MYOBID 250MG TABLET 10'S

Introduction About MYOBID 250MG TABLET

MYOBID 250MG TABLET contains Ethionamide which belongs to the group of medicines called Antitubercular drugs. It is used in the management of active tuberculosis caused by a bacteria called M. tuberculosis resistant to other antibiotics (Ex. isoniazid, rifampicin) or when the patient is intolerant to other medicines. MYOBID 250MG TABLET is generally used in combination with other medicines.

Tuberculosis is a serious bacterial infectious disease that affects the lungs. The symptoms are unusual loss of weight, fever, cough, difficulty in breathing, chest pain, loss of appetite, night sweats, etc. Your doctor may monitor your blood sugar level, thyroid function and visual activity regularly while taking MYOBID 250MG TABLET.

MYOBID 250MG TABLET is not recommended for use in patients having severe liver disease. MYOBID 250MG TABLET is not recommended for use in pregnant women and should be used with caution in breastfeeding women. MYOBID 250MG TABLET is not recommended for use in children (below 12 years of age) except in some specific disease conditions. Ask for your doctor’s advice before giving it to your child.

There is no information available on the use of MYOBID 250MG TABLET in elderly patients, hence, consult your doctor before taking it. The most common side effects of taking MYOBID 250MG TABLET are stomach discomfort, diarrhoea, vomiting, nausea, headache, dizziness, general weakness, yellowing of the skin and eyes, fever, fatigue, etc. If the symptoms do not improve, consult your doctor.

Uses Of MYOBID 250MG TABLET

• Manage active tuberculosis resistant to other antibiotics (Ex. isoniazid, rifampicin) or when the patient is intolerant to other medicines

How MYOBID 250MG TABLET Works

MYOBID 250MG TABLET effectively reduces the tuberculosis infection by inhibiting the peptide synthesis, which is necessary for the bacteria, thereby it kills or suppresses the growth of disease-causing bacteria.

How to use MYOBID 250MG TABLET

Always take MYOBID 250MG TABLET as directed by your physician. Swallow with a glass of water and do not crush or chew it. Your doctor will prescribe the correct dose and duration of MYOBID 250MG TABLET management depending upon your age, body weight and health condition. Do not stop taking MYOBID 250MG TABLET unless your doctor advises you to stop.

Side Effects Of MYOBID 250MG TABLET

How To Manage Side Effects

Nausea:

Take MYOBID 250MG TABLET with or just after meals. Stick to simple meals. Avoid eating rich or spicy food, sugary snacks and drinks. Talk to your doctor if the nausea doesn’t improve.

Drowsiness:

Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the drowsiness doesn’t improve.

Vomiting:

Drink clear or ice-cold drinks, eat light, bland foods and avoid fried, oily or sweet foods. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor if your symptom worsens.

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult with your doctor if diarrhea doesn’t improve.

Stomach pain:

Try to rest and relax. Try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.

Dizziness

Lie or sit down immediately when you feel dizzy. If you're feeling severe episode of spinning (vertigo), lie in a dark and quite place with eyes closed. Try to avoid vehicle driving. Discuss with your doctor if the symptom worsens.

Headache:

Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage on scalp or head with mild pressure. Consult your doctor for advice.

Warning & Precautions

Pregnancy

There are no adequate and well controlled studies about the use of MYOBID 250MG TABLET in pregnant women, hence, it is not recommended for use in women who are pregnant or likely to become pregnant unless considered necessary by the doctor. Consult your doctor about the risks and benefits before taking MYOBID 250MG TABLET.

Breastfeeding

There is no information available on the use of MYOBID 250MG TABLET in breastfeeding women, hence, it should be used only if the benefits outweigh the risks to the baby. New-borns who are breast-fed by mothers taking MYOBID 250MG TABLET should be monitored carefully. Consult your doctor before taking it.

Driving and Using Machines

Do not drive or use any machineries if you feel drowsy or have a headache after taking MYOBID 250MG TABLET.

Alcohol

Avoid consumption of alcohol while taking MYOBID 250MG TABLET as it may cause psychotic reactions.

Liver

MYOBID 250MG TABLET is not recommended for use in patients having severe liver disease. Consult your doctor for advice.

Allergy

Do not take MYOBID 250MG TABLET if you are allergic to Ethionamide or any of the other ingredients of this medicine.

Interactions

A. Drug - Drug interactions:

Before taking MYOBID 250MG TABLET, inform your doctor if you are taking any of the following medicines:

• isoniazid and rifampicin (used to manage tuberculosis)

Overdosage:

If you or anyone else accidentally take too much of MYOBID 250MG TABLET, consult your doctor immediately or visit the nearby hospital.

Synopsis

More Information

• Keep MYOBID 250MG TABLET out of reach of children
• Store MYOBID 250MG TABLET at a temperature below 30°C

FAQs About MYOBID 250MG TABLET

Can pregnant woman take MYOBID 250MG TABLET?

There are no adequate and well controlled studies about the use of MYOBID 250MG TABLET in pregnant women, hence, it is not recommended for use in women who are pregnant or likely to become pregnant unless considered necessary by the doctor. Consult your doctor about the risks and benefits before taking MYOBID 250MG TABLET.

Can MYOBID 250MG TABLET be given to children?

MYOBID 250MG TABLET is not recommended for use in children (below 12 years of age) except in some specific disease conditions. Consult your child's doctor for advice. The doctor will advise a proper dose or select a suitable alternative management for your child.

Can MYOBID 250MG TABLET cause nerve related side effects?

MYOBID 250MG TABLET can cause peripheral neuritis (weakness, pain or numbness in hands and feet) or optic neuritis (inflammation of the optic nerve). Your doctor might prescribe you pyridoxine or vitamin B6 along with MYOBID 250MG TABLET to reduce these side effects. Ask for your doctor’s advice.

For how long should I take MYOBID 250MG TABLET?

MYOBID 250MG TABLET should be taken exactly as directed by your doctor. Do not stop taking it early or use it for a prolonged period. Skipping doses or not completing the full term management of MYOBID 250MG TABLET may decrease the effectiveness of the immediate management and increase the likelihood that bacteria will develop resistance against MYOBID 250MG TABLET and will not be manageable by this medicine or other antibacterial drugs in the future. Ask your doctor if you wish to discontinue.

What are the tests that should be done frequently while taking MYOBID 250MG TABLET?

While taking MYOBID 250MG TABLET, your doctor might ask you to check your blood glucose levels priorly and periodically throughout therapy with MYOBID 250MG TABLET. Patients having diabetes should be particularly alert for episodes of hypoglycaemia. Periodic monitoring of thyroid function tests is recommended while taking MYOBID 250MG TABLET as hypothyroidism may occur. Along with this, your doctor may ask you to perform eye examinations.

Should MYOBID 250MG TABLET be taken with or without meals?

MYOBID 250MG TABLET can be taken with or without meals. It is preferable to take it after meals, as this will help in reducing the gastrointestinal effects of MYOBID 250MG TABLET. Ask for your doctor’s advice.

References

1. KD. Tripathi. Antitubercular drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page – 821.

2. Ethionamide. NIH National Library of Medicine, National Centre for biotechnology information. PubChem. September 2022. [Accessed on 5th September 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Ethionamide

3. Ethionamide. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. NIH National Library of Medicine, National Centre for biotechnology information. December 2020. [Accessed on 5th September 2022]. https://www.ncbi.nlm.nih.gov/books/NBK548025/

4. J B Bass Jr, L S Farer, P C Hopewell, R O'Brien, R F Jacobs, F Ruben, D E Snider Jr, G Thornton. Treatment of tuberculosis and tuberculosis infection in adults and children. American Thoracic Society and The Centers for Disease Control and Prevention. NIH National Library of Medicine, National Centre for biotechnology information. Pubmed.gov. May 1994. [Accessed on 5th September 2022]. https://pubmed.ncbi.nlm.nih.gov/8173779/

5. Micro Labs Limited. World Health Organisation (WHO). [Revised in April 2020]. [Accessed on 5th September 2022]. https://extranet.who.int/pqweb/sites/default/files/TB242part3.pdf

6. Wyeth Pharmaceutical Inc. U.S. Food & Drug Administration. [Revised in August 2016]. [Accessed on 5th September 2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/013026s029lbl.pdf

7. Pfizer. Trecator (Ethionamide). [Revised in July 2020]. [Accessed on 5th September 2022]. https://labeling.pfizer.com/showlabeling.aspx?format=PDF&id=473

Useful Diagnostic Tests

• Mantoux test

Author Details

Written By Dr. Jeenal Rajani - Pharm.D.

Reviewed For Accuracy By Dr. Nitin Sattiwale - MBBS

Last updated on 06 Dec 2022 | 05:25 PM(IST)