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Introduction About TAGRISSO 40MG TABLET
TAGRISSO 40MG TABLET is used in the management of non-small cell lung cancer (NSCLC) in adults who have epidermal growth factor receptor (EGFR) gene mutation. It contains Osimertinib which is an anticancer agent which works by blocking the actions of EGFR genes which is required by the cancer for growth and multiplication. By blocking its actions, Osimertinib stops NSCLC cancer progression which is specific to EGFR mutation.
TAGRISSO 40MG TABLET should be used under medical supervision. It can be taken with or without food. Do not stop taking TAGRISSO 40MG TABLET without consulting your doctor.
Before taking TAGRISSO 40MG TABLET, inform your doctor if you previously had or currently have any lung problems, heart problems or eye problems, or if you are pregnant or breastfeeding as a precaution.
Men and women of childbearing potential must use a suitable contraceptive agent while taking Osimertinib and until 2 months (for women) and 4 months (for men) to avoid pregnancy. If you accidentally became pregnant while taking TAGRISSO 40MG TABLET, inform your doctor immediately.
The most common side effects of taking TAGRISSO 40MG TABLET are diarrhoea, skin rashes, itching, pain, dryness and redness around fingernails, especially in areas exposed to skin, mouth ulcers, loss of appetite, low WBC and platelet count in the blood, hair thinning, Hand-foot syndrome (causing skin redness, swelling, tingling or burning sensation with cracking of the skin on the palms of hands and/or soles of feet). Consult your doctor if any of these side effects trouble you.
Uses Of TAGRISSO 40MG TABLET
- Management of non-small cell lung cancer (NSCLC) in adults who have EGFR gene mutation
How TAGRISSO 40MG TABLET Works
TAGRISSO 40MG TABLET contains Osimertinib which is a kinase inhibitor that works by specifically targeting and blocking a protein called EGFR-gene that has mutated in some cancer cells. This mutated EGFR drives the growth of cancer cells. By blocking this protein, osimertinib slows down or stops the growth of the cancer cells, helping to control the disease.
How to use TAGRISSO 40MG TABLET
Take TAGRISSO 40MG TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy based on your age, body weight and health condition. Do not stop taking TAGRISSO 40MG TABLET without consulting your doctor.
Side Effects Of TAGRISSO 40MG TABLET
Common
- Diarrhoea
- Skin itching, pain, dryness and redness around fingernails, especially in areas exposed to skin
- Mouth ulcers, sores in the oral cavity
- Loss of appetite
- Low WBC and platelet count in the blood
- Increased creatinine in blood
- Mild nasal bleeding
- Hair thinning
- Hand-foot syndrome (causing skin redness, swelling, tingling or burning sensation with cracking of the skin on the palms of hands and/or soles of feet)
- Increased blood creatine phosphokinase
Uncommon
- Hyperpigmentation on the skin
- Inflammation of the blood vessels in the skin causing bruising or patches of non-blanching rash on the skin
Rare
- Inflammation of the muscles
Stop taking TAGRISSO 40MG TABLET and consult your doctor immediately if you experience any of the following side effects such as:
- Sudden difficulty in breathing along with fever and cough (lung inflammation)
- Severe peeling of your skin
- Persistent fever, bruising or bleeding, increasing tiredness, pale skin and infection
- Skin rashes, itching, raised round red patches on the skin
- Target skin lesions with itching and rashes
- Eye problems (watery eyes, light sensitivity, eye pain, redness and vision changes)
- Severe skin reactions (such as reddish target-like macules or circular patches often with central blisters on the trunk, skin peeling, ulcers of mouth, throat, nose, genitals and eyes and be preceded by fever and flu-like symptoms)
- Abnormal heartbeat, breathing difficulties and heart problems
- Aplastic anaemia (a blood disorder caused due to bone marrow suppression characterised by persistent fever, bruising or bleeding more easily, increased tiredness and a decrease in your ability to fight infection)
How To Manage Side Effects
Mouth Ulcers
Maintain good oral hygiene by brushing gently with a soft-bristled toothbrush and using mild, alcohol-free mouthwash. Rinsing your mouth several times a day with a saltwater solution or a baking soda rinse can soothe the ulcers. Avoid spicy, acidic, or hot foods, as they can aggravate the sores. Instead, opt for soft, bland foods like yogurt, mashed potatoes, or smoothies. Stay hydrated by sipping water frequently, and consider using over-the-counter topical gels or mouthwashes designed for ulcers to help reduce pain and promote healing. If ulcers persist or worsen, consult your healthcare provider.
Warning & Precautions
Pregnancy
Consult your doctorBefore taking TAGRISSO 40MG TABLET, inform your doctor if you are pregnant or think you may be pregnant as a precaution. Women of childbearing potential must use a suitable contraceptive agent while taking TAGRISSO 40MG TABLET to avoid pregnancy and until 2 months after taking the last dose of osimertinib. If you accidentally became pregnant while taking TAGRISSO 40MG TABLET, consult your doctor for advice.
Breastfeeding
ContraindicatedTAGRISSO 40MG TABLET is not recommended for use in breastfeeding women due to lack of safety data. Therefore, consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or handle any heavy tools or machines if your ability is affected by TAGRISSO 40MG TABLET.
Allergy
ContraindicatedDo not take TAGRISSO 40MG TABLET if you are allergic to Osimertinib.
Lungs
Use with CautionTAGRISSO 40MG TABLET should be used with caution in patients who suffered from lung inflammation (interstitial lung disease). Therefore, consult your doctor before taking it.
Heart Disease
Use with CautionTAGRISSO 40MG TABLET should be used with caution in patients who have ever had heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
Consult your doctorThere is no proper information regarding the use of TAGRISSO 40MG TABLET in children and adolescents (aged 18 years or below). Therefore, TAGRISSO 40MG TABLET is not recommended for use in children unless considered necessary by the physician.
Use In Geriatrics
Use with CautionTAGRISSO 40MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor for advice.
Others
Before taking TAGRISSO 40MG TABLET, inform your doctor if you:
- Have a history of eye problems
Interactions
A. Drug-Drug interactions:
- St. John’s Wort (Hypericum perforatum used for depression)
- Antiepileptics (such as phenytoin, carbamazepine or phenobarbital)
- Anti-TB agents (such as rifabutin or rifampicin)
- Rosuvastatin (an anti-hyperlipidemic agent)
- Oral hormonal contraceptive pill
- Antihypertensive agents (such as aliskiren, bosentan)
- Anti-HIV agents (such as Efavirenz and etravirine)
- Modafinil (used for sleep disorders)
- Dabigatran (used to prevent blood clots)
- Digoxin (used for irregular heart beat)
Overdosage:
If you or anyone else accidentally taken too many doses of TAGRISSO 40MG TABLET, consult your doctor for advice or visit the hospital straight away.
Synopsis
| Drug | : | Osimertinib |
| Pharmacological Category | : | Kinase inhibitors |
| Therapeutic Indication | : | Non-small cell lung cancer (NSCLC) |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep TAGRISSO 40MG TABLET out of reach of children
- Store TAGRISSO 40MG TABLET at room temperature
FAQs About TAGRISSO 40MG TABLET
Q: What is TAGRISSO 40MG TABLET used for?
A: TAGRISSO 40MG TABLET is used in the management of non-small cell lung cancer (NSCLC) in adults who have epidermal growth factor receptor (EGFR) gene mutation.
Q: How to take TAGRISSO 40MG TABLET?
A: Take TAGRISSO 40MG TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not stop taking TAGRISSO 40MG TABLET without consulting your doctor.
Q: How TAGRISSO 40MG TABLET works?
A: TAGRISSO 40MG TABLET contains Osimertinib which is a kinase inhibitor that works by specifically targeting and blocking a protein called EGFR-gene that has mutated in some cancer cells. This mutated EGFR drives the growth of cancer cells. By blocking this protein, osimertinib slows down or stops the growth of the cancer cells, helping to control the disease.
Q: What are the common side effects of taking TAGRISSO 40MG TABLET?
A: The most common side effects of taking TAGRISSO 40MG TABLET are diarrhoea, skin rashes, itching, pain, dryness and redness around fingernails, especially in areas exposed to skin, mouth ulcers, loss of appetite, low WBC and platelet count in the blood, hair thinning, Hand-foot syndrome (causing skin redness, swelling, tingling or burning sensation with cracking of the skin on the palms of hands and/or soles of feet). Consult your doctor if any of these side effects trouble you.
Q: Can TAGRISSO 40MG TABLET be used during pregnancy?
A: Before taking TAGRISSO 40MG TABLET, inform your doctor if you are pregnant or think you may be pregnant as a precaution. Women of childbearing potential must use a suitable contraceptive agent while taking TAGRISSO 40MG TABLET to avoid pregnancy and until 2 months after taking the last dose of osimertinib. If you accidentally became pregnant while taking TAGRISSO 40MG TABLET, consult your doctor for advice.
Q: What precautions must be followed while taking TAGRISSO 40MG TABLET?
A: TAGRISSO 40MG TABLET should be used under medical supervision. It can be taken with or without food. Do not stop taking TAGRISSO 40MG TABLET without consulting your doctor.
Before taking TAGRISSO 40MG TABLET, inform your doctor if you previously had or currently have any lung problems, heart problems or eye problems, or if you are pregnant or breastfeeding as a precaution.
Men and women of childbearing potential must use a suitable contraceptive agent while taking Osimertinib and until 2 months (for women) and 4 months (for men) to avoid pregnancy. If you accidentally became pregnant while taking TAGRISSO 40MG TABLET, inform your doctor immediately.
Q: Will Olaparib cure cancer?
A: TAGRISSO 40MG TABLET will help you effectively manage cancer. It has been proven to improve overall survival and quality of life in cancer patients. Complete cure of cancer depends on the severity of the disease and how your body responds to the therapy.
References
1. Osimertinib as first-line treatment for recurrent lung cancer patients with EGFR mutation. National Center for Biotechnology Information. National Library of Medicine. PMC. PubMed Central. October 2023. [Accessed on 23rd August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636461/
2. AstraZeneca AB. Osimertinib 40 and 80mg Tablets. EMC. UK. [Revised in February 2024]. [Accessed on 23rd August 2024] https://www.medicines.org.uk/emc/files/pil.7615.pdf
Useful Diagnostic Tests
- Wbc-Total Counts Leucocytes
- Cancer Screening Package For Male
- Cancer Screening Package For Female
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