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Introduction About VALPARIN 200MG ORAL SOLUTION

VALPARIN 200MG ORAL SOLUTIONcontains Sodium valproate, which belongs to the group of medicines called Anti-convulsant. It is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness. Symptoms include temporary confusion, staring spells, stiff muscles, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness, fear, anxiety, or déjà vu.

VALPARIN 200MG ORAL SOLUTION is not recommended for use if you have porphyria (affecting metabolism), liver problems or Alpers-Huttenlocher syndrome. Before taking VALPARIN 200MG ORAL SOLUTION inform your doctor if you have kidney, brain problems, carnitine palmitoyl transferase type II deficiency, diabetes, systemic lupus erythematosus, urea cycle disorder or a genetic problem caused by a mitochondrial disorder in your family.

Do not consume alcohol while taking VALPARIN 200MG ORAL SOLUTION. VALPARIN 200MG ORAL SOLUTION is not recommended or used by pregnant women. Inform your doctor if you are a breastfeeding mother. VALPARIN 200MG ORAL SOLUTION should be used with caution by children. The most common side effects of taking VALPARIN 200MG ORAL SOLUTION are stomach pain, diarrhea, headache, feeling tired and weight gain. Consult your doctor if symptoms become worse while taking VALPARIN 200MG ORAL SOLUTION.

Uses Of VALPARIN 200MG ORAL SOLUTION

Manage epilepsy (fits)

How VALPARIN 200MG ORAL SOLUTION Works

VALPARIN 200MG ORAL SOLUTION increases concentrations of gamma-aminobutyric acid (GABA) which reduces neuronal excitability by inhibiting nerve transmission in the brain, probably due to inhibition of the enzymes responsible for the breakdown of GABA.

How to use VALPARIN 200MG ORAL SOLUTION

Take VALPARIN 200MG ORAL SOLUTION as advised by your physician. Take the medicine by mouth, dilute it only if your doctor tells you to. Measure the suggested dose using the measuring cup and take it with or after food. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.

Side Effects Of VALPARIN 200MG ORAL SOLUTION

Common

stomach pain, feeling or being sick
diarrhea
dry or sore mouth, or swollen gums
shakes (tremors) in a part of your body, or unusual eye movements
feeling tired or sleepy
headache
weight gain
thinning hair, or changes to the color or texture of your hair
irregular or delayed periods

Rare

Stop taking VALPARIN 200MG ORAL SOLUTION and contact your doctor immediately if you experience any of the following side effects:

thoughts of harming or killing yourself
an allergic reaction (rash, joint pain, fever (systemic lupus erythematosus), swallowing or breathing problems, swelling of your lips, face, throat or tongue, lymph node enlargement and possible impairment of other organs
liver problems and problems of the pancreas may show as a sudden illness (feeling and being sick many times; being very tired, sleepy and weak, stomach pain, jaundice, loss of appetite, swelling of legs, worsening of fits
skin rash or skin lesions with a pink/red ring and a pale center which may be itchy, scaly or filled with fluid (on the palms or soles of your feet, can be erythema multiforme)
blistering or bleeding of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever (Stevens-Johnson syndrome)
severe blistering rash where layers of the skin may peel off to leave large areas of raw exposed skin over the body, unwell, fever, chills, and aching muscles (toxic epidermal necrolysis)
bruising more easily and getting more infections than usual (thrombocytopenia), blood clotting problems
changes in mood, loss of memory, lack of concentration and coma
hypothyroidism, which may cause tiredness or weight gain
breathing difficulty and pain due to inflammation of the lungs
changes in behavior including being very alert, and sometimes also aggressive, hyperactive and unusual or inappropriate behavior
changes in the amount of ammonia in the blood (being sick, problems with balance and co-ordination, feeling lethargic or less alert)
feeling shaky (tremor), sleepy or unsteady when walking or jerky muscle movements.
rapid, uncontrollable movement of the eyes
increase in the number and severity of convulsions
liver damage, inflammation of the pancreas, bedwetting, renal dysfunction, overgrowth of gum tissue, aggression, agitation, disturbance in attention, abnormal behavior, hyperactivity and learning disorder in children

How To Manage Side Effects

Diarrhea

Drink lots of water or fruit juice to keep yourself hydrated. Consult your doctor if any of your symptoms get worse or persist.

Headache

Avoid bright lights, take enough rest and drink more water. Consult your doctor if any of your symptoms get worse or persist.

Nausea And Vomiting

VALPARIN 200MG ORAL SOLUTION should be used with caution by the elderly. Consult your doctor for advice.

Others

VALPARIN 200MG ORAL SOLUTION is not recommended for use if you:

have a rare illness called porphyria which affects metabolism
have a known metabolic disorder, i.e., a urea cycle disorder
have a genetic problem caused by a mitochondrial disorder (Alpers-Huttenlocher syndrome)
are a woman of birth-giving age and not using contraceptives (birth control)

Before taking VALPARIN 200MG ORAL SOLUTION, inform your doctor if you:

have diabetes
have a carnitine palmitoyl transferase type II deficiency
have a brain disease or a metabolic condition affecting the brain
have a ‘urea cycle disorder’ where too much ammonia builds up in the body
have an illness called systemic lupus erythematosus (SLE) (an immune system which affects skin, bones, joints and internal organs)
genetic problem caused by a mitochondrial disorder in your family

Interactions

A. Drug-Drug interactions:

Before taking VALPARIN 200MG ORAL SOLUTION, inform your doctor if you are taking any of the following medicine:

medicines used for pain and inflammation (salicylates) (Ex. aspirin)
other medicines used to manage fits (Ex. phenobarbital, primidone, phenytoin, carbamazepine, rufinamide, topiramate, acetazolamide, lamotrigine and felbamate)
medicines used for thinning the blood (Ex. warfarin)
zidovudine, lopinavir and ritonavir (to manage HIV infection)
temozolomide (to manage cancer)
medicines for depression (monoamine oxidase inhibitors (MAOI) such as moclobemide, selegiline, linezolid)
medicines used to calm emotional and mental health problems (Ex. quetiapine, diazepam and olanzapine)
nimodipine (to manage hemorrhage)
propofol (used for anesthesia)
oestrogen-containing products (including some birth control pills)
medicines to manage malaria (Ex. mefloquine and chloroquine)
cimetidine (for stomach ulcers)
carbapenem agents (antibiotics used to manage bacterial infections) Ex. imipenem, meropenem, rifampicin and erythromycin
cholestyramine used to lower blood fat (cholesterol) levels
metamizole, (to manage pain and fever)

Overdosage:

If you or anyone else accidentally take too much of VALPARIN 200MG ORAL SOLUTION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sick or being sick, pupils of the eye becoming smaller, dizziness, loss of consciousness, weak muscles and poor reflexes, breathing problems, headaches fits (seizures), confusion, memory loss and unusual or inappropriate behavior, shortness of breath and chest pain.

Synopsis

Drug	:	Sodium Valproate
Pharmacological Category	:	Anti-convulsant
Therapeutic Indication	:	Epilepsy (fits)
Dosage Forms	:	Tablet, Injection, Syrup, Oral solution, Granules

More Information

Keep VALPARIN 200MG ORAL SOLUTION out of reach from children
Store at room temperature

FAQs About VALPARIN 200MG ORAL SOLUTION

Q: What is VALPARIN 200MG ORAL SOLUTION used for?

A: VALPARIN 200MG ORAL SOLUTION is used in the management of epilepsy (fits). Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.

Q: Can VALPARIN 200MG ORAL SOLUTION be used in pregnant women?

A: VALPARIN 200MG ORAL SOLUTIONis not recommended for use in pregnant women or if you are planning to have a baby as it can cause birth defects and behavioral/learning problems in the baby. Consult your doctor before taking VALPARIN 200MG ORAL SOLUTION.

Q: What if I miss a dose of VALPARIN 200MG ORAL SOLUTION?

A: If you forget to take a dose of VALPARIN 200MG ORAL SOLUTION, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose of VALPARIN 200MG ORAL SOLUTION.

Q: Can I drive while taking VALPARIN 200MG ORAL SOLUTION?

A: Do not drive or use machines while taking VALPARIN 200MG ORAL SOLUTION as it can make you sleepy and weaken your ability to drive. Consult your doctor for more information.

Q: Can VALPARIN 200MG ORAL SOLUTION be used in kidney patients?

A: VALPARIN 200MG ORAL SOLUTIONshould be used with caution in patients with kidney disease. The dose will be adjusted by your doctor. Consult your doctor before taking VALPARIN 200MG ORAL SOLUTION.

References

1. KD Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 444.

2. H. M. Emrich, D. v. Zerssen, W. Kissling, H. -J. Möller & A. Windorfer. Effect of sodium valproate on mania. [Accessed on 19th July 2022] https://link.springer.com/article/10.1007/BF00343800

3. R. M. Pinder, R. N. Brogden, T. M. Speight & G. S. Avery. Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy. [Accessed on 19th July 2022] https://link.springer.com/article/10.2165/00003495-197713020-00001

4. Unither Liquid Manufacturing. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 19th July 2022] https://www.medicines.org.uk/emc/files/pil.516.pdf

5. NHS. Sodium Valproate [Revised in August 2021] [Accessed on 19th July 2022] https://www.nhs.uk/medicines/sodium-valproate/

6. Pubchem. Sodium Valproate. [Accessed on 19th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-valproate#:~:text=Valproate%20sodium%20is%20converted%20into,for%20the%20catabolism%20of%20GABA.

7. Mayoclinic. Sodium valproate. [Revised in October 2021] [Accessed on 19th July 2022] https://www.mayoclinic.org/diseases-conditions/epilepsy/symptoms-causes/syc-20350093#:~:text=Epilepsy%20is%20a%20central%20nervous,races%2C%20ethnic%20backgrounds%20and%20ages.

Useful Diagnostic Tests

Blood tests
Liver function test

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 28 Feb 2023 | 03:14 PM(IST)

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