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Introduction About OLSAR AH TABLET
OLSAR AH TABLET is a combination of Amlodipine, Hydrochlorothiazide and Olmesartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) when management with single agents is not effective.
Hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels supplying several vital organs, such as heart, kidney, or brain. If left unmanageed, it may cause serious complications such as heart attack, heart failure, stroke or even blindness.
During management with OLSAR AH TABLET your doctor will constantly monitor your kidney functions, blood pressure, electrolyte levels and blood sugar levels to avoid the risk of unwanted side effects. Avoid eating grapefruit or drinking grapefruit juice while taking OLSAR AH TABLET as it may severely decrease your blood pressure.
Before taking OLSAR AH TABLET inform your doctor if you have any heart, liver, or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea.
OLSAR AH TABLET is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby. Stop taking OLSAR AH TABLET and inform your doctor immediately if you become pregnant while undergoing therapy with OLSAR AH TABLET.
The most common side effects of taking OLSAR AH TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, muscle cramps and swollen ankles. Contact your doctor if any of these side effect worsens.
Uses Of OLSAR AH TABLET
- Manage Hypertension (high blood pressure)
How OLSAR AH TABLET Works
OLSAR AH TABLET is an antihypertensive medicine. It relaxes your blood vessels and improves blood flow across them. It also reduces thickness of the blood by removing excess fluids from the body in the form of urine. Collectively, these actions reduce the strain on the heart and helps the heart to pump blood more smoothly with less pressure.
How to use OLSAR AH TABLET
Take OLSAR AH TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Try to take OLSAR AH TABLET at the same time each day. OLSAR AH TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Continue to take OLSAR AH TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.
Side Effects Of OLSAR AH TABLET
Common
- low blood pressure
- swelling of ankles and legs (edema)
- headache, dizziness
- nausea, vomiting, stomach pain, constipation, diarrhea, indigestion
- sleepiness or lack of sleep
- abnormal heartbeat (fast or slow)
- muscle cramps
- chest pain, back pain, joint pain
- cough, sore throat, sinus infections, nasal congestion
- high blood potassium levels
- low blood sugar levels
- urinary tract infections
- increased blood cholesterol levels
- increased uric acid levels in blood
Uncommon
- feeling depressed or anxious, changes in mood
- vertigo (spinning sensation), shakiness
- increased sweating
- back pain, tingling of numbness of body parts
- changes in taste
- ringing in the ears
- dry nose, dry mouth
- hair loss
- impotence (inability to obtain an erection), breast enlargement in men
- changes in body weight
- anemia
Rare
Stop taking OLSAR AH TABLET and contact your doctor immediately if you experience any of the following side effects such as:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
- skin rashes or lesions
- eye pain or decrease in vision
- orthostatic hypotension (dizziness while standing up from sitting or lying position)
- severe chronic diarrhea with weight loss
- signs of kidney problems (such as edema, tiredness, bloody urine)
How To Manage Side Effects
Nausea and vomiting:
Take OLSAR AH TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
OLSAR AH TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking OLSAR AH TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with OLSAR AH TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
OLSAR AH TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking OLSAR AH TABLET.
Alcohol
Avoid consumption of alcohol while taking OLSAR AH TABLET as it might make you feel dizzier and drowsier.
Kidney
OLSAR AH TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.
Liver
OLSAR AH TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take OLSAR AH TABLET if you are allergic to Amlodipine, Olmesartan or Hydrochlorothiazide.
Heart Disease
OLSAR AH TABLET is not recommended for use in patients with serious heart problem (such as heart failure or heart attack). It should be used with caution in patients with heart problems (such as irregular heart rhythm and problems with heart muscle or valves). Therefore, consult your doctor before taking it.
Others
OLSAR AH TABLET is not recommended for use if you:
- have cardiogenic shock (heart cannot pump blood suddenly)
- have diabetes related kidney problems
Before taking OLSAR AH TABLET, inform your doctor if you:
- have primary hyperaldosteronism (problems in adrenal gland)
- have low blood pressure
- are severely dehydrated (due to diarrhea, vomiting or excess sweating)
- are on a low-salt diet
- have diabetes
- have hyperkalemia (high blood potassium levels)
- have unstable angina (a type of chest pain)
- have narrowing of arteries
- have gout (painful joints)
- have had skin cancer
Use in pediatrics:
OLSAR AH TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
Use in geriatrics:
OLSAR AH TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
- medicines used to manage bacterial infections (Ex. erythromycin, clarithromycin, telithromycin, trimethoprim)
- medicine used to manage HIV infection (Ex. indinavir, ritonavir, saquinavir)
- medicines used to manage fungal infections (Ex. itraconazole, ketoconazole and fluconazole)
- medicines used for heart problems (such as verapamil, diltiazem)
- dantrolene (a medicine used to manage muscle spasms)
- medicines to suppress immune system (Ex. cyclosporin, tacrolimus, sirolimus, temsirolimus and everolimus)
- simvastatin, cholestyramine and colestipol (medicines to lower the cholesterol)
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
- antidepressants such as lithium, citalopram, fluoxetine, paroxetine, nefazodone, St. John’s wort (herbal medicine used to manage depression)
- other medicines used to manage elevated blood pressure (such as aliskiren, bosentan, methyldopa, guanethidine, captopril, enalapril, lisinopril, verapamil, diltiazem, losartan, valsartan)
- other diuretics (used to reduce edema) Ex. furosemide, bumetanide
- adrenaline or nor-adrenaline (used for low blood pressure, shock, cardiac failure, asthma or allergies)
- medicines used to manage gout (such as probenecid, sulfinpyrazone and allopurinol)
- laxatives (used to manage constipation) Ex. lactulose
- glycyrrhizin (a medicine used to reduce bronchitis)
- anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagliptin, metformin
- corticosteroids (used to manage inflammation) Ex. prednisolone
- iodinated contrast agents (used during X-ray procedures)
- atropine (a medicine used to improve heart rate)
- biperiden (a medicine used to manage parkinsonism)
- antipsychotics (used to manage serious mental illnesses) Ex. clozapine, risperidone
- medicines used to relieve pain (Ex. morphine, aspirin, diclofenac, diflunisal, celecoxib, valdecoxib)
B. Drug-Food interactions:
Do not eat grapefruit or drink grapefruit juice while taking OLSAR AH TABLET as it may increase the risk of side effects
Overdosage:
If you or anyone else accidentally took more OLSAR AH TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, and dizziness.
Synopsis
| Drug | : | Amlodipine, Olmesartan, Hydrochlorothiazide |
| Pharmacological Category | : | Calcium channel blocker, Angiotensin II Receptor Blocker, Thiazide diuretics |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet |
More Information
- Keep OLSAR AH TABLET out of reach of children
- Store OLSAR AH TABLET at room temperature
FAQs About OLSAR AH TABLET
What are the uses of OLSAR AH TABLET?
OLSAR AH TABLET is used to manage hypertension.
What type of a medicine is OLSAR AH TABLET?
OLSAR AH TABLET is an antihypertensive medicine. It relaxes your blood vessels and improves blood flow across them. It also reduces thickness of the blood by removing excess fluids from the body in the form of urine. Collectively, these actions reduce the strain on the heart and helps the heart to pump blood more smoothly with less pressure.
What happens when I stop taking OLSAR AH TABLET?
Do not stop taking OLSAR AH TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take OLSAR AH TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
What is the best time to take OLSAR AH TABLET?
OLSAR AH TABLET can be taken with or without meals. Your doctor will decide the best time for you to take OLSAR AH TABLET based on your age, body weight and disease condition.
What to do if I forgot to take a dose of OLSAR AH TABLET?
If you forgot to take a dose of OLSAR AH TABLET, take it as soon as you remember. However, if it is time for the next dose of OLSAR AH TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of OLSAR AH TABLET to compensate the missed ones.
What precautions should be followed while taking OLSAR AH TABLET?
Before taking OLSAR AH TABLET, inform your doctor if you have any heart, liver or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated. Stop taking OLSAR AH TABLET and consult your doctor immediately if you become pregnant. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Can I consume alcohol while taking OLSAR AH TABLET?
Avoid consumption of alcohol while taking OLSAR AH TABLET as it might make you feel dizzier and drowsier.
What happens if I accidentally take more OLSAR AH TABLET?
If you or anyone else accidentally took more OLSAR AH TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, fainting, drowsiness, nausea, vomiting or confusion.
Can I take OLSAR AH TABLET daily?
Take OLSAR AH TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take OLSAR AH TABLET every day or not.
Is OLSAR AH TABLET safe to use in diabetic patients?
OLSAR AH TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking OLSAR AH TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
What are the side effects of OLSAR AH TABLET?
The most common side effects of taking OLSAR AH TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, muscle cramps and swollen ankles. Contact your doctor if any of these side effect worsens.
Can I stop taking OLSAR AH TABLET once my symptoms subside?
No. Do not stop taking OLSAR AH TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take OLSAR AH TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Can OLSAR AH TABLET be taken during pregnancy?
OLSAR AH TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking OLSAR AH TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with OLSAR AH TABLET, stop taking it and consult your doctor immediately.
Is OLSAR AH TABLET safe to use in kidney disease?
OLSAR AH TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems (such as kidney transplant, narrowing of renal arteries). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking OLSAR AH TABLET as a precaution.
Can the use of OLSAR AH TABLET affect the liver?
Yes. OLSAR AH TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.
References
1. KD. Tripathi. Antihypertensive Drugs. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 559, 505-508, 561 & 562.
2. Lars C. Rump, MD, PhD, Bettina Ammentorp, Petra Laeis, and Jürgen Scholze, MD, PhD. Adding Hydrochlorothiazide to Olmesartan/Amlodipine Increases Efficacy in Patients With Inadequate Blood Pressure Control on Dual-Combination Therapy. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2015. [Accessed on 13th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034748/
3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 13th December 2022] https://www.medicines.org.uk/emc/files/pil.3478.pdf
4. Bristol Laboratories Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 13th December 2022] https://www.medicines.org.uk/emc/product/11442/smpc#DOCREVISION
5. Mylan Pharmaceuticals Inc. U.S. Food and Drug Administration. HYDROCHLOROTHIAZIDE TABLETS, USP 12.5 mg, 25 mg and 50 mg. [Revised in May 2011] [Accessed on 13th December 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/040735s004,040770s003lbl.pdf
6. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 13th December 2022] https://www.medicines.org.uk/emc/files/pil.9886.pdf
7. Cipla Ltd. OLMECIP TRIO Tablets (Olmesartan medoxomil + Hydrochlorothiazide + Amlodipine besylate). Ciplamed.com. [Revised in February 2020]. [Accessed on 13th December 2022] https://www.ciplamed.com/content/olmecip-trio-tablets
8. Central Drugs Standard Control Organization. Amlodipine Besilate IP eq.to Amlodipine 10mg/5mg/5mg/5mg/2.5mg + Olmesartan Medoxomil 40mg/40mg/20mg/5mg/5mg + Hydrochlorothiazide IP 25mg/12.5mg/12.5mg/12.5mg/12.5mg Tablet. November 2011. [Accessed on 13th December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Kidney Function Test
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