New Revised MRP, 100% GST benefit passed REC DZ 5mg RECTAL APPLICATOR 2.5ml
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Introduction About REC DZ 5MG RECTAL APPLICATOR
REC DZ 5MG RECTAL APPLICATOR contains Diazepam which belongs to the group of medicines called Benzodiazepines. REC DZ 5MG RECTAL APPLICATOR helps you to fall asleep and it can also have a calming effect. It is also indicated as a premedication to calm anxious patients before management such as dental extractions and to sedate patients in intensive care units.
REC DZ 5MG RECTAL APPLICATOR is used to control prolonged seizure activity (status epilepticus). It is also used to control muscle spasms and spasticity caused by certain neurological disorders such as cerebral palsy, athetosis (involuntary movements), stiff-man syndrome (body stiffness) and in tetanus. REC DZ 5MG RECTAL APPLICATOR is also used in the management of alcohol withdrawal syndrome including agitation, tremors, delirium tremens and hallucinosis.
Avoid alcohol, grapefruit juice, caffeinated drinks while taking REC DZ 5MG RECTAL APPLICATOR as it may lead to unwanted effects.
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in patients suffering from severe respiratory failure, or chronic obstructive airways disease or have weakness of your chest muscles, phobia, myasthenia gravis, liver disease, sleep apnoea (severe breathing difficulty during sleep), porphyria, acute narrow angle glaucoma and open angle glaucoma. Consult your doctor before receiving the medicine.
REC DZ 5MG RECTAL APPLICATOR should be used with caution in patients with history of alcoholism or drug abuse or dependence, severe kidney problems, depression, self-harming thoughts, epilepsy, arteriosclerosis, heart problems, psychosis, schizophrenia. Consult your doctor before receiving the medicine.
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in pregnant women. REC DZ 5MG RECTAL APPLICATOR is not recommended for use in breast feeding women as it may pass through breast milk. Consult your doctor before receiving.
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in children and adolescents below 12 years of age as its safety is not established. REC DZ 5MG RECTAL APPLICATOR should be used with caution in elderly patients above 60 years of age due to increased risk of falls and fractures. Consult your doctor before receiving.
The most common side effects of receiving REC DZ 5MG RECTAL APPLICATOR are drowsiness, fatigue, loss of muscle coordination (ataxia) and other movement disorders, tremor, confusion, venous thrombosis, and inflammation at the site of injection Consult your doctor in case any of side effects worsens.
Uses Of REC DZ 5MG RECTAL APPLICATOR
It is used:
- to fall asleep and it can also have a calming effect
- as a premedication to calm anxious patients before management such as dental extractions and to sedate patients in intensive care units
- to control prolonged seizure activity
- to control muscle spasms and spasticity caused by certain neurological disorders
- for alcohol withdrawal syndromes including agitation, tremors, delirium and hallucinations
How REC DZ 5MG RECTAL APPLICATOR Works
REC DZ 5MG RECTAL APPLICATOR belongs to benzodiazepines works by calming the brain and nerves by increasing the level of a chemical called gamma-aminobutyric acid (GABA), a naturally occurring inhibitory neurotransmitter in the brain.
How to use REC DZ 5MG RECTAL APPLICATOR
REC DZ 5MG RECTAL APPLICATOR will be administered to you only by a doctor or a nurse into a vein as an intravenously or intramuscularly. Your doctor will administer the exact dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of REC DZ 5MG RECTAL APPLICATOR
Common
- drowsiness, fatigue
- loss of muscle coordination (ataxia) and other movement disorders, tremors
- confusion
- venous thrombosis and phlebitis at the site of injection
Uncommon
- muscles weakness
- memory loss
- difficulty in concentration
- headache
- dizziness
- nausea, vomiting
- constipation, diarrhoea
- increased salivation
- slurred speech
- difficulty in maintaining balance
- itching, skin, redness, rashes and swelling
Rare
- behavioural changes (most seen in children and elderly patients) such as excitation, agitation, restlessness, irritability, aggressiveness, memory loss, inappropriate behaviour, delusion, rages, psychoses, nightmares, or hallucinations
- depression
- difficulty sleeping
- low blood pressure, fainting
- dry mouth
- gynecomastia (breast enlargement in males)
- impotence, changes in sexual drive
- increase in appetite
- loss of bladder control, lack of ability to urinate
- slow heartbeat, heart failure and ceasing of heartbeat
- increased mucus secretion in lungs
- changes in liver enzymes
- blood disorders which may lead to infections, nose bleeds, sore throat
- emotional withdrawal
- decreased alertness
Stop receiving REC DZ 5MG RECTAL APPLICATOR and consult your doctor immediately in case you experience:
- rash, swelling of your lips, tongue and throat or body causing sudden wheezing, fainting or difficulties to swallow.
- respiratory depression such as very slow or shallow breathing.
- respiratory arrest (cessation of breathing)
- jaundice (yellowish discolouration of the skin and whites of eye)
- restlessness, delusion, psychosis, anxiety, hyperexcitation, disorientation, nervousness, hostility, anger, panic, aggression, hallucinations, increased muscle spasticity, insomnia, rage, nightmares, abnormal dreams, sleep problems, stimulation, hyperactivity, inappropriate behaviour
How To Manage Side Effects
Itchy skin:
Avoid taking hot showers because hot water can irritate the skin and do not scratch the affected area. Use sunscreen and protective clothing when going outdoors or use unscented moisturizers to soothe and hydrate the skin and contact your doctor if itching persists.
Nausea or Vomiting:
Receive the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if nausea and vomiting worsen.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of water and exercise regularly. Contact your doctor if constipation persists.
Diarrhoea:
Drink plenty of water or fruit juices to keep you hydrated. Do not take any medicine on your own for managing diarrhoea and contact your doctor if diarrhoea worsen.
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if needed. Do not consume alcohol and contact your doctor if your headache did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel dizziness. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if dizziness worsen.
Warning & Precautions
Pregnancy
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in pregnant women. Consult your doctor before receiving.
Breastfeeding
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in breast feeding women as REC DZ 5MG RECTAL APPLICATOR may pass through breast milk. Consult your doctor before receiving.
Driving and Using Machines
REC DZ 5MG RECTAL APPLICATOR causes sleepiness, forgetfulness, impaired concentration, impaired muscle function, poor coordination, dizziness which can affect your driving ability. Do not drive or operate machines after receiving REC DZ 5MG RECTAL APPLICATOR.
Alcohol
Do not consume alcohol while receiving REC DZ 5MG RECTAL APPLICATOR as it increases the sedative effect of REC DZ 5MG RECTAL APPLICATOR and make you very sleepy.
Kidney
REC DZ 5MG RECTAL APPLICATOR should be used with caution in patients suffering from kidney failure. Consult your doctor before receiving.
Liver
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in patients suffering from liver disease. Consult your doctor before receiving.
Allergy
Do not receive REC DZ 5MG RECTAL APPLICATOR if you are allergic to Diazepam, other benzodiazepines, lactose, or other ingredients of medicine.
Lungs
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in patients with severe respiratory failure, or chronic obstructive airways or have weakness of your chest muscles. Consult your doctor before receiving.
Heart Disease
REC DZ 5MG RECTAL APPLICATOR should be used with caution in patients suffering from heart problem. Consult your doctor before receiving.
Others
REC DZ 5MG RECTAL APPLICATOR is not recommended for use if you have:
- phobia, obsessive behaviour, a personality disorders or other mental illness
- myasthenia gravis (muscle weakness)
- sleep apnoea syndrome
- porphyria (a rare blood disorder)
- acute narrow angle glaucoma and open angle glaucoma
Before receiving REC DZ 5MG RECTAL APPLICATOR inform your doctor if you have:
- depression (with or without anxiety)
- epilepsy or fits
- arteriosclerosis (a narrowing of the blood vessels)
- self-harming thoughts
Use in pediatrics:
REC DZ 5MG RECTAL APPLICATOR is not recommended for use in children and adolescents below 12 years of age as its safety and efficacy is not yet established. Consult your doctor before receiving.
Use in geriatrics:
REC DZ 5MG RECTAL APPLICATOR should be used with caution in elderly patients above 60 years of age due to increased risk of falls and fractures. Consult your doctor before receiving.
Interactions
A. Drug-Drug interactions:
Before receiving REC DZ 5MG RECTAL APPLICATOR, inform your doctor if you are taking any of the following medicine:
- sodium oxybate, modafinil (used for management of narcolepsy)
- fluvoxamine, fluoxetine, isocarboxazid, amitriptyline (medicines used for management of depression)
- clozapine, olanzapine, fluphenazine, zuclopenthixol, haloperidol, methotrimeprazine (medicine used for management of mental disorders)
- cetirizine, chlorpheniramine (medicine used for management of allergies)
- halothane, isoflurane (medicines used during surgeries)
- alprazolam, chlordiazepoxide (medicine used for management of anxiety)
- zolpidem, zopiclone (medicine used for management of sleep disorders)
- erythromycin, clarithromycin (medicines used for management of bacterial infections)
- suxamethonium, tubocurarine (medicine used for muscle relaxation)
- morphine, methadone, and buprenorphine (medicine used as strong painkillers)
- phenobarbital (medicine used for management of epilepsy and mental disorders)
- furosemide, chlorothiazide, diltiazem, verapamil (medicines used for management of high blood pressure)
- isosorbide mononitrate (medicines used in heart patients)
- magnesium carbonate, magnesium hydroxide (medicines used for management of acidity)
- disulfiram (medicine used to manage alcohol addiction)
- phenytoin, carbamazepine, sodium valproate (medicines used in management of epilepsy)
- theophylline (medicine used to manage asthma and other breathing disorders)
- cimetidine, omeprazole, or esomeprazole (medicines used for management of acidity)
- rifampicin, isoniazid (medicine used for management of tuberculosis)
- St John’s wort (herbal medicine used for management of mental illness)
- amprenavir, atazanavir, ritonavir, delavirdine, efavirenz, indinavir, nelfinavir, zidovudine or saquinavir (medicines used for management of viral infections)
- fluconazole, itraconazole, ketoconazole or voriconazole (medicines used for management of fungal infections)
- oral contraceptives (medicines used to manage pregnancy)
- cisapride (medicine used for management of stomach problems)
- betamethasone, dexamethasone (medicines used to manage inflammation)
- levodopa (medicine used to manage Parkinson’s disease)
- ketamine (medicine used during surgeries)
- nabilone (medicine used to manage nausea and vomiting)
- doxazosin and beta blockers such as propranolol, metoprolol (medicine used to manage high blood pressure) and moxonidine (medicine used to manage mild to moderate high blood pressure)
- valproic acid (medicine used to manage fits and mental disorders)
- idelalisib (used to manage cancer)
B. Drug-Food interaction:
Avoid consuming grapefruit juice as it may increase REC DZ 5MG RECTAL APPLICATOR levels in blood. Do not consuming caffeinated drinks while taking REC DZ 5MG RECTAL APPLICATOR as it may reduce the effect of REC DZ 5MG RECTAL APPLICATOR.
Overdosage:
REC DZ 5MG RECTAL APPLICATOR will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of mild overdose of REC DZ 5MG RECTAL APPLICATOR include drowsiness, oversedation, lethargy, hypnotic state, nystagmus (rapid eye movements), mental confusion.
Synopsis
| Drug | : | Diazepam |
| Pharmacological Category | : | Benzodiazepines |
| Therapeutic Indication | : | Status Epilepticus, Muscle spasms, Alcohol withdrawal Syndrome |
| Dosage Forms | : | Tablet, Capsule, Syrup, Suspension, Solution, Suppositories, Injection |
More Information
- Keep REC DZ 5MG RECTAL APPLICATOR out of reach of children.
- Store REC DZ 5MG RECTAL APPLICATOR between 25°C
FAQs About REC DZ 5MG RECTAL APPLICATOR
What is status epilepticus?
Status epilepticus is an emergency in which seizure lasts for longer time or series of seizures occurs where the patient does not regain his consciousness in between.
What are the uses of REC DZ 5MG RECTAL APPLICATOR?
REC DZ 5MG RECTAL APPLICATOR helps you to fall asleep and it can also have a calming effect. It is also indicated as a premedication to calm anxious patients before management such as dental extractions and to sedate patients in intensive care units.
How does REC DZ 5MG RECTAL APPLICATOR work on brain?
REC DZ 5MG RECTAL APPLICATOR belongs to benzodiazepines works by calming the brain and nerves by increasing the level of a chemical called gamma-aminobutyric acid (GABA), a naturally occurring inhibitory neurotransmitter in the brain.
Is REC DZ 5MG RECTAL APPLICATOR a muscle relaxant?
REC DZ 5MG RECTAL APPLICATOR helps in management of muscle spasms in patients suffering from tetanus, management of muscle spasticity due to cerebral palsy.
What are side effects of REC DZ 5MG RECTAL APPLICATOR?
The most common side effects of receiving REC DZ 5MG RECTAL APPLICATOR are drowsiness, fatigue, dizziness, loss of coordination of muscle movements (ataxia) and other movement disorders, tremors, confusion, venous thrombosis, and phlebitis at the site of injection. Consult your doctor in case any of side effects worsens.
How is REC DZ 5MG RECTAL APPLICATOR administered?
REC DZ 5MG RECTAL APPLICATOR will be given to you only by a doctor or a nurse into a vein as an intravenously or intramuscularly. Your doctor will administer the exact dose and duration for you depending upon your age, body weight and disease condition.
References
1. KD Tripathi. Drugs Acting on Central Nervous System. Essentials of Medical Pharmacology. 7th edition. 2013. Page- 418.
2. Jaberpreet S. Dhaliwal, Alan Rosani, Abdolreza Saadabadi. Diazepam. National Centre for Biotechnology. NLM. National Institute of Health. Statpearls. May 2022. [Accessed on 10th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK537022/#article-20488.s6
3. Siegfried Hameln GmbH. Electronic Medicines Compendium. [Revised in December 2021] [Accessed on 12th September 2022] https://www.medicines.org.uk/emc/files/pil.6274.pdf
4. Sandoz Canada Inc. Diazepam [Revised in May 2021] [Accessed on 12th September 2022] https://www.sandoz.ca/sites/www.sandoz.ca/files/Diazepam_Injection_USP_Product_Monograph.pdf
5. Pfizer New Zealand Limited. New Zealand Medicines and Medical devices Safety Authority. [Revised in July 2022] [Accessed on 12th September 2022] https://www.medsafe.govt.nz/profs/Datasheet/d/DBLDiazepaminj.pdf
6. Hospira. Diazepam. [Revised in August 2022] [Accessed on 12th September 2022] https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=7e7dd743-a87b-4ab3-b6ae-f116cd0c8b0f&type=pdf
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