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Introduction About PAMORELIN LA 11.25MG INJECTION
PAMORELIN LA 11.25MG INJECTION contains Triptorelin which belongs to the group of medicines called Gonadotropin-releasing hormone (GnRH) agonists. PAMORELIN LA 11.25MG INJECTION is used in men to manage prostate cancer and in women to reduce the size of uterine fibroids (non-cancerous tumours arising from the smooth muscle layer of the uterus) and to manage endometriosis (a condition in which the tissue that normally lines the uterus grows in other places).
PAMORELIN LA 11.25MG INJECTION can also be used in children to manage central precocious puberty (puberty that occurs before 8 years in girls and 10 years in boys).
PAMORELIN LA 11.25MG INJECTION should be used with caution in patients with high blood pressure, liver, kidney and heart diseaase, diabetes, benign tumour of pituitary gland or have pains in bones and difficulty passing urine. Consult your doctor before receiving it.
PAMORELIN LA 11.25MG INJECTION is not recommended for use in pregnant and breast-feeding women. PAMORELIN LA 11.25MG INJECTION should be used with caution in children (girls under 9 years of age and boys under 10 years of age) for the management of early puberty. Consult your doctor before receiving it.
The most common side effects of receiving PAMORELIN LA 11.25MG INJECTION are hot flushes, weakness, excessive sweating, back pain, pins and needles sensation in the legs, reduced libido and impotence, nausea, dry mouth etc. Contact your doctor if any of the symptoms worsen.
Uses Of PAMORELIN LA 11.25MG INJECTION
PAMORELIN LA 11.25MG INJECTION is used
- in men to manage prostate cancer
- in women to reduce uterine fibroids and to manage endometriosis
- in children to manage central precocious puberty
How PAMORELIN LA 11.25MG INJECTION Works
PAMORELIN LA 11.25MG INJECTION is similar to the gonadotropin releasing hormone which occurs naturally in your body. In men, PAMORELIN LA 11.25MG INJECTION lowers the levels of the hormone testosterone and helps to manage prostate cancer. In women, it reduces oestrogen levels, helps to reduce the size of uterine fibroids and manages endometriosis.
In children PAMORELIN LA 11.25MG INJECTION helps to supress gonadotropin (hormone) secretion in brain and helps to block pubertal development and also reduces the action of sex steroid hormones on bone maturation in order to restore normal long-term growth of the skeleton.
How to use PAMORELIN LA 11.25MG INJECTION
PAMORELIN LA 11.25MG INJECTION will be given to you only by a doctor or a nurse as an intramuscular injection (into a muscle) or subcutaneous injection (just under the skin). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Do not stop using PAMORELIN LA 11.25MG INJECTION unless your doctor advised you to stop. Otherwise, your symptoms are likely to return.
Side Effects Of PAMORELIN LA 11.25MG INJECTION
Common
- hot flushes
- weakness
- excessive sweating
- pins and needles sensation in the legs
- reduced libido and impotence
- nausea, dry mouth, abdominal pain
- bruising, redness and swelling at injection site
- muscle and bone pain, back pain, pain in the arms and legs
- oedema (build-up of fluid in the body tissues)
- allergic reaction
- increase in weight
- dizziness, headache
- depression and mood changes
- pain, swelling and tenderness
- nervousness
- difficulty in sleeping
- breast disorder, breast pain
- ovarian hyperstimulation syndrome
- pain during or after sexual intercourse
- painful periods, vaginal bleeding
- pelvic pain
- dryness of the vagina
- acne, oily skin
Uncommon
- feeling your heartbeat
- ringing in the ears, vertigo
- blurred vision, dry eye
- bloating, flatulence, constipation, diarrhoea, vomiting
- severe shivering associated with sweating and a fever
- sleepiness
- increased weight loss
- change in appetite
- gout (severe pain and swelling in the joints usually in the big toe)
- diabetes
- muscle weakness
- feeling of irritability
- development of enlarged breasts in men,
- reduction in testicular size, pain in testicles
- difficulty in breathing
- hair loss
- waking up to pass urine, problems passing urine
- nosebleeds
- abnormal taste
- loss of sensations
- temporary loss of consciousness
- memory loss, lack of concentration,
- involuntary muscle movement
- anxiety, disorientation
- bleeding after sex
- prolapse
- irregular period, painful period and heavy period
- small cysts (swelling) on the ovaries which can cause pain, discharge from the vagina
- dry skin
- excessive bodily hair
- brittle nails
Rare
- red or purple discolorations on the skin, blisters
- abnormal sensation in the eye
- chest pain
- trouble standing
- flu-like symptoms, fever
- inflammation of the nose or throat
- osteoarthritis
- decreased activity
- having a feeling of elation
- breathlessness when lying flat
Stop receiving PAMORELIN LA 11.25MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction like angioedema or anaphylactic reaction (swallowing or breathing problems, dizziness, a rash, swelling of lips, face, throat or tongue)
- symptoms of brain hemorrhage (pituitary apoplexia) such as sudden headache, vomiting, problems with vision
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating Solution) and apply a pain-relieving balm on the head if necessary. Contact your doctor if your headache did not improve.
Nausea and vomiting:
Receive PAMORELIN LA 11.25MG INJECTION, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting did not improve.
Stomach pain:
Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-manage and contact your doctor if the stomach pain did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not drink alcohol, as it can aggravate your dizziness. Contact your doctor if your dizziness did not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for managing diarrhoea. Contact your doctor if your diarrhoea did not improve.
Constipation:
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals and drink plenty of fluids. Exercise more regularly and stay active. Contact your doctor if constipation persists.
Loss of appetite:
Eat when you are hungry. Eat smaller meals more often than usual. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. Contact your doctor if your appetite did not improve.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Contact your doctor if flatulence persists.
Warning & Precautions
Pregnancy
PAMORELIN LA 11.25MG INJECTION is not recommended for use in pregnant women. Consult your doctor before receiving PAMORELIN LA 11.25MG INJECTION.
Use contraceptives method such as condom or diaphragm (cap) during management with PAMORELIN LA 11.25MG INJECTION and until menses resume.
Breastfeeding
PAMORELIN LA 11.25MG INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving PAMORELIN LA 11.25MG INJECTION.
Driving and Using Machines
Do not drive or operate any machines if you have dizziness, tiredness, sleep disturbances or insomnia, blurry vision after receiving PAMORELIN LA 11.25MG INJECTION.
Alcohol
Inform your doctor if you drink excessive amounts of alcohol as it might cause thinning of bones.
Kidney
PAMORELIN LA 11.25MG INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving PAMORELIN LA 11.25MG INJECTION.
Liver
PAMORELIN LA 11.25MG INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving PAMORELIN LA 11.25MG INJECTION.
Allergy
Do not receive PAMORELIN LA 11.25MG INJECTION if you are allergic to Triptorelin or similar other GnRH agonists or any of the other ingredients of PAMORELIN LA 11.25MG INJECTION.
Heart Disease
PAMORELIN LA 11.25MG INJECTION should be used with caution in patients with high blood pressure, heart rhythm problems, heart attack and heart failure. Consult your doctor before receiving PAMORELIN LA 11.25MG INJECTION.
Others
Before receiving PAMORELIN LA 11.25MG INJECTION, inform your doctor if you:
- or any of your family member have thinning of the bones
- smoke heavily
- have urinary obstruction or compressed nerves in your backbone due to spreading of your prostate cancer
- have surgical removal of testicles
- have diabetes (high blood sugar)
- have benign tumour of pituitary gland
- have pains in your bones or difficulty passing urine
- have back pain, weakness, numbness or tingling in your legs
- have progressive brain tumour (in children)
- have stroke, mini stroke
- have a low level of potassium, calcium or magnesium in your blood
- have a mental illness
- have fits
Use in pediatrics:
PAMORELIN LA 11.25MG INJECTION should be used with caution in children (girls under 9 years of age and boys under 10 years of age) for the management of early puberty. Consult your doctor before receiving PAMORELIN LA 11.25MG INJECTION.
PAMORELIN LA 11.25MG INJECTION is not recommended for use in adolescents and young girls (under 18 years of age) for the management of endometriosis as it might cause thinning of bone. Consult your doctor before receiving it.
Interactions
A. Drug - Drug interactions:
Before receiving PAMORELIN LA 11.25MG INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used to manage heart rhythm problems (Ex. quinidine, procainamide, amiodarone, sotalol)
- methadone (used to relieve pain and in drug dependence detoxification)
- moxifloxacin (used to manage bacterial infections)
- medicines used to manage serious mental illnesses (Ex. olanzapine, risperidone, haloperidol)
- medicines that increase the level of a hormone called prolactin (Ex. clomipramine)
- medicines used to delay blood clotting (Ex. heparin, warfarin)
- medicines used to manage fits (Ex. lamotrigine, carbamazepine)
- medicines used to manage inflammatory conditions (Ex. hydrocortisone, prednisolone)
- reserpine, methyldopa (used to manage high blood pressure)
- metoclopramide (used to manage nausea and vomiting)
- bupropion and selective serotonin reuptake inhibitors Ex. fluoxetine, sertraline and paroxetine (medicines used to manage depression)
Overdosage:
PAMORELIN LA 11.25MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms after receiving PAMORELIN LA 11.25MG INJECTION.
Synopsis
| Drug | : | Triptorelin |
| Pharmacological Category | : | Gonadotropin-releasing hormone (GnRH) agonists |
| Therapeutic Indication | : | Prostate cancer (men), Endometriosis, uterine fibroids (women), Central precocious puberty (children) |
| Dosage Forms | : | Injection |
More Information
- Keep PAMORELIN LA 11.25MG INJECTION out of reach of children
- Store PAMORELIN LA 11.25MG INJECTION below 25°C
FAQs About PAMORELIN LA 11.25MG INJECTION
Will PAMORELIN LA 11.25MG INJECTION lower my hormones immediately?
No. When you first start management with PAMORELIN LA 11.25MG INJECTION, it increases the level of your hormones for a short time, which may make you feel worse initially. After a short time of management with PAMORELIN LA 11.25MG INJECTION, your hormone levels will drop and your symptoms will improve.
Can PAMORELIN LA 11.25MG INJECTION affect my periods?
PAMORELIN LA 11.25MG INJECTION may cause some vaginal bleeding in the first month of management, after which your periods usually stop. Tell your doctor if you have bleeding after the first month of management. They resume approximately 5 months after the last dose of PAMORELIN LA 11.25MG INJECTION. In girls, menstrual bleeding will start on average one year after stopping management for early puberty.
Can I get pregnant while using PAMORELIN LA 11.25MG INJECTION?
PAMORELIN LA 11.25MG INJECTION is not recommended for use in pregnancy. You must use some form of contraception other than the ‘pill’ while you are having management and until you start your next period. Discuss with your doctor regarding use of barrier methods like a condom or diaphragm while receiving PAMORELIN LA 11.25MG INJECTION.
Can I stop receiving PAMORELIN LA 11.25MG INJECTION?
Receive PAMORELIN LA 11.25MG INJECTION as advised by your doctor. Do not stop using PAMORELIN LA 11.25MG INJECTION unless your doctor advised you to stop. Otherwise, your symptoms are likely to return.
Does PAMORELIN LA 11.25MG INJECTION cause weight gain?
PAMORELIN LA 11.25MG INJECTION may cause weight gain- especially in the waist. Eat a healthy diet and getting regular exercise can help you control your weight. Contact your doctor if any of the symptoms worsen.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Prostate cancer. Pharmacotherapy Handbook. Ninth edition. 2015. Page- 663.
2. Bethesda (MD). Triptorelin. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. March 2022. [Accessed on 11th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK548756/
3. Chiocca E, Dati E, Baroncelli GI, Cassio A, Wasniewska M, Galluzzi F, Einaudi S, Cappa M, Russo G, Bertelloni S. Central precocious puberty: treatment with triptorelin 11.25 mg. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. May 2012. [Accessed on 11th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356708/
4. Jean- Claude Carel. Treatment of precocious puberty by GnRH agonists. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed.gov. October 2005. [Accessed on 11th June 2022] https://pubmed.ncbi.nlm.nih.gov/16302717/
5. Ipsen. A Study to Describe the Efficacy of Diphereline Following Conservative Surgery in Deep Infiltrating Endometriosis (DIE) Patients Over a Period of 24 Months (DIE-NIS). NIH U.S. National Library of Medicine ClinicalTrials.gov. December 2018. [Accessed on 11th June 2022] https://clinicaltrials.gov/ct2/show/NCT01942369
6. Ipsen Pharma Biotech. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 11th June 2022] https://www.medicines.org.uk/emc/files/pil.780.pdf
7. Ferring GmbH. Electronic Medicines Compendium (EMC). [Revised in October 2019] [Accessed on 11th June 2022] https://www.medicines.org.uk/emc/files/pil.2229.pdf
8. Ferring GmbH. Health Products Regulatory Authority (HPRA). [Revised in October 2019] [Accessed on 11th June 2022] http://www.hpra.ie/img/uploaded/swedocuments/7143c597-b1e4-450f-9704-fc5131582ad9.pdf
Useful Diagnostic Tests
- Digital rectal exam (DRE)
- Prostate-specific antigen (PSA) test
- Laparoscopy
- GnRH stimulation test
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