SITAMERZ M 50/500 Tablet 15's

Introduction About SITAMERZ M 50/500 TABLET

SITAMERZ M 50/500 TABLET is a combination of Sitagliptin and Metformin used to manage type 2 diabetes effectively by improving blood sugar control.

Take SITAMERZ M 50/500 TABLET at the same time every day to maintain optimum levels in the blood. It is preferably taken with meals, once or twice a day depending on your health condition and doctor’s advice. Do not adjust the dose of SITAMERZ M 50/500 TABLET without consulting your doctor.

Before taking SITAMERZ M 50/500 TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor before taking SITAMERZ M 50/500 TABLET if you are severely dehydrated or suffering from type I diabetes.

Pregnant and breastfeeding women must avoid taking SITAMERZ M 50/500 TABLET, as it includes a risk to the growing baby and nursing infant. The most common side effects of taking SITAMERZ M 50/500 TABLET are nausea, stomach discomfort, gas (flatulence), constipation, dry mouth, low blood sugar levels and headache. Talk to your doctor if any of these side effects trouble you.

Along with the therapy, drink plenty of water or fluids to maintain hydration and limit consumption of alcohol, sugary drinks to help manage blood sugar levels effectively. Consume low-calorie diet and include plenty of vegetables, greens and fibre to complement the therapy on achieving optimum blood sugar levels.

Regularly track your blood sugar levels and check with your if you require any dosage adjustments.

Uses Of SITAMERZ M 50/500 TABLET

• Management of type II diabetes mellitus

Benefits of SITAMERZ M 50/500 TABLET

1. Dual Action for Blood Sugar Control – Combines Sitagliptin (DPP-4 inhibitor) and Metformin (biguanide) to effectively lower high blood sugar levels in type 2 diabetes.
2. Improves Insulin Sensitivity – Helps the body use insulin more efficiently, reducing insulin resistance and promoting better glucose uptake.
3. Reduces Liver Glucose Production – Metformin in SITAMERZ M 50/500 TABLET decreases excess glucose production in the liver, preventing blood sugar spikes.
4. Supports Post-Meal Glucose Control – Sitagliptin enhances incretin hormones, leading to better insulin release and lower post-meal sugar levels.
5. Weight-Neutral & Low Risk of Hypoglycemia – Unlike some diabetes medications, SITAMERZ M 50/500 TABLET does not cause significant weight gain and has a lower risk of low blood sugar when used correctly.

Who Should Take SITAMERZ M 50/500 TABLET:

• Adults with type 2 diabetes mellitus who struggle to maintain healthy blood sugar levels despite diet and exercise alone.
• It is ideal for patients needing a combination therapy to enhance insulin function and reduce glucose production.
• SITAMERZ M 50/500 TABLET is particularly beneficial for individuals with insulin resistance, those inadequately controlled on metformin alone, or those requiring an add-on therapy to other anti-diabetic medications.
• However, it is not suitable for type 1 diabetes or patients with severe kidney disease. Always consult a doctor before using SITAMERZ M 50/500 TABLET to ensure it is the right choice for your diabetes management plan.

How SITAMERZ M 50/500 TABLET Works

SITAMERZ M 50/500 TABLET is a combination of Sitagliptin and Metformin, two effective anti-diabetic medications that help control blood sugar levels in type 2 diabetes.

• Metformin, a biguanide, works by reducing glucose production in the liver, improving insulin sensitivity, and decreasing sugar absorption in the intestines.
• Sitagliptin, a DPP-4 inhibitor, enhances the body's natural insulin release by preventing the breakdown of incretin hormones, which help lower blood sugar levels after meals.

Together, these diabetes medications provide a dual-action approach to improve glycemic control, making SITAMERZ M 50/500 TABLET an effective choice for managing type 2 diabetes mellitus.

How to use SITAMERZ M 50/500 TABLET

SITAMERZ M 50/500 TABLET is a prescription medication which should be used the guidance of a medical practitioner.

How To Take SITAMERZ M 50/500 TABLET:

• Take one tablet as prescribed by your doctor, usually with meals to reduce stomach upset. Do not crush or chew the tablet
• Swallow the medicine whole with a glass of water

SITAMERZ M 50/500 TABLET Dosage for Type 2 Diabetes:

• For Adults:
  • Start with one tablet daily, depending on blood sugar levels.
  • Dose may be adjusted based on effectiveness and tolerability.
• For Kidney Patients:
  • Dosage may need to be reduced based on kidney function.
  • Consult your doctor for adjustments if you have renal issues.

When to Take SITAMERZ M 50/500 TABLET?

• Take once daily with a meal, preferably with breakfast or as directed by your doctor.
• Ensure a consistent time each day for better blood sugar control.

SITAMERZ M 50/500 TABLET Dose Adjustment Based on Blood Sugar Levels:

• Monitor blood sugar levels regularly.
• If blood sugar is high, your doctor may increase the dose.
• If blood sugar is low, your doctor may lower the dose or suggest other adjustments.

What if I forgot to take SITAMERZ M 50/500 TABLET

• Take it as soon as you remember unless it's close to the time for your next dose.
• Do not double dose to make up for the missed dose.
• Consult your doctor if you miss doses frequently.

Overdose

• Seek medical help immediately if you suspect an overdose.
• Symptoms of overdose may include severe nausea, vomiting, and low blood sugar.
• Contact your doctor for guidance on how to proceed.

Side Effects Of SITAMERZ M 50/500 TABLET

Like all medicines, SITAMERZ M 50/500 TABLET may cause certain side effects in some individuals, although not everybody gets them.

Common Side Effects of SITAMERZ M 50/500 TABLET are:

• Nausea
• Diarrhea
• Stomach discomfort, flatulence, constipation, loss of appetite
• Headache
• Hypoglycemia (low blood sugar)
• Swelling of the hands and legs (edema)
• Metallic taste
• Drowsiness, dizziness
• Dry mouth
• Stuffy or runny nose and sore throat
• Upper respiratory infection
• Weakness

When To Seek Medical Attention?

Stop taking and consult your doctor immediately if you experience any of the following side effects:

• serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
• severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
• signs of pancreatitis (severe and persistent pain in the stomach areas that might reach through to your back with or without nausea and vomiting)
• signs of lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

SITAMERZ M 50/500 TABLET – Long-term Safety:

• Generally Safe for Long-Term Use – When taken as prescribed, SITAMERZ M 50/500 TABLET (Sitagliptin + Metformin) is considered safe for long-term management of type 2 diabetes with regular monitoring.
• Monitoring Required for Kidney & Liver Function – Long-term use may require regular tests to assess kidney and liver function to ensure the drug is not causing adverse effects.
• Low Risk of Hypoglycemia – Unlike some other diabetes medications, SITAMERZ M 50/500 TABLET has a low risk of causing hypoglycemia when taken alone, making it safer for long-term use in controlled doses.

How To Manage Side Effects

Warning & Precautions

Other Warnings for SITAMERZ M 50/500 TABLET

Before taking SITAMERZ M 50/500 TABLET, inform your doctor if you:

• have or ever had pancreatitis (inflammation of the pancreas)
• have alcohol dependence
• have high blood lipid levels
• have type I diabetes mellitus (insulin-dependent diabetes)
• are about to have a major surgery
• are fasting
• are malnourished, starved, on an irregular diet, or feeling weak
• perform extreme muscle exercises
• have a vitamin B12 deficiency

Who should not take [GBNKEYWORD

SITAMERZ M 50/500 TABLET is not recommended for use if you:

• have severe, uncontrollable diabetes
• have nausea, vomiting, diarrhea, or rapid weight loss
• have lactic acidosis or ketoacidosis (a buildup of lactic acid or ketones in the body)
• are dehydrated
• have any severe systemic infection
• have shock or problems in blood circulation
• have problems in breathing
• are an alcoholic
• are scheduled for any X-rays in the upcoming days

Safety Advice

Expert Tips To Follow While taking SITAMERZ M 50/500 TABLET:

• Follow a Consistent Dosage Schedule – Take SITAMERZ M 50/500 TABLET at the same time every day with meals to help minimize stomach upset and keep blood sugar levels stable.
• Monitor Blood Sugar Regularly – Keep track of your blood sugar levels frequently, especially during the initial stages of treatment. Adjust doses as advised by your doctor based on your readings.
• Maintain a Healthy Diet – Focus on a balanced, low-GI diet with fiber-rich foods and moderate carbohydrate intake to complement SITAMERZ M 50/500 TABLET action and maintain optimal blood sugar control.
• Stay Hydrated – Drink plenty of water to help prevent dehydration and enhance Metformin's effectiveness, which may be affected by a lack of hydration.
• Regular Check-ups – Schedule routine visits with your doctor for kidney and liver function tests, as SITAMERZ M 50/500 TABLET can affect these organs over long-term use. Regular checks ensure safe and effective management of diabetes.

These tips can help maximize SITAMERZ M 50/500 TABLET effectiveness and manage any potential side effects.

Diet and Lifestyle Advice

What to Eat & Avoid? – Best Foods to Complement SITAMERZ M 50/500 TABLET Therapy

A diabetes-friendly diet is essential to maintain stable blood glucose levels and support SITAMERZ M 50/500 TABLET dual action in controlling blood sugar.

Best Foods for Diabetes (Low-GI & Fiber-Rich Diet):

• Non-starchy vegetables (spinach, broccoli, bell peppers, kale) – High in fiber, low in carbs.
• Whole grains (quinoa, brown rice, oats, whole wheat) – Rich in fiber, promoting slow glucose absorption.
• Lean proteins (chicken, fish, tofu, eggs, legumes) – Helps maintain muscle mass and stabilizes blood sugar.
• Healthy fats (avocados, nuts, seeds, olive oil) – Improves insulin sensitivity and supports heart health.
• Low-GI fruits (berries, apples, oranges, pears) – Provides natural sweetness without blood sugar spikes.
• Probiotic foods (Greek yogurt, kimchi, sauerkraut) – Supports gut health and enhances glucose metabolism.

Foods to Avoid (High-GI & Processed Foods):

• Refined carbohydrates (white bread, pasta, sugary cereals) – Causes rapid blood sugar spikes.
• Sugary foods & beverages (sweets, sodas, fruit juices) – Leads to insulin resistance over time.
• Fried and processed foods (fast food, chips, packaged snacks) – High in unhealthy fats and calories.
• Excessive red and processed meats – May contribute to inflammation and insulin resistance.
• Alcohol in excess – Can interfere with Metformin’s action and lead to low blood sugar episodes (hypoglycemia).

Best Exercises for Diabetes Management:

• Brisk walking (30–45 minutes daily) – Helps lower blood sugar naturally.
• Strength training (2–3 times a week) – Improves muscle mass and insulin response.
• Yoga and stretching – Reduces stress and improves glucose metabolism.
• Cycling or swimming – Low-impact cardio that supports heart health and weight loss.

Maintaining a healthy weight is essential, as excess body fat can lead to insulin resistance. Pairing SITAMERZ M 50/500 TABLET with regular exercise not only enhances its benefits but also reduces the risk of diabetes complications such as heart disease and nerve damage.

Hydration & Sugar Control – Why Drinking Enough Water Helps Metformin Work Better

Proper hydration is crucial for diabetes management, especially when taking Metformin-based medications like SITAMERZ M 50/500 TABLET. Water helps in:

• Flushing out excess glucose through urine.
• Enhancing Metformin’s effect by aiding its metabolism.
• Preventing dehydration, which can lead to high blood sugar levels.

How Much Water Should You Drink?

• Aim for at least 8–10 glasses (2–2.5 liters) per day.
• Increase intake if sweating due to exercise or hot weather.
• Avoid sugary drinks, as they spike blood glucose levels.

By following a balanced diet, regular exercise, and proper hydration, SITAMERZ M 50/500 TABLET users can significantly improve their blood sugar control and overall diabetes management.

Drug - Drug interaction

SITAMERZ M 50/500 TABLET (Sitagliptin + Metformin) may interact with other medications, affecting blood sugar levels or increasing side effects.

Medications that Increase the Risk of Low Blood Sugar (Hypoglycemia):

• Insulin or Sulfonylureas (e.g., Glimepiride, Glyburide) – May cause excessive blood sugar lowering.
• Beta-Blockers (e.g., Propranolol, Metoprolol) – Can mask symptoms of hypoglycemia.

Drugs that Increase the Risk of Lactic Acidosis (Rare but Serious Side Effect of Metformin):

• Alcohol (Excessive Use) – Can increase the risk of lactic acidosis.
• Diuretics (e.g., Furosemide, Hydrochlorothiazide) – May lead to dehydration and increase metformin buildup.
• ACE Inhibitors (e.g., Lisinopril, Ramipril) – May alter kidney function and affect metformin clearance.
• Iodinated Contrast Agents (Used in CT Scans/X-rays) – May cause kidney damage; SITAMERZ M 50/500 TABLET should be stopped before imaging procedures.

Drugs that May Reduce the Effectiveness of SITAMERZ M 50/500 TABLET:

• Corticosteroids (e.g., Prednisone, Dexamethasone) – Can increase blood sugar levels.
• Thyroid Medications (e.g., Levothyroxine) – May reduce the blood sugar-lowering effect of SITAMERZ M 50/500 TABLET.

Drug - Food interaction

Foods to Be Cautious with While Taking SITAMERZ M 50/500 TABLET:

• Excessive Alcohol – Can increase the risk of lactic acidosis and severe hypoglycemia.
• High-Sugar Foods & Refined Carbs – May spike blood sugar levels, counteracting SITAMERZ M 50/500 TABLET effect.
• Grapefruit Juice – May affect Sitagliptin metabolism, potentially altering its effectiveness.
• High-Fat Meals – Can delay Metformin absorption, slightly reducing its effect.

More Information

Relevant Health Articles

Diabetes: 5 Incredible Herbs For Controlling Blood Sugar Levels- Infographic

Diabetic Diet Chart (1600 Calories, Vegetarian)

How to self-monitor glucose levels at home

4 Best-Selling Glucometers To Manage Blood Sugar Levels

FAQs About SITAMERZ M 50/500 TABLET

Q: What is SITAMERZ M 50/500 TABLET?

A: SITAMERZ M 50/500 TABLET is a prescription medication used to manage type 2 diabetes. It combines two powerful ingredients, Sitagliptin (50mg) and Metformin (500mg), which work together to help lower blood sugar levels. Sitagliptin improves insulin production and reduces sugar production by the liver, while Metformin increases the body’s sensitivity to insulin and reduces sugar absorption in the intestines.

Q: Does SITAMERZ M 50/500 TABLET Cause Weight Gain or Loss?

A:SITAMERZ M 50/500 TABLET is not associated with significant weight gain. In fact, it may even help some people lose weight when used as part of a comprehensive diabetes management plan. Metformin, one of the key ingredients, is often linked to modest weight loss, especially when combined with diet and exercise.

Q: What If I Miss a Dose of SITAMERZ M 50/500 TABLET?

A: If you miss a dose of SITAMERZ M 50/500 TABLET, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose—do not take two doses at once. Always follow the prescribed schedule to avoid fluctuations in blood sugar levels.

Q: Can I Take SITAMERZ M 50/500 TABLET with BP Medications?

A: Yes, you can take SITAMERZ M 50/500 TABLET with blood pressure (BP) medications, but it’s essential to monitor your blood sugar and blood pressure levels regularly. Certain BP medications, like ACE inhibitors, may affect kidney function, so ensure your doctor is aware of all your medications to make proper adjustments.

Q: Can I Take SITAMERZ M 50/500 TABLET with Insulin?

A: SITAMERZ M 50/500 TABLET can be taken with insulin for better control of type 2 diabetes. In such cases, your doctor will adjust the dosages to avoid hypoglycemia (low blood sugar). Always follow the dosage instructions provided by your doctor.

Q: Is SITAMERZ M 50/500 TABLET Safe for Older Patients?

A: SITAMERZ M 50/500 TABLET can be used safely by older adults, but dosage adjustments may be necessary based on kidney function and other health factors. Elderly patients should be monitored closely for any adverse effects, including potential issues with kidney function or low blood sugar.

Q: How Long Does SITAMERZ M 50/500 TABLET Take to Work?

A: SITAMERZ M 50/500 TABLET typically starts to lower blood sugar levels within hours of taking the first dose. However, it may take a few weeks to see full benefits and achieve optimal blood sugar control. Consistency in taking the medication as prescribed, along with diet and exercise, is key for effectiveness.

Q: Are There Any Dietary Recommendations While Taking SITAMERZ M 50/500 TABLET?

A: While on SITAMERZ M 50/500 TABLET, it’s recommended to follow a balanced, low-GI diet rich in fiber, vegetables, and whole grains. Avoid high-sugar foods and processed carbs, which may counteract SITAMERZ M 50/500 TABLET blood sugar-lowering effects. Staying hydrated and eating smaller, more frequent meals can also help reduce any digestive discomfort associated with Metformin.

Q: What is the Starting Dose of SITAMERZ M 50/500 TABLET for Adults?

A: The starting dose of SITAMERZ M 50/500 TABLET is typically one tablet once or twice a day with meals. Your doctor may adjust the dosage based on blood sugar levels and individual needs. Always follow the recommended dosage instructions for the best results.

Q: Can I Take SITAMERZ M 50/500 TABLET with Other Diabetes Medications?

A: Yes,SITAMERZ M 50/500 TABLET can be taken with other diabetes medications, including insulin and sulfonylureas. However, dose adjustments may be needed to avoid low blood sugar (hypoglycemia). It’s important to discuss any other medications you are taking with your doctor to ensure they work well together.

Q: Is SITAMERZ M 50/500 TABLET Taken Once or Twice a Day?

A: SITAMERZ M 50/500 TABLET is usually taken once or twice daily, depending on the prescribed dosage and your doctor’s recommendation. It’s generally best to take it with meals to help minimize stomach upset and improve absorption.

Q: What is the Maximum Dose of SITAMERZ M 50/500 TABLET?

A: The maximum dose of SITAMERZ M 50/500 TABLET is typically two tablets per day, with each tablet containing 50mg Sitagliptin and 500mg Metformin. Your doctorr will determine the best dose based on your blood sugar levels and medical history.

Q: Can SITAMERZ M 50/500 TABLET Dosage Be Increased if Blood Sugar is Not Controlled?

A: Yes, if blood sugar is not adequately controlled, your doctor may increase the dose of SITAMERZ M 50/500 TABLET or add other medications to your treatment plan. Regular blood sugar monitoring is important to determine if dosage adjustments are necessary.

Q: What Are the Common Side Effects of SITAMERZ M 50/500 TABLET?

A: The most common side effects of SITAMERZ M 50/500 TABLET include gastrointestinal issues like nausea, diarrhea, and flatulence. Some people may also experience mild headaches or dizziness. These side effects usually improve over time, but contact your doctor if they persist.

Q: Is Weight Gain a Side Effect of Taking SITAMERZ M 50/500 TABLET?

A: SITAMERZ M 50/500 TABLET is not associated with weight gain. In fact, Metformin, one of the ingredients, is known for having a neutral to weight loss effect. If you experience any unexpected weight gain, it’s important to discuss it with your doctor to rule out other causes.

Q: Can SITAMERZ M 50/500 TABLET Cause Stomach Problems Like Nausea or Diarrhea?

A: Yes, stomach problems such as nausea, diarrhea, and bloating are common side effects of Metformin (one of the key ingredients in SITAMERZ M 50/500 TABLET). These effects are typically temporary and can be minimized by taking the tablet with food. If symptoms persist, consult your doctor.

Q: What Should I Do if I Experience Low Blood Sugar on SITAMERZ M 50/500 TABLET?

A: If you experience low blood sugar (hypoglycemia), symptoms may include shakiness, sweating, dizziness, or confusion. Consume fast-acting carbohydrates such as glucose tablets, juice, or hard candy. If symptoms don’t improve, seek medical attention immediately.

Q: Does SITAMERZ M 50/500 TABLET Cause Headaches or Dizziness?

A: Headaches and dizziness can be mild side effects of SITAMERZ M 50/500 TABLET, especially when starting treatment. If these side effects are bothersome or persist, consult your doctor for adjustments.

Q: Can SITAMERZ M 50/500 TABLET Cause Kidney Problems or Affect Kidney Function?

A: In some cases, Metformin (in SITAMERZ M 50/500 TABLET) can affect kidney function, especially in people with pre-existing kidney conditions. Regular kidney function tests are recommended during long-term use of SITAMERZ M 50/500 TABLET to ensure there are no issues.

References

1. Janumet Tablet. Prescribing Information. U.S. Food and Drug Administration. Approval 2007. [Accessed on 5th June 2025].
2. Janumet. Drugs.com. Package insert. [Revised in September 2024]. [Accessed on 5th June 2025].
3. Janumet Xr. Pacakge insert. Merck. [Accessed on 5th June 2025].
4. Janumet. Merck. U.S. Food and Drug Administration. [Revised in July 2022]. [Accessed on 5th June 2025].

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details