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Introduction About NOCULI SOLUTION
NOCULI SOLUTION is a combination of Potassium citrate and Magnesium citrate which belongs to the group of medicines called Urinary alkalizers and Saline laxatives respectively. It is used in the management of renal tubular acidosis with calcium stones and kidney stones (hypocitraturic calcium oxalate nephrolithiasis and uric acid lithiasis with or without calcium stones).
Renal tubular acidosis is a condition in which the kidneys do not remove acids from the blood into the urine as they usually should. Before taking NOCULI SOLUTION, your doctor might want you to take certain blood tests and ECG to understand your existing condition.
NOCULI SOLUTION is not recommended for use in patients with hyperkalemia (high potassium levels in the blood), gastrointestinal disease, peptic ulcer disease, urinary tract infection and kidney disease.
NOCULI SOLUTION is not recommended for use in pregnant and breastfeeding women unless it is clearly advised by the doctor. Safety and effectiveness of NOCULI SOLUTION in children has not been established yet. The most common side effects of taking NOCULI SOLUTION are abdominal discomfort, nausea, vomiting and diarrhea.
Uses Of NOCULI SOLUTION
Manages,
- renal tubular acidosis (RTA) with calcium stones
- hypocitraturic calcium oxalate nephrolithiasis
- uric acid lithiasis (with or without calcium stones)
How NOCULI SOLUTION Works
NOCULI SOLUTION works by reducing the kidney stone formation. Potassium citrate and magnesium citrate, causes the metabolism of absorbed citrate producing an alkaline load. In addition to raising urinary pH and citrate, this also increases urinary potassium and magnesium. In certain patients, potassium citrate causes a transient reduction in urinary calcium. These changes produce urine that is less helpful to the crystallization of stone-forming salts.
How to use NOCULI SOLUTION
Take NOCULI SOLUTION as advised by your physician. Shake well before use. Use a measuring cup or spoon to properly measure a dose. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of NOCULI SOLUTION
Common
- abdominal discomfort
- nausea, vomiting
- diarrhea
- loose bowel movements
Rare
Stop taking NOCULI SOLUTION and contact your doctor immediately if you experience any of the following side effects:
- severe abdominal pain, vomiting or gastrointestinal bleeding
How To Manage Side Effects
Diarrhea
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Try to take NOCULI SOLUTION with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich, fried or spicy foods. Consult your doctor if the symptom does not improve.
Stomach Pain
Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
Monitoring requiredNOCULI SOLUTION should be used in pregnant woman only if considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
Monitoring requiredNOCULI SOLUTION should be used in breast-feeding woman only if considered clearly necessary. Consult your doctor before taking it.
Kidney
ContraindicatedNOCULI SOLUTION is not recommended for use in patients with renal insufficiency. Consult your doctor before taking it.
Allergy
Do not take NOCULI SOLUTION if you are allergic to potassium citrate or magnesium citrate.
Heart Disease
ContraindicatedNOCULI SOLUTION is not recommended for use in patients with severe myocardial damage or heart failure because it impairs the excretion of potassium. Consult your doctor before taking it.
Use In Pediatrics
Consult your doctorSafety and effectiveness of NOCULI SOLUTION have not been established yet in children. Consult your child’s doctor for advice.
Others
NOCULI SOLUTION is not recommended for use if you:
- have hyperkalemia (increased level of potassium in the blood) or pre-disposing factor of hyperkalemia (such as uncontrolled diabetes mellitus, acute dehydration, strenuous physical exercise in unconditioned individuals, adrenal insufficiency, extensive tissue breakdown)
- have cause for arrest or delay in passage through the gastrointestinal tract (such as those suffering from delayed gastric emptying, esophageal compression, intestinal obstruction or stricture)
- have peptic ulcer disease
- have urinary tract infection
Interactions
A. Drug - Drug interactions:
Before taking NOCULI SOLUTION, inform your doctor if you are taking any of the following medicines:
- potassium sparing diuretic Ex. triamterene, spironolactone or amiloride (used to manage high blood pressure and congestive heart failure)
- anticholinergics Ex. clozapine, thorazine (used to control schizophrenia)
Overdosage:
If you or anyone else accidentally take too much of NOCULI SOLUTION, consult your doctor immediately or visit the nearby hospital. Overdosage symptom of NOCULI SOLUTION is hyperkalemia (increased potassium in the blood).
Synopsis
| Drug | : | Potassium citrate, Magnesium citrate |
| Pharmacological Category | : | Urinary alkalizer , Saline laxative |
| Therapeutic Indication | : | Renal tubular acidosis (RTA) with calcium stones, Hypocitraturic calcium oxalate nephrolithiasis, Uric acid lithiasis |
| Dosage Forms | : | Oral solution, Oral suspension, Syrup, Tablet |
More Information
- Keep NOCULI SOLUTION out of reach of children
- Store at room temperature
FAQs About NOCULI SOLUTION
Q: What is NOCULI SOLUTION used for?
A: NOCULI SOLUTION is used in the management of renal tubular acidosis with calcium stones and kidney stones (hypocitraturic calcium oxalate nephrolithiasis and uric acid lithiasis with or without calcium stones).
Q: Can NOCULI SOLUTION be used by pregnant women?
A: NOCULI SOLUTION should be used in pregnant woman only if considered clearly necessary. Consult your doctor before taking this medicine if you are pregnant or planning to get pregnant.
Q: Is NOCULI SOLUTION safe to use in patients with heart problems?
A: NOCULI SOLUTION is not recommended for use in patients with severe myocardial damage or heart failure because it impairs the excretion of potassium. Consult your doctor before taking it.
Q: Can NOCULI SOLUTION be used in children?
A: Safety and effectiveness of NOCULI SOLUTION have not been established yet in children. Consult your child’s doctor for advice to select a suitable alternative therapy for your child to manage the specific condition.
Q: Does NOCULI SOLUTION cause diarrhea?
A: Yes, NOCULI SOLUTION may cause diarrhea in some individuals. To manage this effect, drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom does not improve.
References
1. Goodman Gilmans. Treatment of disorder of bowl motility and water flux. The Pharmacological Basis of Therapeutics. Twelfth Edition. 2011. Page –1331
2. B Ettinger, C Y Pak, J T Citron, C Thomas, B Adams-Huet, A Vangessel. Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 1997. [Accessed on 31st May 2022] https://pubmed.ncbi.nlm.nih.gov/9366314/
3. Cipla Ltd. Ston1 oral solution (Potassium citrate + Magnesium citrate) Ciplamed. [Revised in April 2016] [Accessed on 31st May 2022] https://www.ciplamed.com/content/ston1-oral-solution
Useful Diagnostic Tests
- Uric acid test
- Abdominal ultrasound
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