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Introduction About STAMACE 5MG CAPSULE
STAMACE 5MG CAPSULE is a combination of Amlodipine and Ramipril which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) and certain type of angina (chest pain) called as Prinzmetal or variant angina. It can also be used to manage heart failure and reduce the chances of hospitalization among the heart patients.
It also protects the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus.
Before taking STAMACE 5MG CAPSULE inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any other heart problems apart from hypertension, angina and heart failure (such as cardiogenic shock or narrowing of heart valves).
Talk to your doctor if you are on a low salt diet or have diabetes or are severely dehydrated due to any recent sickness (such as vomiting or diarrhea) before taking STAMACE 5MG CAPSULE as a precaution.
STAMACE 5MG CAPSULE is not recommended for use in patients with severe hypotension (low blood pressure). It is also not suitable for use in women who are pregnant or breastfeeding due to increased risk of side effects.
The most common side effects of taking STAMACE 5MG CAPSULE are dizziness, swelling of ankles or other body parts, headache, sleepiness, tiredness, racing heartbeat, indigestion, constipation and muscle cramps. Contact your doctor if any of these side effects trouble you.
Uses Of STAMACE 5MG CAPSULE
It is used to:
- Manage hypertension and angina
- Prevent heart failure
- Protects kidney functions in patients with hypertension and diabetes
How STAMACE 5MG CAPSULE Works
STAMACE 5MG CAPSULE is a vasodilator. It relaxes the blood vessels supplying the heart and other organs (such as kidneys). This improves blood flow and oxygen supply to the heart muscles which reduces strain on the heart.
It also allows blood to flow more smoothly across the blood vessels with less pressure. It can improve blood supply to the kidneys which helps in delaying the worsening of kidney functions in diabetic patients. As a result, it reduces blood pressure and improves the functions of the heart and the kidneys.
How to use STAMACE 5MG CAPSULE
Take STAMACE 5MG CAPSULE as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. STAMACE 5MG CAPSULE can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Continue to take STAMACE 5MG CAPSULE for the stipulated duration instructed by your doctor to achieve better results.
Side Effects Of STAMACE 5MG CAPSULE
Common
- edema (swelling of the ankles or other body parts)
- headache, dizziness, sleepiness
- palpitations (fast heartbeat)
- flushing (redness and warmth of the skin)
- stomach pain, nausea, diarrhea, constipation, indigestion
- changes in bowel habit
- tiredness, weakness
- blurred vision, double vision
- muscle pains
- dry cough, sinus inflammation
- increased potassium levels in blood
Uncommon
- anxiety, depression
- insomnia (sleeplessness)
- changes in taste
- tingling sensation in limbs, loss of pain sensation
- ringing in the ears
- increased sweating
- increased urination at night
- inability to obtain an erection, enlargement of the breasts in men
- joint pain, back pain
Rare
- confusion
- red, swollen tongue
- loosening or separation of a nail from its bed
- skin rash, itching, redness
- red, itchy, swollen or watery eyes
- low RBC, WBC and platelet counts
Stop taking STAMACE 5MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath (signs of heart attack)
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
- sever stomach pain due to obstruction of the gut or inflammation of pancreas
- dizziness, fainting or lightheadedness, excessive sweating following an exercise or after regular activities (signs of low RBC count in blood)
- signs of liver problems (such as fever, muscle pain, rashes, itching, stomach pain, diarrhea, discoloration of eyes, skin and urine)
- increased bleeding or bruising
How To Manage Side Effects
Nausea and vomiting:
Take STAMACE 5MG CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Warning & Precautions
Pregnancy
STAMACE 5MG CAPSULE is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking this medicine if you are pregnant, think you may be pregnant or planning to have a baby. If you accidentally become pregnant while undergoing therapy with STAMACE 5MG CAPSULE, inform your doctor immediately.
Breastfeeding
STAMACE 5MG CAPSULE is not recommended for use in breast-feeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you feel dizzy after taking STAMACE 5MG CAPSULE.
Alcohol
Avoid consumption of alcohol while taking STAMACE 5MG CAPSULE as it may severely decrease your blood pressure and make you feel dizzier or faint.
Kidney
STAMACE 5MG CAPSULE is not recommended for use in patients with severe kidney impairment (including dialysis or narrowing or renal arteries). It should be used with caution in patients with other kidney problems (including kidney transplantation). Therefore, consult your doctor before taking it.
Liver
STAMACE 5MG CAPSULE should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take STAMACE 5MG CAPSULE if you are allergic to Amlodipine, Ramipril or to any other calcium antagonists (such as nifedipine, diltiazem) or ACE inhibitors (such as captopril, lisinopril, enalapril).
Heart Disease
STAMACE 5MG CAPSULE is not recommended for use in patients with severe heart problems such as heart failure, aortic stenosis (narrowing of arteries) or cardiogenic shock (inability of heart to pump blood). It should be used with caution in patients having a history of recent heart attack or heart failure. Therefore, consult your doctor before taking it.
Others
STAMACE 5MG CAPSULE is not recommended for use if you:
- have severe low blood pressure (hypotension)
- have diabetes with impaired kidney functions
Before taking STAMACE 5MG CAPSULE, inform your doctor if you have:
- severe uncontrollable increase in blood pressure (hypertensive crisis)
- have problems in the blood vessels supplying the brain
- are on a salt-restricted diet
- are severely dehydrated due to any recent sickness such as vomiting or diarrhea
- have low WBC, RBC and platelet count in the blood
- have diabetes
- have any autoimmune disease that affects the skin or collagen (Ex. lupus erythematosus, rheumatoid arthritis or scleroderma)
- are scheduled for any upcoming surgery
- have any desensitization management (used to reduce the effect of an allergy to bee or wasp stings)
- have high blood potassium levels
Use in Paediatrics:
STAMACE 5MG CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before consumption.
Use in Geriatrics:
STAMACE 5MG CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking STAMACE 5MG CAPSULE, inform your doctor if you are taking any of the following medicines such as:
- racecadotril (a medicine used to manage diarrhea)
- medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
- trimethoprim containing antibiotics (used for infections)
- medicines used to manage organ transplant rejection (Ex. ciclosporin, temsirolimus, sirolimus, everolimus)
- heparin (used to manage blood clots)
- medicines used for heart conditions such as hypertension, chest pain, irregular heartbeats or heart failure (Ex. atenolol, propranolol, furosemide, bumetanide, nitroglycerin, valsartan, aliskiren, procainamide, sacubitril/valsartan)
- lithium (a medicine used in some types of mental illness)
- medicines used to relieve pain (Ex. morphine, aspirin, ibuprofen, celecoxib, valdecoxib)
- anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagliptin, metformin
- corticosteroids (used to relieve pain and inflammation) Ex. prednisone
- allopurinol (a medicine used to manage gout)
- other medicines used to manage high blood pressure or angina (Ex. diltiazem, verapamil)
- ketoconazole, itraconazole (used to manage fungal infections)
- ritonavir, indinavir, nelfinavir (used in management of HIV infections)
- rifampicin, erythromycin, clarithromycin (used to manage bacterial infections)
- dantrolene (a medicine used to manage muscle spasms)
- medicines used to control elevated cholesterol levels (Ex. simvastatin)
- St. John’s wort (an herbal medicine used to manage depression)
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking STAMACE 5MG CAPSULE, as it could reduce your blood pressure to an abnormal level.
Overdosage:
If you or anyone else accidentally took more STAMACE 5MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin, fast heartbeat, anxiety, cough and shortness of breath.
Synopsis
| Drug | : | Amlodipine, Ramipril |
| Pharmacological Category | : | Calcium Channel Blockers, ACE inhibitors |
| Therapeutic Indication | : | Hypertension, Angina, Heart Failure, Kidney Failure |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep STAMACE 5MG CAPSULE out of the sight and reach of children
- Store STAMACE 5MG CAPSULE at room temperature
FAQs About STAMACE 5MG CAPSULE
What are the uses of STAMACE 5MG CAPSULE?
STAMACE 5MG CAPSULE is used to manage hypertension (high blood pressure) and certain type of angina (chest pain). It can also be used to manage heart failure and reduce the chances of hospitalization among the heart patients. It also protects the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus.
How STAMACE 5MG CAPSULE works?
STAMACE 5MG CAPSULE is a vasodilator. It relaxes the blood vessels supplying the heart and other organs. This improves blood flow and oxygen supply to the heart muscles which reduces strain on the heart. It also allows blood to flow more smoothly across the blood vessels with less pressure. It can improve blood supply to the kidneys which helps in delaying the worsening of kidney functions in diabetic patients. As a result, it reduces blood pressure and improves the functions of the heart and the kidneys.
What happens when I stop taking STAMACE 5MG CAPSULE?
Do not stop taking STAMACE 5MG CAPSULE without consulting your doctor as your symptoms may re-appear once again. Make sure to take STAMACE 5MG CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.
What is the best time to take STAMACE 5MG CAPSULE?
STAMACE 5MG CAPSULE can be taken with or without meals. Your doctor will decide the best time for you to take STAMACE 5MG CAPSULE based on your age, body weight and disease condition.
What to do if I forgot to take a dose of STAMACE 5MG CAPSULE?
If you have missed a dose of STAMACE 5MG CAPSULE, take it as soon as you remember. However, if it is time for the next dose of STAMACE 5MG CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of STAMACE 5MG CAPSULE to compensate the missed ones.
What precautions should be followed while taking STAMACE 5MG CAPSULE?
Before taking STAMACE 5MG CAPSULE, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have severe high or low blood pressure or other heart problems (such as narrowing of the arteries, cardiogenic shock or a recent heart attack). Do not take STAMACE 5MG CAPSULE if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood tests recommended by your doctor without fail.
Can I consume alcohol while taking STAMACE 5MG CAPSULE?
Avoid consumption of alcohol while taking STAMACE 5MG CAPSULE as it might make you feel dizzier and drowsier.
What happens if I accidentally take more STAMACE 5MG CAPSULE?
If you or anyone else accidentally took more STAMACE 5MG CAPSULE, consult your doctor immediately. Symptoms of overdosage might include dizziness, fainting, light-headedness, weakness, shock, cool or clampy skin fast heartbeat, anxiety, cough and shortness of breath.
Can I take STAMACE 5MG CAPSULE daily?
Take STAMACE 5MG CAPSULE as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take STAMACE 5MG CAPSULE every day or not.
Can STAMACE 5MG CAPSULE cause ankle swelling?
STAMACE 5MG CAPSULE may cause edema or swelling of ankles in few patients. If you experience ankle swelling, keep your legs on a table or slightly elevated from the ground level. If this symptom bothers you, contact your doctor.
What are the side effects of STAMACE 5MG CAPSULE?
The most common side effects of taking STAMACE 5MG CAPSULE are dizziness, swelling of ankles or other body parts, headache, sleepiness, tiredness, racing heartbeat, indigestion, constipation and muscle cramps. Contact your doctor if any of these side effects trouble you.
Can I stop taking STAMACE 5MG CAPSULE once my symptoms subside?
No. Do not stop taking STAMACE 5MG CAPSULE without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take STAMACE 5MG CAPSULE as advised by your doctor for the stipulated duration. Sudden withdrawal of the therapy may increase your blood pressure once again.
Can the use of STAMACE 5MG CAPSULE affect the liver?
Yes. STAMACE 5MG CAPSULE may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.
Can STAMACE 5MG CAPSULE cause erectile dysfunction?
STAMACE 5MG CAPSULE may cause problems in erection in few individuals. Consult your doctor if it bothers you.
Is STAMACE 5MG CAPSULE safe to use in diabetic patients?
STAMACE 5MG CAPSULE may alter the blood sugar levels in your body. It can also hide the symptoms of low blood sugar. Therefore, it is necessary to inform your doctor if you have diabetes before taking STAMACE 5MG CAPSULE as a precaution. Your doctor will closely monitor your blood sugar levels to avoid the risk of side effects. Also, inform your doctor if you experience any unusual tiredness, hunger or thirst while undergoing therapy with STAMACE 5MG CAPSULE.
Can STAMACE 5MG CAPSULE be used during pregnancy?
STAMACE 5MG CAPSULE is not recommended for use in pregnant women as it may cause serious harm to the growing foetus. Therefore, inform your doctor before taking STAMACE 5MG CAPSULE if you are pregnant, think you may be pregnant or planning to have a baby.
What kind of foods should be avoided while taking STAMACE 5MG CAPSULE?
STAMACE 5MG CAPSULE has the capacity to increase blood potassium level which can lead to irregular heartbeat. To manage any such occurrence, it is advisable to avoid potassium rich foods such as bananas, oranges, green leafy vegetables and potassium containing supplements while taking STAMACE 5MG CAPSULE.
References
1. KD Tripathi. Antianginal and Other Anti-ischaemic Drugs. Antihypertensive Drugs. Cardiovascular drugs. Drugs affecting Renin-angiotensin system. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 503, 549 & 562.
2. Roberto Dischinger Miranda, MD, Décio Mion Jr, MD, PhD, Joao Carlos Rocha, MD, José Francisco Kerr Saraiva, MD, Celso Amodeo, MD, PhD, Bráulio Luna Filho, MD, PhD. An 18-week, prospective, randomized, double-blind, multicenter study of amlodipine/ramipril combination versus amlodipine monotherapy in the treatment of hypertension: The assessment of combination therapy of amlodipine/ramipril (ATAR) study. Clinical Therapeutics. September 2008. [Accessed on 8th December 2022]. https://www.clinicaltherapeutics.com/article/S0149-2918(08)00301-9/fulltext
3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 8th December 2022]. https://www.medicines.org.uk/emc/files/pil.3478.pdf
4. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2021] [Accessed on 8th December 2022]. https://www.medicines.org.uk/emc/files/pil.13960.pdf
5. Balkanpharma – Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 8th December 2022]. https://www.medicines.org.uk/emc/files/pil.5890.pdf
6. Sandoz Ltd. Ramipril/Amlodipine. [Revised in July 2019] [Accessed on 8th December 2022]. https://docetp.mpa.se/LMF/Ramipril_Amlodipine%20Sandoz%20capsule,%20hard%20ENG%20PL_09001be6805e3207.pdf
7. Central Drugs Standard Control Organization. Amlodipine 5 mg + Ramipril 2.5mg capsule. October 2004. [Accessed on 8th December 2022]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Kidney Function Test
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