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Introduction About PENTASA 1GM SUPPOSITORY
PENTASA 1GM SUPPOSITORY is used to manage gut inflammation and pain associated with ulcerative colitis or ulcerative proctitis. It contains a medicine called Mesalamine (also known as Mesalazine) which when inserted into the rectum, slowly releases the medicine and acts locally to reduce the inflammation and help relieve or stop the pain.
PENTASA 1GM SUPPOSITORY is for rectal use only. Carefully follow the instructions advised by your doctor on inserting the medicine.
While using mesalamine suppositories, take care to drink plenty of water and fluids as a safety precaution to avoid getting dehydrated easily. Also, make sure to inform your doctor if you are experiencing excessive vomiting, diarrhoea, high fever or any other conditions that can cause severe dehydration.
Before using this medicine, inform your doctor if you have liver problems, kidney problems, asthma, any bleeding conditions or if you are pregnant or breastfeeding. The most common side effects of using PENTASA 1GM SUPPOSITORY are diarrhoea, rectal discomfort, flatulence, stomach pain or headache. These side effects are usually mild, however, consult your doctor if they trouble you.
Uses Of PENTASA 1GM SUPPOSITORY
It is used to provide relief from gut inflammation and pain associated with:
- Ulcerative colitis
- Ulcerative proctitis
How PENTASA 1GM SUPPOSITORY Works
Mesalamine suppository works by reducing inflammation in the lining of the rectum and lower intestine. It is an anti-inflammatory drug that inhibits the production of certain chemicals (prostaglandins and leukotrienes) in the colon, which are involved in causing inflammation, swelling, and tissue damage. By directly targeting the affected area, the suppository form provides localized relief from inflammation, reducing symptoms like rectal bleeding, pain, and diarrhea.
How to use PENTASA 1GM SUPPOSITORY
- Empty your bowels before administering PENTASA 1GM SUPPOSITORY
- Clean your hands thoroughly before and after handling the suppository.
- Lie down on your left side with your right knee bent toward your chest for easy insertion.
- Gently insert the pointed end of the suppository into the rectum about 1 inch deep, ensuring it is fully inserted.
- Stay in a lying position for a few minutes to allow the suppository to dissolve and start working.
Side Effects Of PENTASA 1GM SUPPOSITORY
Common side effects of PENTASA 1GM SUPPOSITORY:
- Diarrhoea
- Abdominal pain
- Nausea, vomiting
- Headache
- Skin rash
- Flatulence (passing wind)
- Rectal discomfort
- Irritation at the site of application
Stop using this medicine and inform your doctor immediately if you experience any of the following side effects such as:
- abdominal pain and cramps, fever, severe headache and rash
- bloody urine with pain in sides of the abdomen
Warning & Precautions
Pregnancy
Consult your doctorThere is only limited information regarding the use of mesalamine during pregnancy. Therefore, consult your doctor for advice before using mesalazine suppositories if you are pregnant or think you may be pregnant.
Breastfeeding
Consult your doctorThere is only limited information regarding the use of mesalamine during breastfeeding. Available studies indicate the risk of causing allergic reactions such as diarrhea in newborn babies. Therefore, do not take mesalazine suppositories without medical supervision.
Driving and Using Machines
SafeThis medicine is not known to affect the ability to drive and/or use machines.
Kidney
Consult your doctorPENTASA 1GM SUPPOSITORY is not recommended for use in patients with severe kidney problems. It should be used with caution in patients suffering from mild to moderate kidney diseases.
Liver
Consult your doctorThis medicine is not recommended for use in patients with severe liver problems. It should be used with caution in patients suffering from mild to moderate liver diseases.
Allergy
ContraindicatedTalk to your doctor before using PENTASA 1GM SUPPOSITORY if you are allergic to Mesalamine (or mesalazine) or other salicylates (such as sulphasalazine).
Lungs
Use with CautionThis medicine should be used with caution in patients suffering from asthma.
Use In Pediatrics
ContraindicatedPENTASA 1GM SUPPOSITORY is not recommended for use in children aged below 18 years.
Others
Before taking this medicine, inform your doctor if you:
- Are currently prone to bleeding conditions
- Are dehydrated or suffer from excessive vomiting, diarrhoea or high fever
Interactions
A. Drug-Drug interactions:
- Azathioprine (used to minimise the risk of graft rejection)
- 6-mercaptopurine or thioguanine
- Anticoagulants (such as warfarin)
Synopsis
| Drug | : | Mesalamine (or Mesalazine) |
| Pharmacological Category | : | Salicylates |
| Therapeutic Indication | : | Ulcerative colitis and proctitis |
| Dosage Forms | : | Suppositories, tablets, Enema, powder |
More Information
Ulcerative Colitis:
- Definition: Ulcerative colitis is a chronic inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the lining of the large intestine (colon) and rectum. The inflammation usually begins in the rectum and may extend into the colon.
- Symptoms:
- Abdominal pain and cramping
- Persistent diarrhea, often with blood or pus
- Rectal bleeding
- Urgent need to have a bowel movement
- Fatigue
- Weight loss
- Fever in severe cases
Ulcerative Proctitis:
- Definition: Ulcerative Proctitis is the inflammation of the lining of the rectum, the lower part of the large intestine. It can be a localized form of ulcerative colitis affecting only the rectum.
- Symptoms:
- Rectal pain or discomfort
- A constant feeling of needing to pass stool (tenesmus)
- Rectal bleeding
- Mucus discharge from the rectum
- Diarrhea or constipation
Both conditions involve inflammation of the bowel, but proctitis is specifically confined to the rectum, whereas ulcerative colitis can affect a larger portion of the colon.
Drug information:
FAQs About PENTASA 1GM SUPPOSITORY
Q: What is PENTASA 1GM SUPPOSITORY used for?
A: PENTASA 1GM SUPPOSITORY is used to manage gut inflammation and pain associated with ulcerative colitis or ulcerative proctitis
Q: How do mesalamine suppositories work?
A: Mesalamine works by reducing inflammation in the rectum by inhibiting the production of inflammatory chemicals like prostaglandins and leukotrienes, providing localized relief.
Q: How often should I use PENTASA 1GM SUPPOSITORY?
A: Typically, mesalamine suppositories are used once daily at bedtime, or as directed by a doctor. The frequency may depend on the severity of your condition.
Q: How long does it take for PENTASA 1GM SUPPOSITORY to work?
A: Improvement in symptoms may occur within a few days, but it can take a few weeks for full effects. It’s important to continue using them as prescribed even if you start feeling better.
Q: What are the common side effects of PENTASA 1GM SUPPOSITORY:
A: The most common side effects of using PENTASA 1GM SUPPOSITORY are diarrhoea, rectal discomfort, flatulence, stomach pain or headache. These side effects are usually mild, however, consult your doctor if they trouble you.
Q: Can I use mesalamine suppositories with other medications?
A: Mesalamine can generally be used with other medications, but you should inform your doctor about all the drugs and supplements you are taking to avoid interactions.
Q: Are mesalamine suppositories safe during pregnancy?
A: There is only limited information regarding the use of mesalamine during pregnancy. Therefore, consult your doctor for advice before using mesalazine suppositories if you are pregnant or think you may be pregnant.
Q: Can mesalamine suppositories cure ulcerative colitis or proctitis?
A: While mesalamine suppositories help manage and control symptoms, they do not cure ulcerative colitis or proctitis. They help maintain remission and reduce flare-ups of inflammation.
References
- Mesalazine Suppositories. EMC. UK. [Revised in January 2023]. [Accessed on 4th October 2024]. click here
- Camber Pharma. Mesalamine Suppositories. Revised in March 2020. [Accessed on 4th October 2024]. click here
- Mesalamine Rectal. MedlinePlus. National Library of Medicine. [Revised in January 2023]. [Accessed on 4th October 2024]. click here
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