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Intas Pharmaceuticals Ltd

TAXOCARE 80 Injection 4ml

Cancer Oncology
MRP ₹11,573.09 (Inclusive of all taxes)
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    Introduction About TAXOCARE 80 INJECTION

    TAXOCARE 80 INJECTION contains Docetaxel which belongs to the group of medicines called Taxoids. TAXOCARE 80 INJECTION is used in the management of breast cancer, special forms of lung cancer (non-small cell lung cancer), prostate cancer, gastric (stomach) cancer and/or head and neck cancer in affected individuals.        

    TAXOCARE 80 INJECTION is not recommended for use in patients who are allergic to docetaxel. It is not recommended for use in patients with low number of white blood cells and in patients suffering from severe liver disease.   

    Before receiving TAXOCARE 80 INJECTION, inform your doctor if you are alcohol dependent, and/or suffering from epilepsy, heart and/or kidney disease.

    TAXOCARE 80 INJECTION is not recommended for use during pregnancy unless it is clearly necessary. Women of child-bearing potential should use effective contraception method to avoid getting pregnant while receiving TAXOCARE 80 INJECTION. The medicine is also not recommended for use in breastfeeding women.  

    TAXOCARE 80 INJECTION should be used with caution in children and adolescents (aged below 18 years) which is also advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.  

    The most common side effects of receiving TAXOCARE 80 INJECTION are infection, hair loss, headache, loss of appetite, indigestion, nausea, vomiting, and/or constipation. Consult your doctor if any of these symptoms worsen.

    Uses Of TAXOCARE 80 INJECTION

    • Manage breast cancer and special forms of lung cancer (non-small cell lung cancer)
    • Manage prostate cancer, gastric cancer and head & neck cancer

    How TAXOCARE 80 INJECTION Works

    TAXOCARE 80 INJECTION works by interfering with the microtubule structures in the cell (substance which aids cancer cells to divide and multiply) thus inhibiting the growth of cancer cells and stopping its spread in affected individuals.   

    How to use TAXOCARE 80 INJECTION

    TAXOCARE 80 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

    Side Effects Of TAXOCARE 80 INJECTION

    Common

    • infections, decrease in red and white blood cells count, low platelet count
    • hair loss
    • headache, loss of appetite, indigestion, nausea, vomiting, constipation, diarrhoea
    • sores in the mouth, dry mouth, difficulty/painful swallowing
    • sleeplessness, tiredness, dizziness, dehydration
    • signs of allergic reactions such as flushing, skin reactions, itching, chest tightness, difficulty in breathing, fever/chills, back pain, low blood pressure
    • tingling/prickling sensation in joints/muscles, redness and swelling of palms of hands / soles of feet, change in the colour of your nails
    • alteration in sense of taste
    • inflammation of throat and nose, bleeding from nose, inflammation of eye/increased tearing of the eyes, breath muscle aches and pains, back pain/bone pain
    • nasal drainage, swelling due to lymphatic drainage
    • shortness of breath, low blood pressure
    • change/absence of menstrual period
    • flu-like symptoms
    • weight gain/loss
    • infection of the upper respiratory tract
    • oral candidiasis
    • hearing impaired, inflammation of oesophagus
    • irregular/rapid heartbeat

    Uncommon

    • skin reactions at injection site
    • fainting, phlebitis (inflammation of the vein)/swelling
    • blood clots
    • blood cancer (may occur when used with other anticancer management)

    Rare

    • inflammation of colon/intestine, intestinal perforation

    Inform your doctor immediately if you experience any of the following side effects while receiving TAXOCARE 80 INJECTION:                     

    • signs of severe allergic reaction such as flushing, skin reactions, itching, chest tightness, difficulty in breathing, fever/chills, back pain, low blood pressure
    • fever
    • signs of serious gastrointestinal toxicity such as abdominal pain/tenderness, diarrhoea, rectal haemorrhage, blood in stool and/or fever
    • vision problems especially blurred vision
    • signs of acute or worsening lung problems such as fever, shortness of breath and/or cough
    • skin reactions such as stevens-johnson syndrome, toxic epidermal necrolysis (associated with signs such as blistering, peeling/bleeding on any part of skin with/without a rash), and acute generalized exanthematous pustulosis (associated with signs such as red, scaly widespread rash with bumps under the swollen skin accompanied with fever)
    • signs of ventricular arrhythmia/ tachycardia (condition marked by irregular heart rhythms) such as irregular/rapid heartbeat, severe shortness of breath, dizziness, and/or fainting
    • signs of tumour lysis syndrome (serious condition marked by massive death of cancer cells) such as seizures, kidney failure and/or heart rhythm disturbance

    How To Manage Side Effects

    Constipation

    Try to eat high-fiber foods such as vegetables, cereals, fresh fruit and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, inform your doctor for receiving alternate management for constipation.

    Diarrhea

    Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Inform your doctor if the symptom gets worse.

    Dizziness Or Drowsiness

    Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Inform your doctor if the symptom worsens.

    Dry Mouth

    Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and use mouthwash. Inform your doctor if the symptom gets worse.

    Headache

    If TAXOCARE 80 INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving TAXOCARE 80 INJECTION. If it lasts more than a week or severe, inform your doctor.

    Indigestion

    Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea or alcohol and lose weight if you are obese. Try to avoid smoking and don’t have rich, fatty or spicy foods. Inform your doctor if the symptom does not improve.

    Nausea And Vomiting

    Receive TAXOCARE 80 INJECTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Inform your doctor if symptom gets worse.

    Tiredness

    Make sure you take rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to receive TAXOCARE 80 INJECTION at a time when you can sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.

    Warning & Precautions

    Pregnancy

    Monitoring required

    TAXOCARE 80 INJECTION is not recommended for use during pregnancy unless it is clearly necessary. Women of child-bearing potential should use effective contraception method while receiving TAXOCARE 80 INJECTION and for 2 months after the end of management, since it may harm the unborn baby. Consult your doctor before receiving the medicine.  

    Breastfeeding

    Contraindicated

    TAXOCARE 80 INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving TAXOCARE 80 INJECTION.

    Driving and Using Machines

    Use with Caution

    Do not drive and operate machines if TAXOCARE 80 INJECTION affects your ability to drive or operate any machines.

    Alcohol

    Consult your doctor

    Avoid consumption of alcohol while receiving TAXOCARE 80 INJECTION since it may cause harmful effects to the patient.

    Kidney

    Use with Caution

    TAXOCARE 80 INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving TAXOCARE 80 INJECTION.  

    Liver

    Consult your doctor

    TAXOCARE 80 INJECTION is not recommended for use in patients with serious liver disease. It should be used with caution in patients with other liver disease. Consult doctor before receiving TAXOCARE 80 INJECTION.   

    Allergy

    Contraindicated

    Do not receive TAXOCARE 80 INJECTION if you are allergic to Docetaxel and/or any other ingredients of this medicine.

    Heart Disease

    Use with Caution

    TAXOCARE 80 INJECTION should be received with caution in patients with heart disease. Consult your doctor before receiving TAXOCARE 80 INJECTION.

    Use In Pediatrics

    Use with Caution

    TAXOCARE 80 INJECTION should be used with caution in children and adolescents (aged below 18 years). Consult your child’s doctor for advice before administration of the medicine.

    Use In Geriatrics

    Use with Caution

    TAXOCARE 80 INJECTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving the medicine. 

    Others

    TAXOCARE 80 INJECTION is not recommended for use if you:

    • have too low number of white blood cells

    Before receiving TAXOCARE 80 INJECTION, inform your doctor if you:

    • are alcohol dependent
    • are suffering from epilepsy

    Interactions

    A. Drug-Drug interactions

    Before receiving TAXOCARE 80 INJECTION inform your doctor if you are taking any of the following medicines:

    • ketoconazole, itraconazole (medicine used to manage fungal infection)
    • ritonavir (medicine used to manage viral infections)
    • cisplatin, cyclosporine (medicine used to manage cancer)
    • doxorubicin (medicine used to manage cancer)
    • erythromycin, troleandomycin (medicine used to manage bacterial infection)
    • terfenadine (medicine used to manage allergy)
    • dalfopristin, quinupristin (medicine used to manage infection of skin and blood)
    • vaccine for BCG, measles, mumps, poliovirus, rotavirus, rubella, smallpox, typhoid, varicella, yellow Fever
    • thalidomide (medicine used to manage skin cancer)

    Overdosage:

    TAXOCARE 80 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

    Synopsis

    Drug :   Docetaxel
    Pharmacological Category :   Taxoids
    Therapeutic Indication :   Breast cancer, Gastric cancer, Prostate cancer, non-small cell lung cancer, head and neck cancer
        
    Dosage Forms :   Injection

    More Information

    • Keep TAXOCARE 80 INJECTION out of reach of children
    • Do not store TAXOCARE 80 INJECTION above 25°C

    FAQs About TAXOCARE 80 INJECTION

    Q: What is TAXOCARE 80 INJECTION used for?

    A: TAXOCARE 80 INJECTION is used in the management of breast cancer, special forms of lung cancer (non-small cell lung cancer), prostate cancer, gastric (stomach) cancer and/or head and neck cancer in affected individuals.

    Q: How TAXOCARE 80 INJECTION works?

    A: TAXOCARE 80 INJECTION works by interfering with the microtubule structures in the cell (substance which aids cancer cells to divide and multiply) thus inhibiting the growth of cancer cells and stopping its spread in affected individuals.

    Q: What are the most common side effects of receiving TAXOCARE 80 INJECTION?

    A: The most common side effects of receiving TAXOCARE 80 INJECTION are infection, hair loss, headache, loss of appetite, indigestion, nausea, vomiting, and/or constipation. Consult your doctor if any of these symptoms worsen.

    Q: How TAXOCARE 80 INJECTION is administered?

    A: TAXOCARE 80 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

    Q: Can TAXOCARE 80 INJECTION be used in pregnant and breastfeeding women?

    A: No, TAXOCARE 80 INJECTION is not recommended for use during pregnancy unless it is clearly necessary. Women of child-bearing potential should use effective contraception method while receiving TAXOCARE 80 INJECTION and for 2 months after the end of management, since it may harm the unborn baby. It is also not recommended for use in breastfeeding women. Consult your doctor before receiving the medicine.   

    References

    1. KD. Tripathi. Anticancer drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page –866.

    2. Nicole G. Farha; Anup Kasi. Docetaxel. NIH National Library of Medicine. National center for Biotechnology information. StarPearls [Internet].  [Revised in February 2022] [Accessed on 8th November 2023] https://www.ncbi.nlm.nih.gov/books/NBK537242/

    3. Ted Zwerdling, Mark Krailo, Philip Monteleone, Rebecca Byrd, Judith Sato, Rose Dunaway, Nita Seibel, Zhengjia Chen, John Strain, Gregory Reaman, Children's Oncology Group. Phase II investigation of docetaxel in pediatric patients with recurrent solid tumors: a report from the Children's Oncology Group. NIH National Library of Medicine. National center for Biotechnology information. PubMed.gov. [Revised in April 2006] [Accessed on 8th November 2023] https://pubmed.ncbi.nlm.nih.gov/16532433/

    4. Manuel Caitano Maia, Allan A Lima Pereira, Liana Valente Lage, Natalia Moreno Fraile, Victor Van Vaisberg, Guilherme Kudo, Romualdo Barroso-Sousa, Diogo Assed Bastos, Carlos Dzik. Efficacy and Safety of Docetaxel in Elderly Patients With Metastatic Castration-Resistant Prostate Cancer. NIH National Library of Medicine. National center for Biotechnology information. PubMed.gov. [Revised in September 2018] [Accessed on 8th November 2023] https://pubmed.ncbi.nlm.nih.gov/30241182/

    5. Accord Healthcare Limited. Electronic Medicines Compodium (EMC) [Revised in May 2021] [Accessed on 8th November 2023] https://www.medicines.org.uk/emc/files/pil.11401.pdf

    6. Getwell Oncology. Taxewell. [Accessed on 8th November 2023] https://www.getwelloncology.com/docetaxel-injection-concentrate

    Useful Diagnostic Tests

    • Mammogram
    • CA-125 blood test
    • CT scan

    Author Details

    Written By Dr. R. Dinesh John Rajkumar - Pharm.D
    Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)
    Last updated on 12 Dec 2023 | 03:37 PM(IST)
    Lab updated