Nitroplus Injection 5ml

Introduction About NITROPLUS INJECTION

NITROPLUS INJECTION contains Nitroglycerin (Glyceryl trinitrate) which belongs to the group of medicines called Vasodilators. It is used in adults to control blood pressure during operations or to improve blood flow during and after heart operations.

NITROPLUS INJECTION can also be given to you after you have had a heart attack or to control angina attacks (sudden pains in chest) when other medicines have failed to work. Angina is a type of chest pain occurring because of reduced blood flow to the heart. Symptoms includes chest pain, difficulty in breathing, dizziness, tiredness etc.

NITROPLUS INJECTION is not recommended to use in patients who have heart or lung diseases, decreased blood pressure, increased pressure within skull, bleeding in brain, anemia, low levels of oxygen in blood or if you are taking medicines to manage erectile function (sildenafil) or increased pressure in the lungs (riociguat).

NITROPLUS INJECTION is generally not recommended for use in pregnant women unless considered clearly necessary by the doctor. NITROPLUS INJECTION is not intended for use in breast-feeding women as it may pass through breast milk and children. Take your doctor’s advice before receiving NITROPLUS INJECTION.

Before receiving NITROPLUS INJECTION inform your doctor if you have severe liver or kidney diseases, malnourishment, low body temperature, thyroid diseases, closed angle glaucoma (increased pressure inside eyes).

Most common side effects of receiving NITROPLUS INJECTION includes headache, abnormal heartrate, weakness, drowsiness, dizziness (while getting up from sitting position), weakness. Consult your doctor if any of these symptoms doesn’t improve or worsen.

Uses Of NITROPLUS INJECTION

It is used to,

• control blood pressure during operations
• improve blood flow during and after heart surgery
• control anginal attacks (sudden pains in chest) when other medicines have failed to work
• manage patients having a history of heart attack

How NITROPLUS INJECTION Works

NITROPLUS INJECTION causes relaxation of smooth muscles within blood vessels which leads to relaxation and widening of blood vessels. This improves blood supply to the heart muscles. As a result, it helps to relieve chest pain and blood pressure.

How to use NITROPLUS INJECTION

NITROPLUS INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion (drip). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of condition.

Side Effects Of NITROPLUS INJECTION

How To Manage Side Effects

Headache:

Drink plenty of water and stay hydrated. Take adequate rest and sleep. Try to be stress and tension free. Avoid drinking alcohol. Reduce screen time. Apply pain balm if needed. Consult doctor before taking any medicines.

Dizziness:

Sit or lie down soon after you feel dizzy. Do not drive or operate any machines. Drink enough water. Consult doctor if it is worsening.

Nausea:

Stick to simple meals while receiving this medicine. Avoid eating rich or spicy food. Do not take any medication by yourself. Ask for your doctor’s advice if nausea doesn’t improve or worsen.

Vomiting:

Drink clear or ice-cold drinks. Eat bland, light foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve or worsen.

Warning & Precautions

Pregnancy

NITROPLUS INJECTION is generally not recommended for use in pregnant women unless considered clearly necessary by the doctor. Take your doctor’s advice before receiving. Inform your doctor if you get pregnant in between the course of management with NITROPLUS INJECTION.

Breastfeeding

NITROPLUS INJECTION is not recommended to be used in feeding women as it may pass through the breast milk. Consult your doctor before receiving it.

Driving and Using Machines

Do not drive and operate machines if you feel dizzy after receiving NITROPLUS INJECTION.

Alcohol

Avoid consuming alcohol while receiving NITROPLUS INJECTION as it may affect your ability to judge and how fast you react.

Kidney

NITROPLUS INJECTION is generally not recommended in patients having severe kidney diseases unless considered clearly necessary by the doctor. Consult your doctor before receiving.

Liver

NITROPLUS INJECTION is generally not recommended in patients having with severe liver diseases unless considered clearly necessary by the doctor. Consult your doctor before receiving.

Allergy

Do not receive NITROPLUS INJECTION if you are allergic to Nitroglycerine, other organic nitrates such as isosorbide dinitrate and isosorbide mononitrate or any other ingredients of this medicine.

Lungs

Do not receive NITROPLUS INJECTION if you are allergic to Nitroglycerine, other organic nitrates such as isosorbide dinitrate and isosorbide mononitrate or any other ingredients of this medicine.

Heart Disease

NITROPLUS INJECTION is not recommended to be given in patients with heart diseases such as inflammation of the outer lining of the heart or compression of the heart due to the collection of fluid around the heart, or angina pectoris (pain or uncomfortable feeling in the chest). Consult doctor before receiving NITROPLUS INJECTION.

Interactions

A. Drug – Drug interactions

 Before receiving NITROPLUS INJECTION inform your doctor if you are taking any of the following:

• medicine used to manage erectile dysfunction (Ex. sildenafil)
• medicine used to manage increased pressure in lungs (Ex. riociguat)
• medicine used to manage increased blood pressure (Ex. enalapril, verapamil, propranolol)
• medicines used to manage depression (Ex. amitriptyline, amoxapine, desipramine)
• medicine used to relieve pain (Ex. morphine)
• medicine used to manage blood clotting (Ex. heparin)

Overdosage

NITROPLUS INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like headache, confusion, fever; vertigo, increased heartrate, altered vision, nausea and vomiting, syncope (low blood pressure and fainting), difficulty to breath, heart block, decreased heartrate, paralysis, coma, fits and death. Some cases of methemoglobinemia (blood disorder) are also noticed.

Synopsis

More Information

• Keep NITROPLUS INJECTION out of reach of children.
• Store NITROPLUS INJECTION at a temperature of 2-8°C

FAQs About NITROPLUS INJECTION

What is NITROPLUS INJECTION used for?

NITROPLUS INJECTION It is used in adults to control blood pressure during operations or to improve blood flow during and after heart operations. NITROPLUS INJECTION can also be given to you after you have had a heart attack or to control angina attacks (sudden pains in chest) when other medicines have failed to work. Consult doctor before receiving.

How is NITROPLUS INJECTION administered?

NITROPLUS INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion (drip). It should not be given as an injection (bolus form). NITROPLUS INJECTION should not be given for more than 3 days. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of disease condition.

What are the most common side effects of receiving NITROPLUS INJECTION?

Most common side effects of receiving NITROPLUS INJECTION includes headache, abnormal heartrate, weakness, increased sleeping tendency, dizziness (while getting up from sitting position), decreased blood pressure. Consult your doctor if any of these symptoms are worsening

Is it safe to use NITROPLUS INJECTION in children?

No. NITROPLUS INJECTION is not recommended for use in children as the safety and effectiveness of NITROPLUS INJECTION is not established in children. Consult with your child’s doctor for advice.

Can I drive after receiving NITROPLUS INJECTION?

Do not drive and operate machines if you feel dizzy after receiving NITROPLUS INJECTION. You can resume with your activities as soon as you feel normal again.

Do I need to undergo any diagnostic tests while being managed with NITROPLUS INJECTION?

Your blood pressure and pulse may be measured often whilst you are being given NITROPLUS INJECTION. Also, your doctor might keep a frequent check on your liver and kidney function.

References

1. KD Tripathi. Anti-anginal and other Anti-ischemic Drugs. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 588-89

2. Kyle H. Kim, Connor C. Kerndt, Ghufran Adnan, Derek J. Schaller. Statpearls. Nitroglycerin. NIH National Library of Medicine, National center for biotechnology information. November 202. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK482382/

3. Ferreira, Julio CB, Daria Mochly-Rosen. Nitroglycerin Use in Myocardial Infarction Patients–Risks and Benefits. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. November 2011. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527093/

4. Sanjay Divakaran, Joseph Loscalzo. The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. November 2018. [Accessed on 8th October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687289/

5. Hospira UK Limited. Electronic Medicines Compendium (EMC) [Revised in July 2021] [Accessed on 8th October 2022] https://www.medicines.org.uk/emc/files/pil.3792.pdf

6. General Injectables and Vaccines. Inc. Nitroglycerin Injection. Dailymed. [Revised in December 2021]. [Accessed on 8th October 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7ea5a071-6f92-4a8a-8e3f-72b74fb2810a

Useful Diagnostic Tests

• ECG
• Chest Xray
• Blood tests

Author Details

Written By Dr. Priyanka Goel - BDS

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 14 Oct 2022 | 10:21 AM(IST)