VINGLYN D 10 Tablet 10's

Introduction About VINGLYN D 10 TABLET

VINGLYN D 10 TABLET is a combination medication used to manage blood sugar levels in adults with type 2 diabetes mellitus which is poorly controlled on metformin monotherapy. Along with a healthy diet and regular exercise, it helps improve blood sugar control by enhancing the proper use of insulin, thereby reducing blood sugar levels effectively.

VINGLYN D 10 TABLET can be taken with or without food at any time of the day, but it’s important to take it consistently at the same time each day. The dosage is determined by your doctor, and it’s crucial not to stop taking it without consulting them, as this could lead to increased blood sugar levels and serious complications like kidney damage or vision problems. It works best as part of a comprehensive diabetes management plan, including weight control, as recommended by your doctor.

Common side effects include low blood sugar (hypoglycemia), urinary tract infections, vaginal inflammation, dizziness, tremors, and headaches. Drinking plenty of fluids can help prevent dehydration, and maintaining good hygiene may reduce the risk of genital fungal infections.

Before starting VINGLYN D 10 TABLET, inform your doctor if you have kidney or liver issues, urinary tract infections, or if you are taking diuretics (water pills). Pregnant or breastfeeding women should consult their doctor before use. Limit alcohol consumption to avoid an increased risk of side effects and monitor your blood sugar levels regularly while on this treatment.

Uses Of VINGLYN D 10 TABLET

• Type II diabetes mellitus

How VINGLYN D 10 TABLET Works

VINGLYN D 10 TABLET contains two active ingredients: Dapagliflozin and Vildagliptin, which work together to manage blood sugar levels in type 2 diabetes. Dapagliflozin is an SGLT2 inhibitor that reduces blood sugar by blocking the reabsorption of glucose in the kidneys, allowing excess sugar to be removed from the body through urine. This helps lower blood sugar levels, especially fasting glucose, and can also assist in weight management and lowering blood pressure.

Vildagliptin is a DPP-4 inhibitor that enhances the body’s natural hormones involved in blood sugar control. It increases insulin secretion in response to meals and reduces the release of glucagon, a hormone that raises blood sugar. This dual action helps stabilize blood sugar levels after eating and throughout the day, providing effective glycemic control when used alongside a healthy diet and exercise. Together, these components complement each other to improve overall diabetes management.

How to use VINGLYN D 10 TABLET

• Take VINGLYN D 10 TABLET exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water, preferably at the same time each day to maintain consistent blood sugar levels.
• VINGLYN D 10 TABLET can be taken with or without food.
• Do not crush, chew, or break the tablet.
• Follow your doctor’s instructions regarding the dosage and duration of use.
• Continue taking the medication regularly, even if you feel better, and do not stop without consulting your doctor, as this could lead to uncontrolled blood sugar levels.
• Ensure to follow a healthy diet, exercise regularly, and monitor your blood sugar levels as advised.

Side Effects Of VINGLYN D 10 TABLET

Like all medicines, VINGLYN D 10 TABLET may cause side effects, although not everybody gets them

Common Side Effects of VINGLYN D 10 TABLET are:

• Dizziness
• Genital infection (thrush) of penis or vagina (itching, irritation, unusual discharge, or odour)
• Back pain
• Frequent or excessive urination than normal
• Rash
• Changes in the blood cholesterol or fat level
• Increased amount of red blood cells
• Decrease in creatinine renal clearance in the beginning of management
• Headache

• Constipation, heartburn
• Swelling of hands, feet or ankle and joint pain
• Dehydration or loss of too much body fluid (very dry or sticky mouth, fast heartbeat, little or no urination)
• Thirst
• Waking in between sleep at night to pass urine
• Weight loss
• Increased urea and creatinine levels

Stop taking VINGLYN D 10 TABLET and contact your doctor immediately if you experience any of the following side effects:

• Angioedema (swollen face, throat or tongue, trouble swallowing and breathing, sudden onset of hives or rash)
• Liver inflammation (yellowing of skin and eyes, nausea, loss of appetite, dark-coloured urine)
• Inflammation of the pancreas (persistent and severe stomach pain which may radiate to your back, nausea, vomiting)
• Diabetic ketoacidosis (nausea, vomiting, stomach pain, excessive thirst, deep and fast breathing, confusion, unusual tiredness or sleepiness, sweet breath odour, metallic or sweet taste in mouth or a different odour in your sweat, rapid weight loss)
• Fournier’s gangrene or necrotising fasciitis of the perineum (soft tissue infection of genitals or between anus and genital which might be serious)
• Urinary tract infection (fever, chills, burning sensation, seeing blood while urinating, back or side pain)
• Low blood sugar level (sweating, shaking, anxiety, fast heartbeat, feeling hungry, headache, change in vision, mood changes or confusion)

How To Manage Side Effects

Diarrhea

To manage diarrhea at home, follow these steps:

1. Stay Hydrated: Drink plenty of fluids, such as water, clear broths, or oral rehydration solutions (ORS), to prevent dehydration. Avoid sugary drinks, caffeine, and alcohol as they may worsen diarrhea.
2. Eat a Bland Diet: Consume easily digestible foods like bananas, rice, applesauce, and toast (the BRAT diet) to soothe your stomach. Avoid spicy, greasy, or high-fiber foods until your symptoms improve.
3. Take Probiotics: Yogurt or probiotic supplements can help restore the natural balance of gut bacteria, speeding up recovery.
4. Avoid Trigger Foods: Steer clear of dairy products, fatty foods, or anything that seems to aggravate your symptoms.
5. Rest: Give your body time to recover by avoiding strenuous activities and getting enough rest.

If diarrhea persists for more than 2–3 days, is accompanied by severe pain, blood in stool, or signs of dehydration (such as extreme thirst, dry mouth, or dizziness), seek medical attention.

Hypoglycemia

To manage hypoglycemia (low blood sugar) at home, follow these steps:

1. Recognize Symptoms: Look for signs like shakiness, sweating, dizziness, irritability, confusion, or rapid heartbeat.
2. Consume Quick-Acting Sugar: Immediately eat or drink something with fast-absorbing sugar, such as:
   • 3–4 glucose tablets.
   • 1/2 cup (120 mL) of juice or regular soda (not diet).
   • 1 tablespoon of honey or sugar.
   • 5–6 hard candies
3. Wait and Recheck: After consuming sugar, wait 15 minutes and recheck your blood sugar. If it’s still low (below 70 mg/dL), repeat the sugar intake.
4. Eat a Small Snack: Once your blood sugar stabilizes, eat a small, balanced snack containing carbohydrates and protein, like a peanut butter sandwich, to prevent another drop.
5. Prevent Recurrence: Monitor blood sugar regularly, eat meals on time, and adjust medications or insulin as directed by your doctor.

If symptoms persist or worsen, or if you lose consciousness, seek emergency medical attention immediately. Always carry a source of sugar if you have diabetes.

Warning & Precautions

Pregnancy

Monitoring required

There are no well controlled human studies regarding the use of Dapagliflozin + Vildagliptin in pregnant women. Animal studies have indicated few harmful side effects in their progeny. Therefore, VINGLYN D 10 TABLET should be taken by pregnant women only if your doctor considers it as clearly necessary.

Breastfeeding

Monitoring required

It is not known whether the medicines, Dapagliflozin + vildgliptin gets excreted in breast milk. Animal studies have reported the excretion of medicine in milk as well as pharmacologically mediated effects in nursing offspring. A risk to the infant cannot be excluded. Therefore, breastfeeding women should not take VINGLYN D 10 TABLET unless considered necessary by the physician.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking VINGLYN D 10 TABLET.

Alcohol

Consult your doctor

VINGLYN D 10 TABLET should be used with caution in patients with a history of alcohol abuse. Consult your doctor for advice.

Kidney

Use with Caution

VINGLYN D 10 TABLET should be used with caution in patients having moderate or severe kidney disease and in those undergoing dialysis. Consult your doctor before taking it.

Liver

Use with Caution

VINGLYN D 10 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take VINGLYN D 10 TABLET if you are allergic to Dapagliflozin, Vildagliptin, or any of the other ingredients of this medicine.

Heart Disease

Use with Caution

VINGLYN D 10 TABLET should be used with caution in patients suffering from heart failure. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

VINGLYN D 10 TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

VINGLYN D 10 TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor for advice.

Interactions

A. Drug-Drug interactions:  

Before taking VINGLYN D 10 TABLET, inform your doctor if you are taking any of the following medicines:      

• Other medicines used to lower blood sugar levels (Ex. glimepiride, glipizide)
• Medicines used to remove excess body fluids from the body (Ex. methyclothiazide, trichlormethiazide, furosemide)
• Medicines used to reduce inflammation (Ex. prednisolone, hydrocortisone)
• Medicines used to manage underactive thyroid (Ex. levothyroxine, liothyronine)
• Medicines used to manage fits (Ex. phenytoin, phenobarbital)

Overdosage:

If you or anyone else accidentally take too much of VINGLYN D 10 TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

FAQs About VINGLYN D 10 TABLET

References

1. KD. Tripathi. Insulin, Oral Anti Diabetic Drugs and Glucagon. Essentials of Medical Pharmacology. Eighth edition. 2013. Page-298, 301.

2. PubChem Compound Summary for CID 9887712, Dapagliflozin. National Center for Biotechnology Information. PubChem. November 2022. [Accessed on 18th November 2022] click here

3. PubChem Compound Summary for CID 6918537, Vildagliptin. National Center for Biotechnology Information. PubChem. November 2022. [Accessed on 18th November 2022] click here

4. Exemed Pharmaceuticals. TORGLIP D 5/ TORGLIP D 10 (Dapagliflozin + Vildagliptin). Torrent Pharmaceuticals Ltd. [Revised in April 2022] [Accessed on 18th November 2022] click here

5. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 18th November 2022] click here

6. Pharmadox Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 18th November 2022] click here

Useful Diagnostic Tests

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Hemoglobin

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 27 Nov 2024 | 04:18 PM(IST)