UTERGIN 0.2MG INJECTION 1ML
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Introduction About UTERGIN
UTERGIN contains Methylergometrine which belongs to a group of medicines called Ergot alkaloids. UTERGIN is used in the routine management of uterine atony (inability of the uterus to contract sufficiently during and after childbirth), haemorrhage and subinvolution of the uterus (delayed return of enlarged uterus to normal size) following delivery of placenta.
UTERGIN is also used to control uterine haemorrhage (heavy/unusual bleeding from uterus) following delivery of anterior shoulder of the foetus (childbirth).
UTERGIN is not recommended for use in patients allergic to Methylergometrine. It is also not recommended for use in patients with high blood pressure, and/or toxemia (blood poisoning due to local bacterial infection).
Before receiving UTERGIN, inform your doctor if you are a smoker, and/or have high cholesterol, obesity, diabetes, heart problems (such as coronary artery disease), kidney problems (such as impaired renal function), and/or liver problems (such as impaired hepatic function).
UTERGIN is generally not recommended for use during pregnancy and in breast feeding women. The medicine should be received with caution in elderly women (aged above 65 years) after consulting the doctor.
The most common side effect of receiving UTERGIN is hypertension associated with seizure, and/or headache. Consult your doctor if the side effect worsens.
Uses Of UTERGIN
- Helps in the routine management of uterine atony, haemorrhage and subinvolution of the uterus following delivery of placenta
- Helps to control uterine haemorrhage following delivery of anterior shoulder of the foetus (childbirth)
How UTERGIN Works
UTERGIN works by causing sustained contractions of uterine smooth muscles by acting directly on the uterine smooth muscle which leads to compression of blood vessels resulting in controlled/reduced blood loss following childbirth.
How to use UTERGIN
UTERGIN will be given to you only by a doctor or a nurse as an intravenous or intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of UTERGIN
Common
- hypertension associated with seizure, and/or headache
Rare
- chest pain, fast/rapid/slow heart rate, coronary arterial spasm (sudden tightening of arteries of heart), heart attack
- vasoconstriction, vasospasm (narrowing of brain blood vessel)
- shortness of breath
- hematuria (blood in urine)
- thrombophlebitis (inflammation of a vein)
- hallucinations, dizziness
- leg cramps, ringing in ears, nasal congestion
- diarrhoea
- diaphoresis (sweating at a usual degree)
- rash
- foul taste
- signs of anaphylaxis reaction (life threatening allergic reaction) such as red itchy welts, low blood pressure, wheezing, and/or trouble in breathing
How To Manage Side Effects
Diarrhoea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult and inform your doctor if the symptom worsens.
Rash:
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Warning & Precautions
Pregnancy
UTERGIN is generally not recommended for use during pregnancy. Consult your doctor before receiving UTERGIN.
Breastfeeding
UTERGIN is generally not recommended for use in breast feeding women since the medicine may pass through breast milk. Consult your doctor before receiving UTERGIN.
Kidney
UTERGIN should be used with caution in patients with kidney problems such as impaired renal function. Consult your doctor before receiving the medicine.
Liver
UTERGIN should be used with caution in patients with liver problems such as impaired hepatic function. Consult your doctor before receiving the medicine.
Allergy
Do not receive UTERGIN if you are allergic to Methylergometrine, and/or any other ingredients of this medicine.
Heart Disease
UTERGIN should be used with caution in patients with heart problems such as coronary artery disease. Consult your doctor before receiving the medicine.
Others
UTERGIN is not recommended for use if you:
- have high blood pressure
- suffer from toxemia (blood poisoning due to local bacterial infection)
Before receiving UTERGIN, inform your doctor if you:
- are a smoker
- suffer from high cholesterol, obesity, diabetes
- have obliterative vascular disease (gradual narrowing of arterial blood vessel), and/or suffer from sepsis (life threatening complication of an infection)
- are in second stage of labor
Use in Geriatrics:
UTERGIN should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving the medicine.
Interactions
A. Drug-Drug interactions:
Before receiving UTERGIN, inform your doctor if you are taking any of the following medicine:
- macrolide antibiotics (medicines used to manage bacterial infections) such as erythromycin, troleandomycin, clarithromycin
- HIV protease/reverse transcriptase inhibitors (medicines used to manage HIV) Ex. atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, nevirapine
- nefazodone, fluoxetine, fluvoxamine (medicines used to manage depression)
- fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, clotrimazole (medicines used to manage fungal disease)
- zileuton (used to manage asthma)
- rifampicin (used to manage infections)
- beta-blockers (used to manage high blood pressure) Ex. acebutolol, atenolol
- aesthetics (medicines used for the induction and maintenance of general anaesthesia) Ex. halothan, methoxyfluran
- glyceryl trinitrate (used to manage angina)
- prostaglandins (used to induce labor/abortion and manage postpartum haemorrhage)
B. Drug-Food interaction:
Grapefruit/or its juice may interact with this medicine and lead to unwanted side effects. Consult your doctor before taking any grapefruit products.
Overdosage:
UTERGIN will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as nausea, vomiting, oliguria (low urine output), abdominal pain, numbness, tingling of the extremities, rise in blood pressure, low blood pressure, respiratory depression, hypothermia (dangerous drop in body temperature), convulsions, and/or coma.
Synopsis
| Drug | : | Methylergometrine |
| Pharmacological Category | : | Ergot alkaloid |
| Therapeutic Indication | : | Routine management of uterine atony, haemorrhage and subinvolution of the uterus (following delivery of placenta), Control uterine haemorrhage following childbirth |
| Dosage Forms | : | Tablet, Injection |
More Information
- Keep UTERGIN out of reach of children
- Store at room temperature
FAQs About UTERGIN
What is UTERGIN used for?
UTERGIN is used in the routine management of uterine atony (inability of the uterus to contract sufficiently during and after childbirth), haemorrhage and subinvolution of the uterus (delayed return of enlarged uterus to normal size) following delivery of placenta. It is also used to control uterine haemorrhage (heavy/unusual bleeding from uterus) following delivery of anterior shoulder of the foetus (childbirth).
How UTERGIN works?
UTERGIN works by causing sustained contractions of uterine smooth muscles by acting directly on the uterine smooth muscle which leads to compression of blood vessels resulting in controlled/reduced blood loss following childbirth.
How UTERGIN is administered?
UTERGIN will be given to you only by a doctor or a nurse as an intravenous or intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What are the most common side effects of taking UTERGIN?
The most common side effect of receiving UTERGIN is hypertension associated with seizure, and/or headache. Consult your doctor if the side effect worsens.
Can UTERGIN be used in pregnant and breastfeeding women?
No, UTERGIN is not recommended for use in pregnant and breastfeeding women. Consult your doctor before receiving the medicine.
References
1. KD. Tripathi. Oxytocin and Other Drugs Acting on Uterus. Essentials of medical pharmacology. Seventh edition. 2013. Page – 331.
2. Bethesda. Methylergonovine. NIH National Library of Medicine. National center of biotechnology Information. Drugs and Lactation database [Internet]. October 2018. [Accessed on 29th Nov 2022] https://www.ncbi.nlm.nih.gov/books/NBK501342/
3. Novartis Pharmaceuticals Corporation. U.S. Food & Drug Administration (USFDA). [Revised in June 2012] [Accessed on 29th Nov 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/006035s078lbl.pdf
Useful Diagnostic Tests
- Activated Partial Thromboplastin Time
- Complete Blood Count
- Prothrombin Time
- Thrombin Time
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