New Revised MRP, 100% GST benefit passed Sompraz IT Capsule 10'S
Netmeds First Membership
Quick Links
Introduction About SOMPRAZ IT CAPSULE
SOMPRAZ IT CAPSULE is a combination of Esomeprazole and Itopride which belongs to the group of medicines called Proton pump inhibitors and Gastroprokinetic agents respectively. It is used to manage Gastroesophageal reflux disease (GERD) in patients who does not respond to esomeprazole alone. Gastroesophageal reflux disease (GERD) occurs when stomach contents flow backwards and cause troublesome symptoms or complications like heartburn, excessive salivation, burping, and regurgitation. Though it is primarily a motility problem, acidity of gastric contents is the most important aggressive factor in causing symptoms and lesions in food-pipe.
Before taking SOMPRAZ IT CAPSULE, inform your doctor if you have severe kidney, liver or skin problems, osteoporosis, or about to take any blood tests. SOMPRAZ IT CAPSULE should be used with caution in pregnant women and it is not recommended for use in breastfeeding women. SOMPRAZ IT CAPSULE should be used with caution in children and adolescents (under 12 years of age) and elderly patients.
The most common side effects of taking SOMPRAZ IT CAPSULE are dizziness, headache, diarrhoea, stomach pain, constipation, flatulence, nausea, vomiting, rash, redness, or itching. Consult your doctor if any of the above side effects worsen.
Uses Of SOMPRAZ IT CAPSULE
- Used to manage gastroesophageal reflux disease (GERD) (in patients who does not respond to esomeprazole alone)
How SOMPRAZ IT CAPSULE Works
SOMPRAZ IT CAPSULE is a combination of Esomeprazole and Itopride, where Esomeprazole suppresses stomach acid secretion by specific blockade of the proton pump at the secretory surface of the stomach cell and Itopride that blocks certain enzyme to increase the stomach motility, lower sphincter pressure of food pipe, stomach emptying and improve the stomach-intestine coordination. This kind of action provides relief from the symptoms of gastroesophageal reflux disease (GERD).
How to use SOMPRAZ IT CAPSULE
Take SOMPRAZ IT CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of SOMPRAZ IT CAPSULE for you depending upon your age, body weight and severity of the condition.
Side Effects Of SOMPRAZ IT CAPSULE
Common
- headache
- dizziness
- shaking of hands
- diarrhoea
- stomach pain
- constipation
- flatulence
- nausea
- vomiting
- easy bruising
- increased milk production
- excessive development of breasts (male)
- yellowing of skin and eyes
- skin rash, redness, and itching
Uncommon
- swelling of the feet and ankles
- difficulty in falling asleep
- tingling or pricking feeling in nerves
- excessive sleepiness
- head spinning sensation (vertigo)
- dry mouth
- hip, wrist, or spine fractures (if used in high dose and long duration)
Rare
- weakness, or more chances of infections (signs of reduced white blood cells)
- weakness, cramps
- feeling agitated, confused, or depressed
- taste changes
- eyesight problems like blurred vision
- suddenly feeling of wheezing or breathlessness
- inflammation inside the mouth
- thrush
- hair loss
- joint or muscle pains
- generally feeling unwell and lacking energy
- increased sweating
Stop taking SOMPRAZ IT CAPSULE and consult your doctor immediately if you experience any of the following side effects:
- signs include extreme tiredness, involuntary muscle contractions, disorientation, fits, dizziness or increased heart rate
- severe allergic reaction (sudden wheezing, swelling of lips, tongue and throat or body, rash, fainting, or trouble swallowing)
- steven-johnson syndrome or toxic epidermal necrolysis (signs include reddening of the skin with blisters or peeling, severe blisters and bleeding in the lips, eyes, mouth, nose, genitals)
- signs of liver problems (such as yellow skin, dark urine, or tiredness)
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly (such as daily walk or run). Consult your doctor if the symptom does not improve.
Diarrhea
Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Avoid eating high-fat or spicy foods. Do not consume any medicine on your own to manage diarrhea without consulting your doctor.
Dizziness Or Drowsiness
Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets worse.
Headache
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Take SOMPRAZ IT CAPSULE with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.
Warning & Precautions
Pregnancy
Monitoring requiredSOMPRAZ IT CAPSULE is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking SOMPRAZ IT CAPSULE.
Breastfeeding
ContraindicatedSOMPRAZ IT CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking SOMPRAZ IT CAPSULE.
Driving and Using Machines
Use with CautionDo not drive or use any machines if you feel dizzy or your vision becomes blurred after taking SOMPRAZ IT CAPSULE.
Kidney
Use with CautionSOMPRAZ IT CAPSULE should be used with caution in patients with severe kidney problems. Consult your doctor before taking SOMPRAZ IT CAPSULE.
Liver
Use with CautionSOMPRAZ IT CAPSULE should be used with caution in patients with severe liver problems. Consult your doctor before taking SOMPRAZ IT CAPSULE.
Allergy
ContraindicatedDo not take SOMPRAZ IT CAPSULE if you are allergic to Esomeprazole or Itopride or any other ingredients of this medicine.
Use In Pediatrics
Use with CautionSOMPRAZ IT CAPSULE should be used with caution in children and adolescents (below 12 years of age) as safety may vary. Consult child’s doctor for advice.
Use In Geriatrics
Use with CautionSOMPRAZ IT CAPSULE should be used with caution in elderly patients, therefore consult your doctor before taking it. If you observe weight loss for no reason, stomach pain or indigestion, vomiting food or blood, passing black stools (blood-stained faeces) and skin rash on exposure to sunlight while taking SOMPRAZ IT CAPSULE, consult your doctor immediately.
Others
SOMPRAZ IT CAPSULE is not recommended for use if you:
- have gastrointestinal bleeding, mechanical obstruction, or perforation
Before taking SOMPRAZ IT CAPSULE inform your doctor if you:
- are scheduled for chromogranin A (CgA) blood test (tumor marker)
- have osteoporosis (weak bones)
Interactions
A. Drug-Drug interactions:
Before taking SOMPRAZ IT CAPSULE, inform your doctor if you are taking any of the following medicines:
- nelfinavir, atazanavir (used to manage HIV infection)
- clopidogrel, warfarin (used to manage blood clots)
- medicines used to manage fungal infections (Ex. ketoconazole, itraconazole, voriconazole)
- medicines used in cancer (Ex. erlotinib, methotrexate)
- medicines used to manage depression (Ex. citalopram, imipramine, clomipramine, St. John’s wort)
- diazepam (used to manage anxiety, fits, or to relax muscles)
- phenytoin (used to manage fits)
- cilostazol (used to manage intermittent claudication)
- cisapride (used to manage indigestion and heartburn)
- digoxin (used to manage heart problems)
- medicines used to manage a variety of conditions, from overactive bladder to chronic obstructive pulmonary disorder (Ex. atropine, dicyclomine)
- tacrolimus (used to prevent organ rejection after transplant)
- rifampicin (used to manage tuberculosis)
- other medicines used to reduce acidity (Ex. pantoprazole, lansoprazole, rabeprazole and omeprazole)
Overdosage:
If you or anyone else accidentally take too much of SOMPRAZ IT CAPSULE, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Esomeprazole, Itopride |
| Pharmacological Category | : | Proton pump inhibitor, Prokinetic benzamide derivative |
| Therapeutic Indication | : | Gastroesophageal reflux disease (GERD) |
| Dosage Forms | : | Tablet, Capsule |
More Information
Storage
- Keep SOMPRAZ IT CAPSULE out of reach of children
- Store at room temperature
FAQs About SOMPRAZ IT CAPSULE
Q: Can I take SOMPRAZ IT CAPSULE for a long period of time?
A: Your doctor will decide the correct duration of SOMPRAZ IT CAPSULE for you depending upon your age, body weight and severity of the condition. If you need to take it for a long time (especially for more than a year), you may require regular monitoring as it may increase your risk of getting hip, wrist, or spine fractures if used for a long time in high doses. Consult your doctor before taking it for a longer time than prescribed.
Q: Does SOMPRAZ IT CAPSULE cause photosensitivity reactions?
A: SOMPRAZ IT CAPSULE may cause rashes in the skin areas exposed to sunlight. Consult your doctor immediately if it happens and ask about precautionary measures that you can take.
Q: Is SOMPRAZ IT CAPSULE safe to use during pregnancy?
A: If you are pregnant, think you may be pregnant or planning to get pregnant, consult your doctor before taking SOMPRAZ IT CAPSULE. Your doctor will decide whether you can take SOMPRAZ IT CAPSULE during pregnancy.
Q: Can SOMPRAZ IT CAPSULE be used in children?
A: SOMPRAZ IT CAPSULE should be used with caution in children and adolescents (below 12 years of age) as safety may vary. Your doctor will decide the correct dose or select a suitable alternative therapy for your child to manage the condition.
Q: What if I forget to take a dose of SOMPRAZ IT CAPSULE?
A: If you forget to take a dose of SOMPRAZ IT CAPSULE, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take SOMPRAZ IT CAPSULE twice to make up for a forgotten dose.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Gastroesophageal Reflux Disease. Pharmacotherapy Handbook. Ninth edition. Page- 206.
2. Zhang, Yinghui, and Liangping LI. Clinical Observation of Itopride Combined with Esomeprazole Magnesium in the Management of Esophageal Motility Dysfunction-induced Gastroesophageal Reflux Disease. China Pharmacy. pesquisa.bvsalud.org. 2017 [Accessed on 2nd June 2022] https://pesquisa.bvsalud.org/portal/resource/pt/wpr-664456
3. PubChem Compound Summary for CID 9568614, Esomeprazole. National Center for Biotechnology Information. May 2022. [Accessed on 2nd June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Esomeprazole#section=Pharmacology
4. PubChem Compound Summary for CID 3792, Itopride. National Center for Biotechnology Information. May 2022. [Accessed on 2nd June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Itopride#section=Metabolism-Metabolites
5. Inventia Healthcare Limited. Nexpro IT (Esomeprazole and Itopride). [Revised in May 2022] [Accessed on 2nd June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2935.pdf
6. Central Drugs Standard Control Organization (CDSCO). Esomeprazole 40mg + Itopride 150mg SR Capsules [Accessed on 2nd June 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Useful Diagnostic Tests
- Esophageal pH monitoring
- Endoscopy
- Manometry
Author Details
