your doctor if you are receiving any of the following medicines:
- halothane (used to cause unconsciousness before a surgical procedure)
- medicines used to manage heart problems such as hypertension, angina, or abnormal heart rate (Ex. atenolol, propranolol, verapamil, amlodipine, nifedipine, amiodarone, and mexiletine)
- diuretics (used to reduce edema and blood pressure) Ex. furosemide, spironolactone, and hydrochlorothiazide
- medicines used to manage HIV infection (Ex. ritonavir, nelfinavir)
- medicines used to manage psychotic disorders (such as chlorpromazine, pimozide, sertindole, olanzapine, quetiapine, and zotepine)
- suxamethonium (used to relax muscles)
- opioid analgesics (used for pain relief) Ex. morphine, pethidine, and fentanyl
- dolasetron (used to manage nausea and vomiting)
- cimetidine (used to manage heartburn and stomach ulcers)
- acetazolamide (used to manage increased eye pressure)
- quinupristin and dalfopristin (used to manage bacterial infections)
- oral contraceptives (birth control pills) Ex. drospirenone, ethinyl estradiol
Overdosage:
XYLOCAINE 2% INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness, numbness of the tongue, or a ringing sound in the ears.
Synopsis
| Drug | : | Lignocaine |
| Pharmacological Category | : | Voltage Gated Sodium Channel Blockers |
| Therapeutic Indication | : | Local anesthesia, Arrythmia |
| Dosage Forms | : | Injection, Gel, Cream, Ointment, Jelly, Topical Solution, Spray, Oral solution, Plaster |
More Information
- Keep XYLOCAINE 2% INJECTION out of reach of children
- Store XYLOCAINE 2% INJECTION at room temperature
FAQs About XYLOCAINE 2% INJECTION
Q: How long will it take for XYLOCAINE 2% INJECTION to induce numbness?
A: It may take around 2–5 minutes for XYLOCAINE 2% INJECTION to create numbness in body parts. However, this period may vary from person-to-person based on the dose and amount of the XYLOCAINE 2% INJECTION that is administered to you.
Q: Is XYLOCAINE 2% INJECTION a narcotic medicine?
A: No. XYLOCAINE 2% INJECTION is not a narcotic. It is a local anaesthetic agent that is used to create a loss of sensation (numbness) in certain body parts following administration.
Q: Can XYLOCAINE 2% INJECTION affect blood pressure?
A: Yes. XYLOCAINE 2% INJECTION may cause changes in blood pressure (high or low blood pressure), so if you experience any unusual symptoms, like feeling extremely dizzy or lightheaded after receiving XYLOCAINE 2% INJECTION, consult your doctor.
Q: What are the common side effects of XYLOCAINE 2% INJECTION?
A: The most common side effects of receiving XYLOCAINE 2% INJECTION are nausea, slow heart rate, dizziness, lower back pain, difficulty walking, and an inability to control urine or bowel movements. Inform your doctor if any of these side effects worsen.
Q: What are the symptoms that could appear if I received an excessive amount of XYLOCAINE 2% INJECTION?
A: XYLOCAINE 2% INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include light-headedness, numbness of the tongue, or a ringing sound in the ears.
Q: Can XYLOCAINE 2% INJECTION be used with children?
A: Yes. XYLOCAINE 2% INJECTION is used in children and in adolescents (aged between 18 years) only if it is considered necessary by the physician. It is not recommended for use in neonates aged below 1 month due to a lack of safety data.
Q: Can XYLOCAINE 2% INJECTION cause nerve damage?
A: Yes. XYLOCAINE 2% INJECTION may cause nerve damage when administered in excess. Therefore, inform your doctor if you experience signs of nerve damage (such as tingling in the hands and feet) while receiving XYLOCAINE 2% INJECTION.
Q: Is XYLOCAINE 2% INJECTION safe for use by pregnant women?
A: XYLOCAINE 2% INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving XYLOCAINE 2% INJECTION.
Q: How long do the effects of XYLOCAINE 2% INJECTION last in the body?
A: The effects of XYLOCAINE 2% INJECTION may last about 10–20 minutes after intravenous administration and for about 60–90 minutes after intramuscular administration. However, the recovery period may vary from person-to-person based on the dose and amount of the XYLOCAINE 2% INJECTION that is administered to you.
References
1. KD. Tripathi. Drugs acting on peripheral (somatic) nervous system. Essentials of medical pharmacology. 8th Edition. 2019. Page – 392.
2. Weinberg L, Peake B, Tan C and Nikfarjam M. Pharmacokinetics and pharmacodynamics of lignocaine: A review. World Journal of Anesthesiology. July 2015. [Accessed on 8th September 2022] https://www.wjgnet.com/2218-6182/full/v4/i2/17.htm
3. JOSE E. USUBIAGA, WILLIAM GUSTAFSON, FRANK MOYA AND BURTON GOLDSTEIN Departments of Anesthesiology and Psychiatry, University of Miami, School of Medicine and Jackson Memorial Hospital, Miami, Florida, US.A. The Effect of Intravenous Lignocaine on Cardiac Arrhythmias During Electroconvulsive Therapy. British Journal of Anesthesia. [Accessed on 8th September 2022] https://www.bjanaesthesia.org.uk/article/S0007-0912(17)51889-9/pdf
4. Mercury Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.4781.pdf
5. Hameln pharma ltd. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.6277.pdf
6. Mercury Pharmaceuticals (Ireland) Ltd. Electronic Medicines Compendium (EMC). [Revised in April 2016] [Accessed on 8th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/2143491.PA0073_112_006.8f88df24-b092-4c3b-bf3f-294aa775a103.000001Lidocaine%20Hydrochloride%202%20PIL.170524.pdf
7. Innovative Pharmaceuticals Pvt Ltd. LIGNOCIN Injection 30ml. [Accessed on 8th September 2022] https://www.innovativepharma.in/product/lignocin-injection/
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