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Introduction About MONOLOSIN DFT CAPSULE
MONOLOSIN DFT CAPSULE is a combination of Deflazacort and Tamsulosin which belongs to the group of medicines called Corticosteroids and Alpha-blockers respectively. It is used in the management of kidney stone by facilitating easy urination. Kidney stones are abnormal hard deposits formed from minerals and salts inside the kidney due to some underlying medical condition or certain medications. It is characterized by severe sharp pain in the either side of the lower back, blood in urine, vague stomach-ache, fever, chills or cloudy urine.
Do not drink grapefruit juice while taking MONOLOSIN DFT CAPSULE. Avoid taking this medicine, if you are allergic to Deflazacort or Tamsulosin or having severe liver infection, serious eye infection, duchenne muscular dystrophy, dizziness (while getting up) or micturition syncope (discomfort while urination). Before taking MONOLOSIN DFT CAPSULE, inform your doctor if you have high blood pressure, osteoporosis (weak bones), kidney or heart diseases.
MONOLOSIN DFT CAPSULE is not recommended for use in pregnant and breast-feeding women since it is used only in men. It is not recommended for use in children and adolescents (aged below 18 years). Also, it is used with caution in elderly patients. The most common side effects of taking MONOLOSIN DFT CAPSULE are dizziness, difficulties in ejaculation, increased appetite, frequent urination, nausea and stomach pain. Consult your doctor if any of the side effect gets worse.
Uses Of MONOLOSIN DFT CAPSULE
- It is used in the management of kidney stones
How MONOLOSIN DFT CAPSULE Works
MONOLOSIN DFT CAPSULE helps in managing kidney stone and facilitates easy urination where Deflazacort blocks the production of certain chemical messengers in the body that cause inflammation and enhances the muscle strength as well as functioning and Tamsulosin binds selectively and competitively to certain receptors, causing muscle relaxation around the bladder exit and prostate gland, thereby allowing easy passage of urine.
How to use MONOLOSIN DFT CAPSULE
Take MONOLOSIN DFT CAPSULE as advised by your physician. Swallow the medicine with the glass of water. Do not crush or chew the medicine. Take this medicine after breakfast or after the first daily meal. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of MONOLOSIN DFT CAPSULE
Common
- dizziness (especially upon an abrupt change in the position)
- difficulties in ejaculation (little or no semen ejaculated at sexual climax)
- cloudy urine following sexual climax, frequent urination
- cushingoid appearance (extra fat build-up on the face)
- increased appetite
- cough
- weight gain
- central obesity
- upper respiratory tract infection such as inflammation in nose and throat or runny nose
- redness of skin, rash, bruise
- fever
- nausea
- back pain
- psychomotor hyperactivity, irritability
- nosebleed
- stretch marks
- abdominal discomfort/pain
Uncommon
- headache
- light-headedness or fainting (due to postural low blood pressure)
- swelling and irritation inside the nose
- constipation
- diarrhoea
- vomiting
- indigestion
- itching, red itchy skin
- weakness, thirst
- increased flow of tears in eyes
- infections such as hordeolum (infection in the eye lid), impetigo (red sores on face), influenza (common cold), otitis externa (an ear infection), pharyngitis (a throat infection), tooth abscess (pus formation beneath the tooth), urinary tract infection, viral infections
- irregular heart rate
- muscle spasms or pain, neck mass, neck pain, pain in extremity (legs and arms)
- mood disorders such as mood swings, aggression, depression, emotional disorder, sleeplessness, restlessness
- urinary disorders such as chromaturia (abnormal colouration of urine), painful urination, hypertonic bladder (disorder causing sudden urge to urinate)
- pain in testes
- shallow or slow breathing
- skin problems such as pimples, baldness
- dermatitis acneiform (condition marked by the formation of acne-like bumps on affected site)
- hot flush
Rare
- syncope (short-term loss of consciousness)
- signs of allergy reactions such as angioedema (rapid swelling beneath the skin) or anaphylaxis (fainting, shortness of breath and noisy breathing)
Stop taking MONOLOSIN DFT CAPSULE and contact your doctor if you experience any of the following side effects:
- serious skin rashes
- signs of stevens-johnson syndrome (a serious hypersensitivity reaction) such as purplish spots or patches on the skin, blisters, skin peeling, (high) fever, joint pain, and/or eye inflammation
- serious allergic reaction such as angioedema (swelling of the face or throat)
How To Manage Side Effects
Constipation
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Diarrhea
Drink lot of fluids such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.
Dizziness Or Drowsiness
MONOLOSIN DFT CAPSULE may cause dizziness which can be managed by lying down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking alcohol or smoking. Consult your doctor if the symptom persists for long or gets worsened.
Nausea And Vomiting
Try to take MONOLOSIN DFT CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich or spicy food. Consult your doctor if the symptom gets worse.
Warning & Precautions
Pregnancy
ContraindicatedMONOLOSIN DFT CAPSULE is not recommended for use in pregnant women since it is used only in men.
Breastfeeding
ContraindicatedMONOLOSIN DFT CAPSULE is not recommended for use in breastfeeding women since it is used only in men.
Driving and Using Machines
Use with CautionMONOLOSIN DFT CAPSULE should be used with caution while driving or operating machines since it might cause dizziness. Consult your doctor before taking MONOLOSIN DFT CAPSULE.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking MONOLOSIN DFT CAPSULE since it may alter the effect of this medicine.
Kidney
Use with CautionMONOLOSIN DFT CAPSULE should be used with caution in patients with severe renal impairment. Consult your doctor for advice before taking MONOLOSIN DFT CAPSULE.
Liver
ContraindicatedMONOLOSIN DFT CAPSULE is not recommended for use in patients with severe liver infection. Consult your doctor before taking MONOLOSIN DFT CAPSULE.
Allergy
ContraindicatedMONOLOSIN DFT CAPSULE is not recommended for use if you are allergic to Deflazacort, Tamsulosin or any other ingredients of this medicine.
Heart Disease
Use with CautionMONOLOSIN DFT CAPSULE should be used with caution in patients with heart disease such as congestive heart disease (inability of heart to pump sufficient blood), recent myocardial infarction (blockage of blood flow to heart). Consult your doctor before taking MONOLOSIN DFT CAPSULE.
Use In Pediatrics
ContraindicatedMONOLOSIN DFT CAPSULE is not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.
Use In Geriatrics
Use with CautionMONOLOSIN DFT CAPSULE should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking MONOLOSIN DFT CAPSULE.
Others
MONOLOSIN DFT CAPSULE is not recommended for use if you:
- have history of angioedema (swelling due to allergic reaction) after using of certain drugs
- feel dizziness when you sit up or stand up from the lying position
- suffer from micturition syncope (malaise or discomfort during or after urinating)
Before taking MONOLOSIN DFT CAPSULE, inform your doctor if you:
- have high blood pressure
- have osteoporosis (condition marked by weak bones)
- are planning for vaccination
- have neuromuscular transmission disorders such as myasthenia gravis
- have thromboembolic disorders such as deep vein thrombosis and pulmonary embolism
- are scheduled to undergo cataract or glaucoma (eye disorder) surgery
- have certain gastro-intestinal (abdominal) disorders such as active or latent peptic ulcers, diverticulitis (small, bulging pouches in digestive tract), fresh intestinal anastomoses (surgical procedure to connect two distant portions of intestine) and non-specific ulcerative colitis (inflammatory bowel disease)
Interactions
A. Drug-Drug Interactions:
Before taking MONOLOSIN DFT CAPSULE, inform your doctor, if you are taking any of the following medicines:
- erythromycin, clarithromycin, rifampin (used to manage bacterial infections)
- ketoconazole, fluconazole (used to manage fungal infections)
- diltiazem, verapamil (used to manage blood pressure)
- efavirenz (used to manage human immunodeficiency virus infection)
- carbamazepine, phenytoin (used to manage epilepsy)
- neuromuscular blocking agents (medicines used to relax muscles) Ex. pancuronium
- over-the-counter medicines (Ex. dietary supplements and herbal products)
- insulin (used to manage diabetes)
- anticoagulants (Ex. warfarin)
- alpha-1 adrenergic receptor (Ex. alfuzosin, doxazosin)
- non-steroidal anti-inflammatory drugs (Ex. diclofenac, aspirin)
B. Drug-Food Interactions:
Avoid drinking grapefruit juice while taking this medicine. Consult your doctor before taking the medicine.
Overdosage:
If you or anyone else accidentally takes too much of MONOLOSIN DFT CAPSULE, consult your doctor immediately or visit the nearby hospital. Overdosage of MONOLOSIN DFT CAPSULE is low blood pressure.
Synopsis
| Drug | : | Deflazacort, Tamsulosin |
| Pharmacological Category | : | Corticosteroids, Alpha-blockers |
| Therapeutic Indication | : | Kidney stones |
| Dosage Forms | : | Capsule, Tablet |
More Information
Storage
- Keep MONOLOSIN DFT CAPSULE out of reach of children
- Store MONOLOSIN DFT CAPSULE at room temperature
FAQs About MONOLOSIN DFT CAPSULE
Q: What is MONOLOSIN DFT CAPSULE used for?
A: MONOLOSIN DFT CAPSULE is used in the management of kidney stone which works by relaxing the muscle around the bladder exit and prostate gland that results in easy urination or free flow of urine.
Q: What happens if you take more MONOLOSIN DFT CAPSULE than your required dose?
A: If you or anyone else accidentally takes too much of MONOLOSIN DFT CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are signs of low blood pressure such as light headedness, dizziness or blurred vision.
Q: Who should avoid taking MONOLOSIN DFT CAPSULE?
A: MONOLOSIN DFT CAPSULE is not recommended for use if you have a history of angioedema (swelling due to allergic reaction) after using of certain drugs, feel dizziness when you sit up or stand up from the lying position, suffer from micturition syncope (malaise or discomfort during or after urinating).
Q: Is MONOLOSIN DFT CAPSULE safe to use in children?
A: MONOLOSIN DFT CAPSULE is not recommended for use in children and adolescents (aged below 18 years) because tamsulosin (one of the drugs in this medicine) does not work in this population. Consult your doctor before taking MONOLOSIN DFT CAPSULE.
Q: Does MONOLOSIN DFT CAPSULE make you pee more at night?
A: No, MONOLOSIN DFT CAPSULE does not make you pee more at night. On contrary to this, tamsulosin (one of the drugs in this medicine) reduces night-time urine production in patients with nocturnal polyuria (disorder causing excess urine production in the night-time). Consult your doctor before taking MONOLOSIN DFT CAPSULE.
Q: What if I forget to take MONOLOSIN DFT CAPSULE dose?
A: If you have forgotten to take MONOLOSIN DFT CAPSULE at the scheduled time, take it anytime later during the day. If you realize this fact only on the next day, continue with the usual dosage scheme. Do not take a double dose to make up for a forgotten dose. Consult your doctor before taking MONOLOSIN DFT CAPSULE.
References
1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) & Drugs for Glaucoma and Corticosteroids. Essentials of medical pharmacology. Seventh edition. 2013. Page-142 & 289.
2. Yoshiyuki Kojima, Shoichi Sasaki, Makoto Imura, Yasue Kubota, Yutaro Hayashi, Kenjiro Kohri. Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: a prospective open-label long-term study using frequency-volume chart. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. October 2011. [Assessed on 28th June 2022] https://pubmed.ncbi.nlm.nih.gov/22038792/
3. Pawel Pasko, Tomasz Rodacki, Renata Domagala-Rodacka, Danuta Owczarek. Interactions between medications employed in treating benign prostatic hyperplasia and food - A short review. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. August 2016. [Assessed on 28th June 2022] https://pubmed.ncbi.nlm.nih.gov/27551761/
4. Zentiva Pharma UK Limited. Electronic Medicine Compendium (EMC). [Revised in May 2021] [Accessed on 28th June 2022] https://www.medicines.org.uk/emc/files/pil.9245.pdf
5. Marathon Pharmaceuticals, LLC. Food and Drug Administration (FDA). [Revised in February 2017] [Accessed on 28th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208684s000,208685s000lbl.pdf
6. Clinical Pharmacology and Biopharmaceutics. Food and Drug Administration (FDA). [Revised in April 2016] [Accessed on 28th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208684,208685Orig1s000ClinPharmR.pdf
7. Olcare Laboratories Pvt. Ltd. Defolt - TM Tablets (Deflazacort + Tamsulosin). [Accessed on 28th June 2022] https://m.olcarelaboratories.com/defolt-tm-tablets-6765246.html
Useful Diagnostic Tests
- Urinalysis
- Abdominal and Pelvic CT (Computed tomography) scan
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