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Introduction About PINFIX O TABLET
PINFIX O TABLET is a combination of Cefixime and ofloxacin, which belongs to the group of medicines called Antibiotics. It is used in adults to manage typhoid fever (an infection caused by Salmonella typhi, accompanied by high fever, stomach pain, headache, and diarrhea).
PINFIX O TABLET is also used to manage bacterial infections of the respiratory tract (Ex. tonsillitis, pharyngitis, and bronchitis), middle ear (otitis media), reproductive organs (gonorrhea), and urinary tract.
Before taking PINFIX O TABLET, inform your doctor if you have any heart, liver, or kidney problems, diabetes, or fits. PINFIX O TABLET is not recommended for use in pregnant and breastfeeding women. Consult your doctor before taking it.
Avoid consumption of alcohol during management with PINFIX O TABLET, as it may impair your ability to concentrate and react. The most common side effects of taking PINFIX O TABLET are indigestion, nausea, stomach pain, vomiting, diarrhea, gas, etc. Consult your doctor immediately if any of the symptoms worsen.
Uses Of PINFIX O TABLET
PINFIX O TABLET manages typhoid fever and bacterial infections that occur in:
- Respiratory tract (Ex. tonsillitis, pharyngitis, and bronchitis)
- Middle ear
- Reproductive tract (gonorrhea)
- Urinary tract
How PINFIX O TABLET Works
PINFIX O TABLET kills the infecting bacteria where Cefixime interferes with the formation of bacterial cell walls and forms holes in them and Ofloxacin inhibits a bacterial enzyme involved in repairing and replicating the DNA (genetic material) of bacteria, thus making the organism unable to reproduce or repair themselves.
How to use PINFIX O TABLET
Take PINFIX O TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PINFIX O TABLET for you depending upon your age, body weight, and disease condition. Do not stop taking PINFIX O TABLET unless your doctor advises you to stop.
Side Effects Of PINFIX O TABLET
Common
- indigestion, stomach pain
- nausea, vomiting
- diarrhea, gas
Uncommon
- irritated or burning eyes
- headaches, sleep disturbances like difficulty sleeping (insomnia)
- dizziness, spinning sensations
- agitation, restlessness
- nasopharyngitis (cough and inflamed sore nose or throat)
- fungal infection
- skin rash or itching
- failure to respond to the management
Rare
- loss of appetite
- fast heartbeat
- drowsiness
- confusion, anxiety, nightmares, seeing, feeling, or hearing things that are not there, depression, mental illness
- sense of taste or smell lost or altered
- shortness of breath or wheezing
- excessive sweating and hot flushes
- light-headedness, which may be due to low blood pressure
- hives, rash with pimples
Stop taking PINFIX O TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction (rash, joint pain, swallowing or breathing problems, swollen lips, face, throat, or tongue)
- signs of liver disease (loss of appetite, yellow skin and eyes, dark urine, itching or tender stomach)
- pseudomembranous colitis (severe watery diarrhea that will not stop, weakness, fever)
- inflammation of the bowel (severe watery diarrhea, which may have blood in it, possibly with stomach cramps and fever)
- swelling of the tendons (pain, tenderness, sometimes restricted movement)
- numbness or tingling in the hands, touch sensitivity, numbness or weakness of the arms and legs
- blurred, double, or altered colour vision
- serious skin reactions (Ex. toxic epidermal necrolysis, Stevens-Johnson syndrome, drug rash with eosinophilia, and systemic symptoms (DRESS))
- convulsive fits
- changes in the way your kidneys work
- Allergic reactions including urticaria, itching, tingling, swelling of the face, tongue, and throat causing shortness of breath, cardiovascular collapse, hypotension/shock, seizure, and loss of consciousness
- pain, swelling, inflammation, or rupture of a tendon
How To Manage Side Effects
Diarrhea
Drink lots of fluids, like water or fruit juice, to maintain hydration. Check with your doctor before taking any medicine for diarrhea. If diarrhea does not get better, contact your doctor.
Dizziness Or Drowsiness
Lie down until dizziness is improved, then get up slowly. Don’t hurry, and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. If dizziness persists, consult your doctor.
Indigestion
Raise your head and shoulders up while sleeping to manage stomach acid from coming up. Do not eat 3 to 4 hours before going to sleep and avoid tea, coffee, cola, or alcohol. If indigestion does not improve, contact your doctor.
Nausea And Vomiting
Take PINFIX O TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea and vomiting worsen.
Skin rash Or Itching
Avoid hot showers because hot water can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash gets worse.
Stomach Pain
Try to rest and relax. Eat and drink slowly, or try eating smaller meals more frequently. Keep a heat pad on your stomach. If your stomach still aches, contact your doctor.
Warning & Precautions
Pregnancy
ContraindicatedPINFIX O TABLET is not recommended for use in pregnant women. Consult your doctor for advice.
Breastfeeding
ContraindicatedPINFIX O TABLET is not recommended for use in breastfeeding women. Consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience fits, confusion, feeling less alert or aware of things than usual, unusual muscle movements, or stiffness after taking PINFIX O TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol during management with PINFIX O TABLET, as it may impair your ability to concentrate and react.
Kidney
Use with CautionPINFIX O TABLET should be taken with caution if you have kidney problems. Consult your doctor for advice.
Liver
Use with CautionPINFIX O TABLET should be taken with caution if you have liver problems. Consult your doctor for advice.
Allergy
ContraindicatedDo not take PINFIX O TABLET if you are allergic to Cefixime, Ofloxacin, other quinolone or cephalosporin antibiotics, or any of the other ingredients of this medicine.
Lungs
Use with CautionPINFIX O TABLET should be used with caution in patients with lung transplants. Consult your doctor before taking it.
Heart Disease
Consult your doctorPINFIX O TABLET is not recommended for use if you have prolongation of the QT interval. It should be used with caution in patients with heart transplants, aortic aneurysm or large vessel peripheral aneurysm (an enlargement or "bulge" of a large blood vessel), aortic dissection (a tear in the aorta wall), leaking heart valves, any vascular disorders, history of heart attack, weak heart, problems with your heartbeat, or any other heart problems. Consult your doctor for advice.
Use In Pediatrics
ContraindicatedPINFIX O TABLET is not recommended for use in children and adolescents (younger than 18 years of age). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionPINFIX O TABLET should be used with caution in the elderly (above 60 years of age) due to increased risk of tendon rupture. Consult your doctor for advice.
Others
Do not take PINFIX O TABLET if you:
- have epilepsy or any risk of having fits
- have a history of tendonitis (inflammation and swelling of the tissue that connects bones to muscles)
- have myasthenia gravis (muscle weakness)
- or any of your family members have glucose-6-phosphate dehydrogenase deficiency (a genetic disorder that affects the red blood cells)
Before taking PINFIX O TABLET, inform your physician if you:
- have a history of mental illness
- have a salt imbalance in the blood (particularly low potassium or magnesium levels in the blood)
- are a female
- have diabetes
- have phenylketonuria (a birth defect that causes an amino acid called phenylalanine to accumulate in the body)
- Had previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs
- Are scheduled for lab tests
Interactions
A. Drug-Drug interactions:
Before taking PINFIX O TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to thin the blood (Ex. warfarin, heparin)
- methotrexate (used in cancer management)
- medicines or dietary supplements containing iron or zinc
- medicines used to relieve acidity or stomach ulcers (Ex. aluminium hydroxide, magnesium carbonate, sucralfate, cimetidine)
- medicines used to control high blood sugar levels (Ex. glibenclamide, metformin)
- medicines used to reduce pain (Ex. ibuprofen, diclofenac)
- medicines used to manage inflammatory conditions (Ex. hydrocortisone, prednisolone)
- theophylline (used for breathing problems)
- certain vaccines and herbal preparations
- probenecid (used to manage gout)
- furosemide (used in heart conditions)
- didanosine (used in HIV management)
- Carbamazepine (medicine used to manage fits)
Overdosage:
If you or anyone else accidentally takes too much of PINFIX O TABLET, consult your doctor immediately or visit the nearby hospital. The most common signs and symptoms of overdosage include drowsiness, nausea, dizziness, hot and cold flushes, facial swelling and numbness, slurring of speech, and mild to moderate disorientation.
Synopsis
| Drug | : | Cefixime, Ofloxacin |
| Pharmacological Category | : | Cephalosporins, Fluoroquinolones |
| Therapeutic Indication | : | Management of bacterial infections |
| Dosage Forms | : | Tablet, Syrup, Suspension, Oral Suspension, Dry Syrup, Dry Suspension, Dispersible Tablet |
More Information
Storage
- Keep PINFIX O TABLET out of reach of children
- Store at room temperature
FAQs About PINFIX O TABLET
Q: Can PINFIX O TABLET be given to children?
A: No. PINFIX O TABLET is not recommended for children and adolescents below 18 years of age. Consult your child’s doctor for advice. The doctor will decide an appropriate dose or recommend a suitable alternative management for your child.
Q: What if I forget to take a dose of PINFIX O TABLET?
A: If you forget to take a dose of PINFIX O TABLET, take it as soon as you remember. However, skip the missed dose if it's almost time for the next one. Do not take PINFIX O TABLET two times to make up for the missed dose.
Q: Can I stop taking PINFIX O TABLET if I feel better?
A: Do not stop taking PINFIX O TABLET without talking to your doctor, even if you feel better, as the infection may come back or get worse again. Consult your doctor for further advice.
Q: Can PINFIX O TABLET be taken in pregnancy?
A: Do not stop taking PINFIX O TABLET without talking to your doctor, even if you feel better, as the infection may come back or get worse again. Consult your doctor for further advice.
Q: Can I take other medicines with PINFIX O TABLET?
A: Before taking PINFIX O TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over the counter, or any herbal medicine, as these might cause serious side effects by interacting with each other.
Q: What is PINFIX O TABLET used for?
A: PINFIX O TABLET is used in adults to manage typhoid fever, bacterial infections of the respiratory tract (Ex. tonsillitis, pharyngitis, and bronchitis), middle ear (otitis media), reproductive organs (gonorrhea), and urinary tract.
Q: What are the side effects of PINFIX O TABLET?
A: The most common side effects of taking PINFIX O TABLET are indigestion, nausea, stomach pain, vomiting, diarrhea, gas, etc. Consult your doctor immediately if any of the symptoms worsen.
Q: Who should not take PINFIX O TABLET?
A: Do not take PINFIX O TABLET if you have epilepsy or any risk of having fits, history of tendonitis, myasthenia gravis, family history of glucose-6-phosphate dehydrogenase deficiency, or are allergic to Cefixime, Ofloxacin, other quinolone or cephalosporin antibiotics or prolongation of the QT interval.
Q: What precautions must be taken while using PINFIX O TABLET?
A: Before taking PINFIX O TABLET, inform your physician if you have a history of mental illness, low potassium or magnesium levels in the blood, diabetes, phenylketonuria, previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs, kidney problems, liver problems, lung transplants, heart transplants, aortic aneurysm or large vessel peripheral aneurysm, aortic dissection, leaking heart valves, any vascular disorders, history of heart attack, weak heart, problems with your heartbeat, or any other heart problems.
Q: How should I take PINFIX O TABLET?
A: Take PINFIX O TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Take one tablet twice daily or as directed by your doctor. Your doctor will decide the correct dose and duration of PINFIX O TABLET for you depending upon your age, body weight, and disease condition. Do not stop taking PINFIX O TABLET unless your doctor advises you to stop.
References
1. KD. Tripathi. Antimicrobial drugs. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page – 763, 778.
2. Tiwaskar M. Cefixime-ofloxacin Combination in the Management of Uncomplicated Typhoid Fever in the Indian Community Setting. NIH National Library of Medicine, National Center for Biotechnology Information. Pubmed.gov. March 2019. [Accessed on 21st September 2024] https://pubmed.ncbi.nlm.nih.gov/31304712/
3. Bakthavatchalam YD, Kumar DT, Tayubi IA, et al. In vitro efficacy and in silico analysis of cefixime-ofloxacin combination for Salmonella typhi from bloodstream infection. NIH National Library of Medicine, National Center for Biotechnology Information. Pubmed.gov. September 2017. [Accessed on 21st September 2024] https://pubmed.ncbi.nlm.nih.gov/28650129/
4. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in June 2022] [Accessed on 21st September 2024] https://www.medicines.org.uk/emc/files/pil.8480.pdf
5. Lupin Limited. U.S. Food and Drug Administration. [Revised in March 2017] [Accessed on 21st September 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202091s005,203195s006lbl.pdf
6. Malik Lifesciences Pvt. Ltd. Omnix O Tablets (Cefixime + Ofloxacin). [Revised in December 2019] [Accessed on 21st September 2024].https://www.ciplamed.com/product-index/omnix-o-tablets
7. Alpha Drugs. Sefmax-O (Cefixime + Ofloxacin). [Accessed on 21st September 2024] https://www.alphadrug.in/product/cefixime-and-ofloxacin-tablets/
8. Advacare Pharma. Cefox Care (Cefixime 200 mg + Ofloxacin 200 mg tablet). [Accessed on 21st September 2024] https://www.advacarepharma.com/en/pharmaceuticals/cefixime-ofloxacin-tablets
9. Ceftas O Tablet (Cefixime and Ofloxacin). Intas Pharmaceuticals Ltd. [Revised in 2011] [Accessed on 21st September 2024] https://www.intaspharma.com/wp-content/uploads/2018/12/CEFTAS.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Serum Electrolytes/ Electrolytes Profile
- Liver Function Test (LFT)
- Kidney Function Test (KFT)
- Healthians Executive Full Body Checkup
- Netmeds Body Care
- Full Body Checkup - Gold
- Full Body Checkup – Silver
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