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Introduction About TOXOCARE TABLET
TOXOCARE TABLET contains Spiramycin which belongs to the group of medicines called Antibiotics. It is used to manage infections in respiratory tract, oral cavity, skin and soft tissues caused by certain bacteria and parasites. It is also used to manage infections like gonorrhoea (sexually transmitted infection that causes painful urination and abnormal discharge) in individuals allergic to the Penicillin medicine as well as used to manage toxoplasmosis infection (caused by toxoplasma gondii parasite seen in cat faeces and contaminated food) in pregnant women.
Symptoms of toxoplasmosis are muscle pain, headache and fever and it may cause abortion or make baby to born too early before completion of pregnancy period.
Before taking TOXOCARE TABLET, your doctor will do few blood tests to determine the exact cause of infection. Inform your doctor if you are suffering from either impaired liver function or abnormal heart rate problems.
TOXOCARE TABLET is not recommended for use in children below 6 years and in patients suffering from meningitis (infection of brain with symptoms of fever and severe headache).
TOXOCARE TABLET should be used in caution in pregnant and breast-feeding women. Consult your doctor before taking it.
The most common side effects of taking TOXOCARE TABLET includes nausea, vomiting, numbness and itching in skin, inflamed bowels. Contact your physician immediately if any of the symptoms worsen with time like chest pain, blood in urine and faeces, dizziness, hypersensitive rashes in skin.
Uses Of TOXOCARE TABLET
Used to manage:
- bacterial infections of the respiratory tract, oral cavity, skin and soft tissues
- gonorrhoea in patients allergic to penicillin medicine
- toxoplasmosis in pregnant women
How TOXOCARE TABLET Works
TOXOCARE TABLET is a macrolide antibiotic that works by blocking protein synthesis of disease-causing bacteria/parasite. This leads to management of growth of bacteria/parasite in the body and helps to reduce the infection and its symptoms.
How to use TOXOCARE TABLET
Take TOXOCARE TABLET exactly as advised by your doctor. It is advised to swallow the medicine with a glass of water and should be taken preferably after meals.
Do not stop taking TOXOCARE TABLET before doctor’s advice even if you feel better. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of infection.
Side Effects Of TOXOCARE TABLET
Common
- nausea
- vomiting
- loose stools
- numbness and itching in skin
Rare
- abnormal liver function tests
- haemolytic anaemia
- low WBC count
Stop taking TOXOCARE TABLET and immediately contact your doctor if you experience any of the following symptoms.
- pain in the chest
- blood in urine and stool
- increased heart rate
- prolonged dizziness (feeling faint)
- severe body rashes
- swollen face and throat
- skin with rashes, blisters, pain along with fever (Steven-Johnson syndrome)
- occurrence of areas with redness and swelling on body along with fever (skin condition called acute generalized exanthematous pustulosis)
How To Manage Side Effects
Nausea and Vomiting:
Avoid eating fried and greasy food. Take simple, light, small meals at frequent intervals. Keep yourself hydrated by drinking lots of fluids.
Diarrhea:
Keep yourself hydrated by drinking plenty of fluids and consult your doctor before taking any medication.
Itchy skin:
Do not rub or scratch your skin as it will make it worse. Apply any moisturizers like oil or calamine lotion. Consult doctor if it worsens with time.
Warning & Precautions
Pregnancy
TOXOCARE TABLET should be used in caution if you are pregnant. Consult your doctor before taking.
Breastfeeding
TOXOCARE TABLET is generally not recommended for use in breast feeding women as it may pass through the breast milk. Consult your doctor before taking it.
Liver
TOXOCARE TABLET should be used in caution in patients suffering from impaired liver function. Consult your doctor before taking.
Allergy
Do not take TOXOCARE TABLET if you are allergic to Spiramycin or any other macrolide antibiotics.
Heart Disease
TOXOCARE TABLET should be taken in caution in patients with heart rate disturbances which may cause cardiac arrest (sudden unexpected loss of heart function, consciousness and breathing). Consult your doctor before taking.
Others
TOXOCARE TABLET is not recommended for use if you:
- are suffering from meningitis
Before taking TOXOCARE TABLET inform your doctor if you are:
- having G6PD enzyme deficiency (rare hereditary disease with symptoms of not feeling well, pale skin appearance and difficulty in breathing)
- suffering an imbalance in blood electrolyte levels (blood test results showing low values compared to normal for elements like sodium and potassium)
Use in pediatrics:
TOXOCARE TABLET is not recommended in newborns and children under 6 years of age. Consult your doctor before taking.
Use in geriatrics:
TOXOCARE TABLET is not recommended in elderly patients over 65 years of age. Consult your doctor before taking.
Interactions
A. Drug-Drug interactions:
Before taking TOXOCARE TABLET inform your doctor if you are taking following medicines.
- medicine used for management of Parkinson’s disease (Ex. levodopa, carbidopa)
- medicines which delay or manage clotting called anticoagulants (Ex. warfarin)
- medicines used for mental problems like antipsychotics. (Ex. chlorpromazine)
- medicines which prolong the QT interval (Ex. erythromycin, antimalarial drugs like chloroquine)
Overdosage:
If you or anyone else accidentally took more of TOXOCARE TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are abdominal discomfort, nausea, loose stools.
Synopsis
| Drug | : | Spiramycin |
| Pharmacological Category | : | Macrolide Antibiotics |
| Therapeutic Indication | : | Manages Bacterial and Parasitic infection |
| Dosage Forms | : | Tablet |
More Information
- Keep TOXOCARE TABLET out of reach of children
- Store at room temperature
FAQs About TOXOCARE TABLET
What is TOXOCARE TABLET used for?
TOXOCARE TABLET is used to manage infections in respiratory tract, oral cavity, skin and soft tissues caused by certain bacteria and parasites. It is also used to manage toxoplasmosis in pregnant women and gonorrhea in patients who are allergic to pencillin medicine.
What should I do if I forgot to take one dose of TOXOCARE TABLET?
If you missed taking a dose of TOXOCARE TABLET on time, then take next dose at regular time and do not take double dose to compensate for missed dose.
Can I stop taking TOXOCARE TABLET without completing the course if I feel better?
It is not recommended to stop TOXOCARE TABLET without your doctor’s permission even if you are feeling better. It is important to complete the course of TOXOCARE TABLET to make complete recovery and eliminate the infection fully.
What happens if I take extra dose of TOXOCARE TABLET?
If you take higher doses of TOXOCARE TABLET than prescribed, you may suffer from nausea, vomiting, diarrhoea, improper heartbeats. It is advised to consult your doctor immediately if you have taken higher doses of TOXOCARE TABLET.
Can I take TOXOCARE TABLET during breast feeding?
It is not advisable to take TOXOCARE TABLET if you are breastfeeding since the active ingredient passes through breast milk. Consult your doctor before taking.
How to take and store TOXOCARE TABLET?
Take TOXOCARE TABLET exactly as advised by your doctor. It is advised to swallow the medicine with a glass of water and should be taken preferably after meals. Do not stop taking TOXOCARE TABLET before doctor’s advice even if you feel better. It is advised to store TOXOCARE TABLET at room temperature.
References
1. KD Tripathi. Autocoids and related drugs. Essentials of Medical Pharmacology.8th edition. 2019. Page – 805.
2. Hagras, Nancy Abd-elkader, Amal Farahat Allam, Hoda Fahmy Farag, Mervat Mostafa Osman, Thanaa Ibrahim Shalaby, Nermine Mogahed Fawzy Hussein Mogahed, Mona Mohamed Tolba, and Amel Youssef Shehab. Successful treatment of acute experimental toxoplasmosis by spiramycin-loaded chitosan nanoparticles. Experimental parasitology [Revised in September 2019] [Accessed on 14th July 2022] https://www.sciencedirect.com/science/article/abs/pii/S0014489419301420
3. Bunnag, Chaweewan, Perapun Jareoncharsri, Siriporn Voraprayoon, Apichai Vitavasiri, Pornchulee Supatchaipisit, and Supornchai Kongpatanakul. Efficacy of spiramycin as an alternative to amoxicillin in the treatment of acute upper respiratory tract infections. Clinical drug investigation. [Revised in August 2012] [Accessed on 14th July 2022] https://link.springer.com/article/10.2165/00044011-199815060-00001
4. Bochenska-Marciniak, M., I. Kuprys, A. Krzywiecki, A. Sliwowski, and P. Kuna. Clinical efficacy and safety of spiramycin and clarithromycin in the treatment of outpatients with lower respiratory tract infections. National Library of Medicine. PubMed Central (PMC) [Accessed on 14th July 2022] https://pubmed.ncbi.nlm.nih.gov/10335027/
5. Odan Laboratories Ltd. Spiramycin [Revised in April 2018] [Accessed on 14th July 2022] https://pdf.hres.ca/dpd_pm/00044997.PDF
6. Famar Lyon France or Sanofi s.p.a,Italy. [Revised in August 2015] [Accessed on 14th July 2022] https://myhealthbox.eu/en/view/3178388/0fac7cd3c40c3b625289b83b620b6f58/leaflet
Useful Diagnostic Tests
- Complete blood count
- Liver function test
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