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Introduction About PIROXITAS 20MG INJECTION
PIROXITAS 20MG INJECTION contains Piroxicam, which belongs to the group of medicines called Non-Steroidal Anti-Inflammatory Drugs. It is used in the management of musculoskeletal disorders (injuries or disorders of muscle, ligaments, joints, and tendons characterised by pain, stiffness, swelling, and restricted movements), acute gout (a form of arthritis with severe pain, redness, and tenderness in joints), postoperative trauma pain (pain due to trauma after surgical intervention), and primary dysmenorrhea (sudden cramping pain in the lower abdomen occurring before or during menstruation).
PIROXITAS 20MG INJECTION exerts its anti-inflammatory actions by inhibiting the enzyme cyclooxygenase-1, thereby, blocking the release of prostaglandins (a substance produced during injury and inflammation that causes pain and swelling) and other chemical mediators that cause pain and swelling. Your doctor may advise you to take relevant tests before recommending this medicine.
PIROXITAS 20MG INJECTION is not recommended for use in patients with liver, kidney, or heart problems. PIROXITAS 20MG INJECTION is not recommended for use by a pregnant or breastfeeding woman. It should be used with caution in children aged 12 years and older. The most common side effects by receiving this medicine are nausea (feeling sick), vomiting, and stomach pain. Contact your doctor if your symptom does not improve.
Uses Of PIROXITAS 20MG INJECTION
- Management of musculoskeletal disorders, acute gout, postoperative trauma pain, and primary dysmenorrhea from 12 years of age or older
How PIROXITAS 20MG INJECTION Works
PIROXITAS 20MG INJECTION exerts its anti-inflammatory actions by inhibiting the enzyme cyclooxygenase-1 thereby, blocking the release of prostaglandins (a substance produced during injury and inflammation causing pain and swelling) and other chemical mediators that cause pain and swelling.
How to use PIROXITAS 20MG INJECTION
PIROXITAS 20MG INJECTION will be administered by your doctor or nurse by injection into a muscle (intramuscular). Your healthcare provider will administer the right dose depending on your health condition.
Side Effects Of PIROXITAS 20MG INJECTION
Common
- signs of gastric perforation and ulceration like burning sensation, severe stomach pain
- signs of pancreatitis include tenderness, vomiting, upper abdominal pain
- gastrointestinal bleeding (including hematemesis vomiting blood, melena (blood in stools or faeces)
- gastritis, epigastric distress (upper abdominal pain)
- nausea (feeling sick)
- constipation
- abdominal discomfort
- flatulence
- abdominal pain
- diarrhoea
- vomiting
- indigestion
- stomatitis (painful mouth ulcers)
How To Manage Side Effects
Nausea or vomiting:
Take this medicine with meals or just after meals. Stick to simple meals. Try to avoid oil-rich or spicy foods, sugary snacks, and drinks. Try to drink liquids slowly along with your meals or in between meals. Consult your doctor if your symptom is not improving.
Stomach pain:
Try to rest and relax. Try to have smaller and more frequent meals. Keep a heating pad on your stomach. Take your physician’s advice.
Warning & Precautions
Pregnancy
PIROXITAS 20MG INJECTION is not recommended for use by pregnant women. Consult your doctor before receiving this medicine.
Breastfeeding
PIROXITAS 20MG INJECTION is not recommended for use by breastfeeding women as it may pass to the baby through breast milk. Discuss the risks and benefits with your doctor.
Driving and Using Machines
The effect of PIROXITAS 20MG INJECTION on the ability to drive or operate machinery has not been studied.
Kidney
PIROXITAS 20MG INJECTION is not recommended for use in patients with severe kidney disease. Consult your doctor for advice.
Liver
PIROXITAS 20MG INJECTION is not recommended for use in patients with severe liver disease. Consult your doctor for advice.
Allergy
Do not receive PIROXITAS 20MG INJECTION if you are allergic to Piroxicam.
Heart Disease
PIROXITAS 20MG INJECTION is not recommended for use in patients with severe heart failure. It should be taken with caution in patients having high blood pressure, and fluid retention. Consult your doctor for advice.
Others
PIROXITAS 20MG INJECTION is not recommended for use if you:
- have stomach or intestinal ulcer, bleeding, or perforation
- have peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Before receiving PIROXITAS 20MG INJECTION, inform your doctor if you:
- have dehydration
Use in pediatrics:
PIROXITAS 20MG INJECTION should be used with caution in children aged 12 years of age and above. Consult your doctor for advice.
Interactions
A. Drug-Drug interactions:
- aspirin, acetylsalicylic acid or other non-steroidal anti-inflammatory drugs for pain relief
- anticoagulants such as warfarin, and heparin (a medicine used to manage blood clots)
- corticosteroids like prednisolone (medicines used to manage a variety of conditions such as allergies and hormone imbalance)
- lithium (a medicine used to manage some mental problems)
- methotrexate (a medicine used for the management of some inflammatory diseases and some cancers)
- ciclosporin and tacrolimus (a medicine used to manage some inflammatory diseases and after transplants)
- cardiac glycosides (Ex. digoxin) used to manage heart problems
- cimetidine (a medicine used to manage stomach ulcers)
- antacids for indigestion and heartburn (ex. calcium carbonate, aluminium hydroxide)
- losartan, valsartan, ramipril, enalapril, furosemide, propranolol, atenolol (medicines used to manage high blood pressure)
- cholestyramine (a medicine used to lower blood cholesterol levels)
Overdosage:
If you or anyone else accidentally received too much of PIROXITAS 20MG INJECTION, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Piroxicam |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drugs |
| Therapeutic Indication | : | Reduce joint pain |
| Dosage Forms | : | Tablet, Capsule, Dispersible tablet, Gel, Injection |
More Information
- Keep PIROXITAS 20MG INJECTION out of reach from children
- Store away from warm temperatures and light
FAQs About PIROXITAS 20MG INJECTION
What are the uses of PIROXITAS 20MG INJECTION?
PIROXITAS 20MG INJECTION is indicated in the management of musculoskeletal disorders, acute gout, postoperative trauma pain, and primary dysmenorrhea (12 years of age or older).
How does PIROXITAS 20MG INJECTION work?
PIROXITAS 20MG INJECTION exerts its anti-inflammatory actions by inhibiting the enzyme cyclooxygenase-1, thereby blocking the release of prostaglandins (a substance produced during injury and inflammation that causes pain and swelling) and other chemical mediators that cause pain and swelling.
Can PIROXITAS 20MG INJECTION be used in patients with heart problems?
PIROXITAS 20MG INJECTION is not recommended for use in patients with severe heart failure. It should be used with caution in patients with high blood pressure and fluid retention. Consult your doctor for advice.
Can PIROXITAS 20MG INJECTION be used by a pregnant woman?
PIROXITAS 20MG INJECTION or other painkiller medicines (NSAIDs) are not recommended for use in pregnancy. Consult your doctor for advice before receiving [GBNKEYEORD].
Can PIROXITAS 20MG INJECTION be given to children?
PIROXITAS 20MG INJECTION should be used with caution in children 12 years of age and older. The correct dose and duration will be determined by your doctor based on your age and body weight. Consult your doctor for advice.
References
1. KD Tripathi. Non-steroidal anti-inflammatory drugs. Essentials of medical pharmacology. Eighth edition. 2013. Page – 218.
2. R N Brogden, R C Heel, T M Speight, G S Avery; Piroxicam: a review of its pharmacological properties and therapeutic efficacy. NIH National Library of Medicine, National centre for biotechnology information. PubMed.gov. September 1981. [Accessed 26th July 2022] https://pubmed.ncbi.nlm.nih.gov/7021122/
3. R L Wiseman, M Kilgour. Intramuscular piroxicam, is a new dosage form, in the treatment of acute musculoskeletal disorders. NIH National Library of Medicine, National Center for biotechnology information. PubMed.gov. May 1985. [Accessed 26th July 2022] https://pubmed.ncbi.nlm.nih.gov/2932357/
4. Sovereign Pharma Pvt. Limited. [Revised in May 2022] [Accessed 26th July 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=14811
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