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Introduction About TROXONE 250 INJECTION
TROXONE 250 INJECTION contains Ceftazidime which belongs to the group of medicines called Antibiotics. It is used to manage urinary tract infections, respiratory infections, skin soft tissue infections, gastrointestinal tract infections and meningitis. It may also be used concomitantly with other antibiotics, such as aminoglycosides, vancomycin, and clindamycin in severe and life-threatening infections and in the immunocompromised patients.
TROXONE 250 INJECTION do not require dose adjustment in mild to moderate liver disease and safety and efficacy is not established in patients with severe liver disease. Contact your doctor before receiving this medicine.
TROXONE 250 INJECTION should be used with caution in patients with kidney disease and history of gastrointestinal disease, such as colitis. Contact your doctor before receiving.
TROXONE 250 INJECTION should be used in pregnancy only if clearly needed as safety of TROXONE 250 INJECTION in pregnancy is not established. Contact your doctor before receiving.
TROXONE 250 INJECTION is generally not recommended for use in breastfeeding women as low concentrations may pass through the breast milk do not receive unless considered clearly necessary. Consult your doctor before receiving it.
The safety and efficacy of TROXONE 250 INJECTION is not established in neonates and infants less than 2 months is not established. Contact your doctor before receiving.
TROXONE 250 INJECTION should be used with caution in elderly patients especially aged above 80 years of age. Contact your doctor before receiving.
The common side effects are receiving TROXONE 250 INJECTION are diarrhoea, swelling and redness along a vein, redness, pain, burning, swelling or inflammation at the injection site. Consult your doctor if any of the above side effects worsen.
Uses Of TROXONE 250 INJECTION
Used to manage:
- urinary tract infections
- respiratory infections
- skin soft tissue infections
- gastrointestinal infections
- meningitis
How TROXONE 250 INJECTION Works
Ceftazidime is a bactericidal (works against bacteria) in nature and acts by inhibiting the enzymes which are responsible for formation of cell wall in bacteria.
How to use TROXONE 250 INJECTION
TROXONE 250 INJECTION will be given to you as intravenously or intramuscularly only by a doctor or a nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight, severity and type of bacterial infection.
Side Effects Of TROXONE 250 INJECTION
Common
- swelling and redness (along a vein)
- diarrhoea
- eosinophilia (increase in number of eosinophils of white blood cells)
- thrombocytosis (increase in number of platelets)
- blood investigation (increase in levels of certain liver enzymes)
- pain, burning sensation, swelling or inflammation (at site of injection)
- red raised skin rashes, itching
Uncommon
- headache
- inflammation of the stomach causing pain or blood in stools
- dizziness
- fungal infections in the mouth, vagina
- increase in the level of urea, urea nitrogen or serum creatinine levels in the blood
- nausea
- vomiting
- fever and chills
Rare
- severe allergic reactions such as severe rash, with fever, fatigue, swelling of the face or lymph glands, increase of eosinophils (type of white blood cells), effects on liver, kidney or lung (a reaction called DRESS)
Stop receiving TROXONE 250 INJECTION and contact your physician immediately if you experience any of the following side effects:
- severe allergic reaction such as raised and itchy rash, swelling, of the face, mouth causing difficulty in breathing
- skin rash, blisters, with central dark spot surrounded by a paler area, with a dark ring around the edge
- signs of Stevens-Johnson syndrome or toxic epidermal necrolysis such as a widespread rash with blisters and peeling skin
- nervous system disorders such as tremors, fits
- symptoms of pseudomembranous colitis such as prolonged or significant diarrhoea, abdominal pain
How To Manage Side Effects
Diarrhoea:
Drink plenty of water or fruit juices to keep you hydrated. Don’t take any medicine on your own for managing diarrhoea. Contact your doctor if diarrhoea worsen.
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if needed. Do not consume alcohol. Contact your doctor if your headache did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel dizziness. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if dizziness worsens.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Use moisturizers to soothe and hydrate the affected skin area. Contact your doctor if itching worsens.
Nausea or Vomiting:
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if nausea and vomiting worsen.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain did not improve.
Warning & Precautions
Pregnancy
TROXONE 250 INJECTION should be used in pregnant women only if clearly necessary as safety of TROXONE 250 INJECTION in pregnancy is not established. Contact your doctor before receiving.
Breastfeeding
TROXONE 250 INJECTION is generally not recommended for use in breastfeeding women unless considered clearly necessary as it may pass through the breast milk. Consult your doctor before receiving TROXONE 250 INJECTION.
Driving and Using Machines
TROXONE 250 INJECTION may cause dizziness which can affect your ability to drive and operate machines. Do not drive or operate any machines if you feel dizzy after receiving TROXONE 250 INJECTION.
Kidney
TROXONE 250 INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving TROXONE 250 INJECTION.
Liver
TROXONE 250 INJECTION should be used with caution hence safety and efficacy is not established in patients with severe liver disease. Contact your doctor before receiving TROXONE 250 INJECTION.
Allergy
Do not receive TROXONE 250 INJECTION if you are allergic to Ceftazidime or other antibiotics such as penicillin, cephalosporin’s, monobactams & carbapenems, or to lignocaine, or to ingredients of the medicine.
Others
Before receiving TROXONE 250 INJECTION, inform your doctor if you:
- have to take blood test (coomb’s test)
- have poor nutritional status
- have a history of gastrointestinal disease, such as colitis
- have severe allergic reactions
Use in pediatrics:
The safety and efficacy of TROXONE 250 INJECTION has not been established for neonates and infants less than 2 years of age. Your doctor will administer the right dose depends on the child’s age, body weight and severity of the infection.
Use in geriatrics:
TROXONE 250 INJECTION should be used with caution in elderly patients (especially aged above 80 years of age). Consult your doctor before receiving TROXONE 250 INJECTION.
Interactions
A. Drug-Drug interactions:
Before receiving TROXONE 250 INJECTION, inform your doctor if you are taking any of the following medicine:
- chloramphenicol, gentamycin, neomycin, tobramycin, streptomycin (medicines used for management of bacterial infections)
- furosemide (medicine used for management of kidney disorders)
- combined oral oestrogen/progesterone contraceptives (medicines used to manage pregnancy)
- hydromorphone (medicine used for severe pain)
- diphenoxylate (medicine used for diarrhoea)
- atropine (medicine used to manage low heart rate)
Overdosage:
TROXONE 250 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Excessive dose of TROXONE 250 INJECTION in patients suffering from kidney disease may lead to fits, encephalopathy (brain disorder that alters brain functions), asterixis (involuntary movements), neuromuscular excitability, and myoclonia (muscle jerks).
Synopsis
| Drug | : | Ceftazidime |
| Pharmacological Category | : | Cephalosporin Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Injection |
More Information
- Keep TROXONE 250 INJECTION out of reach of children
- Store at room temperature
FAQs About TROXONE 250 INJECTION
What is TROXONE 250 INJECTION used for?
TROXONE 250 INJECTION is used to manage urinary tract infections, respiratory infections, skin soft tissue infections, gastrointestinal tract infections and meningitis. It may also be used concomitantly with other antibiotics, such as aminoglycosides, vancomycin, and clindamycin in severe and life-threatening infections and in the immunocompromised patients.
Is TROXONE 250 INJECTION effective?
TROXONE 250 INJECTION effective if used in the dose and duration advised by your doctor. Do not stop receiving it even if you see improvement in your condition.
How do you give TROXONE 250 INJECTION?
TROXONE 250 INJECTION will be given to you as intravenously or intramuscularly only by a doctor or a nurse Your doctor will administer the correct dose and duration for you depending upon your age, body weight, severity and type of bacterial infection.
Is TROXONE 250 INJECTION safe for use in patients with liver disorder?
TROXONE 250 INJECTION should be used with caution hence safety and efficacy is not established in patients with severe liver disease. Contact your doctor before receiving TROXONE 250 INJECTION.
What are side effects of TROXONE 250 INJECTION?
The most common side effects of receiving TROXONE 250 INJECTION are swelling and redness along a vein, pain, burning, swelling or inflammation at the injection site, red raised skin rash, itching, diarrhoea.
References
1. KD Tripathi. Antimicrobial Drugs. Essentials of pharmacology, 7th edition.2013 page 728.
2. Mayra Matesanz, Jose Mensa. Ceftazidime- Avibactam. Official Journal of Spanish Society of Chemotherapy. September 2021. [Accessed on 13th August 2022]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683003/
3. CP Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 13th August 2022] https://www.medicines.org.uk/emc/files/pil.6346.pdf
4. ACS DOBFAR Sp. A. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 13th August 2022] https://www.medicines.org.uk/emc/files/pil.8751.pdf
5. GlaxoSmithKline. U.S. Food & Drug Administration. [Revised in January 2007] [Accessed on 13th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050578s053,050634s020lbl.pdf
6. GlaxoSmithKline Verona. U.S. Food & Drug Administration. [Revised in July 2017] [Accessed on 13th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050578s061,050634s028lbl.pdf
7. Fresenius Kabi Australia Pty Limited. Ceftazidime. [Revised in March 2020] [Accessed on 13th August 2022] https://www.fresenius-kabi.com/au/documents/Ceftazidime_Kabi_PI.pdf
Useful Diagnostic Tests
- Kidney function test
- Liver function test
- Prothrombin time
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