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Introduction About RYZODEG FLEX TOUCH PEN 100IU
RYZODEG FLEX TOUCH PEN 100IU is a combination of Insulin Aspart and Insulin Degludec which belongs to the group of medicines called Antidiabetic agents. It is used to improve glycemic control in patients with diabetes mellitus (both Type I and Type II).
Diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
RYZODEG FLEX TOUCH PEN 100IU is suitable for use both in adults and in children (aged 6 years or older). It must be injected beneath the skin (such as on the thigh, upper arm or abdomen). Avoid sharing needles, as it may increase the risk of infections. Along with the management, avoid smoking and alcohol consumption, and diet with regular physical activity as advised by your doctor.
Talk to your doctor before starting therapy with RYZODEG FLEX TOUCH PEN 100IU if you have any liver, kidney or heart problems. You must also inform your doctor if you have any hormonal problems, made sudden changes to your diet or perform intense exercise as a precaution.
Do not use this medicine if you have hypoglycemia (low blood sugar levels). Consult your doctor before using this medicine if you are pregnant or breastfeeding.
The most common side effects of receiving RYZODEG FLEX TOUCH PEN 100IU are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.
Uses Of RYZODEG FLEX TOUCH PEN 100IU
- It is used to improve glycemic control in patients with diabetes mellitus (both Type I and Type II)
How RYZODEG FLEX TOUCH PEN 100IU Works
RYZODEG FLEX TOUCH PEN 100IU helps your body to make utilize of the circulating blood glucose. It helps in the transport of glucose from the blood into the muscles and fat tissues. It also stops the production of glucose by the liver. As a result, it controls blood sugar levels and improves sugar control in patients with diabetes mellitus.
How to use RYZODEG FLEX TOUCH PEN 100IU
Use RYZODEG FLEX TOUCH PEN 100IU under careful medical supervision. Inject RYZODEG FLEX TOUCH PEN 100IU into your thighs, buttocks, upper arm, or abdomen (i.e., subcutaneously). Do not administer this medicine into the vein or muscle directly. It should be administered at least 10 minutes before meals. Eat a meal or snack containing carbohydrates within 20 minutes of the injection to avoid low blood sugar.
Before administration, roll the vial/cartridge between your hands until the liquid becomes uniformly white and cloudy. While injecting, keep the needle under the skin for at least 6 seconds to make sure that the entire dose is injected.
Prior to the administration, visualize the cartridge/vial for any visible particulate matter and discoloration. Discard the needle and syringe after use and do not share your needles with others to avoid the risk of transmission of infections.
Avoid repeatedly injecting the medicine at the same site to manage skin damage. Instead, rotate the injection site. Make sure to consult your doctor before changing the injection site as a precaution.
RYZODEG FLEX TOUCH PEN 100IU should not be mixed with any other insulins before use. Do not stop therapy with RYZODEG FLEX TOUCH PEN 100IU without consulting your doctor. Your doctor will decide the correct dose and frequency of administration depending upon your age, body weight and health condition.
Side Effects Of RYZODEG FLEX TOUCH PEN 100IU
Common
- Injection site reactions (such as pain, redness, itching or swelling)
- Lipodystrophy (shrinkage of fat tissues beneath the skin)
- Lumps under the skin
- Weight gain, swelling of body parts
- Hypoglycemia (Low blood sugar levels)
Consult your doctor immediately if you experience any of the following side effects:
- allergic reaction (generalized skin rash with itching, sweating, and swelling of layers under the skin, difficulties in breathing, palpitation, vomiting, stomach upset, reduction in blood pressure and fainting)
- signs of severe hypoglycemia (such as cold sweats, cool pale skin, headache, rapid heartbeat, nausea, increased hunger, temporary vision changes, drowsiness, tiredness and weakness, nervousness or tremor, anxiety, confusion and difficulty in concentrating)
- signs of heart failure (such as shortness of breath, edema, rapid weight gain)
How To Manage Side Effects
Hypoglycemia
Managing hypoglycemia, or low blood sugar, involves prompt action to raise blood glucose levels and manage complications. When experiencing hypoglycemia, individuals should quickly consume a source of rapidly-absorbed carbohydrates, such as glucose tablets, fruit juice, or regular soda. Waiting for about 15 minutes and rechecking blood sugar levels is crucial to ensure they rise to a safe range. If hypoglycemia persists, additional carbohydrate intake may be necessary. Once blood sugar levels stabilize, a small snack containing both carbohydrates and protein can help sustain them. Regular monitoring and consultation with a healthcare professional are essential for developing a personalized plan to manage hypoglycemia effectively. In severe cases, emergency assistance may be required.
Injection Site Reactions
Managing injection site reactions is essential for individuals who regularly administer injections. To alleviate discomfort and minimize potential issues, it is crucial to follow proper injection techniques. Rotate injection sites to manage overuse of a single area, allowing tissues to heal. Use a clean, sterile needle and syringe for each injection. Apply an ice pack to the injection site before and after administration to reduce pain and swelling. If redness, swelling, or irritation persists, consult a healthcare professional for guidance. It is essential to report any severe or persistent reactions to ensure appropriate adjustments to the injection routine and to manage potential complications.
Warning & Precautions
Pregnancy
Monitoring requiredRYZODEG FLEX TOUCH PEN 100IU can be used during pregnancy if prescribed by the physician. However, consult your doctor before administration.
Breastfeeding
Use with CautionRYZODEG FLEX TOUCH PEN 100IU should be used with caution in breastfeeding women. Therefore, consult your doctor before administration.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your ability is affected by RYZODEG FLEX TOUCH PEN 100IU.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking this medicine as it could aggravate your existing disease condition.
Kidney
Use with CautionRYZODEG FLEX TOUCH PEN 100IU should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
Liver
Use with CautionRYZODEG FLEX TOUCH PEN 100IU should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
Allergy
ContraindicatedTalk to your doctor before receiving RYZODEG FLEX TOUCH PEN 100IU if you are allergic to Insulin Aspart, Insulin Degludec or to any insulin types (Ex. Lente, ultra-Lente).
Heart Disease
Use with CautionRYZODEG FLEX TOUCH PEN 100IU should be taken with caution in patients with heart disease (such as heart failure). Therefore, consult your doctor before administration.
Use In Pediatrics
Monitoring requiredRYZODEG FLEX TOUCH PEN 100IU can be used in children and adolescents (aged 6 years or older) if prescribed by the physician. Therefore, consult your doctor before administration.
Use In Geriatrics
Use with CautionRYZODEG FLEX TOUCH PEN 100IU should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before administration.
Others
RYZODEG FLEX TOUCH PEN 100IU is not recommended for use if you:
- have or at risk of developing hypoglycemia (low blood sugar levels)
Talk to your doctor before receiving RYZODEG FLEX TOUCH PEN 100IU if you:
- have problems in adrenal, pituitary or thyroid glands
- have or ever had stroke
- have recently changed your diet plan and lifestyle
- are exercising more than usual
- recently became ill or had any infections
- are planning to go abroad (as mealtime and injection timings may get changed)
Interactions
A. Drug-Drug interactions:
Before RYZODEG FLEX TOUCH PEN 100IU is administered, inform your doctor if you are taking any of the following medicines such as:
- other antidiabetic agents (Ex. tolbutamide, glibenclamide, glipizide), biguanides (Ex. metformin, phenformin), thiazolidinediones (Ex. pioglitazone), DPP-4 inhibitors (Ex. sitagliptin, vildagliptin) or SGLT-2 inhibitors (Ex. remogliflozin)
- Antidepressants (Ex. rasagiline, selegiline, phenelzine)
- Heart medicines (Ex. propranolol, atenolol, nebivolol) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
- salicylates (used to relieve pain or fever) Ex. aspirin
- anabolic steroids (used to build muscle and improve athlete performance) Ex. testosterone, nandrolone, oxandrolone
- sulfonamide antibiotics (Ex. sulfasalazine, sulfadiazine, sulfamethoxazole)
- oral contraceptives (birth control pills) Ex. mifepristone,
- thiazide diuretics (Ex. chlorothiazide, hydrochlorothiazide)
- glucocorticoids (used to manage inflammation) Ex. cortisone, betamethasone, beclomethasone, dexamethasone, budesonide, prednisone
- thyroid hormone (Ex. thyroxine, triiodothyronine)
- sympathomimetic agents (used to manage asthma or other circulatory disorders) Ex. ephedrine, adrenaline, salbutamol, or terbutaline
- growth hormone (a hormone used to increase skeletal and somatic growth in the body)
- danazol (a medicine used for endometriosis)
- octreotide (used to manage diarrhea)
- lanreotide (a medicine used for abnormal body growth)
B. Interaction with food or drink:
RYZODEG FLEX TOUCH PEN 100IU should be administered 30 minutes before a meal.
Overdosage:
If you or anyone else took too much of this medicine, contact your doctor immediately or go to a hospital straight away as it may cause severe hypoglycemia. Symptoms of hypoglycemia might include fainting, feeling unwell, sweating, vomiting, difficulty in breathing, fast heartbeat, and dizziness.
Synopsis
| Drug | : | Insulin Aspart, Insulin Degludec |
| Pharmacological Category | : | Insulin Analogs |
| Therapeutic Indication | : | Diabetes mellitus |
| Dosage Forms | : | Injection, Flex pen |
More Information
- Keep out of reach of children
- Store the unopened pack in the refrigerator at 2-8°C. Do not freeze
- During use or when carried as a spare, keep it at room temperature
- Always place the vial/cartridge in the outer carton to protect from light
- Do not use the medicine after 28 days of opening
FAQs About RYZODEG FLEX TOUCH PEN 100IU
Q: Should RYZODEG FLEX TOUCH PEN 100IU be refrigerated?
A: Yes. An unopened pack must be stored in the refrigerator (2-8°C). During use or while carrying it as a spare, keep it at room temperature to ensure uniform resuspension.
Q: Can RYZODEG FLEX TOUCH PEN 100IU be mixed with other insulins?
A: Do not mix RYZODEG FLEX TOUCH PEN 100IU with other insulins. Always consult your doctor before mixing insulins.
Q: Is RYZODEG FLEX TOUCH PEN 100IU safe during pregnancy?
A: Yes. RYZODEG FLEX TOUCH PEN 100IU can be used during pregnancy if prescribed by the physician. Therefore, consult your doctor before administration.
Q: How long does it take for RYZODEG FLEX TOUCH PEN 100IU to start working?
A: RYZODEG FLEX TOUCH PEN 100IU is a fast-acting medicine where it begins to lower blood sugar levels about 30 minutes post administration and its effect would last for about 24 hours.
Q: Can RYZODEG FLEX TOUCH PEN 100IU be given intravenously?
A: No. RYZODEG FLEX TOUCH PEN 100IU is meant for subcutaneous use only (i.e., thighs, buttocks, abdomen, or upper arms). It should not be directly injected into the vein or muscle as it may cause severe hypoglycemia.
Q: What is the best area for injecting RYZODEG FLEX TOUCH PEN 100IU? Should I inject it only at the same site every day?
A: The best place for injecting this medicine is front of your thighs, buttocks, abdomen or upper arms. The insulin would work more quickly if it were injected into the waist (abdomen). Do not repeatedly inject the medicine on the same site. Instead, rotate the injection sites within the same area to avoid the risk of developing lumps or skin pitting.
Q: What is RYZODEG FLEX TOUCH PEN 100IU used for?
A: RYZODEG FLEX TOUCH PEN 100IU is used in the management of diabetes mellitus (both type I and II).
Q: What are the most common side effects of taking RYZODEG FLEX TOUCH PEN 100IU?
A: The most common side effects of injecting RYZODEG FLEX TOUCH PEN 100IU are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.
Q: Can I stop therapy with RYZODEG FLEX TOUCH PEN 100IU without consulting your doctor?
A: No. You should not stop therapy with RYZODEG FLEX TOUCH PEN 100IU without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using RYZODEG FLEX TOUCH PEN 100IU, consult your doctor for advice.
Q: Will taking a higher dose of RYZODEG FLEX TOUCH PEN 100IU be more effective?
A: No, taking a higher dose of RYZODEG FLEX TOUCH PEN 100IU will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with RYZODEG FLEX TOUCH PEN 100IU?
A: It is not advisable to take medicines to control blood pressure while taking RYZODEG FLEX TOUCH PEN 100IU without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with RYZODEG FLEX TOUCH PEN 100IU as they have known interactions with RYZODEG FLEX TOUCH PEN 100IU.
Q: Can RYZODEG FLEX TOUCH PEN 100IU cause weight gain?
A: Yes. RYZODEG FLEX TOUCH PEN 100IU may cause weight gain in some individuals, although not everybody gets them. If you are worried about excessive weight gain, eat a healthy low - carb/fat diet with a regular physical activity. Consult your doctor if the symptom did not improve.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 265-270.
2. Alvin C. Powers and David D’Alessio. Endocrine pancreas and Pharmacotherapy of diabetes mellitus and hypoglycemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page-1251.
3. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2020- 2022 & -2775.
4. Lisa A. Raedler. Tresiba (Insulin Degludec Injection) and Ryzodeg 70/30 (Insulin Degludec and Insulin Aspart Injection): Two New Insulin Analogs for Glycemic Control in Diabetes Mellitus. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2016. [Accessed on 22nd January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013846/
5. Novo Nordisk A/S. U.S. Food & Drug Administration. [Revised in September 2015] [Accessed on 22nd January 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/203313lbl.pdf
6. Novo Nordisk A/S. RYZODEG® 70/30 FlexTouch® and Penfill® (insulin degludec/insulin aspart) solution for injection. [Revised in October 2020]. [Accessed on 22nd January 2024] https://www.novonordisk.com.au/content/dam/nncorp/au/en/pdfs/ryzodeg-product-information-13.pdf
7. Novo Nordisk A/S. RYZODEG® 70/30 FlexTouch 3ml. [Revised in July 2020]. [Accessed on 22nd January 2024] https://www.novonordisk.com.au/content/dam/nncorp/au/en/pdfs/new-ryzodeg-70-30-flextouch-consumer-medicine-information-2020.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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