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Introduction About POZITIV G 1MG TABLET
POZITIV G 1MG TABLET is a combination of Glimepiride and Pioglitazone, which belong to the group of medicines called Antidiabetic agents. It is used in adults in the management of type II diabetes mellitus when diet, exercise, and management with conventional therapies (such as metformin, gliclazide, etc.) do not result in adequate sugar control.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.
Along with management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking POZITIV G 1MG TABLET, as it may aggravate your existing condition.
Before taking POZITIV G 1MG TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalances, are malnourished, starved, or are on an irregular diet as a precaution.
POZITIV G 1MG TABLET is not recommended for use in patients with type I diabetes mellitus or severe heart failure. It is also not suitable for use by pregnant or breastfeeding women.
One of the most common side effects of taking POZITIV G 1MG TABLET is hypoglycemia (low blood sugar levels). To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of POZITIV G 1MG TABLET accordingly.
You can also carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia (such as hunger, restlessness, confusion, or shakiness).
The most common side effects of taking POZITIV G 1MG TABLET are abnormal vision, headache, dizziness, weight gain, numbness, joint pain, impotence, back pain, shortness of breath, and anemia. Consult your doctor if any of these side effects worsen.
Uses Of POZITIV G 1MG TABLET
- Management of type II diabetes mellitus
How POZITIV G 1MG TABLET Works
POZITIV G 1MG TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin, which helps digest the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver.
How to use POZITIV G 1MG TABLET
Take POZITIV G 1MG TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking POZITIV G 1MG TABLET unless your doctor advises you to stop.
Side Effects Of POZITIV G 1MG TABLET
Common
- hypoglycemia (low blood sugar levels causing dizziness, shakiness, or hunger)
- headache, dizziness
- abnormal vision
- joint pain, back pain, and muscle pain
- impotence
- shortness of breath, anemia
- flatulence
- respiratory infection, sinus infection, sore throat
- weight gain
- numbness
Uncommon
- difficulty sleeping (insomnia)
- sugar in urine
- proteins in urine
- spinning sensation (vertigo)
- sweating, tiredness
- increased appetite
Rare
- taste changes
- weight gain
- hair loss
Stop taking POZITIV G 1MG TABLET and contact your physician immediately if you experience any of the following side effects:
- symptoms of heart failure (such as unusual shortness of breath or trouble breathing, a rapid increase in weight or localized swelling (oedema), especially in the ankles or legs, or unusual tiredness)
- signs and symptoms of bladder cancer (such as blood in your urine, pain while urinating, or an urgent need to pee)
- increased risk of fractures (especially in the bones of the hand, upper arm, or foot in women)
- blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
- serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin, or the whites of the eyes)
- severe decrease in blood sugar levels
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive amounts of alcohol. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Hypoglycemia
Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Consult your doctor if there is no improvement in your condition.
Warning & Precautions
Pregnancy
ContraindicatedPOZITIV G 1MG TABLET is not recommended for use by pregnant women. Therefore, consult your doctor before taking it.
Breastfeeding
ContraindicatedPOZITIV G 1MG TABLET is not recommended for use by breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if your abilities are affected by POZITIV G 1MG TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking POZITIV G 1MG TABLET, as it may increase the risk of unwanted side effects.
Kidney
Consult your doctorPOZITIV G 1MG TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorPOZITIV G 1MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take POZITIV G 1MG TABLET if you are allergic to Glimepiride, Pioglitazone, or any other sulfonylureas (Ex. glyburide, gliclazide) or sulphonamides (Ex. sulfasalazine).
Heart Disease
Consult your doctorPOZITIV G 1MG TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedPOZITIV G 1MG TABLET is not recommended for use in children or adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use In Geriatrics
Use with CautionPOZITIV G 1MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
Others
POZITIV G 1MG TABLET is not recommended for use if you:
- have type I diabetes mellitus (insulin-dependent diabetes)
- have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination, and muscular stiffness)
- have bladder cancer
- pass bloody urine
Before taking POZITIV G 1MG TABLET, inform your doctor if you:
- are recovering from any injury, operation, infection, or any form of stress
- have G6PD deficiency
- are fasting or malnourished, starved, on an irregular diet, or feeling weak
- perform extreme physical exercises without proper carbohydrate intake
- have hormonal problems (Ex. disorders of the pituitary gland, adrenal cortex, or thyroid gland)
- are an alcoholic
- have edema (swelling of body parts)
- smoke
- have a special type of diabetic eye disease called macular oedema (swelling of the back of the eye with worsening of your vision)
- have cysts on your ovaries (polycystic ovarian syndrome)
- previously had stroke
- have anemia (low RBC in the blood)
- have any bone problems or are at risk of developing bone fractures
- are a premenopausal woman
- have thyroid problems
Interactions
A. Drug-Drug interactions:
Before taking POZITIV G 1MG TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines used to manage diabetes mellitus (such as insulin or metformin)
- medicines used to manage pain and inflammation (Ex. aspirin, ibuprofen, phenylbutazone, azapropazone, and oxyphenbutazone)
- medicines used to manage urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
- medicines used to manage bacterial infections (such as tetracyclines, chloramphenicol, ciprofloxacin, and clarithromycin)
- medicines used to manage fungal infection (Ex. fluconazole, miconazole)
- medicines used to manage blood clotting (Ex. warfarin)
- medicines used for muscle buildup (Ex. nandrolone, oxymetholone)
- medicines used for male sex hormone replacement therapy (Ex. testosterone)
- medicines used to manage depression (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine)
- medicines used to manage high blood cholesterol levels (Ex. fenofibrate, nicotinic acid, colesevelam)
- medicines used to manage high blood pressure (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, and reserpine)
- disopyramide (a medicine used to manage abnormal heartbeat)
- medicines used to manage gout (Ex. allopurinol, probenecid, sulfinpyrazone)
- medicines used to manage cancer (Ex. cyclophosphamide, ifosfamide, and trofosfamide)
- fenfluramine (a medicine used to manage obesity)
- pentoxifylline (a medicine that can improve blood flow in the body)
- medicines used to manage allergic rhinitis (Ex. tritoqualine)
- alpha blockers (medicines used to manage high blood pressure or prostate problems) Ex. prazosin, doxazosin
- hormonal replacement therapy (used to manage menstrual disorders in women) Ex. estradiol
- thiazide diuretics (used to manage edema and high blood pressure) Ex. hydrochlorothiazide
- levothyroxine (a medicine used to manage thyroid problems)
- medicines to manage mental illness (such as chlorpromazine, prochlorperazine, and lithium)
- corticosteroids (used to manage pain and inflammation) Ex. prednisolone, betamethasone
- medicines used to manage asthma (Ex. salbutamol, terbutaline)
- adrenaline (a medicine used to manage emergency conditions)
- medicines used to manage constipation (Ex. lactulose, liquid paraffin)
- medicines used to manage epilepsy (Ex. phenytoin)
- barbiturates (used to induce sleep) Ex. phenobarbital
- medicines used to reduce increased pressure in the eye (Ex. acetazolamide)
- glucagon, diazoxide (medicines used to manage signs of low blood sugar levels)
- cimetidine (a medicine used to manage stomach ulcers)
- gemfibrozil (a medicine used to manage blood cholesterol levels)
- rifampicin (a medicine used to manage tuberculosis)
Overdosage:
If you or anyone else accidentally took more POZITIV G 1MG TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, a fast heartbeat, and confusion). To manage this, consume any sugary food immediately. If the symptom does not improve or worsens, contact your doctor immediately.
Synopsis
| Drug | : | Glimepiride, Pioglitazone |
| Pharmacological Category | : | Sulfonylureas, Thiazolidinediones |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep POZITIV G 1MG TABLET out of reach of children
- Store POZITIV G 1MG TABLET at room temperature
FAQs About POZITIV G 1MG TABLET
Q: What is POZITIV G 1MG TABLET used for?
A: POZITIV G 1MG TABLET is an antidiabetic medicine used in the management of type II diabetes mellitus when diet, exercise, and management with conventional therapies do not result in an adequate response.
Q: How and when should I take POZITIV G 1MG TABLET?
A: Take POZITIV G 1MG TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Q: How long should I take POZITIV G 1MG TABLET?
A: You need to take POZITIV G 1MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.
Q: What is the best time to take POZITIV G 1MG TABLET?
A: POZITIV G 1MG TABLET must be taken with meals to avoid gastrointestinal side effects.
Q: What should I do if I forget to take a dose of POZITIV G 1MG TABLET?
A: If you forgot to take a dose of POZITIV G 1MG TABLET, take it as soon as you remember. However, if it is time for the next dose of POZITIV G 1MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of POZITIV G 1MG TABLET to compensate for the missed ones.
Q: Can I stop taking POZITIV G 1MG TABLET without consulting your doctor?
A: No, you should not stop taking POZITIV G 1MG TABLET without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using POZITIV G 1MG TABLET, consult your doctor for advice.
Q: Will taking a higher dose of POZITIV G 1MG TABLET be more effective?
A: No, taking a higher dose of POZITIV G 1MG TABLET will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with POZITIV G 1MG TABLET?
A: It is not advisable to take medicines to control blood pressure while taking POZITIV G 1MG TABLET without consulting your doctor, as they have known interactions with POZITIV G 1MG TABLET.
Q: How do you manage the side effects of POZITIV G 1MG TABLET?
A: Low blood sugar is a common side effect of taking POZITIV G 1MG TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar levels once again. If your condition does not improve, consult your doctor immediately.
Q: Can POZITIV G 1MG TABLET be taken with insulin?
A: Co-administration of POZITIV G 1MG TABLET with insulin is considered risky as it can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.
Q: Can POZITIV G 1MG TABLET be used in pregnant women?
POZITIV G 1MG TABLET is not recommended for use by pregnant women. Therefore, consult your doctor for advice before taking it.
Q: Does POZITIV G 1MG TABLET cause bone fractures?
A: POZITIV G 1MG TABLET may cause bone fractures in some individuals. Therefore, it is important for you to inform your doctor before taking POZITIV G 1MG TABLET if you have any bone problems or are at risk of developing any bone fractures (such as menopause).
Q: Does POZITIV G 1MG TABLET cause weight gain?
A: Yes, POZITIV G 1MG TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and engage in regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as the face, legs, or hands), consult your doctor immediately.
Q: What are the side effects of taking POZITIV G 1MG TABLET?
A: The most common side effects of taking POZITIV G 1MG TABLET are decreased blood sugar (hypoglycemia), abnormal vision, headache, dizziness, weight gain, numbness, joint pain, impotence, back pain, shortness of breath, anemia, and increased respiratory infections. Consult your doctor if any of these side effects worsen.
References
1. KD. Tripathi. Insulin, oral hypoglycemic drugs, and glucose Essentials of medical pharmacology. Seventh edition, 2013. Page – 270 and 277.
2. Meng Tan, Don Johns, Guillermo González Gálvez, Oscar Antúnez, Guadalupe Fabián, Fernando Flores-Lozano, Sergio Zúñiga Guajardo, Eduardo Garza, Hector Morales, Christopher Konkoy, Matthias Herz, GLAD Study Group. Effects of pioglitazone and glimepiride on glycemic control and insulin sensitivity in Mexican patients with type 2 diabetes mellitus: A multicenter, randomized, double-blind, parallel-group trial. NIH: National Library of Medicine, National Center of Biotechnology Information Pubmed.gov, May 2004. [Accessed on 18th January 2024] https://pubmed.ncbi.nlm.nih.gov/15220012/
3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 18th January 2024] https://www.medicines.org.uk/emc/files/pil.10742.pdf
4. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 18th January 2024] https://www.medicines.org.uk/emc/files/pil.8836.pdf
5. Sandoz Inc. Pioglitazone Hydrochloride and Glimepiride Tablet. Dailymed.com. [Revised in June 2018]. [Accessed on 18th January 2024] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2aab19ce-1e5e-44ee-85e5-d8f125f9bb1a
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Insulin Postprandial (PP)
- Vital Diabetes Care
- Extended Diabetes Care
- Advance Diabetes Care
- Comprehensive Diabetes Care
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