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Introduction About TRIOLMESAR CH 40MG TABLET
TRIOLMESAR CH 40MG TABLET is a combination of Amlodipine, Chlorthalidone and Olmesartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure). It can also be used to manage heart failure or stroke and can protect the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus.
It can also reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases. Take this medicine preferably in the mornings with food. While taking TRIOLMESAR CH 40MG TABLET, do not drink alcohol/grapefruit juice or go for a low-salt diet, as they may make further reduce your blood pressure. Consult your doctor for the best diet that can suit your health condition.
Before taking TRIOLMESAR CH 40MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, high blood cholesterol levels, dehydration, or very low blood sodium, potassium or magnesium levels as a precaution.
TRIOLMESAR CH 40MG TABLET is not recommended for use in patients with other severe heart problems such as narrowing of heart valves or cardiogenic shock. It is also not suitable for use in patients with severe hypotension (low blood pressure).
Do not take TRIOLMESAR CH 40MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby or breastfeeding without consulting your doctor.
The most common side effects of taking TRIOLMESAR CH 40MG TABLET are headache, dizziness, tiredness, weakness, high blood uric acid levels, low blood sodium or magnesium levels, diabetes, high blood potassium levels, low blood pressure, impotence in men, sore throat, runny nose, cough, flu-like symptoms, urinary tract infections and increased blood cholesterol levels. Contact your doctor if any of these side effects trouble you.
Uses Of TRIOLMESAR CH 40MG TABLET
It is used to manage and prevent:
- Hypertension (high blood pressure)
- Heart failure, Stroke
- Edema (fluid retention)
- Kidney damage among diabetic patients
How TRIOLMESAR CH 40MG TABLET Works
TRIOLMESAR CH 40MG TABLET relaxes the blood vessels supplying various organs (such as heart, kidney, brain or others) which allows the blood to flow more smoothly across the blood vessels. It also removes the excess fluids and electrolytes (sodium and water) from the body in the form of urine which helps in reducing edema and blood thickness. Collectively, these actions improve blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.
How to use TRIOLMESAR CH 40MG TABLET
Always take TRIOLMESAR CH 40MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. TRIOLMESAR CH 40MG TABLET is preferably taken during the mornings with food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking TRIOLMESAR CH 40MG TABLET without consulting your doctor.
Side Effects Of TRIOLMESAR CH 40MG TABLET
Common
- headache, dizziness
- tiredness, weakness
- high blood uric acid levels
- low blood sodium levels (causing tiredness, confusion, muscle twitching, fits or fainting)
- low blood magnesium levels
- high or low blood sugar levels
- high blood potassium levels
- skin rash
- low blood pressure which may make you feel dizzy while standing up
- impotence in men
- nausea, vomiting, stomach pain, constipation, diarrhea, indigestion
- sore throat, runny nose, cough, flu-like symptoms
- back pain, joint pain
- urinary tract infections
- increased blood cholesterol levels
- increased liver enzymes levels
Uncommon
- gout
- sleepiness
- sleep disorders
- racing heartbeat (palpitations)
- shortness of breath
- edema
- cough
- problems in passing urine, increased urination
- inability to obtain an erection, breast enlargement in men
- weight gain or weight loss
Rare
- confusion
- high blood calcium levels (causing agitation, eye pain or inflammation, stomach pain)
- sugar in urine
- skin sensitivity
- fast or slow heartbeat
- pins and needles
- kidney problems
- muscle cramps
Stop taking TRIOLMESAR CH 40MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath (signs of heart attack)
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
How To Manage Side Effects
Nausea and vomiting:
Take TRIOLMESAR CH 40MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
TRIOLMESAR CH 40MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, consult your doctor before taking it.
Breastfeeding
TRIOLMESAR CH 40MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk and harm the nursing infant. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking TRIOLMESAR CH 40MG TABLET.
Alcohol
Avoid consumption of alcohol while taking TRIOLMESAR CH 40MG TABLET as it might make you feel dizzier and drowsier.
Kidney
TRIOLMESAR CH 40MG TABLET is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
TRIOLMESAR CH 40MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with mild to moderate liver diseases. Therefore, consult your doctor before taking it.
Allergy
Do not take TRIOLMESAR CH 40MG TABLET if you are allergic to Amlodipine, Chlorthalidone or Olmesartan.
Heart Disease
TRIOLMESAR CH 40MG TABLET is not recommended for use in patients with severe heart problems such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having a history of recent heart, heart failure, irregular heartbeat, coronary heart disease or problems related with heart muscle or valves). Therefore, consult your doctor before taking it.
Others
TRIOLMESAR CH 40MG TABLET is not recommended for use if you:
- have diabetes related kidney problems
- have abnormally very low blood pressure
- are not passing urine at all
- have low blood potassium levels (hypokalemia)
- have low blood sodium levels (signs include tiredness, confusion, muscle twitching, fits or lack of consciousness)
- high blood calcium levels
- have gout
- have Addison’s disease (a problem in adrenal gland)
Before taking TRIOLMESAR CH 40MG TABLET, inform your doctor if you have:
- severe uncontrollable increase in blood pressure (hypertensive crisis)
- have diabetes
- have high blood cholesterol levels
- have high blood potassium levels
- are undergoing any surgery (including dental surgery)
- are severely dehydrated (due to diarrhea, vomiting or excess sweating)
- are on a low-salt diet
- have primary hyperaldosteronism (problems in adrenal gland)
- are undergoing any major surgery
Use in pediatrics:
TRIOLMESAR CH 40MG TABLET is not recommended for use in children aged below 6 years. It should be used in children and adolescents (aged between 6-17 years) only if prescribed by the physician. Therefore, consult your doctor for advice before administration.
Use in geriatrics:
TRIOLMESAR CH 40MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor for advice before taking it.
Interactions
A. Drug - Drug interactions:
Before taking TRIOLMESAR CH 40MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to reduce elevated blood pressure and other heart problems (Ex. atenolol, propranolol, enalapril, lisinopril, amlodipine, nifedipine, diltiazem, verapamil, methyldopa, guanethidine)
- ketoconazole, itraconazole (used to manage fungal infections)
- ritonavir, indinavir, nelfinavir (used in management of HIV infections)
- rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
- dantrolene (a medicine used to manage muscle spasms)
- medicines used to control elevated cholesterol levels (Ex. simvastatin, cholestyramine, colesevelam)
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
- antacids (medicines used to neutralize stomach acid) Ex. aluminium hydroxide, magaldrate
- medicines used to manage graft rejection and to suppress immune functions (such as tacrolimus, sirolimus, temsirolimus, everlimus, cyclosporine)
- St. John’s wort (an herbal medicine used to manage depression)
- corticosteroids (used to manage pain and inflammation) Ex. prednisolone, betamethasone
- corticotropin (a medicine used to correct hormone problems)
- medicines used for cancer (Ex. cyclophosphamide, methotrexate)
- medicines used to manage asthma (such as salbutamol, formoterol)
- amphotericin B (a medicine used to manage fungal infections)
- carbenoxolone (a medicine used to manage mouth ulcers)
- anticholinergics (used to manage stomach muscle spasms) such as atropine, hyoscine
- lithium (a medicine used to manage various mental health problems)
- digoxin (a medicine used to manage irregular heartbeat)
- allopurinol (a medicine used to manage gout)
- amantadine (a medicine used for parkinsonism or viral infections)
- non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, celecoxib, ibuprofen, aspirin
- calcium and vitamin D supplements
- tricyclic antidepressants (used to manage depression) Ex. amitriptyline, nortriptyline, imipramine
- antipsychotics (used to manage mental illness) Ex. chlorpromazine
- baclofen (a medicine used for relaxing muscles)
- amifostine (a kidney protectant used along with chemotherapeutic agents)
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking TRIOLMESAR CH 40MG TABLET, as it could further decrease your blood pressure.
Overdosage:
If you or anyone else accidentally took more TRIOLMESAR CH 40MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin, and shortness of breath.
Synopsis
| Drug | : | Amlodipine, Chlorthalidone, Olmesartan |
| Pharmacological Category | : | Calcium Channel Blockers, Thiazide Diuretics, Angiotensin-II Receptor Blockers |
| Therapeutic Indication | : | Hypertension, Angina, Heart failure, Edema |
| Dosage Forms | : | Tablet |
More Information
- Keep TRIOLMESAR CH 40MG TABLET out of the sight and reach of children
- Store TRIOLMESAR CH 40MG TABLET at room temperature
FAQs About TRIOLMESAR CH 40MG TABLET
Q: What are the uses of TRIOLMESAR CH 40MG TABLET?
A: TRIOLMESAR CH 40MG TABLET is used to manage hypertension (high blood pressure). It can also be used to manage heart failure or stroke and can protect the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus. It can also reduce the chances of fluid retention (edema) in the body that occurs due to some kidney or liver diseases.
Q: What type of a medicine is TRIOLMESAR CH 40MG TABLET?
A: TRIOLMESAR CH 40MG TABLET relaxes the blood vessels supplying various organs (such as heart, kidney, brain or others) which allows blood to flow more smoothly across the blood vessels. It also removes the excess fluids and electrolytes (sodium and water) from the body in the form of urine. Collectively, these actions decrease fluid retention, improves blood flow, reduces the strain on the heart and helps the heart to pump more blood with less pressure.
Q: What happens when I stop taking TRIOLMESAR CH 40MG TABLET?
A: Do not stop taking TRIOLMESAR CH 40MG TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take TRIOLMESAR CH 40MG TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
Q: What is the best time to take TRIOLMESAR CH 40MG TABLET?
A: Take this medicine preferably in the mornings with food. However, consult your doctor for advice.
Q: What to do if I forgot to take a dose of TRIOLMESAR CH 40MG TABLET?
A: If you have missed a dose of TRIOLMESAR CH 40MG TABLET, take it as soon as you remember. However, if it is time for the next dose of TRIOLMESAR CH 40MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of TRIOLMESAR CH 40MG TABLET to compensate the missed ones.
Q: What precautions should be followed while taking TRIOLMESAR CH 40MG TABLET?
A: Before taking TRIOLMESAR CH 40MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have severe high or low blood pressure, or other heart problems (such as narrowing of the arteries, cardiogenic shock or a recent heart attack). Do not take TRIOLMESAR CH 40MG TABLET if you are pregnant and breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while taking TRIOLMESAR CH 40MG TABLET?
A: Avoid consumption of alcohol while taking TRIOLMESAR CH 40MG TABLET as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more TRIOLMESAR CH 40MG TABLET?
A: If you or anyone else accidentally took more TRIOLMESAR CH 40MG TABLET, consult your doctor immediately. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin and shortness of breath.
Q: Can I take TRIOLMESAR CH 40MG TABLET daily?
A: Take TRIOLMESAR CH 40MG TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take TRIOLMESAR CH 40MG TABLET every day or not.
Q: What are the side effects of TRIOLMESAR CH 40MG TABLET?
A: The most common side effects of taking TRIOLMESAR CH 40MG TABLET are headache, dizziness, tiredness, weakness, high blood uric acid levels, low blood sodium or magnesium levels, diabetes, high blood potassium levels, low blood pressure, impotence in men, sore throat, runny nose, cough, flu-like symptoms, urinary tract infections and increased blood cholesterol levels. Contact your doctor if any of these side effects trouble you.
Q: Can I stop taking TRIOLMESAR CH 40MG TABLET once my symptoms subside?
A: No. Do not stop taking TRIOLMESAR CH 40MG TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take TRIOLMESAR CH 40MG TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Q: Can TRIOLMESAR CH 40MG TABLET causes electrolyte imbalance?
A: Yes. TRIOLMESAR CH 40MG TABLET may alter the levels of certain electrolytes (sodium or potassium) in the body. To avoid this, your doctor will closely monitor the electrolytes levels in the blood periodically. However, if you experience any unusual symptoms such as chest pain, muscle weakness, irregular heartbeat, confusion, drowsiness, nausea, or vomiting, consult your doctor for advice.
Q: Can the use of TRIOLMESAR CH 40MG TABLET affect my sexual life?
A: Yes. TRIOLMESAR CH 40MG TABLET may cause impotence in men and low sex drive in both men and women. Consult your doctor if they trouble you.
Q: Can TRIOLMESAR CH 40MG TABLET be taken during pregnancy?
A: TRIOLMESAR CH 40MG TABLET is not recommended for use in pregnant women as it may harm the growing baby. Therefore, consult your doctor before taking it.
Q: Is TRIOLMESAR CH 40MG TABLET safe to use in kidney disease?
A: TRIOLMESAR CH 40MG TABLET is not recommended for use in patients with severe kidney problems (such as kidney stones, renal artery stenosis, dialysis). It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Q: Can the use of TRIOLMESAR CH 40MG TABLET affect the liver?
A: Yes. TRIOLMESAR CH 40MG TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Q: Does TRIOLMESAR CH 40MG TABLET cause frequent urination?
A: Yes. TRIOLMESAR CH 40MG TABLET may cause frequent urination. It is because TRIOLMESAR CH 40MG TABLET contains a medicine called chlorthalidone which is a diuretic (water pill). It excretes the excess water from the body in the form of urine. Therefore, it is advised to take TRIOLMESAR CH 40MG TABLET at least 5 hours before bedtime to avoid the urge at night to urinate.
References
1. KD Tripathi. Antianginal and Other Anti-ischaemic Drugs. Antihypertensive Drugs. Diuretics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 549, 562, 559 & 583. 561 & 562.
2. Connor C. Kerndt; Jayesh B. Patel. Chlorthalidone. StatPearls [Internet]. NIH. National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. November 2022. [Accessed on 2nd January 2023] https://www.ncbi.nlm.nih.gov/books/NBK553174/
3. Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che, and Michael R. Hamblin. Management of Hypertension Using Olmesartan Alone or in Combination. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. March 2017. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446820/
4. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.3478.pdf
5. Bristol Laboratories Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/product/11442/smpc#DOCREVISION
6. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.9886.pdf
7. Atlantic Pharma. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 2nd January 2023] https://www.medicines.org.uk/emc/files/pil.11982.pdf
8. Torrent Pharmaceuticals Ltd. Triolsar. [Revised in July 2020]. [Accessed on 2nd January 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2956.pdf
Useful Diagnostic Tests
- Kidney function test
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