Pioz 7.5mg Tablet 10'S

Introduction About PIOZ 7.5MG TABLET

Pioz 7.5mg Tablet is an oral anti-diabetic medicine containing Pioglitazone, which belongs to the thiazolidinedione (glitazone) class of drugs. It works by improving the body’s sensitivity to insulin, thereby helping in better control of blood sugar levels. This medicine is commonly prescribed to adults with type 2 diabetes mellitus, especially when diet, exercise, or other medicines alone do not provide adequate control. By lowering blood sugar, it helps reduce the risk of diabetes-related complications such as kidney problems, nerve issues, and heart disease.

This tablet is generally suitable for patients who need additional support in achieving stable blood sugar levels and may be prescribed as monotherapy or along with other medicines like metformin, sulfonylureas, or insulin. It is particularly considered in patients with insulin resistance and those struggling with fluctuating sugar levels despite lifestyle modifications. However, it is not used in type 1 diabetes or for diabetic ketoacidosis.

It should be taken once daily, with or without food, at the same time each day for maximum benefit. The dose is individualized based on the patient’s blood sugar profile and doctor’s recommendation. Regular monitoring of blood glucose and HbA1c is important while on this medication. It should always be combined with a healthy diet plan, exercise routine, and regular check-ups to get the best results.

 Pioz 7.5mg Tablet should be used with caution in patients with liver or heart problems, as it may cause fluid retention or worsen heart failure. It is not recommended during pregnancy or breastfeeding due to limited safety data. Elderly patients should also use it under strict medical guidance. Common side effects may include weight gain, swelling (edema), headache, and muscle pain. Any unusual symptoms such as shortness of breath, rapid weight gain, or severe fatigue should be promptly reported to the doctor.

Uses Of PIOZ 7.5MG TABLET

• Type II diabetes mellitus in adults along with diet and exercise

Benefits of PIOZ 7.5MG TABLET

Pioz 7.5mg Tablet for Blood Sugar Control

Pioz 7.5mg Tablet is commonly prescribed for people with type 2 diabetes to help keep blood sugar levels within a healthy range. It works by making the body respond better to insulin, which lowers excess sugar in the blood. By improving blood sugar control, it helps reduce the risk of long-term diabetes-related complications such as kidney, heart, and nerve problems. This tablet is usually taken along with a healthy diet, regular exercise, and sometimes in combination with other diabetes medicines.

Pioz 7.5mg Tablet – Improve Insulin Sensitivity

The main benefit of Pioz 7.5mg Tablet is that it improves the body’s sensitivity to insulin. In type 2 diabetes, the body often produces insulin but cannot use it effectively, a condition known as insulin resistance. Pioz helps overcome this resistance, allowing muscles and fat cells to absorb and use glucose more efficiently. Unlike some medicines, it does not force the pancreas to release more insulin, which lowers the risk of sudden low blood sugar when taken alone. Over time, this improves overall blood sugar balance and helps in better diabetes management.

How PIOZ 7.5MG TABLET Works

Pioz 7.5mg Tablet – Mechanism of Action

Pioz 7.5mg Tablet contains Pioglitazone, which belongs to the group of medicines called thiazolidinediones (glitazones). It works mainly by targeting insulin resistance, which is the main problem in type 2 diabetes.

Pioglitazone activates a specific receptor in the body called PPAR-γ (Peroxisome Proliferator-Activated Receptor gamma). This activation improves how the body’s cells—especially those in muscles, fat, and the liver—respond to insulin. As a result, glucose is absorbed and used more effectively, reducing high blood sugar levels.

Unlike some other diabetes medicines, Pioz does not make the pancreas release more insulin. Instead, it helps the body use its natural insulin better. This action leads to improved long-term blood sugar control without causing sudden low sugar episodes when used alone. 

How to use PIOZ 7.5MG TABLET

How to take Pioz 7.5mg tablet

• Take Pioz 7.5mg Tablet exactly as prescribed by your doctor; do not change the dose on your own.
• It can be taken with or without food but try to take it at the same time each day for best results.   
• Swallow the tablet whole with a glass of water; do not crush or chew it.  
• Your doctor may adjust the dose based on blood sugar levels, response, and overall health condition. 
• Keep taking this medicine regularly even if you feel well, as stopping suddenly may cause your blood sugar to rise.
• Always follow your doctor’s advice on diet, exercise, and regular monitoring while taking this medicine.

What if I forgot to take PIOZ 7.5MG TABLET

If you forget to take a Pioz 7.5mg tablet, take it as soon as you remember unless it is nearly time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing routine. Do not take two doses at the same time to make up for the missed tablet, as this can increase your risk of side effects. Maintaining consistency helps your treatment work effectively, so try to take your medication at the same time each day.  

Overdose

If you or anyone else accidentally took more pioz 7.5mg tablet, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include hypoglycaemia which may cause increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. 

Side Effects Of PIOZ 7.5MG TABLET

Common Side Effects of Pioz 7.5mg tablet:

• hypoglycaemia (low blood sugar levels causing dizziness, shakiness or hunger)
• headache, dizziness
• abnormal vision
• joint pain, back pain, muscle pain
• impotence
• shortness of breath, anaemia
• flatulence
• respiratory infection, sinus infection, sore throat
• weight gain
• numbness
• difficulty in sleeping (insomnia)
• sugar in urine
• proteins in urine
• spinning sensation (vertigo)
• sweating, tiredness
• increased appetite

When to Seek Medical Attention?

Stop taking Pioz 7.5mg tablet and contact your physician immediately if you experience any of the following side effects:

• symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
• signs and symptoms of bladder cancer (such as blood in your urine, pain while urinating or urgent need to pee)
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
• serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

How To Manage Side Effects

Headache

• Staying hydrated by drinking plenty of water helps prevent dehydration-related headaches.
• Resting in a quiet, dim room can ease headache pain.
• Applying a cold or warm compress on the forehead or neck provides relief.
• Practicing relaxation techniques such as deep breathing or meditation reduces tension.
• Using essential oils like peppermint or lavender on temples may soothe headache symptoms.

Sore Throat

• Warm saltwater gargle: Gargling with a glass of warm water mixed with ½ teaspoon of salt can reduce swelling and kill germs.  
• Honey in warm water/tea: Honey has soothing and antibacterial properties. Mix it in warm water or herbal tea for relief.
• Ginger tea: Fresh ginger boiled in water helps reduce inflammation and provides comfort to a sore throat.
• Turmeric milk: Drinking warm milk with a pinch of turmeric (golden milk) can help ease throat irritation.
• Steam inhalation: Inhaling steam from hot water (you can add a few drops of eucalyptus oil) keeps the throat moist and reduces dryness.
• Stay hydrated: Drink plenty of warm fluids like soups, herbal teas, and warm water to keep the throat moist.
• Lozenges or warm candies: Sucking on lozenges or sugar-free candies can keep your throat moist and relieve dryness.

Warning & Precautions

Pregnancy

Contraindicated

Pioz 7.5mg tablet is generally not recommended during pregnancy due to limited safety information. Consult your doctor before using it if you are pregnant or planning to become pregnant.    

Breastfeeding

Contraindicated

This medicine is not recommended for breastfeeding women, as it is unclear whether it passes into breast milk. Speak with your doctor before taking it while breastfeeding. 

Driving and Using Machines

Use with Caution

Avoid driving or operating heavy machinery if you experience vision changes or dizziness after taking Pioz 7.5mg ablet.

Alcohol

Contraindicated

Alcohol may increase the risk of side effects while taking this medicine. It is best to limit or avoid alcohol and discuss with your doctor.

Liver

Consult your doctor

 Pioz 7.5mg tablet is not recommended for patients with severe liver disease. Use with caution if you have other liver conditions and consult your doctor before starting the medicine.

Allergy

Contraindicated

Do not take Pioz 7.5mg tablet if you are allergic to Pioglitazone or any other ingredient in the medicine.

Heart Disease

Consult your doctor

This medicine is not recommended for patients with severe heart problems such as heart failure. Use with caution if you have other heart conditions and consult your doctor beforehand.

Use In Pediatrics

Contraindicated

Pioz 7.5mg tablet is not recommended for children or adolescents under 18 years. Consult your doctor before use.

Use In Geriatrics

Use with Caution

Elderly patients (65 years or older) should use Pioz 7.5mg tablet with caution. Consult your doctor before taking it.

Other Warnings for PIOZ 7.5MG TABLET

Before taking pioz 7.5mg tablet, inform your doctor if you:

• have fluid retention and swelling
• have other urinary problems
• smoke
• have special type of diabetic eye disease called macular oedema (swelling of the back of the eye with worsening of your vision)
• have cysts on your ovaries (polycystic ovary syndrome
• previously had stroke
• have anaemia (low RBC in blood)
• have any bone problems or at risk of developing bone fractures
• are a premenopausal woman

Who should not take [GBNKEYWORD

Pioz 7.5mg tablet is not recommended for use if you:

• have diabetic ketoacidosis (increased levels of ketone bodies in the blood)
• have bladder cancer
• pass bloody urine

Safety Advice

• Take Pioz 7.5mg Tablet exactly as prescribed by your doctor. Do not change the dose on your own.      
• Monitor for signs of fluid retention, such as swelling in the feet, ankles, or hands, and report them to your doctor.    
• Inform your doctor about all other medicines you are taking to avoid potential interactions.  
• Do not use in children or adolescents under 18 years of age.
• Attend regular follow-ups so your doctor can monitor blood sugar, liver function, and overall response to therapy.

Diet and Lifestyle Advice

• Follow a balanced diet with plenty of vegetables, fruits, whole grains, and lean proteins to help manage blood sugar levels.
• Limit sugar and refined carbohydrates (like sweets, pastries, white bread) to avoid spikes in blood glucose.
• Maintain a moderate carbohydrate intake in each meal to support steady blood sugar control.
• Stay hydrated by drinking enough water throughout the day.
• Include regular physical activity like walking, swimming, or yoga, after consulting your doctor, to improve insulin sensitivity and overall health.
• Monitor your weight regularly; Pioglitazone may cause fluid retention or weight gain.
• Reduce intake of very salty or processed foods to minimize fluid retention.
• Take the medicine at the same time each day, preferably with or without food, to maintain consistent blood sugar control.
• Schedule regular check-ups with your doctor to monitor blood sugar, liver function, and overall health while on therapy.

1.Pioz 7.5mg Tablet and Pioz MF Tablet:

2. Pioz 7.5mg Tablet and Insulin injections in terms of long-term use:

Drug - Drug interaction

1. Insulin or Other Antidiabetic Medicines

• Interaction: Using pioglitazone with insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycaemia).
• Management: Blood sugar should be monitored closely, and your doctor may adjust the dose of one or both medicines.

2. Rifampicin, Phenytoin, or Carbamazepine (enzyme-inducing drugs)

• Interaction: These medicines can reduce the effectiveness of pioglitazone by increasing its breakdown in the liver.
• Management: Your doctor may adjust the dose of Pioz or consider alternative medications.

3. CYP2C8 Inhibitors (e.g., Gemfibrozil, Ketoconazole)

• Interaction: These drugs can increase pioglitazone levels in the body, raising the risk of side effects.
• Management: Dose adjustment or close monitoring for side effects may be required.

4. Estrogens, Oral Contraceptives, or Other Hormonal Therapies

• Interaction: May affect blood sugar control, potentially reducing pioglitazone’s effectiveness.
• Management: Blood sugar levels should be monitored regularly, and doses adjusted if necessary.

5. Diuretics or Drugs Affecting Kidney Function

• Interaction: Can increase the risk of fluid retention and swelling when taken with pioglitazone. 
• Management: Your doctor may monitor weight, signs of swelling, and adjust medications as needed.

6. Other Liver-Metabolized Drugs

• Interaction: Drugs metabolized by the liver may interact with pioglitazone, altering its levels.
• Management: Regular liver function tests and monitoring for side effects are recommended.

Drug - Food interaction

1. High-Sugar Foods or Refined Carbohydrates

• Interaction: Foods high in sugar can reduce the effectiveness of pioglitazone in controlling blood glucose levels.
• Management: Follow a balanced diet with controlled carbohydrate intake to maintain steady blood sugar.

2. High-Fat Meals

• Interaction: Fatty meals can slow digestion and may delay the absorption of pioglitazone slightly.
• Management: Pioglitazone can still be taken with meals but aim for balanced meals to optimize effect.

3. Grapefruit and Grapefruit Juice

• Interaction: May slightly affect liver metabolism of certain medicines, including pioglitazone, though the effect is minor.
• Management: Occasional consumption is usually safe but discuss regular intake with your doctor.

4. Foods Affecting Sodium Balance (e.g., very salty foods)

• Interaction: Excess salt may worsen fluid retention, a possible side effect of pioglitazone.
• Management: Maintain a moderate-sodium diet and monitor for swelling or weight gain.

Synopsis

More Information

FAQs About PIOZ 7.5MG TABLET

References

1.K.D. Tripathi. Insulin, oral hypoglycaemic drugs, and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 277.    

2.Cyrus V. Desouza1,2 and Vijay Shivaswamy1,2. Pioglitazone in the Treatment of Type 2 Diabetes: Safety and Efficacy Review. NIH: National Library of Medicine, National centre for biotechnology information. PMC. PubMed Central. [Revised in 3rd August 2010]. [Accessed on 8th September 2025] 

3.Takeda Pharmaceuticals America, Inc. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 8th September 2025] 

Useful Diagnostic Tests

• HbA1C, also known as Glycated Haemoglobin, Glycosylated Haemoglobin
• Fasting Blood Sugar (FBS)
• Random Blood Sugar (RBS)

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 10 Sep 2025 | 09:31 AM(IST)