SYNDOPA 110 Tablet 15's

Introduction About SYNDOPA 110 TABLET

Syndopa 110 is a combination medicine that contains Levodopa and Carbidopa. It is designed to manage dopamine levels in the brain, which play a key role in motor control and coordination. This tablet is often recommended as a part of neurological health support to improve the signs of Parkinsonism.

Levodopa converts to dopamine in the brain, while Carbidopa helps reduce the breakdown of Levodopa before it reaches the brain. This dual action supports more efficient dopamine availability and may assist in improving movement-related functions.

SYNDOPA 110 TABLET is not recommended for use in women who are pregnant or breastfeeding, including children and adolescents (aged below 18 years).

It is important for caregivers to notice and report doctor immediately that if the patient develops any addictive symptoms like craving for large doses of SYNDOPA 110, unusual behaviour, gambling, excessive eating or spending, an abnormally high sex drive or any other activities that could harm themselves or others.

Try to avoid eating a heavy meal that includes a lot of protein (such as beef, pork, cheese, fish and eggs) while taking SYNDOPA 110, as it may interfere with its absorption.

The common side effects of taking SYNDOPA 110 TABLET are nausea, vomiting, abnormal muscle movements, loss of appetite, dry mouth, bitter taste and tiredness. Consult your doctor if any of the side effects worsen.

Uses Of SYNDOPA 110 TABLET

• Used to improve the signs of Parkinsonism

Benefits of SYNDOPA 110 TABLET

1. Supports dopamine regulation in the brain:

• Contains Levodopa, a precursor to dopamine, which helps support dopamine levels in the brain

2. Combines Levodopa and Carbidopa for better absorption:

• Carbidopa helps to manage premature breakdown of Levodopa, improving its effectiveness in the body

3. May help improve mobility and motor coordination:

• Commonly used to assist individuals experiencing symptoms related to dopamine deficiency affecting movement

4. Convenient Dosage Form:

• Available as an oral tablet for easy daily administration

How SYNDOPA 110 TABLET Works

How Levodopa and Carbidopa work together?

SYNDOPA 110 effectively controls the signs of parkinsonism, where levodopa acts by converting itself into a substance called dopamine (a chemical messenger that controls body movement) and carbidopa acts by managing the breakdown of levodopa outside the brain, thereby allowing greater proportion of levodopa to enter the brain. Collectively they supplement the brain with sufficient dopamine levels which ultimately results in improving the signs of parkinsonism.

How to use SYNDOPA 110 TABLET

1. Doctor-Directed Use: Why Individual Advice Matters:

Always take Syndopa 110 Tablet exactly as advised by your healthcare professional. The dosage and frequency depend on individual health status and response.

2. Recommended Dosage and Timing Guidelines:

• Typically, the starting dose is carefully adjusted based on your needs. The usual dose may be taken two to three times daily, but your doctor will determine the exact amount
• Swallow Whole: Take the tablet with a sufficient amount of water. Do not crush, chew, or break the tablet unless directed by your healthcare provider
• Consistency is Key: Take Syndopa 110 at the same times every day to maintain steady levels in your bloodstream

3. Can Syndopa 110 Be Taken With Food?

• Syndopa 110 can be taken with or without food. However, taking it with food might help reduce stomach discomfort in some cases. Avoid high-protein meals immediately around the time of taking the tablet, as they may affect absorption

4. Do not stop suddenly:

• Consult your healthcare provider before stopping Syndopa 110, as abrupt discontinuation can lead to worsening symptoms

What if I forgot to take SYNDOPA 110 TABLET

Missing doses may affect the overall support provided by the medication. If a dose is missed, take it as soon as you remember unless it is near the time for your next dose.

Overdose

If you or anyone else accidentally take too much of SYNDOPA 110 TABLET, contact your doctor immediately or go to a hospital straight away.

Side Effects Of SYNDOPA 110 TABLET

Common

• abnormal body movements (dyskinesia, chorea, dystonia)
• nausea, vomiting, dry mouth, bitter taste
• loss of appetite
• low blood pressure while standing up from sitting or lying position (orthostatic hypotension), fainting
• confusion, dizziness, nightmares, drowsiness, tiredness, sleeplessness
• feeling euphoria (an extremely strong feeling of happiness)

When to consult doctor?

• signs of allergic reactions (such as skin rash, itching, swelling
  of your face, lips, tongue or throat, which may cause difficulty in breathing or swallowing)
• chest pain, uneven heartbeat or palpitations
• signs of bleeding in the stomach which may be shown as blood in faeces or darkened faeces
• signs of low blood counts (such as pale skin, fever, tiredness, sore throat or mild bruising and prolonged bleeding after injury)
• signs of neuroleptic malignant syndrome (muscle stiffness with high fever, sweating, increased salivation, inability to sit still, impaired consciousness)
• mental changes including hallucinations, delusions and depression
• fits (convulsions)

What to do if I feel uneasy after taking Syndopa?

Feeling uneasy or experiencing mild discomfort can occur. If this happens, ensure you are taking the medication with food or water as recommended. If symptoms persist or worsen, consult your healthcare professional for guidance.

Are there long-term side effects of Syndopa 110?

Long-term use of medications like Syndopa 110 should be regularly reviewed by a healthcare provider to ensure ongoing safety and effectiveness. Regular check-ups help manage any potential effects and adjust dosage if necessary.

Can Syndopa 110 affect sleep or movement?

Some users may notice changes in sleep patterns or movement after starting Syndopa 110. Reporting these experiences to your healthcare provider helps in managing these effects effectively.

Warning & Precautions

Pregnancy

Contraindicated

Limited data is available from controlled studies in pregnant women. SYNDOPA 110 TABLET is not recommended for use in pregnant women and in women who think that they might be pregnant.

Breastfeeding

Contraindicated

There is limited information regarding the presence of these medications in human breast milk and the impact on infants. SYNDOPA 110 TABLET is not recommended for use in breastfeeding women.

Driving and Using Machines

Use with Caution

Do not drive or operate any heavy tools or machines, as SYNDOPA 110 TABLET may cause sudden sleep attacks or can make you feel sleepy suddenly.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking SYNDOPA 110 TABLET, as it could make you feel dizzier or drowsier.  

Kidney

Use with Caution

Caution to be exercised  among patients who have or had any kidney diseases in the past.

Liver

Use with Caution

Caution to be exercised  among patients who have or had any liver diseases in the past.

Allergy

Contraindicated

Do not take if you are allergic to Levodopa, Carbidopa or any other ingredients of this medicine.

Heart Disease

Use with Caution

SYNDOPA 110 TABLET should be taken with caution among patients with heart disease (such as previous history of heart attack, heartbeat problems, circulation or breathing problems).  

Use In Pediatrics

Contraindicated

SYNDOPA 110 is generally not recommended for use in children and adolescents (aged below 18 years).

Use In Geriatrics

Consult your doctor

SYNDOPA 110 is considered safe for use in elderly patients (aged 65 years or above). However, proper dose adjustment and careful monitoring is required in such patients.

Other Warnings for SYNDOPA 110 TABLET

Before taking SYNDOPA 110, inform your physician if you:

• have a history of fits (epilepsy)
• have had an ulcer in the stomach
• have vomited blood
• have any hormonal problems
• have or had depression or any other similar mental problems
• have chronic wide-angle glaucoma (a painless eye condition that can affect your vision)
• feel sleepy or having sudden sleep attacks (Ex. narcolepsy)
• are due to have a surgery
• are due to have a blood/urine test

Who should not take [GBNKEYWORD

SYNDOPA 110 is not recommended for use in patients who:

• have ever had any forms of skin cancer
• have any unusual moles in the skin that has not yet been examined by the doctor
• have narrow-angle glaucoma (increased pressure in the eye)
• have a severe mental disorder (Ex. severe panic disorder, psychosis, severe depression, bipolar disorder)

Safety Advice

Important safety information about Syndopa 110 Tablet

• Inform your healthcare provider if you have liver, kidney, or heart conditions
• Avoid operating heavy machinery if you experience drowsiness or dizziness
• Hydration and a balanced diet may support overall neurological function
• Do not stop or alter dosage without consulting a medical expert

Diet and Lifestyle Advice

Balanced Diet

• Maintaining a nutritious, balanced diet can support overall well-being. Focus on fresh fruits, vegetables, whole grains, and lean proteins.
• Be mindful of protein intake timing. High-protein meals taken close to Syndopa 110 dosing may reduce its absorption. Consider spacing protein-rich foods and medication by a few hours.

Hydration

• Staying well-hydrated by drinking enough water throughout the day can help support general health

Physical Activity

• Regular light to moderate exercise, such as walking, stretching, or yoga, may help support mobility and muscle strength
• Always consult your healthcare provider before starting any new exercise program

Sleep Hygiene

• Good sleep habits contribute to better daily functioning. Establish a regular sleep schedule and create a restful environment

Avoid Smoking and Alcohol

• Limiting or avoiding smoking and alcohol may reduce unwanted effects and support overall health

Regular Medical Check-ups

• Keep routine appointments with your healthcare provider to monitor your health status and medication effects

How the body may respond to levodopa and carbidopa

• Levodopa and Carbidopa, the active components of Syndopa 110 Tablet, work together to support dopamine levels in the brain. When you start taking this medication, your body may respond in different ways as it adjusts

Important Considerations for New Users of Syndopa 110

1. Adjustment Period: Some users may experience mild side effects as the body adapts. These may lessen over time with continued use.

2. Variability in Response: Everyone’s experience can differ based on individual health factors. It is important to follow your healthcare provider’s instructions closely.

3. Monitoring Symptoms: Keep track of any new or unusual feelings and communicate these to your healthcare professional promptly

4. Consistency is Important: Taking Syndopa 110 consistently at prescribed times helps maintain stable effects.

5. Avoid Sudden Changes:  Do not alter or stop your medication without consulting your healthcare provider, as this could affect your response.

Drug - Drug interaction

Common medications that may interact with Syndopa 110:

1. Monoamine Oxidase Inhibitors (MAOIs)

• Taking Syndopa with MAOIs (used for depression or Parkinson's disease) may cause serious side effects
• It is essential to avoid non-selective MAOIs within 14 days before or after starting Syndopa

2. Antipsychotic Drugs

• Some antipsychotics can reduce the effectiveness of Syndopa by blocking dopamine receptors

3. Antihypertensive Medications

• Syndopa may enhance the blood pressure-lowering effects of certain drugs, requiring monitoring

4. Iron Supplements

• Iron can interfere with the absorption of Levodopa, potentially reducing its effectiveness

5. Vitamin B6 (Pyridoxine)

• High doses of Vitamin B6 may reduce the therapeutic effect of Levodopa unless combined with Carbidopa.

6. Other Dopaminergic Agents

• Concurrent use with other medications affecting dopamine levels should be managed carefully by a healthcare provider

Drug - Food interaction

• Try to avoid eating a heavy meal that includes a lot of protein (such as beef, pork, fish and eggs) while taking SYNDOPA 110, as it may interfere with its absorption

Synopsis

More Information

Understanding the Action of Dopaminergic Medicines

• Dopaminergic medicines, including those with Levodopa and Carbidopa, support the brain’s dopamine levels which is a key chemical that helps regulate movement and coordination
• Since dopamine itself cannot cross into the brain, these medicines work by increasing dopamine availability inside the brain, which may assist in improving motor function. Carbidopa helps by managing early breakdown of Levodopa outside the brain, allowing more of it to reach the brain where it is needed
• This combination helps the nervous system work more effectively, supporting smoother movement and better control

Understanding Parkinson's Disease and the Role of Dopamine

• Parkinson's disease is a neurological condition linked to a reduction of dopamine, a chemical messenger in the brain responsible for controlling movement and coordination
• Lower dopamine levels can affect muscle control, leading to symptoms such as stiffness and difficulty with movement

Medications like Syndopa 110 aim to support dopamine availability in the brain, helping the nervous system manage these changes. Understanding the role dopamine plays can help users appreciate how their medication supports everyday function.

Related medicines

• Madopar 250mg Tablet 10'S

FAQs About SYNDOPA 110 TABLET

References

1. KD. Tripathi. Drugs acting on central nervous system. Antiparkinsonian drugs. Essentials of medical pharmacology. 8th Edition. 2019. Page – 452-457.

2. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 657 & 2455.

3. Dr. Rebecca Gilbert. The many variations of carbidopa/levodopa – the mainstay of Parkinson’s disease treatment. American Parkinson Disease Association. March 2021. [Accessed on 21st May 2025] 

4. Masahiro Nomoto, Masahiro Nagai, , Rina Ando, Yoshifumi Kagamiishi, Koji Yano, Shigeto Saito, Atsushi Takeda. Pharmacokinetics and safety/efficacy of levodopa pro-drug ONO-2160/carbidopa for Parkinson's disease. Sciencedirect.com. December 2018. [Accessed on 21st May 2025] 

5. Merck Sharp & Dohme B.V. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 21st May 2025] 

6. Merck Sharp & Dohme B.V. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 21st May 2025]  

7. Fair-Med Healthcare GmbH. Health Products Regulatory Authority (HPRA). [Revised in October 2018] [Accessed on 21st May 2025] 

8. Torrent Pharmaceuticals Ltd. Tidomet Forte (Carbidopa 25mg and Levodopa 250 mg tablets). [Revised in June 2018] [Accessed on 21st May 2025] 

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 22 May 2025 | 10:52 PM(IST)