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Introduction About VORIER 200MG INJECTION
VORIER 200MG INJECTION contains Voriconazole which belongs to the group of medicines called Antifungal agents. It is used to manage various fungal infections (such as invasive aspergillosis, candidaemia, invasive Candida sp. infections) in both adults and in children (aged 2 years or above). It can also be used to manage fungal infections in high-risk bone marrow transplant recipients.
VORIER 200MG INJECTION is highly intended for patients with worsening or life-threatening fungal infections. It is important to complete the full course of therapy with VORIER 200MG INJECTION to achieve better control over infection.
Before receiving VORIER 200MG INJECTION inform your doctor if you have any liver or heart problems. Do not receive VORIER 200MG INJECTION if you are pregnant or breast-feeding without consulting your doctor.
Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VORIER 200MG INJECTION. During management with VORIER 200MG INJECTION, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
The most common side-effects of receiving VORIER 200MG INJECTION are visual impairment, fever, rash, nausea, vomiting, diarrhoea, headache, swelling of the extremities, stomach pain and breathing difficulties. Consult your doctor if any of these side effect troubles you.
Uses Of VORIER 200MG INJECTION
It is used in adults and in children (aged 2 years or older) to:
- Manage and manage severe fungal infections
How VORIER 200MG INJECTION Works
VORIER 200MG INJECTION is an antifungal medication. It effectively controls fungal infections within the body. It disrupts the fungal cell membrane by blocking the production of certain chemicals (ergosterol) within the cell which is required for its survival. As a result, it stops the fungal cell from multiplication, thereby managing the further spread of infection.
How to use VORIER 200MG INJECTION
VORIER 200MG INJECTION will be administered to you only by a doctor or a nurse into the vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not skip doses or stop therapy with VORIER 200MG INJECTION without consulting your doctor.
Side Effects Of VORIER 200MG INJECTION
Common
- vision problems (such as blurred vision, colour changes, light sensitivity)
- fever, chills, weakness
- headache, dizziness, sleepiness
- nausea, vomiting, diarrhoea, stomach pain
- constipation, indigestion
- swelling of the extremities
- inflammation of the sinuses
- low RBC, WBC and platelet count in blood
- low blood sugar levels, low blood pressure
- low blood potassium or sodium levels
- breathing difficulties
- anxiety, depression, inability to sleep
- fits
- hair loss
Uncommon
- enlarged lymph glands
- problems in adrenal gland
- underactive thyroid gland
- shaking or Parkinsonism
- abnormal sense of taste
- hearing difficulties, vertigo, ringing in the ears
- increased blood cholesterol and urea levels
Rare
Contact your doctor immediately if you experience any of the following side effects while or after receiving VORIER 200MG INJECTION:
- signs of allergic reactions (such as severe skin rash with itching, blistering and peeling of the skin, mouth, eyes, throat, genitals, swelling of the face and tongue, bleeding under the skin causing appearance of red-pin point dots on the skin, skin swelling, along with fever, tiredness, confusion or jaundice)
- skin rashes, sun burn
- bone pain, inflammation of the tissue surrounding the bone
- skin cancer
- red, scaly patches or ring-shaped skin lesions
- jaundice (yellowing of the skin and whites of the eye)
- signs of adrenal insufficiency (such as severe tiredness, weak muscles, loss of appetite, weight loss, stomach pain)
- signs of Cushing’s syndrome (such as round face, weight gain, fatty hump between the shoulders, dark skin, skin thinning, easy bruising, high blood sugar levels, excessive hair growth and excessive sweating)
How To Manage Side Effects
Nausea or vomiting:
Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
VORIER 200MG INJECTION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with VORIER 200MG INJECTION.
Breastfeeding
VORIER 200MG INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving it.
Driving and Using Machines
Do not drive or operate any machines if you experience vision problems after receiving VORIER 200MG INJECTION.
Liver
VORIER 200MG INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
Talk to your doctor before receiving VORIER 200MG INJECTION if you are allergic to Voriconazole or to any other azole antifungal agents (such as fluconazole, ketoconazole).
Heart Disease
VORIER 200MG INJECTION should be used with caution in patients with heart problems (such as cardiomyopathy, irregular or slow heart rate, prolong QT interval). Therefore, consult your doctor before receiving it.
Others
Use in paediatrics:
VORIER 200MG INJECTION is not recommended for use in children under 2 years of age. Therefore, consult your doctor before receiving it.
Use in geriatrics:
VORIER 200MG INJECTION can be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
Interactions
A. Drug – Drug Interactions:
Before receiving VORIER 200MG INJECTION, inform your doctor if you are taking any of the following medicines such as:
- medicines used for allergy (Ex. terfenadine, astemizole)
- medicines used for symptoms of chronic heart failure (Ex. ivabradine)
- medicines used for stomach problems (Ex. cisapride)
- medicines used for managing mental illness (Ex. pimozide, phenytoin, phenobarbital, midazolam, triazolam and lurasidone)
- carbamazepine, phenytoin (medicines used to manage fits)
- medicines used for irregular heartbeat (Ex. quinidine)
- medicines used for managing tuberculosis (Ex. rifampicin, rifabutin)
- medicines used for managing HIV (Ex. efavirenz, ritonavir, efavirenz, delavirdine, nevirapine)
- medicines used for migraine (Ex. ergotamine, dihydroergotamine)
- medicines used in transplant patients (Ex. sirolimus, ciclosporin, tacrolimus)
- St. John’s Wort (herbal supplement used to manage depression)
- medicines used to manage constipation (Ex. naloxegol)
- medicines used to manage hyponatremia (Ex. tolvaptan)
- medicines used in managing patients with blood cancer (Ex. venetoclax)
- medicines used for managing cancer (Ex. glasdegib, vincristine, vinblastine)
- warfarin (a medicine used to manage blood clotting)
- medicines used for diabetes (Ex. tolbutamide, glipizide, glyburide)
- medicines used for lowering cholesterol (Ex. atorvastatin, simvastatin)
- medicines used for managing stomach ulcers (Ex. omeprazole)
- oral contraceptives (used to manage pregnancy) Ex. ethinylestradiol
- medicines used to manage drug addiction (Ex. methadone)
- painkillers used for surgical procedures (Ex. alfentanil, fentanyl, sufentanil)
- medicines used to manage moderate to severe pain (Ex. oxycodone, hydrocodone, ibuprofen, diclofenac)
- other medicines used to manage fungal infections (Ex. fluconazole)
- medicines used for managing advanced kidney cancer and in transplant patients (Ex. everolimus)
- medicine used for managing cytomegalovirus (CMV) disease after bone marrow transplant (Ex. letermovir)
- medicines used to manage cystic fibrosis (Ex. ivacaftor)
Overdosage:
VORIER 200MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Voriconazole |
| Pharmacological Category | : | Azole Antifungal agents |
| Therapeutic Indication | : | Fungal infections |
| Dosage Forms | : | Tablet, Injection, Eye Drops |
More Information
- Keep VORIER 200MG INJECTION out of reach of children
- Store VORIER 200MG INJECTION at room temperature
FAQs About VORIER 200MG INJECTION
What is the use of VORIER 200MG INJECTION?
VORIER 200MG INJECTION is used to manage various fungal infections (such as invasive aspergillosis, candidaemia, invasive Candida sp. infections) in both adults and in children (aged 2 years or above). It can also be used to manage fungal infections in high-risk bone marrow transplant recipients.
How VORIER 200MG INJECTION works?
VORIER 200MG INJECTION is an antifungal medication. It effectively controls fungal infections within the body. It disrupts the fungal cell membrane by blocking the production of certain chemicals (ergosterol) within the cell which is required for its survival. As a result, it stops the fungal cell from multiplication, thereby managing the further spread of infection.
How long should I receive VORIER 200MG INJECTION?
You need to receive therapy with VORIER 200MG INJECTION for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Is VORIER 200MG INJECTION safe?
VORIER 200MG INJECTION is safe at doses prescribed by the physician. Therefore, do not alter the dose of VORIER 200MG INJECTION without consulting your doctor.
Can I stop receiving VORIER 200MG INJECTION without consulting your doctor?
No. You should not stop receiving VORIER 200MG INJECTION without consulting your doctor as it may reduce its effectiveness. Therefore, receive VORIER 200MG INJECTION for the stipulated duration recommended by your doctor to achieve maximum results.
Will receiving a higher dose of VORIER 200MG INJECTION be more effective?
No, receiving a higher dose of VORIER 200MG INJECTION will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can VORIER 200MG INJECTION be used in pregnant women?
VORIER 200MG INJECTION is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before receiving it.
References
1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 795.
2. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Voriconazole. [Accessed on 22nd November 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Voriconazole
3. Aspire Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in February 2022]. [Accessed on 22nd November 2022]. https://www.medicines.org.uk/emc/files/pil.12389.pdf
Useful Diagnostic Tests
- Complete Blood Count
- Liver Function Test
- Kidney Function Test
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