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Introduction About STPASE 1500000IU INJECTION
STPASE 1500000IU INJECTION contains Streptokinase which belongs to the group of medicines called Anti-thrombotic agents. It is used to dissolve blood clots formed within the blood vessels. By dissolving blood clots, it helps in reducing the risk of heart attack, stroke, pulmonary embolism (blood clot in the lungs), deep vein thrombosis (blood clot in the blood vessels supplying the legs) and arterial thrombosis (blood clot in arteries).
It can also be used for clearing the blockage (occlusion) of arteriovenous cannulae (a device used for blood circulation) as an alternative to surgical intervention when acceptable flow cannot otherwise be achieved.
Before receiving STPASE 1500000IU INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any bleeding or blood clotting disorders, stroke, stomach inflammation or any internal conditions that can increase of bleeding, or if you have recently undergone a surgery as a precaution.
STPASE 1500000IU INJECTION is not recommended for use in patients with uncontrollably high blood pressure and in women who recently delivered a child or suffered a miscarriage. It is also not suitable for use in pregnant or breastfeeding women.
The most common side effects of receiving STPASE 1500000IU INJECTION are bleeding at the injection site, bruising of the skin, increased bleeding tendency, irregular heartbeat, nausea, vomiting, diarrhoea, stomach pain, headache, fever and chills. Consult your doctor if any of these side effect troubles you.
Uses Of STPASE 1500000IU INJECTION
- Used to dissolve blood clots formed within the blood vessels
- Prevents heart attack, stroke, pulmonary embolism, deep vein thrombosis and arterial thrombosis
- Used to unclog occlusion of arteriovenous cannulae
How STPASE 1500000IU INJECTION Works
STPASE 1500000IU INJECTION is fibrinolytic agent. It works by dissolving the harmful fibrin blood clots formed within the blood vessels. As a result, it improves blood flow within the blood vessels which helps in the management of complications caused due to blood clots such as heart attack, stroke, pulmonary embolism, deep vein thrombosis and arterial thrombosis.
How to use STPASE 1500000IU INJECTION
STPASE 1500000IU INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or into the artery (intraarterially).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of infection.
Side Effects Of STPASE 1500000IU INJECTION
Common
- bleeding at the injection site
- bruising of the skin
- increased bleeding tendency, nasal bleeds
- slow or fast heartbeat
- nausea, vomiting
- diarrhoea, stomach pain
- headache
- muscle pain, back pain
- fever, chills, weakness, tiredness
- increased infections
Uncommon
- bleeding into eyes or joints
Rare
Consult your doctor immediately if you experience any of the following side effects after receiving STPASE 1500000IU INJECTION:
- signs of severe allergic reactions (such as skin rash, flushing, itching, blistering, swelling of the face, lips, throat or tongue causing difficulty in breathing or swallowing, low blood pressure)
- severe headache, dizziness, breathing difficulties, chest pain, pain and swelling in legs
How To Manage Side Effects
Diarrhea
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if nausea worsens.
Warning & Precautions
Pregnancy
ContraindicatedSTPASE 1500000IU INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Breastfeeding
ContraindicatedSTPASE 1500000IU INJECTION may pass through breast milk. Therefore, it is not recommended for use in breastfeeding women. However, consult your doctor before receiving it.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving STPASE 1500000IU INJECTION.
Kidney
ContraindicatedSTPASE 1500000IU INJECTION is not recommended for use in patients with severe kidney problems. Therefore, consult your doctor before receiving it.
Liver
ContraindicatedSTPASE 1500000IU INJECTION is not recommended for use in patients with severe liver problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedTalk to your doctor before receiving STPASE 1500000IU INJECTION if you are allergic to Streptokinase.
Lungs
Use with CautionSTPASE 1500000IU INJECTION should be used with caution in patients with tuberculosis or severe bronchitis. Therefore, consult your doctor before receiving it.
Heart Disease
Consult your doctorSTPASE 1500000IU INJECTION is not recommended for use in patients with uncontrollably high blood pressure or inflammation surrounding the membranes of the heart (endocarditis). It should be used with caution in patients with other heart problems (such as high blood pressure). Therefore, consult your doctor before receiving it.
Use In Pediatrics
ContraindicatedSTPASE 1500000IU INJECTION is not recommended for use in children and in adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before receiving it.
Use In Geriatrics
Use with CautionSTPASE 1500000IU INJECTION should be used with caution in the elderly patients. Therefore, consult your doctor before receiving it.
Others
STPASE 1500000IU INJECTION is not recommended for use if you:
- currently have or recently suffered any internal bleeding condition
- recently suffered a stroke or serious head injury
- recently had a surgery on your head or spine
- have brain tumour or any tumour which can increase the risk of bleeding
- have weak or abnormally bulged arteries (aneurysm)
- have blood clotting disorders
- are taking medicines to stop blood clotting
- have increased bleeding tendency
- have inflammation of the pancreas
Before receiving STPASE 1500000IU INJECTION, inform your doctor if you:
- have bleeding in the gut or recently had a stomach condition that led to internal bleeding
- recently undergone any major surgery
- recently delivered a child or suffered a miscarriage
- have problems in genital tract or urinary tract
- have septic thrombotic disease (blood poisoning that causes clotting)
- have any disease affecting your brain or arteries
- have a bacterial infection (rheumatic fever, throat infection)
- have an eye damage caused due to diabetes
Interactions
A. Drug-Drug Interactions:
Before receiving STPASE 1500000IU INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used for blood thinning (Ex. warfarin, heparin)
- dipyridamole (an antiplatelet medicine used for managing blood clots)
- dextran (used for managing shock and managing blood clots)
Overdosage:
STPASE 1500000IU INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms.
Synopsis
| Drug | : | Streptokinase |
| Pharmacological Category | : | Fibrinolytic agents |
| Therapeutic Indication | : | Blood clots |
| Dosage Forms | : | Injection |
More Information
- Keep STPASE 1500000IU INJECTION out of reach of children
- Store STPASE 1500000IU INJECTION in a refrigerator between 2-8°C
FAQs About STPASE 1500000IU INJECTION
Q: What is the use of STPASE 1500000IU INJECTION?
A: STPASE 1500000IU INJECTION is used to dissolve blood clots formed within the blood vessels. By dissolving blood clots, it helps in reducing the risk of heart attack, stroke, pulmonary embolism (blood clot in the lungs), deep vein thrombosis (blood clot in the blood vessels supplying the legs) and arterial thrombosis (blood clot in arteries). It can also be used for clearing the blockage (occlusion) of arteriovenous cannulae (a device used for blood circulation).
Q: How STPASE 1500000IU INJECTION works?
A: STPASE 1500000IU INJECTION is fibrinolytic agent. It works by dissolving the harmful fibrin blood clots formed within the blood vessels. As a result, it improves blood flow within the blood vessels which helps in the management of complications caused due to blood clots such as heart attack, stroke, pulmonary embolism, deep vein thrombosis and arterial thrombosis.
Q: Can STPASE 1500000IU INJECTION be used during pregnancy?
A: STPASE 1500000IU INJECTION may affect the growing baby. Therefore, it is not recommended for use in pregnant women. Kindly, consult your doctor before receiving it.
Q: What medicines should be avoided while taking STPASE 1500000IU INJECTION?
A: Before receiving STPASE 1500000IU INJECTION, inform your doctor if you are taking anticoagulants (Ex. heparin, warfarin) or antiplatelet medicines (Ex. dipyridamole) for managing blood clots. Avoid using them concomitantly without consulting your doctor as a precaution.
Q: Can the use of STPASE 1500000IU INJECTION affect the liver?
A: Yes. STPASE 1500000IU INJECTION may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. Kindly, consult your doctor before receiving it.
Q: Should I stop using STPASE 1500000IU INJECTION before any surgery?
A: Yes. STPASE 1500000IU INJECTION is a fibrinolytic agent which may make you bleed more easily even after minor cuts or injuries. As surgeries are always associated with increased bleeding tendency, simultaneous use of STPASE 1500000IU INJECTION is not recommended as it may make you bleed more.
Q: What are the side effects of STPASE 1500000IU INJECTION?
A: The most common side effects of receiving STPASE 1500000IU INJECTION are bleeding at the injection site, bruising of the skin, increased bleeding tendency, irregular heartbeat, nausea, vomiting, diarrhoea, stomach pain, headache, fever and chills. Consult your doctor if any of these side effect troubles you.
Q: How STPASE 1500000IU INJECTION is administered?
A: STPASE 1500000IU INJECTION will be administered to you only by a doctor or a nurse into the vein (intravenously) or into the artery (intraarterially).
References
1. KD. Tripathi. Drugs affecting blood and blood formation. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 626.
2. Zachary Edwards; Shivaraj Nagalli. Streptokinase. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 20th March 2023] https://www.ncbi.nlm.nih.gov/books/NBK553215/
3. Tetris Pharma Ltd. Streptokinase 2,50,000 IU. Electronic Medicines Compendium (EMC). [Revised in September 2019]. [Accessed on 20th March 2023] https://www.medicines.org.uk/emc/product/13114/smpc#gref
4. Bharat Serums & Vaccines Ltd. Thromboflux. Streptokinase Injection. [Accessed on 20th March 2023] https://bsvgroup.com/assets/pdf/products/Thromboflux.pdf
5. BiofactorGmbH. Streptokinase Karma 1 500 000. [Revised in June 2019]. [Accessed on 20th March 2023] https://www.streptokinase.com/file_data/flextemp/files/streptokinase-karma-pil-1500000.pdf
6. CSL Behring Canada, Inc. Streptase® (Streptokinase Injection). [Revised in February 2007]. [Accessed on 20th March 2023] https://pdf.hres.ca/dpd_pm/00003639.PDF
Useful Diagnostic Tests
- Blood Platelet count
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