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Introduction About TRINEUROSOL HP INJECTION
TRINEUROSOL HP INJECTION contains Hydroxocobalamin, which belongs to a group of medicines called Vitamin B12. It is used to manage certain types of anaemia, such as Addisonian pernicious anaemia (caused by a decrease in the stomach's ability to absorb vitamin B12), and macrocytic anaemias (due to a lack of vitamin B12). It is also used to manage tobacco amblyopia (vision problems caused by tobacco) and Leber’ optic atrophy (impaired vision and loss of central vision).
Symptoms of vitamin B12 deficiency are memory loss, depressed mood, a sore mouth, and tongue, tingling sensations, and numbness in the limbs and legs. Your doctor may advise you to take relevant tests to evaluate and monitor your condition.
Before using TRINEUROSOL HP INJECTION inform your doctor if you have megaloblastic anaemia (known by enlarged red blood cells). TRINEUROSOL HP INJECTION is generally not recommended for use by pregnant women to manage megaloblastic anaemia unless you also have a vitamin B12 deficiency. TRINEUROSOL HP INJECTION should be used with caution in breastfeeding women.
The most common side effects of receiving TRINEUROSOL HP INJECTION are pain, swelling or itchy skin at the injection site, nausea, vomiting, diarrhoea, headache, feeling dizzy, hot flushes, etc. Contact your doctor if any of your symptoms get worse or persist.
Uses Of TRINEUROSOL HP INJECTION
Prevent and manage certain types of anaemia:
- Addisonian pernicious anaemia (caused by a decrease in the stomach's ability to absorb vitamin B12)
- macrocytic anaemias (due to vitamin B12 deficiency)
Manage:
- tobacco amblyopia (vision problems caused by tobacco)
- leber’s atrophy (damage of vision and loss of central vision)
How TRINEUROSOL HP INJECTION Works
TRINEUROSOL HP INJECTION is a synthetic form of vitamin B12, which is required for the synthesis of various metabolic functions such as the metabolism of carbohydrates, proteins, DNA, and fatty acids for cell growth and division, and is essential for producing red blood cells.
How to use TRINEUROSOL HP INJECTION
TRINEUROSOL HP INJECTION must be given by a doctor or a nurse into the muscle as an intramuscular injection. Depending on your age, body weight, and medical state, your doctor will determine the appropriate dose and duration for you.
Side Effects Of TRINEUROSOL HP INJECTION
Common
- pain, swelling or itchy skin at the injection site
- nausea, vomiting, diarrhoea
- headache, feeling dizzy
- hot flushes
Rare
Stop receiving TRINEUROSOL HP INJECTION and contact your physician immediately if you experience any of the following side effects:
- serious allergic reactions such as swelling of the face, eyelids, lips, difficulty in breathing, rash or itching particularly those that cover your entire body and collapse
- irregular heartbeat due to low potassium levels
How To Manage Side Effects
Diarrhoea:
Drink plenty of water and fruit juice to keep yourself hydrated. Contact your doctor if the diarrhoea does not improve.
Headache:
Rest and relax. If necessary, apply a balm to your forehead to relieve the pain. Contact your doctor if the headache does not improve.
Nausea and vomiting:
Receive the medicine with or just after a meal. Stick to simple meals. Avoid eating oily or spicy foods. If your symptoms do not improve, consult your doctor.
Dizziness:
Try to rest and relax. Get enough sleep. Contact your doctor if the dizziness does not improve.
Skin rash:
Hot water can irritate your skin further, so avoid having hot showers. Do not scratch the affected area. Contact your doctor if the rashes do not improve.
Warning & Precautions
Pregnancy
TRINEUROSOL HP INJECTION is generally not recommended for use during pregnancy, unless recommended by your doctor. It is recommended for use in pregnant women with vitamin B12 deficiency. However, contact your doctor before receiving TRINEUROSOL HP INJECTION.
Breastfeeding
TRINEUROSOL HP INJECTION should be used with caution in breastfeeding women. Although TRINEUROSOL HP INJECTION may pass through breast milk, it is unlikely to harm your baby. Contact your doctor before receiving TRINEUROSOL HP INJECTION.
Driving and Using Machines
Do not drive or operate machines if you feel dizzy or drowsy after receiving TRINEUROSOL HP INJECTION.
Allergy
Do not receive TRINEUROSOL HP INJECTION if you are allergic (hypersensitive) to hydroxocobalamin or other ingredients in this medicine.
Others
Before receiving TRINEUROSOL HP INJECTION inform your doctor if you have:
- megaloblastic anaemia (known by enlarged red blood cells)
Interactions
A. Drug-Drug interactions:
Tell your doctor if you have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplements, or herbal products.
- antibiotics (used for managing bacterial infections) Ex. Chloramphenicol
- antimetabolites (medicines used to stop cell growth in blood cancer (leukaemia) Ex. mercaptopurine
- oral contraceptives (used to manage pregnancy)
Overdosage:
TRINEUROSOL HP INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely for you to receive an overdose. Contact your physician if you experience worsening of any unusual symptoms.
Synopsis
| Drug | : |
Hydroxocobalamin |
| Pharmacological Category | : |
Vitamin B12 |
| Therapeutic Indication | : |
Addisonian pernicious anaemia, macrocytic anaemia, tobacco amblyopia, leber’s atrophy |
| Dosage Forms | : |
Injection |
More Information
- Keep TRINEUROSOL HP INJECTION out of the sight and reach from children
- Store TRINEUROSOL HP INJECTION below 25°C
FAQs About TRINEUROSOL HP INJECTION
What is TRINEUROSOL HP INJECTION used for?
TRINEUROSOL HP INJECTION is used to manage certain types of anaemia, such as Addisonian pernicious anaemia (caused by a decrease in the stomach's ability to absorb vitamin B12), macrocytic anaemias (due to a lack of vitamin B12) and used to manage tobacco amblyopia (vision problems caused by tobacco), leber’s atrophy (damage of vision and loss of central vision). Contact your doctor before receiving it.
Can I use TRINEUROSOL HP INJECTION in pregnancy?
TRINEUROSOL HP INJECTION is generally not recommended for use during pregnancy to manage megaloblastic anaemia (known by enlarged red blood cells) unless a vitamin B12 deficiency is also present. Contact your doctor before receiving TRINEUROSOL HP INJECTION.
How does TRINEUROSOL HP INJECTION work?
TRINEUROSOL HP INJECTION is a synthetic form of vitamin B12, which is required for the synthesis of various metabolic functions such as the metabolism of carbohydrates, proteins, DNA, and fatty acids for cell growth and division, and is essential for producing red blood cells.
Can I use TRINEUROSOL HP INJECTION while breastfeeding?
TRINEUROSOL HP INJECTION should be used with caution in breastfeeding women. Although TRINEUROSOL HP INJECTION is present in breast milk, it is unlikely to damage your infant. Contact your doctor before receiving TRINEUROSOL HP INJECTION.
How do you administer TRINEUROSOL HP INJECTION?
TRINEUROSOL HP INJECTION will be given to you by a doctor or a nurse into the muscle as an intramuscular injection. Depending on your age, body weight, and medical state, your doctor will determine the appropriate dose and duration for you.
What are the symptoms of low vitamin B12?
Symptoms of vitamin B12 deficiency (anaemia) include extreme tiredness, lack of energy, shortness of breath, feeling faint, headache, pale skin, palpitations, etc. However, consult your doctor for advice.
How long does it take for TRINEUROSOL HP INJECTION to work?
TRINEUROSOL HP INJECTION may take a few days or weeks to stabilize your vitamin B12 levels in the body, and thereby it eventually relieves symptoms such as extreme tiredness or lack of energy, a sore mouth, and tongue, tingling and numbness in the limbs and legs.
Can TRINEUROSOL HP INJECTION cause tiredness?
TRINEUROSOL HP INJECTION may cause low potassium levels in the body and this can cause muscle cramps, extreme fatigue, and an irregular heartbeat. Contact your doctor if your symptoms get worse.
References
1. K D Tripathi. Drugs affecting blood and blood formation. Essentials of medical pharmacology. 8th edition. 2019. Page – 220.
2. Ramezanpour Ahangar E, Annamaraju P. Hydroxocobalamin. National Institute of Health. NLM. National centre for biotechnology information. Stat Pearls. July 2022. [Accessed on 8th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK557632/
3. Wasserburger Arzneimittelwerk GmbH. Health Products Regulatory Authority (HPRA). [Revised in June 2021] [Accessed on 8th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/284cec55-e822-44c8-819e-28a759e885b0.pdf
4. Wasserburger Arzneimittelwerk GmbH. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 8th August 2022] https://www.medicines.org.uk/emc/files/pil.9746.pdf
5. Delpharm Tours. Electronic Medicines Compendium (EMC). [Revised in January 2018] [Accessed on 8th August 2022] https://www.medicines.org.uk/emc/files/pil.6620.pdf
Useful Diagnostic Tests
- Complete blood count
- Ferritin
- Iron Serum
- Iron Studies
- Vitamin B12
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