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Introduction About RIFAXIGYL M TABLET
RIFAXIGYL M TABLET is a combination of Metronidazole and Rifaximin which belongs to the group of medicines called Antibiotics. It is used in the management of stomach and intestine infections causing diarrhoea.
RIFAXIGYL M TABLET should not be used if the patient has fever, blood in the stools, blockage of bowel, passed 8 or more unformed stools in last 24 hours. RIFAXIGYL M TABLET has to be used with caution in patients having liver problems, disease related to nervous system and patients undergoing dialysis.
RIFAXIGYL M TABLET is not recommended for use in pregnant and breast-feeding women. Avoid the use of alcohol while taking RIFAXIGYL M TABLET and for 48 hours after finishing your course as it may cause undesirable effects.
RIFAXIGYL M TABLET is not recommended for use in children and adolescents (under 18 years of age) and it should be used with caution in elderly patients.
The most common side effects of taking RIFAXIGYL M TABLET are headache, abdominal bloating and pain, constipation, diarrhoea, urgency to empty your bowels, nausea and vomiting. Consult your doctor if any of the side effect worsens.
Uses Of RIFAXIGYL M TABLET
- Manage stomach and intestine infections causing diarrhoea
How RIFAXIGYL M TABLET Works
RIFAXIGYL M TABLET manages stomach and intestine infections causing diarrhoea where metronidazole and rifaximin are antibiotics that acts on the bacteria present in the gastrointestinal region and leads to disruption of bacterial cell which destroys the bacteria.
How to use RIFAXIGYL M TABLET
Take RIFAXIGYL M TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of RIFAXIGYL M TABLET for you depending upon your age, body weight and disease condition.
Side Effects Of RIFAXIGYL M TABLET
Common
- headache
- wind
- abdominal problems including bloating and pain
- constipation, diarrhoea
- urgency to empty your bowels
- nausea, vomiting
- involuntary and painful or ineffective straining
- fever
Uncommon
- cold sore, thrush, inflammation or infection of the nose and throat
- loss of appetite, dehydration
- abnormal dreams, sleeplessness, nervousness, depressed mood
- numbness, migraine, sinus headache, drowsiness, tingling or pricking sensation
- double vision
- earache, balance problems (vertigo)
- increased blood pressure, hot flushes
- cough, dry throat, sore throat, runny nose, blocked nose
- upper abdominal pain, indigestion, intestinal movement disorder, dry lips
- abnormalities in stools (hard stools, blood in the stools, mucus in stools)
- changes in taste
- sunburn
- back pain, muscle cramps, muscle pain, neck pain, muscle weakness
- frequent and excessive urination
- frequent periods
- chills, cold sweat, increased sweating
- flu-like illness, pain
Rare
Stop taking RIFAXIGYL M TABLET and inform your doctor immediately if you experience any of the following side-effects:
- stomach pain, loss of appetite, fever, malaise, nausea, vomiting, fatigue, vertigo (spinning sensation), jaundice, dark urine, putty or mastic-coloured stools or itching
- signs of severe allergic reactions severe allergic reaction such as rash, hives or itchy skin, shortness of breath, wheezing, racing heart, welling of the mouth, face, ankles or any other body part, extreme tiredness, dizziness or feeling faint
- steven johnson syndrome or toxic epidermal necrolysis (reddish target-like spots or circular patches accompanied with central blisters on the trunk, ulcers of the mouth, throat, nose, genitals and eyes)
- acute generalised exanthematous pustulosis characterized by red, scaly widespread rash with bumps under the skin and blisters with fever found on skin folds, trunk and upper extremities
- encephalopathy (fever, stiff neck, headache or seeing or hearing things that aren’t there)
- yellowing of the skin and eyes which could be due to a liver problem (jaundice)
- unexpected infections, mouth ulcers, bruising, bleeding gums or severe tiredness that could be caused by a blood problem
- severe stomach pain which may radiate through to your back (pancreatitis)
How To Manage Side Effects
Nausea or vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables, whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, inform your doctor.
Warning & Precautions
Pregnancy
RIFAXIGYL M TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
RIFAXIGYL M TABLET is not recommended for use in breastfeeding women as small traces of this medicine may pass through mother’s milk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel drowsy, dizzy, vertigo, confusion, hallucinations, convulsion, eyesight problems (blurred or double vision) after taking RIFAXIGYL M TABLET.
Alcohol
Avoid the use of alcohol while taking RIFAXIGYL M TABLET and for 48 hours after finishing your course as it may cause side effects such nausea, vomiting, stomach pain, hot flushes, very fast or uneven heartbeat and headache.
Kidney
RIFAXIGYL M TABLET should be used with caution in patients undergoing kidney dialysis. Consult your doctor before taking RIFAXIGYL M TABLET.
Liver
RIFAXIGYL M TABLET should be used with caution in patients having liver disease. Consult your doctor before taking RIFAXIGYL M TABLET.
Allergy
Do not take RIFAXIGYL M TABLET if you are allergic to Rifaximin, Metronidazole or nitroimidazoles (such as tinidazole) or similar type of antibiotics (such as rifampicin or rifabutin).
Others
RIFAXIGYL M TABLET is not recommended for use if you:
- have fever
- are having blood in the stools
- have blockage of bowel
- have passed 8 or more unformed stools in last 24 hours
Before taking RIFAXIGYL M TABLET tell your doctor if you:
- have diseases related to nervous system
Use in paediatrics:
RIFAXIGYL M TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
RIFAXIGYL M TABLET should be used with caution in elderly patients especially at higher doses. Consult your doctor before taking it.
Interactions
A. Drug–Drug Interactions:
Before taking RIFAXIGYL M TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to supress body’s immune system (Ex. cyclosporin)
- medicines used to manage blood clotting (Ex. warfarin)
- oral contraceptives such as ethinylestradiol and norethindrone (used to manage pregnancy)
- lithium (used to manage mental illness)
- 5-fluorouracil (used for cancer)
- busulfan (used to manage leukaemia)
- activated charcoal (used to manage wind or diarrhoea)
- phenobarbital or phenytoin (used to control epilepsy)
- disulfiram (used to manage chronic alcoholism)
Overdosage:
If you or anyone else accidentally takes too much of RIFAXIGYL M TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Metronidazole, Rifaximin |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Stomach and intestine infections causing diarrhoea |
| Dosage Forms | : | Tablet |
More Information
- Keep RIFAXIGYL M TABLET out of reach of children
- Store at room temperature
FAQs About RIFAXIGYL M TABLET
Q: What is RIFAXIGYL M TABLET and why is it given?
A: RIFAXIGYL M TABLET is a combination of two antibiotics namely metronidazole and rifaximin, which is used to manage stomach and intestine infections causing diarrhoea. Consult your doctor before taking it.
Q: Is RIFAXIGYL M TABLET safe for pregnant and breast-feeding women?
A: RIFAXIGYL M TABLET is not recommended for use in pregnant women or breast-feeding mothers as the traces may pass into mother’s milk. Consult your doctor for advice to select an alternative medicine to manage the specific condition.
Q: Can RIFAXIGYL M TABLET be used in patients with liver problems?
A: RIFAXIGYL M TABLET should be used with caution in patients having liver problem. Your doctor may monitor your liver function test during and after management with this medicine to manage the risk of any unusual effects. Consult your doctor before taking it.
Q: Can I consume alcohol while taking RIFAXIGYL M TABLET?
A: Avoid the use of alcohol while taking RIFAXIGYL M TABLET and for 48 hours after finishing your course as it may cause side effects such nausea, vomiting, stomach pain, hot flushes, very fast or uneven heartbeat and headache.
Q: How does RIFAXIGYL M TABLET work?
A: RIFAXIGYL M TABLET manages stomach and intestine infections causing diarrhoea where metronidazole and rifaximin are antibiotics that acts on the bacteria present in the gastrointestinal region and leads to disruption of bacterial cell which destroys the bacteria.
References
1. K.D. Tripathi. Antiamoebic and Other Antiprotozoal Drugs & Drugs for Constipation and Diarrhoea. Essentials of medical pharmacology. Seventh edition. 2013. Page – 837 & 681.
2. Connor B. Weir, Jacqueline K. Le. Metronidazole. NIH National Library of Medicine, National center for biotechnology information. April 2022. [Accessed on 31st May 2022] https://www.ncbi.nlm.nih.gov/books/NBK539728/#:~:text=Go%20to%3A-,Mechanism%20of%20Action,cell%20death%20in%20susceptible%20organisms
3. Kyle D. Robertson, Shivaraj Nagalli. Rifaximin. NIH National Library of Medicine, National center for biotechnology information. April 2022. [Accessed on 31st May 2022] https://www.ncbi.nlm.nih.gov/books/NBK562329/
4. Alfasigma S.p.A. Electronic Medicines Compendium (EMC). [Revised in October 2020]. [Accessed on 31st May 2022] https://www.medicines.org.uk/emc/files/pil.4752.pdf
5. Famar Health Care Services Madrid. Electronic Medicines Compendium (EMC). [Revised in Dec 2021]. [Accessed on 31st May 2022] https://www.medicines.org.uk/emc/files/pil.9238.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)
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