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Introduction About VAXIRAB INJECTION
VAXIRAB INJECTION contains Rabies Virus, which belongs to the group of medicines called Vaccines. It is used to manage rabies before exposure to rabies virus (pre-exposure prophylaxis) or after exposure to rabies virus (post-exposure prophylaxis) in all age groups. Rabies is an infection that can be transmitted when a person is bitten, scratched, or even just licked by an infected animal.
VAXIRAB INJECTION is not recommended for use if you have an acute illness with a high fever. VAXIRAB INJECTION should be used with caution in patients who have a history of allergies (such as asthma or hay fever). Consult your doctor before receiving it.
VAXIRAB INJECTION can be used in pregnant and breast-feeding women who have had or are likely to have contact with the virus and is also used for pre-exposure prophylaxis. Consult your doctor before receiving it.
The most common side effects of receiving VAXIRAB INJECTION are headache, dizziness, rash, hives, general discomfort, fatigue, weakness, and fever. Contact your doctor if any of the symptoms worsen.
Uses Of VAXIRAB INJECTION
- To manage rabies
How VAXIRAB INJECTION Works
VAXIRAB INJECTION contains a rabies virus that has been killed, which stimulates the immune system (the body's natural defense system) to form antibodies against rabies viruses. These antibodies protect from infections or diseases caused by the rabies virus.
How to use VAXIRAB INJECTION
VAXIRAB INJECTION will be given to you only by a doctor or a nurse into a muscle as an injection into a muscle (usually in the upper arm or, in small children, into the muscle of the thigh). Your doctor will decide the correct dose and duration for you depending upon your age, body weight, previous vaccination status, and disease condition. Do not administer the medicine to the buttocks, under the skin, or into a blood vessel.
Side Effects Of VAXIRAB INJECTION
Common
- headache, dizziness
- rash, hives
- general discomfort
- fatigue, weakness
- fever
- swollen glands
- decreased appetite
- nausea, vomiting, diarrhea, stomach pain
- muscle pain, joint pain
- pain, redness, swelling, itching, or bruising at the site of injection
- hardness of the skin at the site of injection
Rare
- tingling sensations
- sweating, chills
Stop receiving VAXIRAB INJECTION and contact your doctor if you experience any of the following side effects:
- signs of anaphylactic reactions (serious allergic reactions) such as shock (severe drop of blood pressure), itching, skin rash, swelling of the face and/or neck, breathing difficulties, bluish discoloration of the tongue or lips, low blood pressure, rapid heart rate, weak pulse, skin coldness, dizziness, and fainting
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Contact your doctor if your dizziness does not improve.
Headache
Rest and relax. Drink plenty of fluids, such as water or ORS (Oral Rehydrating Solution), and apply a pain-relieving balm to the head if necessary. Contact your doctor if your headache did not improve.
Nausea And Vomiting
Receive VAXIRAB INJECTION, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting does not improve.
Skin rash Or Itching
Avoid hot baths because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if the rashes worsen.
Stomach Pain
Try to have smaller meals but take them frequently. Keep a heating pad on your stomach. Do not self-manage and contact your doctor if the stomach pain does not improve.
Warning & Precautions
Pregnancy
Consult your doctorVAXIRAB INJECTION can be used in pregnant women who have had or are likely to have contact with the virus and used for pre-exposure prophylaxis (before exposure to the rabies virus). Consult your doctor before receiving VAXIRAB INJECTION.
Breastfeeding
Consult your doctorVAXIRAB INJECTION can be used in breast-feeding women who have had or are likely to have contact with the virus and for pre-exposure prophylaxis (before exposure to the rabies virus). Consult your doctor before receiving VAXIRAB INJECTION.
Allergy
ContraindicatedVAXIRAB INJECTION is not recommended for use if you are allergic to the rabies vaccine, beta-propiolactone, or any of the other ingredients of this medicine.
Lungs
Use with CautionVAXIRAB INJECTION should be used with caution in patients who have a history of allergies (such as asthma). Consult your doctor before receiving VAXIRAB INJECTION.
Use In Pediatrics
Use with CautionVAXIRAB INJECTION should be used with caution in children (below 1 year). Consult your doctor before receiving VAXIRAB INJECTION.
Others
VAXIRAB INJECTION is not recommended for use if you:
- have an acute illness with a high fever that requires management
Before receiving VAXIRAB INJECTION, inform your doctor if you:
- have history of any other reactions to the vaccine
- have any blood disorders that make you bruise or bleed easily, such as haemophilia or thrombocytopenia?
- have poor immunity status
- have or has a severe allergy to eggs or egg products or to polygeline or latex
- have/has a severe allergy to the antibiotics like neomycin, chlortetracycline, or amphotericin B.
- fainted with a previous injection of VAXIRAB INJECTION
- has a history of allergies (such as hay fever)
Interactions
A. Drug-Drug Interactions:
Before receiving VAXIRAB INJECTION, inform your doctor if you are taking any of the following medicine:
- immunosuppressants (medicines that lower the body’s immune responses) such as corticosteroids Ex. dexamethasone, beclomethasone
Overdosage:
VAXIRAB INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Rabies Vaccine |
| Pharmacological Category | : | Vaccine |
| Therapeutic Indication | : | Manage Rabies |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep VAXIRAB INJECTION out of the sight and reach of children.
- Store VAXIRAB INJECTION in a refrigerator (at 2°C to 8°C). Do not freeze.
FAQs About VAXIRAB INJECTION
Q: Can I take other vaccines with VAXIRAB INJECTION?
A: VAXIRAB INJECTION can be given at the same time as other inactivated vaccines. A different injection site will be used for each type of vaccine. Consult your doctor before receiving VAXIRAB INJECTION.
Q: Can I receive VAXIRAB INJECTION with a fever?
A: VAXIRAB INJECTION is generally not recommended for use in people who are ill with a high temperature or acute infection; the vaccination will be postponed until you or your child have recovered. Your doctor may still decide to give the vaccine even if this applies to you or your child. This is because rabies is a serious disease.
Q: What side effects are seen with VAXIRAB INJECTION?
A: The most common side effects of receiving VAXIRAB INJECTION are headache, dizziness, rash, hives, general discomfort, fatigue, weakness, and fever. Contact your doctor if any of the symptoms worsen.
Q: Who should avoid using VAXIRAB INJECTION?
A: VAXIRAB INJECTION is not recommended for use if you have an acute illness with a high fever that requires management or are allergic to the rabies vaccine, beta-propiolactone, or any of the other ingredients of this medicine. Consult your doctor before receiving VAXIRAB INJECTION.
Q: How frequently should I receive VAXIRAB INJECTION?
A: The pre-exposure immunization course consists of 3 injections at Day 0, Day 7, and either Day 21 or Day 28. If you are at high risk of exposure to rabies, your doctor will assess the need and plan further booster injections in line with official guidance. Post-exposure prophylaxis should be initiated as early as possible after suspected rabies exposure. Proper wound care must be done immediately or as early as possible after exposure. It must be before the administration of the rabies vaccine or rabies antibodies. The vaccine should be administered on Days 0, 3, 7, 14, and 28 for post-exposure prophylaxis.
Q: What is VAXIRAB INJECTION used for?
A: VAXIRAB INJECTION is used to manage rabies before exposure to rabies virus (pre-exposure prophylaxis) or after exposure to rabies virus (post-exposure prophylaxis) in all age groups.
Q: How does VAXIRAB INJECTION work?
A: VAXIRAB INJECTION contains a rabies virus that has been killed, which stimulates the immune system (the body's natural defense system) to form antibodies against rabies viruses. These antibodies protect from infections or diseases caused by the rabies virus.
Q: How is VAXIRAB INJECTION given?
A: VAXIRAB INJECTION will be given to you only by a doctor or a nurse into a muscle as an injection into a muscle (usually in the upper arm or in small children, into the muscle of the thigh). Your doctor will decide the correct dose and duration for you depending on your age, body weight, previous vaccination status, and disease condition. Do not administer the medicine to the buttocks, under the skin, or into a blood vessel.
Q: Is VAXIRAB INJECTION safe for kids?
A: VAXIRAB INJECTION should be used with caution in children (below 1 year). Consult your doctor before receiving VAXIRAB INJECTION.
Q: Can VAXIRAB INJECTION be used in pregnancy?
A: VAXIRAB INJECTION can be used in pregnant women who have had or are likely to have contact with the virus and used for pre-exposure prophylaxis (before exposure to the rabies virus). Consult your doctor before receiving VAXIRAB INJECTION.
References
1. KD. Tripathi. Vaccines and Sera. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 922.
2. Huang G, Liu H, Cao Q, Liu B, Pan H, Fu C. Safety of post-exposure rabies prophylaxis during pregnancy. NIH National Library of Medicine, National Center for Biotechnology Information. January 2013. [Accessed on 27th August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667934/
3. Bethesda (MD). Rabies Vaccine. Drugs and Lactation Database (LactMed): National Institute of Child Health and Human Development. June 2020. [Accessed on 27th August 2024] https://www.ncbi.nlm.nih.gov/books/NBK501090/
4. Bavarian Nordic A/S. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 27th August 2024] https://www.medicines.org.uk/emc/files/pil.2502.pdf
5. Sanofi Pasteur. Electronic Medicines Compendium (EMC). [Revised in December 2023] [Accessed on 27th August 2024] https://www.medicines.org.uk/emc/files/pil.15572.pdf
Useful Diagnostic Tests
- Fluorescent antibody test (FAT)
- Reverse transcriptase-polymerase chain reaction (RT-PCR)
- Healthy Midlife Checkup
- Men Health Checkup - Advanced
- Complete Women Checkup
- Full Body Checkup - Gold
- Elderly Checkup - Female
- Elderly Checkup – Male
- Full Body Checkup – Silver
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