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Introduction About VALERA M 500 TABLET
VALERA M 500 TABLET contains Evogliptin and Metformin which belongs to the group of medicines called Anti-diabetic agents. It is used to manage type 2 diabetes mellitus. Evogliptin is a Glucagon-like peptide-1 (GLP-1) is secreted from alimentary canal in response to meal that promotes insulin secretion from pancreas and regulates blood sugar post meal by controlling glucagon secretion. It exhibits a hypoglycemic effect by controlling the decomposition of GLP-1 by inhibiting dipeptidyl peptidase-4 (DPP-4) activity and thereby increasing blood concentration of active form GLP-1. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also manages glucose production by the liver and reduces its absoprtion in the body.
Along with the therapy, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption. Before taking VALERA M 500 TABLET inform your doctor if you have any liver, kidney, and heart problems. VALERA M 500 TABLET is not recommended for use in pregnant and breastfeeding women. Consult your doctor before taking the medicine.
The most common side effects of taking VALERA M 500 TABLET are hypoglycemia, stomach pain, indigestion, common cold, pain, diarrhoea and itching and nausea. Consult your doctor if any of the above side effects worsens or persists for a longer duration.
Uses Of VALERA M 500 TABLET
- Used in the management of type 2 diabetes mellitus
How VALERA M 500 TABLET Works
Evogliptin is a Glucagon-like peptide-1 (GLP-1) is secreted from alimentary canal in response to meal that promotes insulin secretion from pancreas and regulates blood sugar post meal by controlling glucagon secretion. It exhibits a hypoglycemic effect by controlling the decomposition of GLP-1 by inhibiting dipeptidyl peptidase-4 (DPP-4) activity and thereby increasing blood concentration of active form GLP-1. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also manages glucose production by the liver and reduces its absoprtion in the body.
How to use VALERA M 500 TABLET
Take VALERA M 500 TABLET as advised by your physician. Swallow VALERA M 500 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking VALERA M 500 TABLET without informing your doctor.
Side Effects Of VALERA M 500 TABLET
Common
- hypoglycemia
- stomach pain
- indigestion
- common cold
- pain
- diarrhoea
- itching
- nausea, vomiting
- loss of appetite
- changes in taste, metallic taste
Stop taking VALERA M 500 TABLET and consult your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty in breathing or swallowing)
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
- signs of lactic acidosis (cold hands or feet, dizziness, or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea, or vomiting)
How To Manage Side Effects
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Hypoglycemia
Eat or drink 15 to 20 grams of fast-acting carbohydrates. These are sugary foods or drinks without protein or fat that are easily converted to sugar in the body. Have a snack or meal.
Nausea And Vomiting
Take VALERA M 500 TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.
Stomach Pain
Try putting a heating pad or hot towel on your abdomen. The heat can help relax the muscles and relieve cramping. Taking a hot shower or bath with salt may also help.
Warning & Precautions
Pregnancy
ContraindicatedVALERA M 500 TABLET is not recommended for use in pregnant women. Consult your doctor before taking the medicine.
Breastfeeding
ContraindicatedVALERA M 500 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking the medicine.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you experience low blood sugar levels after taking VALERA M 500 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking VALERA M 500 TABLET as it may increase the risk of unwanted side effects.
Kidney
ContraindicatedVALERA M 500 TABLET is not recommended for use in patients with severe kidney problems (including kidney infections). Therefore, consult your doctor before taking it.
Liver
Consult your doctorVALERA M 500 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take VALERA M 500 TABLET if you are allergic (hypersensitive) to Evogliptin or Metformin or any other ingredients of this medicine.
Lungs
Consult your doctorVALERA M 500 TABLET is not recommended for use in patients with severe infection of lungs or respiratory tract. It should be used with caution if you have any breathing problems. Therefore, consult your doctor before taking it.
Heart Disease
ContraindicatedVALERA M 500 TABLET is not recommended for use in patients with heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.
Use In Pediatrics
Consult your doctorVALERA M 500 TABLET should be used in children and adolescents (aged 10 years or older) only if prescribed by the physician. It is not recommended for use in children (aged below 10 years). However, consult your doctor before taking it.
Use In Geriatrics
Use with CautionVALERA M 500 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor for advice before taking the medicine.
Others
VALERA M 500 TABLET is not recommended for use, if you have:
- diabetic coma
- type 1 diabetes
- severe, uncontrollable diabetes
- lactic acidosis or ketoacidosis (buildup of lactic acid or ketones in the body)
- are dehydrated (due to severe vomiting or diarrhea during recent days)
- any systemic infection
- shock or problems in blood circulation
Before taking VALERA M 500 TABLET inform your doctor if you:
- have a history of pancreatitis
- are about to have any X-ray or scan or a major surgery
- are in fasting
Interactions
Before taking VALERA M 500 TABLET inform to your doctor if you are taking any of these medicines:
- Other medicines used for diabetes mellitus (such as insulin or metformin, teneligliptin, rosiglitazone, pioglitazone, glimepiride)
- Clarithromycin, rifampicin (used to manage infection)
- Diuretics (used to reduce oedema and manage hypertension) Ex. furosemide, hydrochlorothiazide
- Medicines used to manage pain and inflammation (such as ibuprofen and celecoxib)
- Medicines used to manage high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
- Medicines used to manage asthma (Ex. salbutamol or terbutaline)
- Corticosteroids (used to manage pain and inflammation) Ex. hydrocortisone, prednisolone
- Verapamil (a medicine used to manage heart problems)
- Rifampicin (a medicine used to manage tuberculosis)
- Cimetidine (a medicine used to manage stomach ulcer)
- Dolutegravir (a medicine used to manage HIV infection)
- Ranolazine (a medicine used to manage chest pain)
- Trimethoprim (a medicine used to manage bacterial infection)
- Vandetanib, crizotinib and olaparib (medicines used for abnormal growth cells)
- Isavuconazole (a medicine used to manage fungal infection)
Overdosage:
If you or anyone else accidentally take more VALERA M 500 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.
Synopsis
| Drug | : | Evogliptin, Metformin |
| Pharmacological Category | : | Dipeptide peptidase-4 (DPP-4) inhibitor, Biguanides |
| Therapeutic Indication | : | Type 2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep VALERA M 500 TABLET out of reach of children
- Store at room temperature
FAQs About VALERA M 500 TABLET
Q: How and when to take VALERA M 500 TABLET?
A: Take VALERA M 500 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration depending upon your age, body weight and disease condition.
Q: What to do if I forgot to take a dose of VALERA M 500 TABLET?
A: If you forgot to take a dose of VALERA M 500 TABLET, take it as soon as you remember. However, if it is time for the next dose of VALERA M 500 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of VALERA M 500 TABLET to compensate the missed ones.
Q: Can I stop taking VALERA M 500 TABLET without consulting the doctor?
A: No. You should not stop taking VALERA M 500 TABLET without consulting the doctor because it may cause some side effects.
Q: Will taking a higher dose of VALERA M 500 TABLET be more effective?
A: No, taking a higher dose of VALERA M 500 TABLET will not be effective. Always stick to the dose and duration prescribed by your doctor.
Q: Can VALERA M 500 TABLET be used in pregnant women?
A: VALERA M 500 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.
Q: How much VALERA M 500 TABLET should I take?
A: VALERA M 500 TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Q: Is it safe to use VALERA M 500 TABLET on elderly patients?
A: VALERA M 500 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor for advice before taking the medicine.
References
- KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270 and 275
- Xueying Tan and Jingbo Hu. Evogliptin: a new dipeptidyl peptidase inhibitor for the treatment of type 2 diabetes. National library of medicine. June 2016. [Accessed on 4 Jan 2024] https://pubmed.ncbi.nlm.nih.gov/27156529/
- Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls [Internet]. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 4 Jan 2024] https://www.ncbi.nlm.nih.gov/books/NBK518983/#article-25065.s
- Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 4 Jan 2024] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126704
- Alkem Laboratories Ltd. [Revised on April 21st, 2020] [Accessed on 4 Jan 2024] https://www.alkemlabs.com/pdf/adverse/Evogliptin.pdf
- Geropharm. [Accessed on 4 Jan 2024] https://geropharm.com/portfolio/endokrinologiya/evodin-evogliptin
- Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 4 Jan 2024] https://www.medicines.org.uk/emc/files/pil.594.pdf
- Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 4 Jan 2024] https://www.medicines.org.uk/emc/files/pil.11951.pdf
- Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 4 Jan 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
- Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 4 Jan 2024] http://diabetix-francoindian.com/glyciphage.html
Useful Diagnostic Tests
- HbA1C, also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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