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Introduction About SEACURE AQ 25MG INJECTION
SEACURE AQ 25MG INJECTION is used for the maintenance of early pregnancy in patients who faced documented history of repeated miscarriages due to luteal phase defect (a problem in menstrual cycle caused due to deficiency of progesterone during the midway of the menstrual cycle).
It can also be used as an adjuvant to infertility techniques (such as in vitro fertilization (IVF) or gamete intra-fallopian transfer (GIFT)) to facilitate successful implantation of the fertilized egg in the uterus. It is also used to manage threatened abortions and to manage abnormal uterine bleeding caused due to hormonal imbalance.
It can be used as a diagnostic tool in progesterone withdrawal testing to diagnose the endocrinal causes of secondary amenorrhea (irregular or lack of menstrual periods) and to judge the chances of pregnancy among infertile women.
It contains a medicine called progesterone which is a steroid hormone that functions similar to the endogenous female sex hormones.
Before receiving SEACURE AQ 25MG INJECTION inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have diabetes, high blood pressure, asthma, epilepsy, or migraine headaches before receiving SEACURE AQ 25MG INJECTION as a precaution.
SEACURE AQ 25MG INJECTION is not recommended for use in patients with breast cancer, ovarian cancer, uterine cancer, blood clot problems or any vaginal infections. SEACURE AQ 25MG INJECTION is not recommended for use in breast-feeding women and in children and adolescents (below 18 years of age).
SEACURE AQ 25MG INJECTION can be used during the first three months of pregnancy. However, it should not be used in women who have ectopic pregnancy (pregnancy outside the womb) and in women who had a history of idiopathic jaundice (severe itching of the skin) or other skin problems during their earlier pregnancies.
The most common side effects of receiving SEACURE AQ 25MG INJECTION are pain, redness, itching, irritation or swelling at the injection site, vaginal bleeding, headache, bloating, nausea, hair loss, abnormal hair growth in the body, darkening of the facial skin or difficulty in sleeping. Consult your doctor if any of these side effect bothers you. Talk to your doctor immediately if you experience any changes in body weight or feel depressed while receiving SEACURE AQ 25MG INJECTION.
Uses Of SEACURE AQ 25MG INJECTION
It is used:
- To maintain early pregnancy in patients with history of repeated miscarriages
- As an adjunct to infertility techniques (such as in vitro fertilization (IVF) or gamete intra-fallopian transfer (GIFT)) to facilitate successful implantation of the fertilized egg in the uterus
- To manage threatened abortions
- To manage dysfunctional uterine bleeding
- To diagnose the endocrinal causes of secondary amenorrhea (irregular or lack of menstrual periods) among infertile women
How SEACURE AQ 25MG INJECTION Works
SEACURE AQ 25MG INJECTION is a steroid hormone used to manage progesterone deficiency in the body. It supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women and in women who face repeated/threatened abortions by increasing the thickness of uterine wall. It also regulates hormonal balance in the body and corrects abnormal uterine bleeding.
How to use SEACURE AQ 25MG INJECTION
- SEACURE AQ 25MG INJECTION will be given to you only by a doctor or a nurse either into the muscles (as intramuscular injection) or under the skin (as subcutaneous injection).
- Your doctor will decide the correct dose and duration of therapy for you according to your age, body weight and disease condition.
Side Effects Of SEACURE AQ 25MG INJECTION
Common Side Effects of SEACURE AQ 25MG INJECTION:
- pain, redness, itching, irritation or swelling at the injected site
- uterine cramps
- vaginal bleeding or discharge
- headache
- bloating, stomach pain, constipation, nausea, vomiting
- changes in breast, breast pain or tenderness
- tingling or uncomfortable irritation or itching of the vaginal skin and the surrounding area
- hardening or bruising of area around the administration site
- extreme tiredness, exhaustion, lethargy
- hair loss or abnormal hair growth in the body
- darkening of facial skin
- fever
- mood changes
- dizziness, insomnia (problems in sleeping)
- stomach and intestinal discomfort (stomach tenderness, gas, painful cramps, retching)
- breast swelling or enlargement
- feeling hot
- general feeling of discomfort or pain
Contact your doctor immediately if you experience any of the following side effects after receiving SEACURE AQ 25MG INJECTION:
- lower stomach pain, thirst, nausea and sometimes vomiting, passing low quantities of concentrated urine, weight gain (signs of overstimulation of the ovaries)
- feeling extremely depressed
- jaundice (yellow skin and white of the eyes)
- severe allergic reaction which may cause trouble in breathing, swelling of the face and throat or a severe rash
- heart attack (signs include chest or back pain, deep aching, and throbbing in one or both arms, sudden breathlessness, sweating, dizziness, lightheadedness, nausea, palpitations)
- stroke (signs include severe headache or vomiting, dizziness, vision or speech changes, weakness or numbness of an arm or leg)
- blood clots in the eyes or anywhere in the body (eye pain, pain and swelling in your ankles, feet, and hands)
- severe headache or bulging of the eye and changes in vision
Warning & Precautions
Pregnancy
Consult your doctorSEACURE AQ 25MG INJECTION can be used during the first three months of pregnancy if prescribed by the doctor. It should not be used in women with ectopic pregnancy (pregnancy outside the womb) and in women who had a history of idiopathic jaundice (severe itching of the skin), severe itching or pemphigoid gestationis (an abnormal lesions on the skin caused due to autoimmune reactions) during their earlier pregnancies. Therefore, consult your doctor for advice.
Breastfeeding
ContraindicatedSEACURE AQ 25MG INJECTION is not recommended for use during breast-feeding. Therefore, consult your doctor before receiving it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy or drowsy after receiving SEACURE AQ 25MG INJECTION.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving SEACURE AQ 25MG INJECTION.
Kidney
Use with CautionSEACURE AQ 25MG INJECTION should be used with caution in patients with kidney problems.
Liver
Contraindicated
SEACURE AQ 25MG INJECTION is not recommended for use in patients who have or had any liver problems in the past.
Allergy
ContraindicatedDo not receive SEACURE AQ 25MG INJECTION if you are allergic to Progesterone or to any of the other ingredients of this medicine.
Lungs
Consult your doctorSEACURE AQ 25MG INJECTION is not recommended for use in patients who have or had any blood clots in the lungs (pulmonary embolism). It should be used with caution in patients with asthma.
Heart Disease
Use with CautionSEACURE AQ 25MG INJECTION should be used with caution in patients with heart problems.
Use In Pediatrics
ContraindicatedSEACURE AQ 25MG INJECTION is not recommended for use in children and adolescents (under 18 years of age).
Others
SEACURE AQ 25MG INJECTION is not recommended for use if you:
- have vaginal infection or unusual vaginal bleeding (other than normal periods)
- had miscarriage and your doctor suspects about the existence of few more tissue in the uterus
- have known or suspected cancer of the breast, ovaries or uterus
- had or have blood clots in the legs (thrombophlebitis), eyes (retinal thrombosis) or anywhere in the body (venous or arterial thromboembolism) or stroke
Before receiving SEACURE AQ 25MG INJECTION, inform your doctor if you:
- have fits
- have migraine headache (severe headache affecting one side of the head)
- have porphyria (an inherited blood disorder)
- have sensitivity to light (photosensitivity)
- have diabetes (high blood sugar)
- have high blood pressure
- have depression
- have a habit of smoking
- are overweight or obese
- are aged 35 years or above
- have any risk of atherosclerosis (such as high blood fat levels)
- are scheduled for any blood tests
Interactions
A. Drug-Drug interactions:
Before receiving SEACURE AQ 25MG INJECTION, inform your doctor if you are taking any of the following medicines:
- Antiepileptics (Ex. carbamazepine, phenytoin, phenobarbital)
- bromocriptine (a medicine used to stop breast milk secretion, infertility, or Parkinson’s disease)
- rifampicin (a medicine used to manage bacterial infections)
- Antifungal agents (Ex. griseofulvin, ketoconazole)
- St. john’s wort (a medicine used to manage depression)
- cyclosporine (a medicine used to suppress immune function)
- Antidiabetic agents (Ex. glimepiride, metformin)
Overdosage:
SEACURE AQ 25MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as drowsiness after receiving SEACURE AQ 25MG INJECTION.
Synopsis
| Drug | : | Progesterone |
| Pharmacological Category | : | Progestins (female hormones) |
| Therapeutic Indication | : | Supports early pregnancy, Manages Abnormal uterine bleeding, Diagnose the causes for secondary amenorrhea, Manages threatened abortion |
| Dosage Forms | : | Tablet, Soft gel Capsule, Pessaries, Injection, Vaginal Gel, Vaginal spray |
More Information
Progesterone Deficiency occurs when a woman’s body produces insufficient amounts of the hormone progesterone, which plays a critical role in regulating the menstrual cycle, supporting pregnancy, and maintaining a healthy uterine lining.
Disease Description:
- Progesterone’s Role: Progesterone is a key hormone in the second half of the menstrual cycle (luteal phase), preparing the uterus for pregnancy by thickening the uterine lining (endometrium). It also prevents uterine contractions that could disrupt implantation.
- Deficiency Symptoms: Low progesterone levels can cause irregular or missed periods, spotting between periods, mood swings, anxiety, and difficulty maintaining pregnancy. It can also lead to conditions like premenstrual syndrome (PMS) and estrogen dominance, where estrogen levels are higher relative to progesterone.
Female Infertility Due to Progesterone Deficiency:
- Impact on Pregnancy: Progesterone deficiency is a common cause of luteal phase defect, where the uterine lining doesn't mature properly, making it difficult for an embryo to implant or for the pregnancy to continue. Inadequate progesterone levels during early pregnancy can also lead to recurrent miscarriages.
- Infertility and Treatment: Women with progesterone deficiency may have difficulty conceiving due to the inability of the uterine lining to support implantation. Treatment often involves progesterone supplementation during the luteal phase or early pregnancy to correct hormone levels and support a healthy pregnancy.
FAQs About SEACURE AQ 25MG INJECTION
Q: Does SEACURE AQ 25MG INJECTION cause weight gain?
A: Yes, SEACURE AQ 25MG INJECTION might cause weight gain due to overstimulation of ovaries in some individuals. Stop receiving SEACURE AQ 25MG INJECTION and consult your doctor as soon as you notice that your weight has increased abnormally.
Q: Does SEACURE AQ 25MG INJECTION make you feel tired?
A: Yes. SEACURE AQ 25MG INJECTION may cause tiredness in some individuals. To manage this, drink plenty of fluids and eat balanced diet and frequent meals. Get enough rest and follow regular sleep schedule.
Q: How is SEACURE AQ 25MG INJECTION administered?
A: SEACURE AQ 25MG INJECTION will be given to you only by a doctor or by a nurse into the muscle (intramuscular injection). Your doctor will decide the correct dose and duration of therapy with SEACURE AQ 25MG INJECTION for you depending on your age, body weight and disease condition.
Q: Who should avoid taking SEACURE AQ 25MG INJECTION?
A: SEACURE AQ 25MG INJECTION is not recommended for use in women who have or had ectopic pregnancy and in women who have a history of repeated miscarriages, idiopathic jaundice (severe itching of the skin), severe itching or pemphigoid gestationis (an abnormal lesions on the skin caused due to autoimmune reactions) during their earlier pregnancies. It should not be used in patients with breast cancer, ovarian cancer, or uterine cancer. You must also inform your doctor before taking SEACURE AQ 25MG INJECTION if you have any severe liver problems, blood clot problems or any vaginal infections before receiving SEACURE AQ 25MG INJECTION.
Q: Why is SEACURE AQ 25MG INJECTION necessary for pregnancy?
A: SEACURE AQ 25MG INJECTION supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women and in women who face repeated/threatened abortions by increasing the thickness of uterine wall.
Q: When is progesterone produced in the reproductive cycle?
A: The typical menstrual cycle takes approximately 28 to 32 days and is divided into three distinct phases namely the follicular phase, the ovulatory phase and the luteal phase. The luteal phase is the period when the body produces progesterone, the hormone that makes the uterus prepare its lining to receive the egg.
Q: What are the side effects of SEACURE AQ 25MG INJECTION?
A: The most common side effects of receiving SEACURE AQ 25MG INJECTION are injection site reactions (pain, swelling, redness and itching), stomach pain, breast pain, darkening of facial skin, hair loss, abnormal hair growth in the body, nausea, and difficulty in sleeping. Consult your doctor if any of these side effects bothers you.
References
1. KD. Tripathi. Estrogens, Progestins, and Contraceptives. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 316.
2. Michaela Jewson, Prashant Purohit, Mary Ann Lumsden. Progesterone and abnormal uterine bleeding/menstrual disorders. ScienceDirect. November 2020. [Accessed on 16th October 2024] click here
3. Institut Biochimique SA. Progesterone. Product Monograph. Inprosub (Progesterone Injection) [Revised in June 2021] [Accessed on 16th October 2024] click here
4. Pharmasure Limited. Lubion 25 mg solution for injection. Progesterone. [Revised in March 2018] [Accessed on 16th October 2024] click here
Progesterone Solution for Injection. Australian Product Information. [Revised in September 2023]. [Accessed on 16th October 2024]. click here
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