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Introduction About XONE XP 1.125GM INJECTION
XONE XP 1.125GM INJECTION is a combination of Ceftriaxone and Tazobactam which belongs to the group of medicines called Antibiotics. It is used to manage several bacterial infections like lower respiratory tract infections such as pneumonia, acute bacterial otitis media lower respiratory tract infections, pneumonia, infection in the ear, skin, urinary tract infections, gonorrhoea, pelvic inflammatory disease, bacterial septicaemia, bone and joint infections, intra-abdominal infections, including peritonitis and biliary tract infections, bacterial meningitis, surgical prophylaxis (pre-operative antibiotics, infections in neutropenic patients).
Pneumonia is an infection which causes inflammation in the air sac producing cough with phlegm and shortness of breath. Urinary tract infection affects the urinary bladder later gets spreads to the kidneys. Bacteraemia is an infectious condition indicating presence of bacteria in the blood stream. Bacterial meningitis is an infection caused by bacteria in the region surrounding the brain. Neutropenic is low levels of neutrophils (a type of white blood cells) in our body.
Inform your doctor or your health- care professional before any laboratory tests as XONE XP 1.125GM INJECTION will interact with medical investigations. Inform your doctor if you are allergic to any antibiotics or to any other medicines.
XONE XP 1.125GM INJECTION should not be used in patients allergic to penicillin antibiotics, cefepime, tazobactam and other beta-lactam antibiotics.
XONE XP 1.125GM INJECTION should be used with caution in patients with or history of allergic reactions, diarrhoea, gastrointestinal disease (colitis) kidney and liver diseases.
Avoid concomitant use of other antibiotics and diuretics along with XONE XP 1.125GM INJECTION. XONE XP 1.125GM INJECTION should be used with caution in pregnant and breast-feeding women. Consult your doctor before receiving the medicine.
XONE XP 1.125GM INJECTION should be used with caution in new-borns, children and adolescents. XONE XP 1.125GM INJECTION is not recommended for use in pre-mature babies and in children with or history of jaundice and hyperbilirubinemia. Consult your doctor before receiving the medicine.
XONE XP 1.125GM INJECTION should be used with caution in elderly people. The common side effect of receiving XONE XP 1.125GM INJECTION are diarrhoea, nausea, vomiting and skin allergies. Consult your doctor if any of the above side effects worsen or persist for a longer duration.
Uses Of XONE XP 1.125GM INJECTION
It is used to manage bacterial infections such as:
- lower respiratory tract infections
- pneumonia
- infection in the ear
- skin infections
- complicated and uncomplicated urinary tract infections
- sexually transmitted disease (gonorrhoea affecting cervix, urethra and rectal)
- pelvic inflammatory disease (infection affecting reproductive organs)
- bacterial septicaemia
- bone and joint infections
- intra-abdominal infections (peritonitis and biliary tract infections)
- bacterial meningitis
- surgical prophylaxis (pre-operative antibiotics)
- infections in neutropenic patients
How XONE XP 1.125GM INJECTION Works
XONE XP 1.125GM INJECTION works by destroying the bacterial growth responsible for causing infections. XONE XP 1.125GM INJECTION have combination of Ceftriaxone and Tazobactam where Ceftriaxone works by interrupting the cell wall formation by binding with the enzymes responsible for cell wall synthesis. This binding causes defects in the cell wall leading to cell death causing death of the organism. Tazobactam present in XONE XP 1.125GM INJECTION is responsible for the irreversible termination of enzymes (beta- lactamases) that protect the organism from antibiotics. Thus, produces less anti-bacterial actions when given alone so it’s always used in combination with other antibiotics. Thus, both the substances works by inhibiting the bacterial growth.
How to use XONE XP 1.125GM INJECTION
XONE XP 1.125GM INJECTION will be administered into the vein (intravenously) or into the muscle (intramuscularly) by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of XONE XP 1.125GM INJECTION
Common
- abnormal cell count in blood
- diarrhoea
- nausea, vomiting
- elevations of liver enzymes
- skin allergies
Uncommon
- headache
- dizziness
- increased creatinine, abnormal discharge in urine
- vaginal infections (in women)
- increased sweating, hot flush
- taste changes
Rare
- breathing difficulty, swelling in face or tongue
- sore mouth, voice changes
- decreased urine, glucose, blood in urine
How To Manage Side Effects
Nausea or Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods. Avoid fried, greasy or sweet foods. Eat slowly and eat smaller, more frequent meals, drinking gradually larger amounts of clear liquids, avoid solid food until the vomiting episode has passed, take rest. If the symptom does not improve, contact your doctor.
Warning & Precautions
Pregnancy
XONE XP 1.125GM INJECTION should be used with caution in pregnant women only if clearly needed. Consult your doctor before taking XONE XP 1.125GM INJECTION.
Breastfeeding
XONE XP 1.125GM INJECTION should be used with caution in breastfeeding women as it may pass into the breast milk. Consult your doctor before taking XONE XP 1.125GM INJECTION.
Driving and Using Machines
Do not drive or handle heavy machines if you experience side effects like dizziness, drowsiness, tired or if you have blurred vision while taking this XONE XP 1.125GM INJECTION.
Alcohol
Consumption of alcohol is not recommended during management with XONE XP 1.125GM INJECTION.
Kidney
XONE XP 1.125GM INJECTION should be used with caution in patients with kidney disease. Consult your doctor before taking XONE XP 1.125GM INJECTION.
Liver
XONE XP 1.125GM INJECTION should be used with caution in patients with liver disease. Consult your doctor before taking XONE XP 1.125GM INJECTION.
Allergy
Do not take if you are allergic to Ceftriaxone, Tazobactam, other beta- lactam or any other ingredients of this medicine.
Lungs
XONE XP 1.125GM INJECTION should be used with caution in patients with pneumonia. Consult your doctor before taking.
Others
Before taking XONE XP 1.125GM INJECTION inform your doctor if you:
- have or ever had allergic reactions
- have diarrhoea
- have or had gastrointestinal disease (colitis)
Use in pediatrics:
XONE XP 1.125GM INJECTION is not recommended for use in premature new-born babies and in children with or history of jaundice and hyperbilirubinemia. If needed your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking it.
Use in geriatrics:
XONE XP 1.125GM INJECTION should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking XONE XP 1.125GM INJECTION, inform your doctor if you are taking any of the following medicine:
- other antibiotics used to manage bacterial infections (Ex. chloramphenicol)
- medicines used to manage fluid accumulation (Ex. furosemide)
- probenecid (used to manage gout)
- disulfiram (used to manage alcohol dependence)
- medicines used to manage pregnancy (Ex. ethinyl estradiol, estradiol)
Overdosage:
If you or anyone else accidentally took more of XONE XP 1.125GM INJECTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include nausea, vomiting and diarrhoea.
Synopsis
| Drug | : | Ceftriaxone, Tazobactam |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial Infections |
| Dosage Forms | : | Injection |
More Information
- Keep XONE XP 1.125GM INJECTION out of reach of children
- Store at room temperature below 30°C
FAQs About XONE XP 1.125GM INJECTION
Q: Does XONE XP 1.125GM INJECTION cause any side effect?
A: The common side effect of receiving XONE XP 1.125GM INJECTION are diarrhoea, nausea, vomiting and skin allergies. Consult your doctor if any of the above side effects worsen or persist for a longer duration.
Q: What is XONE XP 1.125GM INJECTION used for?
A: XONE XP 1.125GM INJECTION is used in the management of various bacterial infections affecting the respiratory tract (such as pneumonia), ears (acute bacterial otitis media), skin, urinary tract (such as gonorrhoea), blood (bacterial septicaemia), bone and joints, stomach (such as peritonitis and biliary tract infections), brain (bacterial meningitis). It can also be used for surgical prophylaxis and to support immune functions among neutropenic patients.
Q: Can XONE XP 1.125GM INJECTION be used in children?
A: XONE XP 1.125GM INJECTION is not recommended for use in premature new-born babies and in children with or history of jaundice and hyperbilirubinemia. If needed your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking it.
Q: How long will XONE XP 1.125GM INJECTION take to act?
A: XONE XP 1.125GM INJECTION will start working once it is injected in the blood stream. It will work faster compared with oral antibiotics as it is injected directly into the blood stream. However full course of antibiotic should be given to obtain its efficacy. Your doctor will decide the dose adjustments and termination of the medicine depending upon your health condition.
Q: Is XONE XP 1.125GM INJECTION safe?
A XONE XP 1.125GM INJECTION is safe if used as advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if you experience any side effects.
Q: Is XONE XP 1.125GM INJECTION an antibiotic?
A Yes, XONE XP 1.125GM INJECTION is an antibiotic medicine containing ceftriaxone and Tazobactum as active ingredients.
Q: Does XONE XP 1.125GM INJECTION affect laboratory test results?
A XONE XP 1.125GM INJECTION may interfere with urine test (for sugar) and blood test giving false-positive results. Therefore, if you are about to undergo any laboratory tests, inform your doctor.
Q: Does XONE XP 1.125GM INJECTION cause diarrhoea?
A: XONE XP 1.125GM INJECTION may cause diarrhoea as a common side effect. However, if the condition persists, worsens or notices blood or mucus in stools, consult a doctor immediately.
Q: Is XONE XP 1.125GM INJECTION used to manage viral infections?
A: No, XONE XP 1.125GM INJECTION is not used to manage viral infections. It is an antibiotic which is used to manage only bacterial infections.
Q: Is XONE XP 1.125GM INJECTION safe for patients with kidney problems?
A XONE XP 1.125GM INJECTION should be used with caution in patients with kidney problems as it may increase the risk of adverse effects. Therefore, Consult your doctor before taking it. Your doctor will evaluate your health condition and prescribe the suitable dosage for you.
Q: What is the route of administration of XONE XP 1.125GM INJECTION?
A: XONE XP 1.125GM INJECTION will be administered into the vein (intravenously) or into the muscle (intramuscularly) by your doctor or nurse.
References
1. K.D. Tripathi Beta-Lactam Antibiotics Essentials of Pharmacology seventh edition 2013 Page no -727, 725.
2. S.M. Shrivastava Comparative study of efficacy of fixed dose combination of ceftriaxone sulbactam and ceftriaxone tazobactam October 2009 Journal of Pure and Applied Microbiology. [Accessed on 14th June 2022] https://www.researchgate.net/publication/288200470_Comparative_study_of_efficacy_of_fixed_dose_combination_of_ceftriaxone_sulbactam_and_ceftriaxone_tazobactam
3. Biocon Limited. [Accessed on 14th June 2022] https://www.biocon.com/docs/prescribing_information/ccd/supravatz_pi.pdf
4. Cipla med. [Revised in March 2014] [Accessed on 14th June 2022] https://www.ciplamed.com/print-product-pdf/23645
5. Cipla med. [Revised in November 2013] [Accessed on 14th June 2022] https://www.ciplamed.com/print-product-pdf/24155
6. Zuventus healthcare Ltd. [Accessed on 14th June 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=76
7. Abbott. [Accessed on 14th June 2022] https://www.abbott.in/products.f.html#tabsComp
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