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Introduction About NEBI 5MG TABLET
Nebi 5mg Tablet contains Nebivolol, a medically approved beta-blocker, often recommended for managing high blood pressure and certain heart-related conditions. It is designed to support cardiovascular health by relaxing blood vessels, enabling smoother blood flow.
Take Nebi 5mg Tablet as directed by a healthcare provider, preferably at the same time daily. Swallow whole with water; do not crush or chew. Avoid missing doses to keep blood pressure stabilized.
Use of Nebi 5mg Tablet during pregnancy or breastfeeding should only be under medical supervision. Healthcare professionals can provide individualized guidance for expectant or nursing caregivers.
Along with Nebi 5mg Tablet, your doctor might advise you to make certain lifestyle changes, such as healthy eating, sleep, weight and stress management, quitting smoking and alcohol.
Before starting the management with Nebi 5mg, inform your doctor if you have diabetes or an overactive thyroid gland. The most possible side effects are tiredness, headache, or slow heart rate. Immediate medical advice is recommended if dizziness or severe reactions occur. Consult the leaflet for a comprehensive side effect list and risk minimization.
Discuss with a doctor before starting Nebi 5mg, especially if living with asthma, diabetes, or kidney concerns. Disclose current medications to avoid possible interactions. Store in a cool, dry place away from sunlight and out of children’s reach.
Uses Of NEBI 5MG TABLET
Used to manage:
- High blood pressure
- Certain heart-related conditions
Benefits of NEBI 5MG TABLET
- Supports Blood Pressure Control: Nebi 5mg Tablet helps regulate elevated blood pressure by slowing heart rate and reducing the force of heart contractions, making it easier for the heart to circulate blood throughout the body
- Reduces Cardiovascular Risks: Regular use can lower the risk of serious complications associated with high blood pressure
- Helps in Heart Failure Management (in elderly): Particularly for those aged 70 or above, Nebi 5mg supports heart function by easing the workload on the heart, which can reduce symptoms like fatigue, shortness of breath, and swelling in the legs or feet
- Enhanced Tolerability: Nebivolol is known for cardioselectivity, which may lead to fewer side effects compared to older beta-blockers, and for its beneficial effect in widening blood vessels using nitric oxide-mediated mechanisms
How NEBI 5MG TABLET Works
How Nebi 5mg Tablet Works in the Body
Nebivolol primarily blocks beta-1 adrenergic receptors in the heart, making it highly cardioselective at regular doses. This reduces heart rate and the force of each contraction, lowering the heart’s workload and improving the efficiency of blood circulation.
How does nebivolol act as a beta blocker?
Unlike traditional beta-blockers, nebivolol not only targets beta-1 receptors but also stimulates beta-3 receptors in blood vessel walls. This stimulation encourages the release of nitric oxide, a natural compound that relaxes and widens blood vessels (vasodilation), resulting in decreased vascular resistance and easier blood flow.
How does nebivolol help with blood pressure?
By combining beta-1 blockade with nitric oxide–mediated vasodilation, nebivolol effectively lowers both systolic and diastolic blood pressure. This dual effect is especially useful for patients with hypertension and those who may have endothelial dysfunction, such as individuals with diabetes or cardiovascular risk factors.
Action of nebivolol in cardiovascular health
Nebivolol’s action not only aids in maintaining optimal blood pressure but also supports overall heart health by minimizing strain on the heart, promoting arterial flexibility, and improving endothelial function. These benefits contribute to a reduced risk of cardiovascular complications over time and favorable tolerability, particularly for patients sensitive to the side effects of older beta-blockers. This distinctive mechanism enables Nebi 5mg Tablet to offer effective, patient-friendly support for cardiovascular well-being with reduced side effect risk compared to some other beta-blockers.
How to use NEBI 5MG TABLET
- Take the tablet as directed by a healthcare provider, preferably at the same time daily
- Swallow whole with water; do not crush or chew
- Avoid missing doses to keep blood pressure stabilized
1. What is the recommended dosage of Nebi 5mg Tablet?
The typical starting dosage for adults is one Nebi 5mg Tablet taken once daily, as prescribed by a healthcare professional. The dose may be adjusted according to individual response and clinical assessment.
2. How should I take Nebi 5 Tablet?
Nebi 5mg Tablet should be swallowed whole with a glass of water and taken at the same time each day for best results. It is important not to crush or chew the tablet.
3. Can Nebi 5mg Tablet be taken with food?
Yes, Nebi 5mg Tablet can be taken with or without food. There is no significant impact of meals on the absorption of nebivolol.
What if I forgot to take NEBI 5MG TABLET
If a dose is missed, take it as soon as remembered. However, if it is nearly time for the next scheduled dose, skip the missed one and take the next dose at the regular time. Avoid taking a double dose to compensate.
Overdose
If you or anyone else accidentally takes too much of Nebi 5mg Tablet, consult your doctor immediately or visit the nearby hospital.
Side Effects Of NEBI 5MG TABLET
Common side effects
- tiredness
- headache
- slow heart rate
When to consult a doctor?
- dizziness or severe reactions occur
Warning & Precautions
Pregnancy
Consult your doctorUse of Nebi 5mg during pregnancy should only be under medical supervision. Healthcare professionals can provide individualized guidance for expectant or nursing caregivers.
Breastfeeding
Consult your doctorUse of Nebi 5mg during breastfeeding should only be under medical supervision. Healthcare professionals can provide individualized guidance for expectant or nursing caregivers.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience dizziness or fatigue after taking Nebi 5mg.
Kidney
Use with CautionNebi 5mg should be used with caution in patients with severe kidney disease or patients who are undergoing dialysis.
Liver
ContraindicatedNebi 5mg is not recommended for use in patients with liver disease.
Allergy
ContraindicatedDo not take Nebi 5mg if you are allergic to Nebivolol or to any other ingredients of this medicine.
Lungs
ContraindicatedNebi 5mg is not recommended for use in patients with lung disease such as asthma or wheezing.
Heart Disease
Consult your doctorNebi 5mg Tablet is not recommended in patients having heart diseases such as low blood pressure, very slow heartbeat, heart rhythm problems, or heart failure. It should be used with caution in patients having Prinz metal angina, unmanaged chronic heart failure, and first-degree heart block.
Use In Pediatrics
Consult your doctorSafety and effectiveness in pediatric patients have not been established. Pediatric studies in ages newborn to 18 years old have not been conducted because of incomplete characterization of developmental toxicity and possible adverse effects on long-term fertility.
Use In Geriatrics
Consult your doctorNo overall differences in efficacy or in the incidence of adverse events were observed between older and younger patients.
Other Warnings for NEBI 5MG TABLET
Before taking Nebi 5mg, inform your doctor if you:
- have diabetes
- have an overactive thyroid gland
- have planned surgery and require anesthesia
- have lactose intolerance
Who should not take [GBNKEYWORD
Nebi 5mg is not recommended for use if you:
- have serious circulation problems in arms or legs
- have unmanaged pheochromocytoma
- have diabetic ketoacidosis
Diet and Lifestyle Advice
Heart-Healthy Habits
- Regular Physical Activity: Engage in at least 30 minutes of moderate exercise—such as walking, cycling, or swimming—on most days.
- Weight Management: Aim for a healthy weight. Losing even a modest amount (5–10% of body weight) can positively impact blood pressure and reduce cardiovascular strain.
- Stress Reduction: Practice relaxation techniques, such as deep breathing, mindfulness meditation, or yoga, to lower stress levels that can otherwise negatively affect blood pressure and heart rhythm.
- Consistent Sleep Routine: Ensure 7–8 hours of restful sleep per night, as inadequate sleep is linked with higher blood pressure and increased heart risk.
Dietary Tips
- Limit Salt and Sodium: Reduce sodium intake by avoiding processed and packaged foods; flavor meals with herbs and spices instead of salt. Aim for less than 2,300 mg of sodium per day, or lower as advised.
- Choose Heart-Healthy Foods: Focus on fruits, vegetables, whole grains, lean proteins (such as fish, poultry, beans), and healthy fats (like olive oil and nuts). Restrict intake of saturated fats and trans fats.
- Monitor Portion Sizes: Control portion sizes and avoid overeating to maintain healthy blood sugar and cholesterol levels, further supporting heart health.
- Stay Hydrated: Drink plenty of water and limit sugary drinks.
Additional Supportive Measures
- Medication Adherence: Take Nebi 5mg Tablet exactly as prescribed, and never stop abruptly without consulting a healthcare provider.
- Routine Monitoring: Attend regular check-ups to track blood pressure and overall cardiovascular status.
- Education and Support: Stay informed about your heart health. Seek support from family, friends, or heart health community groups for added motivation.
Drug - Drug interaction
|
Drug/Class |
Type of Interaction |
Clinical Effect / Risk |
Recommendation |
|
Theophylline/Aminophylline |
Pharmacodynamic (major) |
Increased risk of serious breathing problems in asthma/COPD |
Avoid use together unless essential; monitor closely |
|
Diltiazem, Verapamil |
Pharmacodynamic (major) |
Increased risk of bradycardia, heart block, hypotension |
Use with extra caution and monitor heart function |
|
Digoxin, Amiodarone |
Pharmacodynamic |
Increased risk of slow heart rate (bradycardia) |
Monitor heart rate and rhythm, adjust dose if needed |
|
Other Beta-blockers |
Additive effects |
Excessive slowing of heart/low blood pressure |
Avoid combination |
|
NSAIDs (e.g., Ibuprofen) |
Pharmacodynamic (minor/moderate) |
Reduced antihypertensive effect of nebivolol |
Monitor blood pressure, may need dose adjustment |
|
Clonidine |
Withdrawal risk |
Risk of rebound hypertension if stopped abruptly |
Withdraw clonidine gradually under supervision |
|
Antiarrhythmics (Quinidine, Dronedarone) |
Additive risk |
Cardiac rhythm disturbances |
Use with caution, monitor ECG |
|
Insulin, Oral antidiabetics |
Masking of hypoglycemia signs |
Beta-blockers may mask hypoglycemia warning symptoms |
Monitor blood glucose closely |
|
Select Antidepressants (SSRIs, MAOIs) |
Pharmacokinetic/dynamic |
May alter nebivolol metabolism and enhance side effects |
Use with caution; monitor for adverse effects |
Drug - Food interaction
|
Food/Drink |
Interaction/Evidence |
Risk/Advice |
Recommendation |
|
General Food |
No significant interaction |
Does not affect absorption or efficacy. |
Can be taken with or without food. |
|
High-Sodium Foods |
Dietary sodium may reduce antihypertensive efficacy |
High sodium intake can counteract blood pressure management. |
Follow low-sodium diet for best results. |
|
High-Fat Processed Foods |
General cardiovascular risk |
May negatively affect heart health and blood pressure control. |
Limit processed/fried/fatty foods. |
Synopsis
| Drug | : | Nebivolol |
| Pharmacological Category | : | Selective Beta-blockers |
| Therapeutic Indication | : | Hypertension, Mild to moderate chronic heart failure |
| Dosage Forms | : | Tablet |
More Information
Comparison of Nebivolol versus Conventional beta-blockers
|
Feature/Property |
Nebivolol |
Conventional Beta-blockers (e.g., atenolol, metoprolol) |
|
Cardioselectivity |
Highly selective for beta-1 receptors |
Mostly beta-1 selective, but lower selectivity than nebivolol |
|
Nitric Oxide Vasodilation |
Stimulates NO release via β3 agonism; leads to direct endothelial vasodilation and improved arterial compliance |
No NO-mediated vasodilatory effect; mainly reduce cardiac workload |
|
Impact on Exercise |
Does not significantly inhibit normal heart rate increase with exercise at low doses (<10mg) |
Often blunt exercise-induced heart rate response |
|
Effect on Arterial Stiffness |
Specifically improves small artery distensibility and arterial compliance |
Little/no impact; may leave arterial stiffness unaddressed |
|
Oxidative Stress Protection |
Demonstrated reduction in oxidative stress and protection against target organ damage |
No direct antioxidative effects |
|
Tolerability/Safety |
Side effect profile similar to placebo; fewer issues like fatigue and sexual dysfunction. Superior tolerability reported in trials |
Fatigue, sexual dysfunction, and metabolic effects relatively common |
FAQs About NEBI 5MG TABLET
Q: Can Nebi 5mg Tablet be taken with food?
A: Yes, Nebi 5mg can be taken with or without food, as per preference or doctor’s instructions.
Q: What should I do if I miss a dose of Nebi 5mg?
A: Take the missed dose as soon as remembered, but skip if close to the next scheduled dose.
Q: Is routine monitoring needed for Nebi 5mg?
A: Regular blood pressure and heart rate checks are important to optimize safety and results.
Q: What is Nebi 5mg used for?
A: Nebi 5mg is used in the management of essential hypertension (high blood pressure). It also controls heart pumping strength and in the management of mild and moderate chronic heart failure (above 70 years of age).
Q: Can I stop taking Nebi 5mg on my own?
A: No, do not alter or discontinue the daily dose of Nebi 5mg after feeling better without consulting your doctor. Your doctor will decide the correct dose and duration of this medicine for you depending upon your age, body weight, and disease condition.
Q: Does Nebi 5mg have side effects?
A: Nebi 5mg can cause tiredness, diarrhea, constipation. Consult a doctor immediately if any of the effects worsen or continue for a long time.
Q: Can Nebi 5mg cause constipation?
A: Yes, constipation is a common side effect of taking Nebi 5mg. In case you are suffering from constipation, take foods rich in fiber in your diet for better digestion, such as fresh fruits, vegetables, and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active.
Q: How and when should Nebi 5mg be taken?
A: Take Nebi 5mg as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.
Q: Can Nebi 5mg cause headache?
A: Yes, headache is one of the most common side effects of taking Nebi 5mg. In case you are experiencing a headache after taking the medicine, try to rest and relax. Keep drinking plenty of fluids, such as water or electrolytes. Apply a pain-relieving balm on the forehead if needed. Do not consume too much alcohol. Consult your doctor if the headache persists for a long time.
Q: Can Nebi 5mg be taken by pregnant women?
A: No studies of this medicine were conducted in pregnant women. Use of Nebi 5mg during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Q: Is Nebi 5mg safe for children?
A: Safety and effectiveness in pediatric patients have not been established. Pediatric studies in ages newborn to 18 years old have not been conducted because of incomplete characterization of developmental toxicity and possible adverse effects on long-term fertility.
Q: Who should not use Nebi 5mg?
A: Nebi 5mg is not recommended for use if you have serious circulation problems in arms or legs, unmanaged pheochromocytoma (tumor of the adrenal gland), or have diabetic ketoacidosis, liver disease, lung disease such as asthma or wheezing, heart diseases such as low blood pressure, a very slow heartbeat, heart rhythm problems, or heart failure, or are allergic to Nebivolol.
Q: What precautions must be taken while using Nebi 5mg?
A: Before taking Nebi 5mg, inform your doctor if you have diabetes, an overactive thyroid gland, have planned surgery and require anesthesia, or have lactose intolerance, severe kidney disease, patients who are undergoing dialysis, Prinz metal angina, unmanaged chronic heart failure, and first-degree heart block.
References
1. KD. Tripathi. Antiadrenergic Drugs and Drugs for Glaucoma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 149.
2. Shivani Priyadarshni, Bryan H. Curry. Nebivolol. NIH. National Library of Medicine, National Center for Biotechnology Information. Nov 2021. [Accessed on 19th September 2025] 
3. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in July 2019] [Accessed on 19th September 2025] 
4. Glenmark Pharmaceuticals Europe Limited. Electronic Medicines Compendium (EMC). [Revised in Dec 2018] [Accessed on 19th September 2025]
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