Seroflo 50mcg/100mcg Multihaler 200Mdi

Introduction About SEROFLO 50MCG/100MCG MULTIHALER

SEROFLO 50MCG/100MCG MULTIHALER is a combination of Fluticasone and Salmeterol which belongs to the group of medicines called Corticosteroids and Bronchodilators respectively. It is used to manage asthma and chronic obstructive pulmonary disease (COPD) in adults and in children (aged 4 years or above). It also helps in reducing the flare-ups of COPD symptoms.

Use SEROFLO 50MCG/100MCG MULTIHALER every day until your doctor tells you to stop. It is meant for inhalation use only. Do not stop using this medicine once your symptoms subside without consulting your doctor.

SEROFLO 50MCG/100MCG MULTIHALER should not be used to relieve a sudden asthma attack (such as sudden breathing problems). Instead contact your doctor or use a fast-acting ‘rescue’ inhaler to subside the symptoms.

Before using SEROFLO 50MCG/100MCG MULTIHALER inform your doctor if you have any lung infections, liver problems or heart problems. You must also inform your doctor if you have diabetes, hypertension, fits, overactive thyroid functions, osteoporosis, adrenal gland problems or a weak immune system as a precaution.

SEROFLO 50MCG/100MCG MULTIHALER should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. The most common side effects of using SEROFLO 50MCG/100MCG MULTIHALER are headache, cold, oral thrush or oral sores, throat irritation, hoarse voice, muscle pain and joint pain. Contact your doctor if any of these side effect worsens.

Uses Of SEROFLO 50MCG/100MCG MULTIHALER

It is used in adults and in children (aged 4 years or above) to manage, manage the symptoms of:

• Asthma
• Chronic Obstructive Pulmonary Disease (COPD)

How SEROFLO 50MCG/100MCG MULTIHALER Works

SEROFLO 50MCG/100MCG MULTIHALER is a combination of two medicines namely, fluticasone and salbutamol. Fluticasone is an inhalation corticosteroid. It blocks the release of certain chemical messengers in the airways (such as prostaglandins, leukotrienes) that cause inflammation and swelling.

Salmeterol is a bronchodilator. It relaxes the smooth muscles of the airways and widens them. Collectively, they reduce airway inflammation, allows the air to pass through more freely and makes breathing easier.

How to use SEROFLO 50MCG/100MCG MULTIHALER

Use SEROFLO 50MCG/100MCG MULTIHALER every day until your doctor tells you to stop. It is meant for inhalation use only. Inhale the medicine only through your mouth into the lungs and not via nose.

Closely follow the instructions given by your doctor regarding the number of inhalations and dosing intervals.

• Slide the lever given beside the mouthpiece up to the marking present on the device
• Place the mouthpiece of the device between your teeth and close your mouth tightly. Breath in through your mouth deeply and rapidly
• Hold your breath for 10 seconds or for as long as is comfortable and then breathe out normally. Repeat the same steps for further inhalations as well

Once inhalation is over, rinse your mouth with water and spit it out or brush your teeth.

Do not start using this medicine unless your doctor or health care provider has taught you how to use and you understand how to use it correctly.

Side Effects Of SEROFLO 50MCG/100MCG MULTIHALER

How To Manage Side Effects

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Throat irritation:

Gargle your throat with salt water twice a day. Always try to drink warm water. Avoid chilled, cooled, or sweetened food items or beverages. Drinking turmeric milk or ginger tea mixed with honey and pepper powder can ease the soreness. Consult your doctor if the symptom did not improve.

Muscle pain or cramps:

Rub a pain-relieving balm or place a heat pack on the affected area for some time, as it could ease the pain. Do not move the affected area frequently. Try to do some simple movements every day which would improve blood circulation and reduce further incidence of muscle pain. Try to eat a well-balanced protein rich diet, so that it can help to repair and rebuild the damaged muscle. Consult your doctor if the symptom did not improve.

Joint pain:

Rub a pain-relieving balm or place a heat pack on the affected area for some time, as it could ease the pain. Do not move the affected area frequently. Consume calcium and vitamin supplements regularly, particularly if you are elderly. Consult your doctor if the symptom did not improve.

Allergic skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom did not improve.

Warning & Precautions

Pregnancy

SEROFLO 50MCG/100MCG MULTIHALER should be used in pregnant women only if it is considered necessary by the doctor. Your doctor may prescribe this medicine after outweighing the risk and benefits to you and your baby. Therefore, inform your doctor before using it.

Breastfeeding

SEROFLO 50MCG/100MCG MULTIHALER should be used in breastfeeding women only if it is considered necessary by the doctor. Therefore, consult your doctor for advice before using it.

Driving and Using Machines

Do not drive or operate any heavy tools or machines if your ability is affected by SEROFLO 50MCG/100MCG MULTIHALER.

Liver

SEROFLO 50MCG/100MCG MULTIHALER should be taken with caution in patients with liver diseases. Therefore, consult your doctor before using it.

Allergy

Do not use SEROFLO 50MCG/100MCG MULTIHALER if you are allergic to Salmeterol or Fluticasone.

Lungs

SEROFLO 50MCG/100MCG MULTIHALER should be taken with caution among patients who have or previously had tuberculosis or any other lung infections. Therefore, consult your doctor before using it.

Heart Disease

SEROFLO 50MCG/100MCG MULTIHALER should be taken with caution in patients with heart diseases (such as irregular or fast heartbeat). Therefore, consult your doctor before using it.

Interactions

A. Drug-Drug interactions:

Before using SEROFLO 50MCG/100MCG MULTIHALER, inform your physician if you are taking any of the following medicines such as:

• other beta-blockers (used to manage high blood pressure or other heart conditions) Ex. atenolol, propranolol and sotalol
• medicines used to manage fungal infection (such as ketoconazole and itraconazole)
• medicines used to manage HIV infection (Ex. ritonavir, atazanavir, indinavir, nelfinavir, saquinavir or cobicistat)
• clarithromycin, erythromycin (used to manage bacterial infections)
• other corticosteroids (taken orally or via injections to manage pain or inflammation) Ex. dexamethasone
• potassium-sparging diuretics (used to manage high blood pressure by increasing urine output) Ex. spironolactone, acetazolamide
• other medicines that can cause bronchodilation (such as salbutamol, formoterol)
• xanthine medicines (used to manage asthma) Ex. theophylline and aminophylline
• nefazodone (used to manage depression)
• medicines used to manage depression such as (rasagiline, selegiline, phenelzine, amitriptyline, nortriptyline, doxepin, imipramine, desipramine)

Overdosage:

If you or anyone else accidentally inhaled excessive amount of this medicine, contact your doctor immediately or go to the hospital straight away. Symptoms of overdosage might include shortness of breath, chest pain, fast heartbeat, feeling shaky, dizziness, headache, muscle weakness and joint pain.

Synopsis

More Information

• Keep SEROFLO 50MCG/100MCG MULTIHALER out of reach of children
• Store SEROFLO 50MCG/100MCG MULTIHALER at room temperature

FAQs About SEROFLO 50MCG/100MCG MULTIHALER

What is the use of SEROFLO 50MCG/100MCG MULTIHALER?

SEROFLO 50MCG/100MCG MULTIHALER is used to manage asthma and chronic obstructive pulmonary disease (COPD) in adults and in children (aged 4 years or above). It also helps in reducing flare-ups of COPD symptoms.

How SEROFLO 50MCG/100MCG MULTIHALER works in my body?

SEROFLO 50MCG/100MCG MULTIHALER relaxes the smooth muscles of the airways and widens them. It also reduces the inflammation of airway tract. Therefore, it allows the air to pass through more freely and makes breathing easier.

Can SEROFLO 50MCG/100MCG MULTIHALER be used on an asthma attack?

SEROFLO 50MCG/100MCG MULTIHALER is only used to manage or manage the symptoms of asthma and COPD (such as breathlessness or wheezing). If your asthma or breathing gets worse suddenly, contact your doctor immediately or go to the straight away to avoid further exacerbation of the attack. Meanwhile use a fast-acting rescue inhaler containing salbutamol along with this medicine.

Is SEROFLO 50MCG/100MCG MULTIHALER safe?

SEROFLO 50MCG/100MCG MULTIHALER is considered safe at doses prescribed by the physician.

What are the side effects of using SEROFLO 50MCG/100MCG MULTIHALER?

The most common side effects of using SEROFLO 50MCG/100MCG MULTIHALER are headache, cold, oral thrush or oral sores, throat irritation, hoarse voice, muscle pain and joint pain. Contact your doctor if any of these side effect worsens.

Can I stop using SEROFLO 50MCG/100MCG MULTIHALER once my symptoms subside?

No. Use SEROFLO 50MCG/100MCG MULTIHALER every day until your doctor tells you to stop. Do not stop using this medicine abruptly or reduce the dose without consulting your doctor, as it could make your breathing even worse. Your doctor will access your disease condition regularly and will increase or decrease the dose accordingly.

Will SEROFLO 50MCG/100MCG MULTIHALER more effective if taken at higher doses?

Always consume the dose prescribed for you by your physician. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the disease. Do not take a higher dose of this medicine without consulting your doctor as it could lead to unwanted side effects. It your symptoms are not relieved by the prescribed dose, consult your doctor so that he might adjust the dose according to your health condition or can suggest an alternative therapy.

I’m pregnant. Can I use SEROFLO 50MCG/100MCG MULTIHALER?

SEROFLO 50MCG/100MCG MULTIHALER should be used in pregnant women only if it is considered necessary by the physician. Your doctor will prescribe you with SEROFLO 50MCG/100MCG MULTIHALER after evaluating the risks and benefits of the therapy.

Can SEROFLO 50MCG/100MCG MULTIHALER be used in children?

SEROFLO 50MCG/100MCG MULTIHALER is considered safe for use in children (aged 4 years or above). However, it is not recommended for use in children younger than 4 years due to lack of safety data. Kindly consult your doctor before taking.

How long will it take for SEROFLO 50MCG/100MCG MULTIHALER to relieve the symptoms and how long the effects can last?

Generally, SEROFLO 50MCG/100MCG MULTIHALER takes about 10-15 minutes to relieve the symptoms of asthma or COPD. However, the onset of action slightly differs from person to person based upon their disease condition. The effects of SEROFLO 50MCG/100MCG MULTIHALER can last for 12-18 hours, because salmeterol present in this medicine is considered as a longer-acting beta-1 adrenergic agonist.

Can SEROFLO 50MCG/100MCG MULTIHALER cause infection in the mouth?

Yes. SEROFLO 50MCG/100MCG MULTIHALER may cause fungal infections of the mouth (oral thrush). To avoid this, make sure to rinse your mouth with water after inhaling the medicine. However, if an infection develops, consult your doctor.

What happens when you forget to use SEROFLO 50MCG/100MCG MULTIHALER?

If you forget to use SEROFLO 50MCG/100MCG MULTIHALER, use it as soon as you remember. However, if it's time for the next dose, skip the missed dose and take the next dose. Do not use a double dose to compensate the missed dose.

Can SEROFLO 50MCG/100MCG MULTIHALER be used if you have an infection?

Inform your doctor if you have any bacterial, fungal, or viral infection before using SEROFLO 50MCG/100MCG MULTIHALER. Your doctor will evaluate your existing health condition and advise changes in management accordingly. Also, inform your doctor if have exposure to an infectious environment or with a person with infectious diseases, as SEROFLO 50MCG/100MCG MULTIHALER may mask your symptoms of the infection.

References

1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 221-224 & 230-233

2. Monika Gappa, Wolfgang Zachgo, Andrea von Berg, Wolfgang Kamin, Catrin Stern-Sträter, Gratiana Steinkamp, VIAPAED Study Group. Add-on salmeterol compared to double dose fluticasone in pediatric asthma: a double-blind, randomized trial (VIAPAED). NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2009. [Accessed on 16th November 2022]. https://pubmed.ncbi.nlm.nih.gov/19824054/

3. Stephen J Fowler, Graeme P Currie, Brian J Lipworth. Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2002. [Accessed on 16th November 2022]. https://pubmed.ncbi.nlm.nih.gov/12063520/

4. G P Currie, N J Syme-Grant, L C McFarlane, F A Carey, B J Lipworth. Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. July 2003. [Accessed on 16th November 2022]. https://pubmed.ncbi.nlm.nih.gov/12823118/

5. Rashmi Mehta, Kylie Riddell, Ashutosh Gupta, Margaret Louey. Comparison of the Pharmacokinetics of Salmeterol and Fluticasone Propionate 50/100 µg Delivered in Combination as a Dry Powder Via a Capsule-Based Inhaler and a Multi-Dose Inhaler. ScienceDirect. March 2015. [Accessed on 16th November 2022]. https://www.researchgate.net/publication/274089299_Comparison_of_the_Pharmacokinetics_of_Salmeterol_and_Fluticasone_Propionate_50100_g_Delivered_in_Combination_as_a_Dry_Powder_Via_a_Capsule-Based_Inhaler_and_a_Multi-Dose_Inhaler

6. Xiaofen Jin, Lianfang Wu, Ji Wang, and Malong Feng. The comparison of fluticasone propionate/formoterol with fluticasone propionate/salmeterol for paediatric asthma: a meta-analysis of randomized controlled trials. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2021. [Accessed on 16th November 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330866/

7. Glaxo Wellcome Production. Electronic Medicines Compendium (EMC). [Revised in March 2020] [Accessed on 16th November 2022]. https://www.medicines.org.uk/emc/files/pil.5504.pdf

8. Cipla Ltd. SEROFLO Rotacaps (Salmeterol + Fluticasone propionate). Ciplamed.com. [Revised in August 2020]. [Accessed on 16th November 2022]. https://www.ciplamed.com/content/seroflo-rotacaps

9. Cipla Ltd. SEROFLO Inhaler (Salmeterol + Fluticasone propionate). Ciplamed.com. [Revised in March 2020]. [Accessed on 16th November 2022]. https://www.ciplamed.com/content/seroflo-inhaler

10. GlaxoSmithKline. U.S. Food & Drug Administration. [Accessed on 16th November 2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021077s042lbl.pdf

Useful Diagnostic Tests

• Absolute eosinophil count
• Complete blood count

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 18 Nov 2022 | 05:28 PM(IST)