Ondero 5mg Tablet 10'S

Introduction About ONDERO 5MG TABLET

Ondero 5mg Tablet contains Linagliptin, an anti-diabetic medication used to manage type 2 diabetes mellitus. It works by inhibiting the DPP-4 enzyme, which helps increase incretin hormone levels in the body. This enhances insulin secretion and reduces excess glucose production in the liver, helping to control blood sugar levels effectively. Ondero 5mg Tablet is usually prescribed along with a proper diet and exercise routine to achieve better glycemic control.

This tablet is typically taken once daily, with or without food, as directed by the doctor. It is suitable for patients with kidney impairment as it does not require dose adjustments based on kidney function. However, it should not be used in individuals with type 1 diabetes or diabetic ketoacidosis. Regular monitoring of blood sugar levels is recommended to prevent the risk of hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar), especially if combined with other diabetes medications like sulfonylureas or insulin.

Common side effects of Ondero 5mg Tablet include stuffy nose, sore throat, headache, and mild hypoglycemia when used with other antidiabetic drugs. Serious side effects, though rare, may include pancreatitis (severe abdominal pain) or allergic reactions. It is important to inform the doctor about any pre-existing medical conditions and ongoing medications before starting this treatment. Maintaining a healthy lifestyle with a balanced diet and regular physical activity can enhance the effectiveness of this medication in managing diabetes.

Uses Of ONDERO 5MG TABLET

• Manage type 2 diabetes mellitus in adults

Benefits of ONDERO 5MG TABLET

1. Effective Blood Sugar Control

Ondero (Linagliptin) helps to lower blood glucose levels by inhibiting the DPP-4 enzyme, which increases insulin production and reduces glucagon secretion, thereby controlling blood sugar levels more effectively?

2. No Dose Adjustment for Renal Impairment

Unlike many other diabetes medications, Ondero 5mg does not require dose adjustment for patients with kidney disease, making it a safer choice for those with compromised kidney function?

3. Minimal Risk of Hypoglycemia

When used alone, Ondero carries a lower risk of causing hypoglycemia compared to other diabetes medications like sulfonylureas or insulin?

How ONDERO 5MG TABLET Works

Ondero 5mg Tablet contains Linagliptin, which helps lower blood sugar in people with type 2 diabetes. It works by blocking an enzyme called DPP-4, which normally breaks down hormones called incretins. Incretins help the body release more insulin when blood sugar is high and reduce sugar production in the liver. By preventing their breakdown, Linagliptin increases insulin levels and decreases sugar release from the liver, keeping blood sugar stable. Unlike some other diabetes medicines, it has a lower risk of causing dangerously low blood sugar (hypoglycemia) and is safe for people with kidney problems.

How to use ONDERO 5MG TABLET

How To Take Ondero 5mg Tablet?

• Take one tablet (5mg) once daily, or as directed by your doctor.
• You can take it with or without food at any time of the day, but try to take it at the same time each day for the best results.
• Swallow the tablet whole with water; do not crush, chew, or break it.

What is the correct dosage of Ondero 5mg Tablet?

1. Adult Dosage:

• Standard Dosage: The typical dosage for Ondero 5mg tablet (Linagliptin) is 5 mg once daily.
• It can be taken with or without food?

2. Special Populations:

• Elderly Patients: The dosage remains the same for elderly individuals unless there is a specific medical condition requiring changes?

What if I forgot to take ONDERO 5MG TABLET

If a dose of Ondero 5mg is missed, the patient should take it as soon as they remember, unless it is close to the time for the next dose. In that case, they should skip the missed dose and continue with their regular schedule. Do not double up on doses?

Overdose

In case of an overdose, symptoms of hypoglycemia may occur, though Ondero is not typically associated with causing significant hypoglycemia. Immediate medical attention should be sought if an overdose is suspected?.

Side Effects Of ONDERO 5MG TABLET

Like all medicines, Ondero 5 mg Tablet may cause certain side effects, although not everybody gets them.

What are the common side effects of Ondero 5mg Tablet?

• Stuffy or runny nose
• Sore throat
• Cough
• Diarrhoea

What are the rare but serious side effects of Ondero 5mg Tablet?

Stop taking ONDERO 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• Signs of low blood sugar (hypoglycaemia) (such as trembling, sweating, anxiety, blurred vision, tingling lips, paleness, mood change or confusion, headache, drowsiness, weakness, dizziness, irritability, hunger, fast heartbeat, shaking or feeling jittery)
• Signs of serious allergic reactions (such as swelling of your face, lips, tongue, throat, and other areas on skin, difficulty with swallowing or breathing, raised red areas on the skin (hives), skin rash, itching, flaking or peeling of the skin)
• Signs of inflamed pancreas (pancreatitis) (such as severe and persistent stomach pain, nausea and vomiting)
• Bullous pemphigoid (blisters or breakdown of the outer skin layer (erosion))
• Heart failure symptoms (such as increasing shortness of breath or trouble breathing, especially when you lie down, swelling or fluid retention, especially in the feet, ankles or legs, an unusually fast increase in weight, unusual tiredness)

Does Ondero 5mg Tablet cause hypoglycemia?

Ondero 5mg Tablet (Linagliptin) generally does not cause hypoglycemia when used alone, as it works by increasing insulin production in response to elevated blood glucose levels without directly lowering blood sugar in the absence of food or insulin. However, when used in combination with other medications like insulin or sulfonylureas, which can increase insulin levels, there is a risk of hypoglycemia (low blood sugar)?

Can Ondero 5mg Tablet cause skin reactions?

Skin reactions are a rare side effect of Ondero 5mg Tablet. Common side effects include symptoms like nasopharyngitis or respiratory issues. Though not very common, allergic reactions, including skin rashes or itching, can occur in some individuals. If you notice any unusual skin reactions, it's important to seek medical advice immediately

How To Manage Side Effects

Diarrhea

1. Stay Hydrated

• Diarrhea can lead to dehydration, so it's important to replace lost fluids. Drink water, oral rehydration solutions (ORS), broth, or clear juices to prevent dehydration. Avoid sugary drinks, caffeinated beverages, and alcohol, as they can worsen dehydration .

2. Eat a Bland Diet (BRAT Diet)

• A bland diet like the BRAT diet (Bananas, Rice, Applesauce, Toast) can help soothe your stomach. These foods are easy to digest and can help firm up stools .
• Other good options include boiled potatoes, plain crackers, and chicken without skin or fat.

3. Avoid Dairy Products

• Some people may experience lactose intolerance after an episode of diarrhea. It's a good idea to avoid dairy products like milk and cheese until your stomach settles .

4. Rest

• Resting allows your body to recover and helps prevent further strain on your digestive system .

5. Avoid Spicy or Fatty Foods

• Avoid foods that are hard to digest, such as spicy or fatty foods, which may irritate the stomach and make diarrhea worse.

Warning & Precautions

Pregnancy

Consult your doctor

Ondero 5 mg Tablet is generally not recommended for use in pregnant women as it is unknown if it is harmful to the unborn child. Consult your doctor before taking it. In animal studies, Linagliptin did not show any teratogenic effects (i.e., causing malformations) in rats and rabbits at doses far higher than those used in humans but there are no well-controlled studies in pregnant women. Therefore, consult your doctor before taking this medicine if you are pregnant or think you may be pregnant.

Breastfeeding

Consult your doctor

It is not known if Ondero 5 mg Tablet passes though breast milk. Consult your doctor before taking it. Animal studies showed Linagliptin is excreted in breast milk. In these studies, the concentration was low, but the effect on nursing infants has not been fully studied.

Driving and Using Machines

Use with Caution

Ondero 5 mg Tablet has no or negligible effect on the ability to drive or use machines. Consult your doctor if you feel any side effects during management that may stop you from driving or using machines.

Alcohol

Consult your doctor

Ondero 5 mg Tablet should be used with caution in patients with a history of alcoholism. Consult your doctor before taking it.

Kidney

Use with Caution

Ondero 5 mg Tablet should be taken with caution in patients with kidney problems. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take Ondero 5 mg Tablet if you are allergic to Linagliptin. Inform your doctor if you had an allergic reaction to any other medicines that you take to control blood sugar levels.

Heart Disease

Use with Caution

Ondero 5 mg Tablet should be taken with caution in patients with a history of heart failure. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

Ondero 5 mg Tablet is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

Ondero 5 mg Tablet should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.

Other Warnings for ONDERO 5MG TABLET

Before taking Ondero 5 mg Tablet, inform your doctor if you:

• Have type 1 diabetes (body does not produce any insulin)
• Have diabetic ketoacidosis (complication of diabetes with high blood sugar, rapid weight loss, nausea or vomiting)
• Have or have had a disease of the pancreas
• Have diabetic skin lesions

Drug - Drug interaction

1. Insulin and Insulin Secretagogues (e.g., Sulfonylureas):

• Ondero 5mg Tablet (Linagliptin) can be used in combination with insulin or insulin secretagogues like sulfonylureas, but this combination may increase the risk of hypoglycemia (low blood sugar). If these medications are used together, your healthcare provider may need to adjust the insulin or sulfonylurea dose to reduce this risk?

2. Metformin:

• Ondero can be safely combined with metformin, a common medication for Type 2 diabetes, as there are no significant interactions between the two. In fact, this combination is often used for enhanced glycemic control?

3. Other Antidiabetic Medications:

• Ondero does not interact significantly with other antidiabetic agents like glyburide, pioglitazone, or sitagliptin?

4. CYP Enzyme Interaction:

• Ondero (Linagliptin) is a weak inhibitor of CYP3A4, an enzyme involved in the metabolism of many medications. However, Ondero does not significantly interfere with the activity of other CYP enzymes, meaning it is less likely to cause significant drug interactions compared to other drugs that strongly inhibit CYP enzymes?

5. Warfarin (Coumadin):

• Ondero does not cause significant interactions with warfarin, an anticoagulant. However, when combining any drug with warfarin, it is crucial to monitor the International Normalized Ratio (INR) to ensure blood clotting levels remain stable?.

6. Digoxin:

• Similarly, Ondero does not interact significantly with digoxin, a heart medication. However, any changes in kidney function should be closely monitored?

7. Other Medications:

• There are no major interactions between Ondero and common drugs like statins (e.g., atorvastatin), antihypertensives, or oral contraceptives?

Drug - Food interaction

1. Alcohol:

• Alcohol consumption should be avoided or limited while taking Ondero, as alcohol can lead to hypoglycemia (low blood sugar), especially if consumed on an empty stomach or after exercise. Chronic alcohol use may also affect glucose tolerance. Therefore, it's advised that individuals with diabetes restrict alcohol intake to one drink per day for women and two for men?

2. High-Fat Meals:

• While Ondero can be taken with or without food, high-fat meals may slightly reduce its peak concentration in the bloodstream but not to a clinically significant extent. Therefore, it's generally safe to take Ondero with meals, but individuals should avoid excessively fatty or greasy foods?

3. Foods Impacting Glucose Levels:

• As Ondero works by improving insulin response, it's important to maintain a balanced diet to optimize its effectiveness. Foods rich in simple sugars or carbs may increase blood sugar, so these should be limited. A consistent low glycemic index (GI) diet is recommended to support overall diabetes management?

Synopsis

More Information

Alternatives to Ondero 5mg

• Januvia 100mg Tablet (Sitagliptin)
• Trajenta 5mg Tablet (Linagliptin)
• Glyxambi 25mg/5mg Tablet (Empagliflozin + Linagliptin)

Linagliptin Vs. Other Antidiabetic Agents

FAQs About ONDERO 5MG TABLET

References

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-275.
2. Rachael Aletti, Angela Cheng-Lai. Linagliptin: the newest dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. February 2012. [Accessed on 27th March 2025] Click here
3. Boehringer Ingelheim Hellas Single Member S.A. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 27th March 2025] Click here
4. Boehringer Ingelheim Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in June 2023] [Accessed on 27th March 2025] Click here

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 27 Mar 2025 | 02:51 PM(IST)