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Fourrts India Laboratories Pvt Ltd

Nefrosave Tablet 15'S

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    Introduction About NEFROSAVE TABLET

    Nefrosave Tablet is a Kidney supplement commonly prescribed for Diabetic nephropathy and other Kidney-related conditions. It contains Acetylcysteine and Taurine, which help protect renal cells and reduce oxidative stress.

    Nefrosave Tablet helps in managing diabetic nephropathy, supports kidney function and reduces inflammation and oxidative stress in kidneys. Nefrosave is beneficial in reduction of microalbuminuria associated with CKD Stages 1-3. It reduces microalbuminuria & TGF β levels by 50%.

    N-acetylcysteine has been found to be safe in chronic renal failure patients. Taurine is an amino acid that occurs naturally within the body and is generally recognized as safe by USFDA.

    Take 1 tablet twice a day or as directed by your healthcare provider. Do not self-medicate or exceed the prescribed dosage.

    Nefrosave Tablet is not recommended during pregnancy or lactation unless advised by a doctor. Before taking Nefrosave Tablet, inform your doctor if you have liver or heart issues.

    The common side effects of Nefrosave Tablet are nausea, upset stomach or headache. In rare condition, it may also cause allergic reactions. Consult your doctor if side effects persist or worsen. Nefrosave Table should be kept out of reach of children.

    Key Composition

    • Acetylcysteine - 150mg
    • Taurine - 500mg

    Uses Of NEFROSAVE TABLET

    • Used for kidney support and diabetic nephropathy

    Benefits of NEFROSAVE TABLET

    • Helps manage Diabetic nephropathy
    • Supports Kidney function
    • Reduces inflammation and Oxidative stress in kidneys

    How NEFROSAVE TABLET Works

    How does it help protect kidneys?

    Mechanism of action

    Active ingredient

    How it protects the kidneys

    Reduces Oxidative Stress

    N-Acetylcysteine (NAC)

    NAC boosts glutathione levels, a powerful antioxidant that neutralizes free radicals, reducing oxidative damage to kidney cells and manages the progression of kidney disease.

    Manages kidney inflammation

    N-Acetylcysteine (NAC) + Taurine

    Both NAC and Taurine possess anti-inflammatory properties, reducing inflammation in kidney tissues, which helps manage the development of fibrosis (scarring) and preserves kidney function.

    Improves renal blood circulation

    Taurine

    Taurine enhances microcirculation and vascular health in the kidneys, ensuring better blood flow to kidney tissues, which is essential for their proper function and repair.

    Supports detoxification

    N-Acetylcysteine (NAC)

    NAC promotes the detoxification process by aiding in the removal of toxins and harmful substances from the kidneys, allowing them to function more efficiently and reducing kidney damage.

    Regulates blood pressure & blood sugar

    Taurine

    Taurine helps in regulating blood pressure and improves insulin sensitivity, reducing the strain on the kidneys from high blood pressure and uncontrolled blood sugar levels. These are common causes of kidney damage.

    Protects against kidney fibrosis

    N-Acetylcysteine (NAC)

    NAC helps reduce kidney fibrosis (scarring) by inhibiting pro-fibrotic enzymes, preserving kidney tissue and function in individuals with chronic kidney disease (CKD).

    How to use NEFROSAVE TABLET

    How to take Nefrosave Tablet:

    • Nefrosave Tablet should be taken orally with water
    • Swallow the tablet whole, do not crush or chew it to ensure that it works effectively
    • It is usually recommended to follow your doctor’s guidance based on your health needs, but take the tablet consistently at the same time each day to help establish a routine

    Nefrosave Tablet dosage instructions:

    • Typical Dosage: Take 1 tablet twice a day or as directed by your healthcare provider
    • Do not self-medicate or exceed the prescribed dosage
    • The specific dosage may vary based on your kidney condition (e.g., diabetic nephropathy or chronic kidney disease)

    Can it be taken on an empty stomach?

    • Nefrosave Tablet should be taken after food or as directed by the physician

    What if I forgot to take NEFROSAVE TABLET

    • If you miss a dose, take it as soon as you remember
    • If it is almost time for your next dose, skip the missed dose
    • Do not take two doses at the same time to make up for the missed dose

    Side Effects Of NEFROSAVE TABLET

    Common:

    • nausea or upset stomach
    • headache

    Rare:

    • allergic reactions

    How To Manage Side Effects

    Headache

    • Aim for at least 8 glasses (2 liters) of water, or more if you are in a hot climate or have been physically active
    • Lie down in a quiet, dark room, close your eyes, and relax. Take a short nap (15-30 minutes) to help reset your body and alleviate the headache
    • Apply a cold compress (ice pack wrapped in a cloth) to your forehead or the back of your neck for a migraine. For a tension headache, apply a warm compress to the neck or shoulders

    Nausea And Vomiting

    • Boil a few slices of fresh ginger in water for 5–10 minutes. Drink the tea slowly to relieve nausea
    • Squeeze fresh lemon juice into a glass of water and sip it slowly
    • Chew a small amount of fennel seeds after meals or make fennel tea by adding 1 teaspoon of seeds in hot water for 5–10 minutes
    • Drink small sips of water throughout the day. If you are unable to keep water down, try drinking clear broth or electrolyte-rich fluids like coconut water

    Warning & Precautions

    Pregnancy

    Monitoring required

    Nefrosave Tablet is not recommended for use in pregnant women unless clearly necessary. Your doctor will determine the suitability and safety of the use of this medicine.

    Breastfeeding

    Monitoring required

    Nefrosave Tablet is not recommended for use in breastfeeding women unless absolutely necessary and the potential benefits outweigh the risks involved. Doctor may advise to stop breastfeeding for a certain period of time depending on clinical condition of patients.

    Driving and Using Machines

    Use with Caution

    Nefrosave Tablet does not affect the ability to drive or operate machinery. However, always remain cautious and be aware of how you feel when taking any medication, especially in the first few days of use or when changing your dosage.

    Alcohol

    Consult your doctor

    Chronic or heavy consumption of alcohol can exacerbate kidney and liver damage, so it is best to consult your healthcare provider to discuss any risks and how alcohol might affect your specific health condition and treatment plan.

    Kidney

    Consult your doctor

    It is necessary to consult a doctor, before starting Nefrosave as dose adjustments and close monitoring of kidney function may be required, especially for individuals with severe kidney dysfunction.

    Liver

    Use with Caution

    Nefrosave Tablet should be used with caution in patients with liver impairment.

    Allergy

    Contraindicated

    Do not take Nefrosave Tablet if you are allergic to any of its ingredients.

    Lungs

    Contraindicated

    Nefrosave Tablet is not recommended for use in patients suffering from a severe and sudden attack of asthma. It is advised to closely monitor asthma patients during treatment with this medicine.

    Heart Disease

    Use with Caution

    Nefrosave Tablet should be used with caution in patients with heart conditions.

    Use In Geriatrics

    Use with Caution

    Nefrosave Tablet should be used with caution in geriatric patients, especially in those with reduced kidney function or other age-related health concerns. Dose adjustments may be necessary, and regular monitoring of kidney and liver function is essential.

    Who should not take [GBNKEYWORD

    • Nefrosave Tablet is not recommended for patients with Keratoconjunctivitis  

    Diet and Lifestyle Advice

    Food/Drink to avoid while using Nefrosave:

    • high-sodium foods
    • high-sugar foods and drinks
    • caffeinated beverages
    • foods high in potassium (if kidney function is impaired)
    • high-protein foods (if kidney function is impaired)

    Diet & hydration tips for Kidney health:

    • Focus on Low Glycemic Index (GI) Foods: quinoa, barley, oats, spinach, lentils, chickpeas
    • Limit High-Protein Foods and include chicken breast, fish, or tofu, and aim for plant-based proteins like beans and legumes
    • Take Heart-healthy fats: olive oil, avocado, flaxseeds, and omega-3-rich foods
    • Reduce Sodium and Processed Foods: canned soups, snacks, and fast food
    • Control carbohydrate intake: Limit refined carbs (e.g., white bread, pastries) and focus on complex carbs that are rich in fiber
    • Aim to drink 6-8 glasses of water per day, depending on your kidney function and doctor's advice
    • Limit sugary drinks like sodas or energy drinks that can spike blood sugar and increase kidney strain
    • Herbal teas (without added sugar) are a good alternative
    • Avoid excessive caffeine as both can dehydrate the body and put additional stress on the kidneys

    Safe exercise routines for people with Kidney disease:

    • Walking: Start with 20-30 minutes a day, and gradually increase intensity
    • Cycling: Using a stationary bike or outdoor cycling can be gentle on the joints and kidneys
    • Swimming: A great low-impact activity that helps improve cardiovascular health without putting pressure on the joints

    Managing stress to protect Kidney health:

    • Mindfulness Meditation: mediate 10-20 minutes a day
    • Breathing Exercises: Deep breathing exercises, such as diaphragmatic breathing or 4-7-8 technique, can activate the body’s relaxation response and reduce stress
    • Physical Relaxation: Activities like progressive muscle relaxation (PMR), where you progressively tense and relax muscles in your body, can help relieve physical stress and tension
    • Sleep Hygiene: Establish a regular sleep schedule and create a relaxing nighttime routine.

    Drug - Drug interaction

    Nefrosave Tablet 15'S interactions with other medications:

    1. Medications that affect kidney function (Nephrotoxic drugs):

    • Common drugs: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, or aspirin, certain antibiotics like gentamicin or vancomycin and some chemotherapy agents

    2. Drugs that may increase the risk of gastrointestinal side effects:

    • Common drugs: NSAIDs, antibiotics, steroids.

    3. Interaction with Antitussives (Cough Suppressants):

    • Common drugs: dextromethorphan and codeine

    4. Interaction with Nitroglycerin:

    • Enhancement of Nitroglycerin’s Effects: There is some evidence to suggest that NAC might enhance the effects of nitroglycerin because of its ability to improve endothelial function and reduce oxidative stress, which could make nitroglycerin work more effectively
    • This may potentially increase the risk of hypotension (low blood pressure), dizziness, or fainting when both are used together

    Synopsis

    Drug :   Acetylcysteine, Taurine
    Pharmacological Category :   Kidney Supplement
    Therapeutic Indication :   Used for kidney support and diabetic nephropathy        
    Dosage Forms :   Tablet

    More Information

    Chronic Kidney Disease (CKD):

    Chronic Kidney Disease (CKD) is a long-term condition in which the kidneys gradually lose their function over time. It can progress without noticeable symptoms in the early stages, making it crucial to detect it early. CKD can result from a variety of causes, including diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease.

    Symptoms of CKD:

    • fatigue and weakness
    • swelling (edema)
    • changes in urination
    • shortness of breath
    • high blood pressure (hypertension)
    • nausea and vomiting
    • loss of appetite
    • itchy skin
    • muscle cramps

    Tips to improve kidney health

    • Hydrate properly
    • Follow a kidney-friendly diet: reduce salt intake, control protein consumption, eat more fruits and vegetables
    • Exercise regularly
    • Monitor blood pressure and blood sugar
    • Avoid overuse of painkillers

    Natural remedies for Kidney health:

    1. Stay hydrated:

    • Water helps flush toxins and waste from the kidneys
    • Aim for 8–10 glasses a day unless otherwise directed by a doctor

    2. Eat kidney-friendly foods:

    • Cranberries: May help manage urinary tract infections
    • Blueberries & Strawberries: High in antioxidants and anti-inflammatory compounds
    • Leafy greens (in moderation): Rich in vitamins, but avoid excessive potassium if you have kidney issues
    • Garlic: Helps reduce inflammation and lower blood pressure

    3. Herbal teas for kidney support:

    • Nettle tea: Anti-inflammatory and helps eliminate waste
    • Dandelion root tea: Acts as a diuretic to support toxin elimination
    • Parsley tea: Traditionally used to cleanse kidneys

    4. Apple cider vinegar:

    • It helps flush toxins and may reduce kidney stone risk (1–2 teaspoons diluted in water)

    5. Lemon water:

    • It contains citrate, which may help manage kidney stones and improve hydration

    6. Turmeric:

    • It has anti-inflammatory and antioxidant properties that benefit the kidneys

    What is Diabetic Nephropathy?

    Diabetic nephropathy is damage to the small blood vessels in the kidneys that occurs due to high blood sugar levels over time. This damage affects the kidney’s ability to filter waste and excess fluids properly, leading to a gradual loss of kidney function.

    Symptoms of Diabetic Nephropathy (often silent in early stages)

    • Swelling in feet, ankles, or hands
    • Fatigue
    • Frequent urination
    • Foamy or bubbly urine
    • High blood pressure
    • Poor appetite or nausea (in advanced stages)

    How diabetes affects kidney function:

    1. High blood sugar overloads the kidneys

    • Elevated glucose levels force the kidneys to work harder to filter blood
    • Over time, this extra effort damages the filtering units (nephrons)

    2. Damage to glomeruli (filtering units)

    • The tiny blood vessels in the glomeruli become leaky and less efficient
    • Protein (especially albumin) starts leaking into the urine (an early sign of kidney damage)

    3. Increased blood pressure

    • Diabetes often causes or worsens hypertension, which further damages kidney vessels
    • This creates a cycle of declining kidney function

    4. Inflammation and scarring

    • Chronic high glucose levels trigger inflammation
    • This can lead to fibrosis (scarring) and irreversible kidney damage over time

    Nefrosave 15's vs. Soihenz Tablet

    Feature

    Nefrosave 15's

    Soihenz Tablet

    Composition

    Taurine 500 mg + Acetylcysteine 150 mg

    Taurine 500 mg + Acetylcysteine 150 mg

    Primary use

    Kidney protection (CKD, diabetic nephropathy)

    Kidney protection (CKD, diabetic nephropathy)

    Manufacturer

    Fourrts India Laboratories Pvt. Ltd.

    La Renon Healthcare Pvt. Ltd.

    Packaging

    Strip of 15 tablets

    Strip of 10 tablets

    Common side effects

    Nausea, abdominal pain, rash, throat irritation

    Nausea, abdominal pain, rash, throat irritation

    Prescription needed

    Yes

    Yes

    Availability

    Widely available in India

    Widely available in India

     

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    FAQs About NEFROSAVE TABLET

    Q: What is Nefrosave Tablet used for?

    A: Nefrosave Tablet is a Kidney supplement commonly prescribed for Diabetic nephropathy and other Kidney-related conditions.

    Q: How does Nefrosave Tablet work?

    A: Nefrosave Tablet works by using two key ingredients, Taurine and Acetylcysteine  which help protect and improve kidney function, especially in people with chronic kidney disease or diabetic nephropathy.

    Q: Can Nefrosave Tablet be taken with alcohol?

    A: It is not recommended to take Nefrosave Tablet with alcohol.

    Q: Can Nefrosave be taken with other medications?

    A: Yes, but always inform your doctor about your current medication to avoid interactions.

    Q: Is Nefrosave safe for long-term use?

    A: Yes, when taken under medical supervision. Regular monitoring of kidney function is advised.

    Q: Is Nefrosave Tablet addictive?

    A: No, Nefrosave Tablet is not addictive, both of which are naturally occurring or medically used antioxidants, not linked to addiction or dependence.

    Q: Where can I buy Nefrosave Tablet 15'S?

    A: You can buy Nefrosave Tablet from a trusted online pharmacy like Netmeds.

    Q: Is Nefrosave safe for elderly or those with liver issues?

    A: Nefrosave Tablet can be safe for elderly individuals and those with liver issues, but only under medical supervision.

    Q: How should I take Nefrosave Tablet?

    A:Take 1 tablet twice a day or as directed by your healthcare provider. Do not self-medicate or exceed the prescribed dosage.

    Q: Does Nefrosave Tablet cause drowsiness or dizziness?

    A: Nefrosave Tablet typically does not cause drowsiness or dizziness in most people, but these side effects are rarely reported and may occur in sensitive individuals.

    Q: Can Nefrosave Tablet cure kidney disease?

    A: No, Nefrosave Tablet does not cure kidney disease, but it can help manage and slow down its progression, especially in conditions like diabetic nephropathy or chronic kidney disease (CKD).

    Q: Is Nefrosave Tablet genuine or counterfeit?

    A: Nefrosave Tablet is a genuine, medically approved product when purchased from reputable sources like licensed pharmacies or trusted online platforms.

    Q: Can Nefrosave Tablet help with stage 1 or stage 2 kidney disease?

    A: Yes, Nefrosave Tablet can be helpful in stage 1 or stage 2 kidney disease, especially when used as part of an overall kidney-protective management plan.

    References

    1. Misty D. Smith, Cameron S. Metcalf, and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 303-326.

    2. Felix Zahnert, Kristina Krause, Ilka Immisch, Lena Habermehl, Iris Gorny, Izabella Chmielewska, Leona Möller, Anna M. Weyand, Peter M. Mross, Jan Wagner, Katja Menzler and Susanne Knake. Brivaracetam in the Treatment of Patients with Epilepsy - First Clinical Experiences. Journal of Frontiers in neurology. February 2018. [Accessed on 26th April 2025]

    3. Farbod Khaleghi, and Eric C. Nemec. A Novel Adjunctive Therapy for Partial-Onset Seizures. February 2017. [Accessed on 26th April 2025]

    4. UCB Pharma limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 26th April 2025]

    Author Details

    Written By Dr. Janet.C - Pharm.D
    Reviewed For Accuracy By Dr. Narayanasetty Sai Swaroop - Pharm.D
    Last updated on 29 Apr 2025 | 12:33 PM(IST)
    Lab updated