UROGRAFIN 76 Injection 50ml
Netmeds First Membership
Quick Links
Introduction About UROGRAFIN 76 INJECTION
UROGRAFIN 76 INJECTION contains Diatrizoate Meglumine and Diatrizoate Sodium which belongs to group of medicines called Radiology contrast agents/X-ray dyes. It is used as contrast medium in various radiographic examinations such as excretion urography, paediatric angiocardiography, aortography, peripheral arteriography, selective visceral arteriography, selective renal arteriography, selective coronary arteriography, contrast enhancement during computed tomographic brain imaging and during intravenous digital subtraction angiography. UROGRAFIN 76 INJECTION is also used to enhance the contrast during body’s computed tomography.
UROGRAFIN 76 INJECTION is not recommended for use in patients having severe liver disturbances, severe kidney dysfunction, heart failure, an overactive thyroid gland, acute inflammation of the pancreas, or heart failure.
UROGRAFIN 76 INJECTION should be used with caution in patients with severe liver disturbances, severe kidney dysfunction, pulmonary emphysema, and bronchial asthma. UROGRAFIN 76 INJECTION should also be used with caution in pregnant females, breastfeeding mothers, the elderly, children, and adolescents (under 16 years of age).
The common side effects associated with the use of UROGRAFIN 76 INJECTION are nausea, vomiting, erythema (redness of the skin), pain, warmth, mild swelling of the face, lips, tongue, or throat, and conjunctivitis (inflammation of the eyes). Consult your doctor immediately or visit the nearby hospital.
Uses Of UROGRAFIN 76 INJECTION
- As contrast medium in various radiographic examinations of the body such as excretion urography (examination of kidney, ureters, & bladder), aortography (examination of aorta), paediatric angiocardiography (examination of blood vessels & heart), peripheral arteriography (examination of arteries of legs & arms), selective renal arteriography (examination of an artery of the kidneys), selective visceral arteriography (examination of arteries of various organs), selective coronary arteriography (examination of arteries suppling blood to heart)
How UROGRAFIN 76 INJECTION Works
UROGRAFIN 76 INJECTION helps in radiographic examination where diatrizoate meglumine and diatrizoate sodium are the iodine containing agents that readily diffuse in the vascular (inside the blood vessels) as well as extra-vascular (outside the blood vessels) spaces and absorb the X-rays. The relative differences in the concentration of the contrast medium in the tissues help in differentiating normal and abnormal tissues, thereby helping in monitoring as well as diagnosing the disease.
How to use UROGRAFIN 76 INJECTION
UROGRAFIN 76 INJECTION will be given to you only by a doctor or a nurse into the vein. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of UROGRAFIN 76 INJECTION
Common
- nausea
- vomiting
- erythema (redness of the skin)
- pain
- warmth
- mild swelling in the face, tongue, or throat
- conjunctivitis (inflammation of the eyes)
- coughing
- itching
- running nose
- sneezing
- hives
- headache
- difficulty in breathing
- local pain which usually occurs during examination of blood
Uncommon
- low blood pressure
- throat swelling
- generally feeling of being unwell
- chills or sweating
- dizziness and fainting
- abnormal heartbeat and heart function
- fast heartbeat
- heart attack
- agitation
- confusion
- stomach pain
- swelling and redness along a vein
- blood clot in a vein
- dizziness
- loss of memory
- disturbed vision, speech, and hearing
- seizures
- tremor
- weakness leading to loss of movement/paralysis
- unpleasant sensitivity to light
- temporary blindness
- coma
- sleepiness
Rare
- delayed contrast medium reactions such as fever, rash, flu-like symptoms, joint pain, and itchiness
- abnormal body temperature
- swelling of salivary glands
- breathing arrest
- fluid build-up in the lungs
- severe skin disease (pain, reddening, blisters, peeling of skin)
- temporary kidney failure causing fatigue, shortness of breath, and swelling
Stop receiving UROGRAFIN 76 INJECTION and contact your doctor if you experience any of the following side effects:
- convulsions (repeated and uncontrolled contraction and relaxation of muscles)
- cerebral haemorrhage (bleeding in the brain)
- coma (loss of consciousness)
- paralysis
- arachnoiditis (swelling of a membrane surrounding the nerves of spinal cord)
- acute renal failure causing fatigue, shortness of breath, and swelling
- cardiac arrest (sudden stoppage of heart functioning)
- seizures
- rhabdomyolysis (complex medical condition occurring due muscle tear/injury)
- high body temperature
- brain oedema (water retention in brain)
- permanent paralysis
- myocardial infarction (blockage of blood supply to heart)
- stroke (restricted blood supply to brain)
- signs of severe allergic reaction in the skin
How To Manage Side Effects
Dizziness Or Drowsiness
Lie down until the dizziness passes, and then get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for a long time or gets worse.
Headache
Take rest and drink plenty of water. Avoid receiving alcohol and skipping meals. Do not strain your eyes by watching the screen for a long time. Consult your doctor if the condition persists for a long time or gets worse.
Nausea And Vomiting
Try to take UROGRAFIN 76 INJECTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
Monitoring requiredUROGRAFIN 76 INJECTION should be used cautiously in pregnant females only if it is considered clearly necessary. Consult your doctor before receiving it.
Breastfeeding
ContraindicatedUROGRAFIN 76 INJECTION is not recommended for use by breastfeeding mothers since it may pass into the milk. Consult your doctor before receiving it.
Driving and Using Machines
Use with CautionDo not drive or operate machines after receiving UROGRAFIN 76 INJECTION as may you experience delayed reactions such as fever, rash, flu-like symptoms, joint pain, and itchiness . Consult your doctor before receiving it.
Kidney
Use with CautionUROGRAFIN 76 INJECTION should be used with caution in patients with severe kidney dysfunction. Consult your doctor before receiving it.
Liver
Use with CautionUROGRAFIN 76 INJECTION should be used with caution in the patients having severe liver disturbances. Consult your doctor before receiving it.
Allergy
ContraindicatedUROGRAFIN 76 INJECTION is not recommended for use if you are allergic to diatrizoate meglumine, diatrizoate sodium, any other ingredients of this medicine, food, or had any reactions to dyes used during previous X-ray procedures. Consult your doctor before receiving it.
Lungs
Use with CautionUROGRAFIN 76 INJECTION should be used with caution in patients having pulmonary emphysema (serious lung disease that can cause difficulty in breathing) or bronchial asthma. Consult your doctor before receiving it.
Heart Disease
Consult your doctorUROGRAFIN 76 INJECTION is not recommended for use in patients with heart failure (inability of heart to pump sufficient blood in the body). It should be used with caution in patients with other heart diseases. Consult your doctor before receiving it.
Use In Pediatrics
Use with CautionUROGRAFIN 76 INJECTION should be used with caution in children and adolescents (below 16 years). Consult your doctor before receiving UROGRAFIN 76 INJECTION.
Use In Geriatrics
Use with CautionUROGRAFIN 76 INJECTION should be used with caution in elderly patients (above 65 years). Consult your doctor before receiving UROGRAFIN 76 INJECTION.
Others
UROGRAFIN 76 INJECTION is not recommended for use if you:
- have overactive thyroid gland
- have acute inflammation of the pancreas
Before receiving UROGRAFIN 76 INJECTION, inform your doctor if you:
- have multiple myeloma (cancer of blood cells)
- have pheochromocytoma (high blood pressure caused by a rare tumour of the adrenal gland)
- have homozygous sickle cell disease
- have blood circulatory disease such as advanced cerebral arteriosclerosis (disease affecting)
- brain due thickening of the walls of blood vessel of brain), or stroke (insufficient blood supply to brain)
- have diabetes mellitus
- have cerebral spasmodic conditions
- have neck swelling due to thyroid gland enlargement
- are suffering from overproduction of proteins
- have myasthenia gravis (condition in which the muscles become weak and tire easily)
Interactions
A. Drug-Drug Interactions:
Before receiving UROGRAFIN 76 INJECTION, inform your doctor, if you are taking any of the following medicine:
- medicines used to manage diabetes such as biguanides Ex. metformin
- medicines used to manage high blood pressure or other heart conditions such as beta blockers Ex. metoprolol
- medicines used to regulate immune responses Ex. interleukin
B. Drug-Food Interactions:
Avoid taking flatulent food such as peas, beans, lentils, salads, fruit, bread, and uncooked vegetables two days prior to the examination.
Overdosage:
UROGRAFIN 76 INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely that you will receive an overdose. Symptoms of overdose are cyanosis (bluish discoloration of nails, lips, and skin due to lack of oxygen in the blood), bradycardia (slow heartbeat), acidosis (acid build-up in the blood stream), pulmonary haemorrhage (bleeding in the lungs), convulsions (repeated and uncontrolled contraction and relaxation of muscle), coma, and cardiac arrest. Consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Diatrizoate Meglumine, Diatrizoate Sodium |
| Pharmacological Category | : | Radiology contrast agents/X-ray dyes |
| Therapeutic Indication | : | Radiographic examinations |
| Dosage Forms | : | Injection |
More Information
- keep the medicine out of reach of children
- store UROGRAFIN 76 INJECTION at room temperature
FAQs About UROGRAFIN 76 INJECTION
Q: What is UROGRAFIN 76 INJECTION used for?
A: UROGRAFIN 76 INJECTION is used as a contrast medium in various radiographic examinations, such as excretion urography, paediatric angiocardiography, aortography, peripheral arteriography, selective visceral arteriography, selective renal arteriography, selective coronary arteriography, contrast enhancement during computed tomographic brain imaging, and intravenous digital subtraction angiography. It is also used to enhance the contrast during the body’s computed tomography. Consult your doctor before receiving UROGRAFIN 76 INJECTION.
Q: What happens if you take more UROGRAFIN 76 INJECTION than your required dose?
A: UROGRAFIN 76 INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely that you will receive an overdose. Symptoms of overdose are cyanosis, bradycardia, acidosis, pulmonary haemorrhage, convulsions, coma, and cardiac arrest. Consult your doctor immediately or visit the nearby hospital.
Q: What side effects are seen with UROGRAFIN 76 INJECTION?
A: The common side effects associated with the use of UROGRAFIN 76 INJECTION are nausea, vomiting, erythema (redness of the skin), pain, warmth, mild swelling of the face, lips, tongue, or throat, and conjunctivitis (inflammation of the eyes). Consult your doctor immediately or visit the nearby hospital.
Q: Who should avoid receiving UROGRAFIN 76 INJECTION?
A: UROGRAFIN 76 INJECTION is not recommended for use in patients with severe liver disturbances, severe kidney dysfunction, heart failure, an overactive thyroid gland, acute inflammation of the pancreas, or heart failure. It should be used with caution in patients with severe liver disturbances, severe kidney dysfunction, pulmonary emphysema, and bronchial asthma. It should also be used with caution in pregnant females, breastfeeding mothers, the elderly, children, and adolescents (under 16 years of age). Consult your doctor before receiving UROGRAFIN 76 INJECTION.
Q: How does UROGRAFIN 76 INJECTION work?
A: UROGRAFIN 76 INJECTION helps in radiographic examination, where diatrizoate meglumine and diatrizoate sodium are the iodine-containing agents that readily diffuse in the vascular (inside the blood vessels) as well as extra-vascular (outside the blood vessels) spaces and absorb the X-rays. The relative differences in the concentration of the contrast medium in the tissues help in differentiating normal from abnormal tissues, thereby helping in monitoring as well as diagnosing the disease.
Q: Can I drive while receiving alcohol?
A: Do not drive or operate machines after receiving UROGRAFIN 76 INJECTION as you may experience delayed reactions such as fever, rash, flu-like symptoms, joint pain, and itchiness. Consult your doctor before receiving UROGRAFIN 76 INJECTION.
Q: What is the method of receiving UROGRAFIN 76 INJECTION?
A: UROGRAFIN 76 INJECTION will be given to you only by a doctor or a nurse and placed into the vein. Your doctor will determine the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: What medications should I avoid while receiving UROGRAFIN 76 INJECTION?
A: Before receiving UROGRAFIN 76 INJECTION, inform your doctor if you are taking medicines that are used to manage diabetes (metformin), high blood pressure or heart conditions (metoprolol), or interleukins. Consult your doctor before receiving UROGRAFIN 76 INJECTION.
Q: Can UROGRAFIN 76 INJECTION cause flu?
A: Yes. UROGRAFIN 76 INJECTION may cause flu-like symptoms such as fever, chills, sore throat, and cough in some patients, which are generally temporary and resolve with time. However, contact your doctor if this condition worsens.
Q: How long does it take for UROGRAFIN 76 INJECTION to leave the body?
A: The normal kidney eliminates the UROGRAFIN 76 INJECTION almost immediately. However, in infants and small children, excretion occurs somewhat more promptly than in adults, where, in patients with kidney dysfunction, excretion is delayed for around 30 minutes or more after injection. In patients with severe kidney function impairment, the excretion process may not get initiated.
References
1. Perry B. Molinoff. Thyroid And Anti-Thyroid Drugs. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. Twelfth Edition. 2011. Page – 1153.
2. H D Humes, D A Hunt, M D White. Direct toxic effect of the radiocontrast agent diatrizoate on renal proximal tubule cells. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. November 1987. [Assessed 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/3812740/
3. Liebel-Flarsheim Company LLC. Food and Drug Administration (FDA). [Revised in March 2017] [Accessed 7th July 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019292s011lbl.pdf
4. Bayer Australia Ltd. UROGRAFIN Injection (Diatrizoate Meglumine & Diatrizoate Sodium). [Revised in February 2020] [Accessed 7th July 2020] https://www.nps.org.au/assets/medicines/3b06073a-6161-48a5-889b-a53300ff003f.pdf
Useful Diagnostic Tests
- cognitive and neurological tests
- brain scans
- psychiatric evaluation
Author Details
