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Introduction About MYORIL INJECTION
MYORIL INJECTIONcontains Thiocolchicoside, which belongs to the group of medicines called Muscle relaxants. It is used in adults and adolescents 16 years of age and older as an add-on therapy for painful muscle contractions and acute painful conditions related to the spine.
Muscle spasms (muscle cramps) are painful contractions and tightening of your muscles. They’re usually common, involuntary, and unpredictable. The symptoms may include swelling, pain, stiffness, tenderness, and fatigue.
Before receiving MYORIL INJECTION inform your doctor if you have flaccid paralysis (sagging of the face), muscular hypotonia (weak muscles), diarrhoea, lactose intolerance, seizure or epilepsy. MYORIL INJECTION is not recommended for use in pregnant or breastfeeding women.
MYORIL INJECTION is not recommended for use in children and adolescents below 16 years of age. The most common side effects of receiving MYORIL INJECTION are skin allergic reactions, drowsiness, diarrhea and gastric symptoms. Consult your doctor if any of your symptoms get worse or persist.
Uses Of MYORIL INJECTION
- Manage painful muscle contractions
- Manage acute painful conditions related to the spine
How MYORIL INJECTION Works
MYORIL INJECTION works through selective binding to the GABA-A receptor (neurotransmitter). It manages muscle contractions by activating the GABA-inhibitory motor pathway and inhibiting the glycine receptors (neurotransmitters). Thus, relaxing the muscle pain and spasms.
How to use MYORIL INJECTION
MYORIL INJECTION will be given to you only by a doctor or a nurse into the muscles (intramuscularly). Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Side Effects Of MYORIL INJECTION
Common
- digestive disorders such as diarrhoea and stomach pain
- gastralgia
- drowsiness
- pain at the injection site
Uncommon
- itching, redness, bumps, vesicles or blisters on the skin
- allergic skin reaction
- nausea and vomiting
Rare
- allergic skin reactions like hives/urticaria
Stop receiving MYORIL INJECTION and contact your doctor immediately if you experience any of the following side effects:
- seizures
- signs of a liver problem (loss of appetite, nausea or vomiting, abdominal discomfort, unexplained fatigue, dark-coloured urine, jaundice, fever, itching)
- angioedema (sudden swelling of the neck and face, possibly causing difficulty breathing)
- anaphylactic shock (drop in blood pressure, possibly preceded by an eruption of bumps, itching, redness of the skin, difficulty breathing, swelling of the face and/or neck)
How To Manage Side Effects
Nausea:
Try to take MYORIL INJECTION with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your symptom gets worse.
Itchy skin:
Avoid taking hot showers as they can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when going outdoors or use unscented moisturizers to soothe and hydrate the skin. Consult your doctor if your symptom gets worse.
Diarrhoea:
Drink plenty of water or fruit juices to keep yourself hydrated. Don’t take any medicine on your own to manage diarrhoea. Consult your doctor if your symptom gets worse.
Warning & Precautions
Pregnancy
MYORIL INJECTION is not recommended for use in pregnant women, planning to have a baby or women of childbearing potential not taking contraceptives. Consult your doctor before receiving MYORIL INJECTION.
Breastfeeding
MYORIL INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving MYORIL INJECTION.
Driving and Using Machines
Do not drive or use machines while receiving MYORIL INJECTION as it can make you drowsy. Consult your doctor.
Allergy
Before receiving MYORIL INJECTION inform your doctor if you are allergic to Thiocolchicoside or any other ingredients of this medicine.
Others
MYORIL INJECTION is not recommended for use if you:
- flaccid paralysis (sagging face)
- muscular hypotonia (muscle weakness)
Before receiving MYORIL INJECTION, inform your doctor if you:
- have diarrhoea
- have epilepsy or risk of seizure
- lactose intolerant
Use in pediatrics:
MYORIL INJECTION is not recommended for use in children below 16 years of age. Consult your doctor before receiving MYORIL INJECTION.
Interactions
A. Drug-Drug interactions:
Before receiving MYORIL INJECTION, inform your doctor if you are taking any of the following medicine:
- taking or have taken any other medicines, muscle relaxants or central nervous system sedatives
Overdosage:
MYORIL INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Thiocolchicoside |
| Pharmacological Category | : | Muscle relaxant |
| Therapeutic Indication | : | Painful muscle contractions, Acute painful conditions related to the spine |
| Dosage Forms | : | Gel, Tablet, Capsule, Injection |
More Information
- Keep MYORIL INJECTION out of reach from children
- Store at room temperature
FAQs About MYORIL INJECTION
What is MYORIL INJECTION used for?
MYORIL INJECTION is used in adults and adolescents 16 years of age and older as an add-on therapy for painful muscle contractions and acute painful conditions related to the spine.
Can children receive MYORIL INJECTION?
No, MYORIL INJECTION is not recommended for use in children below 16 years of age. Consult your doctor before receiving MYORIL INJECTION.
How does MYORIL INJECTION work?
MYORIL INJECTION works through selective binding to the GABA-A receptor (neurotransmitter). It manages muscle contractions by activating the GABA-inhibitory motor pathway and inhibiting the glycine receptors (neurotransmitters). Thus, relaxing the muscle pain and spasms.
When is MYORIL INJECTION contraindicated?
MYORIL INJECTION is not recommended for use in patients with flaccid paralysis, muscular hypotonia and hypersensitivity to this medicine. Consult your doctor before receiving MYORIL INJECTION.
Can a pregnant woman receive MYORIL INJECTION?
MYORIL INJECTION is not recommended for use in pregnant women, planning to have a baby or women of childbearing potential not taking contraceptives. Consult your doctor before receiving MYORIL INJECTION.
References
1. KD Tripathi. Skeletal Muscle Relaxants. Essentials of medical pharmacology. Eighth Edition. 2019. Page –383-384.
2. Marco Gervasi, Davide Sisti, Piero Benelli, Eneko Fernández-Peña, Cinzia Calcabrini, Marco B.L. Rocchi, Luigi Lanata, Michela Bagnasco, Andrea Tonti, Stocchi Vilberto, and Piero Sestili. The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness. [Accessed on 6th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627858/
3. A.R Umarkar, S.R Bavaskar & P.N.Yewale. Thiocolchicoside as Muscle Relaxant: A Review. [Revised in September 2011] [Accessed on 6th July 2022] http://www.ijpbsonline.com/uploads/1/2/1/8/12183777/364-371.pdf
4. Iasis Pharma Hellas s.a. Thiocolchicoside [Revised in October 2014] [Accessed on 6th July 2022] https://iasispharma.com/wp-content/uploads/pdf/RELIEF_PIL_ENG.pdf
5. European Medical Agency. Thiocolchicoside. [Revised on November 2013] [Accessed on] https://www.ema.europa.eu/en/documents/referral/thiocolchicoside-article-31-referral-annex-iii_en.pdf
6. Thiocolchicoside. Pubchem. [Revised in July 2022] [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Thiocolchicoside#section=Associated-Disorders-and-Diseases
7. Thiocolchicoside. Clevelandclinic. [Revised in March 2021] [Accessed on 6th July 2022] https://my.clevelandclinic.org/health/diseases/15466-muscle-spasms
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