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Introduction About NEVIR 200MG TABLET
NEVIR 200MG TABLET contains Nevirapine which belongs to the group of medicines called Antiretroviral drugs. It indicated for the management of Human Immunodeficiency Virus (HIV) infection in combination with other anti-retroviral medicines in adults, adolescents and children.
HIV is a virus which severely damages the immune system and leads to Acquired Immune Deficiency Syndrome (AIDS) which is characterized by fever, chills, rash, night sweat, muscle aches, sore throat, fatigue. During management, your doctor will advise you to take certain blood tests to monitor your liver function.
NEVIR 200MG TABLET should be used with caution in patients having inflammation of liver (hepatitis B or C) or abnormal liver function tests. Before taking NEVIR 200MG TABLET, inform your doctor if are undergoing kidney dialysis or have any heart disease. NEVIR 200MG TABLET should be used with caution in pregnant woman and is not intended for use in breastfeeding women.
Your doctor will prescribe the right dose of NEVIR 200MG TABLET for your child depending on their age, body weight and body surface area. The most common side effects of taking NEVIR 200MG TABLET are skin rash, headache, fatigue (feeling tired), nausea, vomiting, abdominal pain, diarrhea, fever, etc.
Uses Of NEVIR 200MG TABLET
- Used in adults, adolescents and children to manage Human Immunodeficiency Virus (HIV) infection in combination with other anti-retroviral medicines
How NEVIR 200MG TABLET Works
NEVIR 200MG TABLET helps control HIV-1 infection by stopping reverse transcriptase (an enzyme needed by HIV in order to multiply) from working.
How to use NEVIR 200MG TABLET
Take NEVIR 200MG TABLET as advised by your physician. Swallow with a glass of water, do not crush or chew it. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking NEVIR 200MG TABLET unless your doctor advises you to stop.
Side Effects Of NEVIR 200MG TABLET
Common
- skin rash
- decreased numbers of white blood cells which makes you more prone to infection
- headache, fatigue (feeling tired)
- nausea, vomiting, stomach pain, diarrhoea
- signs of inflammation of the liver (hepatitis) like jaundice, nausea, dark urine, light coloured stools, abdominal pain
- fever
Uncommon
- angioedema (fluid retention under the skin), hives
- anaemia (decreased red blood cells count)
- joint or muscle pain
- high blood pressure
Rare
- signs of sudden and intense inflammation of the liver or fulminant hepatitis like swollen belly, upper right abdomen pain, vomiting, etc
- drug reaction with systemic symptoms (drug reaction with increased eosinophil count or eosinophilia)
Stop taking NEVIR 200MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- symptoms of infection
- muscle weakness, weakness beginning in the hands and feet and moving upwards the trunk of the body, throbbing sensation, shakiness or hyperactivity
- changes in body fat
- osteonecrosis (a bone disorder causing joint stiffness, aches and pains especially of the hip, knee and shoulder and difficulty in movement)
- rash that appears as blistering skin reaction, which can be severe or life-threatening (Ex. toxic epidermal necrolysis, Stevens-Johnson syndrome)
- symptoms of severe allergic or anaphylactic reaction like rash, swelling of face, breathing difficulty, anaphylactic shock, fever, skin blisters, mouth sores, eye inflammation, muscle or joint pain, feeling unwell, liver or kidney failure
- liver damage (loss of appetite, nausea, vomiting, yellow skin, abdominal pain)
How To Manage Side Effects
Diarrhoea:
To avoid dehydration in your body, drink plenty of fluids such as water, fruit juices or electrolytes. If symptom persists, contact your doctor.
Muscle pain:
Rest and elevate the painful area. Place ice packs to reduce inflammation and heat to improve blood flow. Taking a warm shower may help in relaxation. Take pain killer medicines after consulting your doctor. If symptom persists, contact your doctor.
Nausea or vomiting:
Take NEVIR 200MG TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. If symptom persists, contact your doctor.
Headache:
Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage the scalp or head with mild pressure. If symptom persists, contact your doctor.
Skin rash:
Try to avoid hot showers because it may cause skin irritation. Avoid frequent contact and rubbing over the affected area. Use sunscreen and protective clothing when outdoors. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
NEVIR 200MG TABLET should be used with caution in woman who are pregnant or planning to become pregnant. Women should use effective contraception methods during management with NEVIR 200MG TABLET. Consult your doctor before taking it.
Breastfeeding
NEVIR 200MG TABLET is not recommended for use in breastfeeding women as your baby may become infected with HIV through breastmilk. Consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any machines if you feel extremely tired after taking NEVIR 200MG TABLET.
Alcohol
Avoid consumption of alcohol while taking NEVIR 200MG TABLET as it may increase the risk of bone problems.
Kidney
NEVIR 200MG TABLET should be taken with caution in patients undergoing kidney dialysis. Consult your doctor before taking it.
Liver
NEVIR 200MG TABLET should be used with caution in patients having inflammation of liver (hepatitis B or C) or abnormal liver function tests. Consult your doctor before taking it.
Allergy
Do not take NEVIR 200MG TABLET if you are allergic to Nevirapine or any of the other ingredients of this medicine.
Heart Disease
NEVIR 200MG TABLET should be taken with caution in patients having heart disease. Consult your doctor before taking it.
Others
NEVIR 200MG TABLET is not recommended for use if you:
- have previously discontinued management with nevirapine due to severe skin rashes or liver problems
Use in Pediatrics:
Your doctor will prescribe the right dose of NEVIR 200MG TABLET for your child depending on their age, body weight and body surface area. Consult your child’s doctor for advice.
Use in Geriatrics:
NEVIR 200MG TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking NEVIR 200MG TABLET, inform your doctor if you are taking any of the following medicines:
- St. John’s Wort (herbal medicine used for depression)
- rifampicin, rifabutin (used to manage tuberculosis)
- clarithromycin (used to manage bacterial infections)
- fluconazole, ketoconazole, itraconazole (medicines used to manage fungal infections)
- methadone (medicine used in management of opiate addicts)
- warfarin (used to reduce clotting of blood)
- medicines used to manage pregnancy (Ex. ethinyl estradiol, progestin)
- atazanavir, lopinavir, ritonavir, fosamprenavir, efavirenz, etravirine, zidovudine, elvitegravir, cobicistat, rilpivirine (other medicines used to manage HIV-infection)
Overdosage:
If you or anyone else accidentally take too much of NEVIR 200MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of NEVIR 200MG TABLET overdose include swelling, redness, tiredness, fever, headache, sleep problems, nausea, rash, spinning sensation, vomiting and weight loss.
Synopsis
| Drug | : | Nevirapine |
| Pharmacological Category | : | Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) |
| Therapeutic Indication | : | HIV infection |
| Dosage Forms | : | Tablet, Oral suspension, Suspension |
More Information
- Keep NEVIR 200MG TABLET out of reach of children
- Store at room temperature
FAQs About NEVIR 200MG TABLET
Can I stop taking NEVIR 200MG TABLET if I feel better?
Do not stop taking NEVIR 200MG TABLET unless your doctor advises you to stop. Taking all doses at the appropriate times increases the effectiveness of your medicine and reduces the chances of you developing resistance to your antiretroviral medicine. If you stop taking NEVIR 200MG TABLET for more than 7 days, your doctor will advise you to start the 14 day 'lead-in' period once again, before returning to the usual dose.
What should I do if I forget to take a dose of NEVIR 200MG TABLET?
If you forget a dose of NEVIR 200MG TABLET, take it as soon as you remember. If you notice that you have missed a dose within 8 hours of when it was due, take it as soon as possible. If it has been more than 8 hours since the dose was due, then take the next dose at the usual time. Do not take NEVIR 200MG TABLET two times to make up for the forgotten dose.
Does NEVIR 200MG TABLET manage HIV infection?
NEVIR 200MG TABLET does not completely manage HIV infection; it reduces the amount of virus in your body and keeps a check at it. Therefore, you may continue to develop infections and other illnesses associated with HIV infection and thus, you should remain in regular contact with your doctor.
Can I get other infections while on management with NEVIR 200MG TABLET?
In some patients with AIDS and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after NEVIR 200MG TABLET management is started. It is assumed that these symptoms are due to an improvement in the body’s immune response, enabling the body to fight infections that may have been present with no obvious symptoms. If you notice any symptoms of infection while taking NEVIR 200MG TABLET, please inform your doctor immediately.
References
1. KD. Tripathi. Antiretroviral drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –864.
2. J-J Parienti , R Verdon. Nevirapine and cardiovascular risk. National Library of Medicine, National center for biotechnology information. PubMed.gov. September 2010. [Accessed 9th December 2022].https://pubmed.ncbi.nlm.nih.gov/20434285/
3. Ena J, Amador C, Benito C, Pasquau F. Pharmacological and clinical evidence of nevirapine immediate- and extended-release formulations. NIH National Library of Medicine, National Centre for biotechnology information. Pubmed Central. November 2012. [Accessed 9th December 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501953/
4. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed 9th December 2022]. https://www.medicines.org.uk/emc/files/pil.7063.pdf
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed 9th December 2022]. https://www.medicines.org.uk/emc/files/pil.8888.pdf
6. Boehringer Ingelheim Pharmaceuticals, Inc. Viramune (Nevirapine). [Revised in June 2022] [Accessed 9th December 2022]. https://content.boehringer-ingelheim.com/DAM/4e167be8-c829-4ca6-ba08-af1e01215de4/viramune-us-pi.pdf
Useful Diagnostic Tests
- Antibody test
- Complete blood count
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