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Introduction About SULSEAS 500 TABLET
SULSEAS 500 TABLET contains Sulfasalazine which belongs to the group of medicines called Aminosalicylates. It is used to manage inflammatory bowel disease such as Ulcerative Colitis, Crohn’s disease and rheumatoid arthritis.
Ulcerative Colitis is an inflammatory disease which affects only the large bowel (colon and back passage), the lining of the bowel becomes inflamed (red and swollen) and symptoms include abdominal pain and diarrhea (may have blood and mucus).
Crohn’s disease is an inflammatory disease which affect any part of the digestive system from the mouth to the anus, most commonly affects the last part of the small bowel and the first part of the large bowel, symptoms include abdominal pain and diarrhea (may be bloody). It can also be used to manage rheumatoid arthritis (swelling, pain, stiffness of joints)
Your doctor might want you to take certain blood, kidney and liver function tests during the management. Drink enough fluids during this management to avoid problems with kidney.
Before taking SULSEAS 500 TABLET inform your doctor if you have porphyria (a rare blood pigment disorder), jaundice, kidney, liver, blood problems, glucose-6-phosphate dehydrogenase deficiency, history of recurring chronic infection, asthma, arthritis.
Inform your doctor if you are pregnant or breastfeeding. SULSEAS 500 TABLET is not recommended for use in children below 2 years of age.
The most common side effects of taking SULSEAS 500 TABLET are indigestion, heartburn, nausea, dizziness and headache. Consult your doctor if side effects gets worse.
Uses Of SULSEAS 500 TABLET
It is used to manage:
- ulcerative colitis
- crohn’s disease
- rheumatoid arthritis
How SULSEAS 500 TABLET Works
SULSEAS 500 TABLET works by suppressing the overactivity of the immune system in autoimmune diseases and blocks the chemical messengers that cause inflammation (swelling).
How to use SULSEAS 500 TABLET
Take SULSEAS 500 TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.
Side Effects Of SULSEAS 500 TABLET
Common
- indigestion
- heartburn
- nausea
- dizziness
- headache
- changes in taste
- ringing in the ears
- cough
- itching of the skin
- purple discolorations on the skin
- joint pain
- protein in urine
- fever
Uncommon
- depression
- shortness of breath
- abdominal pain
- diarrhea
- vomiting
- hair loss
- hives
- puffiness around the eyes and face
Rare
Stop taking SULSEAS 500 TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction such as sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (affecting the whole body)
- jaundice
- severe skin rash that causes blistering (affects the mouth and tongue), life-threatening skin rashes (exfoliate dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis)
- fever, pains in your joints, hives, swollen glands, rash and itching (signs of serum sickness)
- any unexplained bleeding
- bruising, fever, rash, pallor (paleness), severe sore throat or tiredness (signs of abnormality in blood)
- rash or fever or swollen gland may be a sign of DRESS (drug rash with eosinophilia and systemic symptoms)
How To Manage Side Effects
Nausea:
Stick to simple meals. Avoid eating oily or spicy food. Inform your doctor if symptoms do not reduce.
Headache:
Avoid bright lights, drink lots of water and take rest. Inform your doctor if symptoms do not reduce.
Cough:
Drink more of warm water, take honey, ginger for relief. Taking steam also helps. Inform your doctor if symptoms do not reduce.
Indigestion:
Eat smaller meals, chew the food thoroughly. drink lemon or ginger tea. Inform your doctor if symptoms do not reduce.
Warning & Precautions
Pregnancy
Inform your doctor if you are pregnant or planning to have a baby before taking SULSEAS 500 TABLET. Your doctor will decide whether to take it or not.
Breastfeeding
Avoid breastfeeding while taking SULSEAS 500 TABLET as there have been reports of diarrhea or blood in the stools of babies. Consult your doctor before taking it.
Driving and Using Machines
SULSEAS 500 TABLET is unlikely to affect your ability to drive or use machines.
Kidney
SULSEAS 500 TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking.
Liver
SULSEAS 500 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking.
Allergy
Do not take SULSEAS 500 TABLET if you are allergic to Sulfasalazine, salicylates (Ex. aspirin) or sulfonamides (type of antibiotic) or any other ingredients of this medicine.
Lungs
SULSEAS 500 TABLET should be used with caution in patients with asthma. Consult your doctor before taking.
Others
SULSEAS 500 TABLET is not recommended for use if you:
- have porphyria (a rare blood pigment disorder)
- have jaundice
Before taking SULSEAS 500 TABLET, inform your doctor if you:
- have blood disorders
- have glucose-6-phosphate dehydrogenase deficiency (an inherited condition)
- have a history of recurring chronic infections
- your child has arthritis
Use in pediatrics:
SULSEAS 500 TABLET is not recommended for use in children below 2 years of age. Consult your doctor before taking.
Use in geriatrics:
SULSEAS 500 TABLET should be used with caution in elderly patients. Consult your doctor before taking.
Interactions
A. Drug-Drug interactions:
Before taking SULSEAS 500 TABLET, inform your doctor if you are taking any of the following medicine:
- medicine for high blood sugar (Ex. metformin, glipizide)
- digoxin (to manage heart failure)
- folic acid or folate (Ex. Spina Bifida) to reduce risk of neural tube defect
- azathioprine and mercaptopurine (help to suppress your body’s immune response in organ transplantation and certain chronic inflammations (Ex. rheumatoid arthritis))
- methotrexate (used to manage rheumatoid arthritis)
- methenamine (for managing urinary tract infections)
Overdosage:
If you or anyone else accidentally takes too much of SULSEAS 500 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea and vomiting.
Synopsis
| Drug | : | Sulfasalazine |
| Pharmacological Category | : | Anti-inflammatory |
| Therapeutic Indication | : | Ulcerative colitis, Crohn’s disease, Rheumatoid arthritis |
| Dosage Forms | : | Tablet |
More Information
- Keep SULSEAS 500 TABLET out of reach of children
- Store below 25°C
FAQs About SULSEAS 500 TABLET
What is SULSEAS 500 TABLET used for?
SULSEAS 500 TABLET is used to manage inflammation caused by rheumatoid arthritis or inflammatory bowel disease (ulcerative colitis, Crohn’s disease). You must talk to a doctor if you do not feel better or if you feel worse.
Can SULSEAS 500 TABLET be used in children?
SULSEAS 500 TABLET is not recommended for use in children below 2 years of age. It is not recommended if you have systemic-onset juvenile rheumatoid arthritis (Stills disease). Consult your doctor before taking.
What if I take more of SULSEAS 500 TABLET accidentally?
If you or anyone else accidentally take too much of SULSEAS 500 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea and vomiting.
How does SULSEAS 500 TABLET work?
SULSEAS 500 TABLET works by suppressing the overactivity of the immune system in autoimmune diseases and blocks the chemical messengers that cause inflammation (swelling).
Any tests to be taken while on management with SULSEAS 500 TABLET?
Your doctor will take blood tests to check your blood, urine (for protein), kidneys before you start management with SULSEAS 500 TABLET and regularly during management.
References
1. KD Tripathi. Drugs for Constipation and Diarrhea. Essentials of medical pharmacology. Eighth Edition. 2019. Page –734-735.
2. Jaehwa Choi, Ardy Fenando. Sulfasalazine. [Revised on June 2021] [Accessed on 13th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK557809/
3. Sanford L. Taffet MD & Kiron M. Das. Adverse effects and desensitization. [Accessed on 13th July 2022] https://link.springer.com/article/10.1007/BF01296907?error=cookies_not_supported&code=2ace1a56-374d-45e8-bf48-7272a0022469
4. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 13th July 2022] https://www.medicines.org.uk/emc/files/pil.3838.pdf
5. Recipharm Uppsala. Health Products Regulatory Authority (HPRA). [Revised in September 2018] [Accessed on 13th July 2022] https://www.hpra.ie/img/uploaded/swedocuments/d3fcb110-b8d2-45fc-bfd2-d9d4dfeeca41.pdf
6. Sulfasalazine. Drugs.com. [Revised in June 2022] [Accessed on 13th July 2022] https://www.drugs.com/cons/sulfasalazine.html
Useful Diagnostic Tests
- Blood and urine test
- Kidney function test
- Liver test
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