New Revised MRP, 100% GST benefit passed PEG RELIGRAST Prefilled Syringe(Pfs) 0.6ml
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Introduction About PEG RELIGRAST PREFILLED SYRINGE(PFS)
PEG RELIGRAST PREFILLED SYRINGE(PFS) contains Pegfilgrastim which belongs to the group of medicines called Colony stimulating factors. It is used to manage the destruction of white blood cells (WBC) in blood that is caused due to chemotherapy. It reduces the occurrence of neutropenia (low WBC count in blood) and febrile neutropenia (low WBC count in blood with fever) among patients receiving chemotherapy.
Talk to your doctor before receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) if you have any problems in your lungs or with blood circulation. You must also inform your doctor if you are allergic to Pegfilgrastim or filgrastim or have breast cancer, lung cancer or anemia as a precaution
Inform your doctor before receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) if you are pregnant or breastfeeding. The most common side effects of receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) are bone pain, nausea, headache, skin rashes, pain, redness and discomfort at the site of injection and muscle pain. Inform your doctor if any of these side effect troubles you.
Uses Of PEG RELIGRAST PREFILLED SYRINGE(PFS)
- Prevents the risk of neutropenia and febrile neutropenia (low WBC count in blood) that is caused due to chemotherapy
How PEG RELIGRAST PREFILLED SYRINGE(PFS) Works
PEG RELIGRAST PREFILLED SYRINGE(PFS) works by stimulating the bone marrow to produce more white blood cells. It also enhances the survival of the white blood cells by protecting it against the harmful effects of chemotherapy. This reduces the risk of neutropenia and its associated complications (such as fever, flu, and risk of infections) among patients receiving chemotherapy.
How to use PEG RELIGRAST PREFILLED SYRINGE(PFS)
PEG RELIGRAST PREFILLED SYRINGE(PFS) should be administered beneath the skin (subcutaneously). It is either administered to you by a doctor or a nurse or can be self-administered if instructed by the doctor. Carefully follow the instructions given by your doctor in case of self-administration.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of PEG RELIGRAST PREFILLED SYRINGE(PFS)
Common
- bone pain
- nausea, headache
- skin rash
- pain, redness, bleeding or bruising at the site of injection
- general aches and pains in the joints and muscles
Uncommon
- inflammation of the blood vessels in the skin
- kidney damage
- coughing up blood
Rare
Inform your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and throat causing difficulty in breathing or swallowing)
- signs of severe skin reactions (such as skin redness, itching, blistering and peeling or skin, red circular patches or pin-point dots with raised bumps accompanied with fever and tiredness)
- cough, fever and difficulty in breathing
- swelling of body parts with low urine output, difficulty in breathing, abdominal swelling and feeling of fullness, and a general feeling of tiredness (signs of Capillary Leak Syndrome)
- signs of spleen problems (such as left upper abdominal pain or pain at the tip of shoulder)
- blood cancer (signs include tiredness, fever, and easy bruising or bleeding)
- signs of inflammation in the aorta (such as fever, stomach pain, tiredness, back pain and increased inflammatory markers)
How To Manage Side Effects
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
Nausea And Vomiting
Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Warning & Precautions
Pregnancy
Consult your doctorPEG RELIGRAST PREFILLED SYRINGE(PFS) is not tested in pregnant women. Therefore, consult your doctor before this medicine is administered to you.
Breastfeeding
Monitoring requiredPEG RELIGRAST PREFILLED SYRINGE(PFS) should be used in breast-feeding women only if considered necessary by the physician. Kindly consult your doctor before receiving it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected by PEG RELIGRAST PREFILLED SYRINGE(PFS).
Alcohol
ContraindicatedAvoid consumption of alcohol before receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) to avoid unwanted reactions.
Kidney
Use with CautionPEG RELIGRAST PREFILLED SYRINGE(PFS) should be used with caution in patients with kidney diseases. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedTalk to your doctor before receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) if you are allergic to Pegfilgrastim or filgrastim.
Lungs
Use with CautionPEG RELIGRAST PREFILLED SYRINGE(PFS) should be used with caution in patients with lung problems (such as recent, serious lung infection (pneumonia), pulmonary oedema (fluid build-up in lungs) or lung inflammation or an abnormal chest x-ray). Therefore, consult your doctor before receiving it.
Use In Pediatrics
ContraindicatedPEG RELIGRAST PREFILLED SYRINGE(PFS) is not suitable for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before receiving it.
Use In Geriatrics
Use with CautionPEG RELIGRAST PREFILLED SYRINGE(PFS) should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.
Others
Before receiving PEG RELIGRAST PREFILLED SYRINGE(PFS), inform your doctor if you:
- are allergic to latex or acrylic adhesives
- have any problems with spleen
- have abnormal blood count (such as high or low RBC or platelet counts)
- have sickle cell anemia (low RBC count)
- have breast cancer or lung cancer
Interactions
A. Drug - Drug interactions:
Before receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) inform your doctor if you are taking any other prescription, non-prescription and over-the-counter medicines.
Overdosage:
PEG RELIGRAST PREFILLED SYRINGE(PFS) will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Pegfilgrastim |
| Pharmacological Category | : | Colony Stimulating Factor |
| Therapeutic Indication | : | Prevents Neutropenia |
| Dosage Forms | : | Injection, Pre-Filled Syringe |
More Information
- Keep PEG RELIGRAST PREFILLED SYRINGE(PFS) out of reach of children
- Store PEG RELIGRAST PREFILLED SYRINGE(PFS) in a refrigerator between 2-8°C
FAQs About PEG RELIGRAST PREFILLED SYRINGE(PFS)
Q: What is the use of PEG RELIGRAST PREFILLED SYRINGE(PFS)?
A: PEG RELIGRAST PREFILLED SYRINGE(PFS) is used to manage the destruction of white blood cells (WBC) in blood that is caused due to chemotherapy. It reduces the occurrence of neutropenia (low WBC count in blood) and febrile neutropenia (low WBC count in blood with fever) among patients receiving chemotherapy
Q: How PEG RELIGRAST PREFILLED SYRINGE(PFS) works?
A: PEG RELIGRAST PREFILLED SYRINGE(PFS) works by stimulating the bone marrow to produce more white blood cells. It also enhances the survival of the white blood cells by protecting it against the harmful effects of chemotherapy.
Q: When is PEG RELIGRAST PREFILLED SYRINGE(PFS) given?
A: PEG RELIGRAST PREFILLED SYRINGE(PFS) is given after 24 hours of your last dose of chemotherapy at the end of each chemotherapy cycle.
Q: Where PEG RELIGRAST PREFILLED SYRINGE(PFS) should be administered?
A: PEG RELIGRAST PREFILLED SYRINGE(PFS) should be administered beneath the skin (subcutaneously). It is either administered to you by a doctor or a nurse or can be self-administered if instructed by the doctor.
Q: What are the side effects of PEG RELIGRAST PREFILLED SYRINGE(PFS)?
A: The most common side effects of receiving PEG RELIGRAST PREFILLED SYRINGE(PFS) are bone pain, nausea, headache, skin rashes, pain, redness and discomfort at the site of injection and muscle pain. Inform your doctor if any of these side effect troubles you.
Q: Can PEG RELIGRAST PREFILLED SYRINGE(PFS) be given during pregnancy?
A: PEG RELIGRAST PREFILLED SYRINGE(PFS) is not tested in pregnant women. Therefore, consult your doctor before this medicine is administered to you.
Q: Will PEG RELIGRAST PREFILLED SYRINGE(PFS) reduce the effects of chemotherapy?
A: PEG RELIGRAST PREFILLED SYRINGE(PFS) will only manage from the harmful effects of chemotherapy. It does not reduce the effectiveness of chemotherapy.
Q: Is PEG RELIGRAST PREFILLED SYRINGE(PFS) effective?
A: Yes. PEG RELIGRAST PREFILLED SYRINGE(PFS) effectively manages the risk of low WBC count among patients receiving chemotherapy.
References
1. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. Inflammation, Immunomodulation and Hematopoiesis. 12th Edition. Page – 1075.
2. Savannah D. Parker; Nafisa King; Tibb F. Jacobs. Pegfilgrastim. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. August 2022. [Accessed on 14th February 2023]. https://www.ncbi.nlm.nih.gov/books/NBK532893/
3. Zhisheng Zhang, Huan Li, Jiacheng Zhang, Xuan Ye, Hongyue Liu, Qing Zhai, Bo Yu, Qiong Du. Effect of 3 mg versus 6 mg pegfilgrastim on the prevention of febrile neutropenia in breast cancer patients receiving docetaxel and cyclophosphamide: a retrospective study. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. Pubmed.gov. May 2021. [Accessed on 14th February 2023]. https://pubmed.ncbi.nlm.nih.gov/33977742/
4. Amgen Europe B.V. Neulasta 6 mg solution for injection pegfilgrastim. Electronics Medicines Compendium. [Revised in June 2021]. [Accessed on 14th February 2023]. https://www.medicines.org.uk/emc/files/pil.10091.pdf
5. Amgen Inc. NEULASTA® (pegfilgrastim) injection, for subcutaneous use. U.S. Food and Drug Administration. [Revised in April 2019]. [Accessed on 14th February 2023]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125031s198lbl.pdf
Useful Diagnostic Tests
- Complete Blood count
- Peripheral Smear Examination
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