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Introduction About VISVIN 30 INJECTION
VISVIN 30 INJECTION contains Decitabine which belongs to the group of medicines called Anti-cancer agents. It is used in adults to manage myelodysplastic syndromes (MDS-group of cancers associated with blood and bone marrow) and acute myeloid leukemia (cancer of blood cells).
Before receiving VISVIN 30 INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low RBC, WBC or platelet count in blood or currently have any infection as a precaution. VISVIN 30 INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with this medicine. Men may seek advice on sperm preservation, if necessary, prior to the therapy with this medicine.
The most common side effects of receiving VISVIN 30 INJECTION are increased bleeding, increased infections, tiredness, nausea, vomiting, diarrhea, headache, sore nose and throat, and ulcers of mouth or tongue. Consult your doctor if any of these side effects trouble you.
Uses Of VISVIN 30 INJECTION
It is used in adults to manage:
Myelodysplastic Syndromes (MDS-group of cancers associated with blood and bone marrow)
- Acute Myeloid Leukaemia (AML-blood cancer of WBC)
How VISVIN 30 INJECTION Works
VISVIN 30 INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.
How to use VISVIN 30 INJECTION
VISVIN 30 INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of VISVIN 30 INJECTION
Common
- Urine infection
- Increased infection (bacterial, viral, or fungal)
- Increased bleeding or bruising tendency
- Low RBC count causing anemia, tiredness and pale skin
- Increased blood sugar levels
- Headache
- Nasal bleed
- Vomiting
- Nausea
- diarrhea
- Sore or runny nose, sore sinuses
- Sore mouth or tongue
- Increased level of bilirubin in the blood
Uncommon
- Red, raised painful patches on the skin along with fever and an increase in the number of white blood cells – indicative of ‘Acute Febrile Neutrophilic Dermatosis’ or ‘Sweet’s Syndrome’
Consult your doctor immediately if you experience any of the following side effects after receiving VISVIN 30 INJECTION:
- Signs of increased infections such as fever due to low WBC count in blood
- Swelling of hands, legs and feet with chest pain
- Lung infections causing fever, chest pain and shortness of breath
- Bleeding within the head or bleeding within the stomach causing bloody stools, bloody urine, or bleeding under the skin causing red pinpoints dots to appear on the skin
- Signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing, fainting)
- Signs of serious immune reaction (such as fever, cough, difficulty in breathing, skin rashes, low urine output, hypotension, swelling of the arms or legs and rapid weight gain)
How To Manage Side Effects
Diarrhea
Stick to simple meals. Avoid eating oil rich or spicy food. Drinking Oral Rehydration Solution can be beneficial. Consult your doctor if diarrhea persists for long or worsens with time.
Headache
Take rest and drink plenty of fluids. Do not drink too much alcohol. Ask your doctor to recommend a painkiller. It is recommended to talk to your doctor if they last for a longer duration or are severe in nature.
Nausea And Vomiting
Expose yourself to fresh air. Drink plenty of water or fruit juices and take lot of rest. Avoid listening to music or watching a screen. Keep regular fluid intake. Prefer taking ginger or peppermint tea. Eat small and frequent meals.
Sore Throat
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Warning & Precautions
Pregnancy
ContraindicatedVISVIN 30 INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, inform your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive to avoid pregnancy while undergoing therapy with VISVIN 30 INJECTION and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving VISVIN 30 INJECTION, inform your doctor immediately.
Breastfeeding
ContraindicatedVISVIN 30 INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving it.
Driving and Using Machines
Use with CautionVISVIN 30 INJECTION may cause tiredness or weakness. Therefore, do not drive or operate any machines if your ability is affected by VISVIN 30 INJECTION.
Kidney
Use with CautionVISVIN 30 INJECTION should be used with caution in patients with kidney diseases. Therefore, inform your doctor before receiving it.
Liver
Use with CautionVISVIN 30 INJECTION should be used with caution in patients with liver diseases. Therefore, inform your doctor before receiving it.
Allergy
ContraindicatedTalk to your doctor before receiving VISVIN 30 INJECTION if you are allergic to decitabine.
Heart Disease
Use with CautionVISVIN 30 INJECTION should be used with caution in patients with heart diseases. Therefore, inform your doctor before receiving it.
Use In Pediatrics
ContraindicatedVISVIN 30 INJECTION is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use In Geriatrics
Use with CautionVISVIN 30 INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
Others
Inform your doctor, before receiving VISVIN 30 INJECTION, if you:
- Have low RBC, WBC or platelet count in blood
- Have any active infection in the body
Interactions
A. Drug-Drug Interactions:
Before receiving VISVIN 30 INJECTION, inform your doctor about all the prescription medicines, non-prescription medicines and over-the counter health or herbal supplements taken by you as a precaution.
Overdosage:
VISVIN 30 INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual side effects.
Synopsis
| Drug | : | Decitabine |
| Pharmacological Category | : | Cytidine Analogs |
| Therapeutic Indication | : | Blood cancer, Myelodysplastic syndromes |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep VISVIN 30 INJECTION out of reach of children
- Store VISVIN 30 INJECTION at room temperature
FAQs About VISVIN 30 INJECTION
Q: What is VISVIN 30 INJECTION used for?
A. VISVIN 30 INJECTION is an anticancer drug used to manage myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and acute myeloid leukemia (cancer of blood cells).
Q: Is it safe to use VISVIN 30 INJECTION in teenagers?
A: VISVIN 30 INJECTION is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Q: How does VISVIN 30 INJECTION works?
A: VISVIN 30 INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it manages abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.
Q: Can I take VISVIN 30 INJECTION during breastfeeding?
A: No. VISVIN 30 INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.
Q: Can VISVIN 30 INJECTION increase the risk of infections?
A: VISVIN 30 INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving VISVIN 30 INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.
Q: Can the use of VISVIN 30 INJECTION make me feel tired?
A: Yes. VISVIN 30 INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving VISVIN 30 INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.
Q: Can I drive a car after receiving VISVIN 30 INJECTION?
A: VISVIN 30 INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by VISVIN 30 INJECTION.
Q: How VISVIN 30 INJECTION is administered?
A: VISVIN 30 INJECTION will be given to you only by a doctor into the vein (intravenously).
Q: How to control nausea caused due to VISVIN 30 INJECTION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with VISVIN 30 INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-manage nausea.
Q: Can VISVIN 30 INJECTION manage cancer?
A: The manage rate of cancer depends upon the severity of the disease. However, VISVIN 30 INJECTION acts by managing the abnormal growth and multiplication of cancer cells in the body, which may help in managing cancer completely.
Q: Can the use of VISVIN 30 INJECTION cause hair loss?
A: Hair loss is one of the uncommon side effects of receiving VISVIN 30 INJECTION. This side effect is usually temporary and disappears once after therapy with this medicine stops completely. If it bothers you, consult your doctor for advice.
Q: Is VISVIN 30 INJECTION a chemo drug?
A: Yes. VISVIN 30 INJECTION contains a medicine called Cabozantinib which is a chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.
Q: What happens if I stop undergoing therapy with VISVIN 30 INJECTION?
A: No. Do not stop therapy with VISVIN 30 INJECTION without consulting your doctor as it may make your symptoms reappear. Therefore, take VISVIN 30 INJECTION as advised by your doctor for the stipulated duration.
References
1. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. Chemotherapy of Neoplastic Diseases. 12th Edition. Page-1700.
2. Jabbour E, Issa JP, Garcia-Manero G, Kantarjian H. Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies. Cancer. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. June 2008. [Accessed on 30th March 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784235/#:~:text=Decitabine%20(5%2Daza%2D2,and%20cytotoxicity%20at%20high%20doses.
3. Janssen Pharmaceutica NV. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 30th March 2023] https://www.medicines.org.uk/emc/files/pil.2838.pdf
4. MSN Laboratories Private Limited. Decitabine. [Revised in August 2019] [Accessed on 30th March 2023] http://novadozpharma.com/wp-content/uploads/2019/09/Decitabine_Injection_Leaflet.pdf
5. Central Drugs Standard Control Organization. Decitabine Lyophilized powder for injection 50mg/20ml vial. April 2009 and April 2014. Decitabine injection 30mg/vial. February 2015. [Accessed on 1st April 2023] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Complete Blood Count (CBC)
- Liver Function Test
- Kidney Function Test
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