Miprogen 100 mg Pessaries 10'S
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Introduction About MIPROGEN 100 MG PESSARIES
MIPROGEN 100 MG PESSARIES contains Progesterone which belongs to the group of medicines called Steroid hormones. It is used as a supplementation to support embryo implantation and early pregnancy in women taking part in Assisted Reproductive Technology (ART) management program for infertile women.
It is also used from second trimester of pregnancy to manage pregnant women from going into early labor and manages pre-menstrual syndrome (occurs during the 7 to 10 days before monthly period) and post-childbirth depression.
Prior to MIPROGEN 100 MG PESSARIES management, your doctor might perform a physical examination including special attention to the breasts, abdomen and pelvic organs.
MIPROGEN 100 MG PESSARIES is not recommended for use in patients with undiagnosed vaginal or urinary tract bleeding, miscarriage with suspected tissue still in the womb, known or suspected cancer of the breast or reproductive tract, blood clots or porphyria disorders (a group of genetic or acquired disorders of certain enzymes).
Before using MIPROGEN 100 MG PESSARIES, inform your doctor if you have liver, heart or kidney problems, fits, migraine, asthma, diabetes, depression or if you are about to undergo any planned surgery.
MIPROGEN 100 MG PESSARIES is not recommended for use in pregnant women unless advised by the doctor. It is not recommended for use in breast-feeding women, children and adolescents (below 18 years of age).
The most common side effects of using MIPROGEN 100 MG PESSARIES are drowsiness, stomach discomfort or pain, breast pain, irritation or itching at the insertion site and unusual tiredness. Consult your doctor if any of the symptoms deteriorate.
Uses Of MIPROGEN 100 MG PESSARIES
It is used:
- as a supplementation to support embryo implantation and early pregnancy in women taking part in Assisted Reproductive Technology (ART) management program for infertile women
- from second trimester of pregnancy to manage pregnant women from going into early labor
- to manage pre-menstrual syndrome and post-childbirth depression
How MIPROGEN 100 MG PESSARIES Works
MIPROGEN 100 MG PESSARIES helps prepare your uterus to receive and maintain a fertilized egg. It also works by adjusting the hormonal balance within the body, which gets imbalanced during pre-menstrual syndrome or related problems.
How to use MIPROGEN 100 MG PESSARIES
Use MIPROGEN 100 MG PESSARIES as advised by your physician. It is for vaginal use only. Wash your hands thoroughly with soap and water before and after each use. Insert MIPROGEN 100 MG PESSARIES between the lips of the vagina and push it upwards deep into the vagina. You may find it easier to administer if you are lying down or in squatting position.
Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition. Do not stop using MIPROGEN 100 MG PESSARIES unless your doctor advises you to stop.
Side Effects Of MIPROGEN 100 MG PESSARIES
Common
- headache, drowsiness
- stomach discomfort or pain, bloating
- nausea, vomiting
- breast pain or tenderness
- acne, hot flushes
- mood swings, irritability, changes in libido
- location irritation or itching at the site of insertion
- unusual tiredness or weakness
- weight gain
- swelling face, ankles and feet (oedema)
- insomnia
- increase blood pressure (in susceptible individuals)
- loss or gain of body facial or scalp hair or brown spots on exposed skin (melasma)
Rare
Stop using MIPROGEN 100 MG PESSARIES and contact your doctor immediately if you experience any of the following side effects:
- possible clots in the legs, heart or lungs (pain in the calves or chest, sudden breathlessness or coughing blood)
- possible clots in the brain or eye (severe headache or vomiting, dizziness or changes in vision or speech, weakness or numbness of an arm or leg)
- worsening of depression
- allergic reaction (itchy skin rash)
- migraine
- jaundice (yellow skin or the whites of the eyes)
How To Manage Side Effects
Nausea:
Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, consult your doctor.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. If you stomach still aches, consult your doctor.
Headache:
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Tiredness:
Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
MIPROGEN 100 MG PESSARIES is not recommended for use if you are pregnant unless advised by the doctor. Consult your doctor before using it.
Breastfeeding
MIPROGEN 100 MG PESSARIES is not recommended for use during breast-feeding. Consult your doctor before using it.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy or drowsy after using MIPROGEN 100 MG PESSARIES.
Alcohol
Before using MIPROGEN 100 MG PESSARIES, inform your doctor if you consume alcohol as it might act as a risk factor for preterm labour and may worsen the dizziness or light-headedness due to this medicine.
Kidney
MIPROGEN 100 MG PESSARIES should be used with caution in patients with kidney dysfunction. Consult your doctor before using MIPROGEN 100 MG PESSARIES.
Liver
MIPROGEN 100 MG PESSARIES is not recommended for use in patients who have or had severe liver problems. MIPROGEN 100 MG PESSARIES should be used with caution in patients with liver problems like jaundice (yellow skin and whites of the eyes). Consult your doctor before using MIPROGEN 100 MG PESSARIES.
Allergy
Do not use MIPROGEN 100 MG PESSARIES if you are allergic to Progesterone or any other ingredients of this medicine. Inform your doctor if you are allergic to any other substances like foods, preservatives or dyes.
Lungs
MIPROGEN 100 MG PESSARIES is not recommended for use in patients who had or have blood clot in the lungs (pulmonary embolism). It should be used with caution in patients with asthma. Consult your doctor before using MIPROGEN 100 MG PESSARIES.
Heart Disease
MIPROGEN 100 MG PESSARIES should be used with caution in patients with cardiac dysfunction. Consult your doctor before using MIPROGEN 100 MG PESSARIES.
Others
MIPROGEN 100 MG PESSARIES is not recommended for use if you:
- have undiagnosed vaginal or urinary tract bleeding
- have known or suspected cancer of the breast, womb lining or reproductive tract
- have porphyria disorders (a group of genetic or acquired disorders of certain enzymes)
- have or had blood clots in the legs, eyes or somewhere else in the body
- have thrombophlebitis (inflammation of the vessel wall associated with blood clot)
- have a miscarriage and your doctor suspects some tissue is still in the uterus or pregnancy outside the womb
Before using MIPROGEN 100 MG PESSARIES, inform your doctor if you:
- have fits
- have migraine
- have a history of depression
- have diabetes (high blood sugar)
- have hyperlipidemia (disturbed cholesterol or lipid metabolism)
- are about to have any surgery
Use in pediatrics:
MIPROGEN 100 MG PESSARIES is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
There is no proper information about the use of MIPROGEN 100 MG PESSARIES in elderly patients (aged above 65 years). Consult your doctor before using it.
Interactions
A. Drug - Drug interactions:
Before using MIPROGEN 100 MG PESSARIES, inform your doctor if you are taking any of the following medicines:
- medicines used to manage fits (Ex. carbamazepine, phenytoin, phenobarbital, aminoglutethimide)
- medicines used to manage bacterial infections (Ex. rifampicin, rifabutin)
- other vaginal products (such as antifungal products)
Overdosage:
If you or anyone else accidentally swallow or use too much of MIPROGEN 100 MG PESSARIES, consult your doctor immediately or visit the nearby hospital. Symptoms after accidental ingestion includes nausea, vomiting, euphoria or menstrual cramps.
Synopsis
| Drug | : | Progesterone |
| Pharmacological Category | : | Progestins (female hormones) |
| Therapeutic Indication | : | Premenstrual syndrome, Post-natal depression, Supports embryo implantation and early pregnancy, Manages early labor |
| Dosage Forms | : | Tablet, Soft gel Capsule, Pessaries, Injection, Vaginal Gel, Vaginal spray |
More Information
- Keep MIPROGEN 100 MG PESSARIES out of reach of children
- Store between 15-30°C
FAQs About MIPROGEN 100 MG PESSARIES
What if I forget to use a dose of MIPROGEN 100 MG PESSARIES?
If you forget to use a dose of MIPROGEN 100 MG PESSARIES, use it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not use MIPROGEN 100 MG PESSARIES two times to make up for the missed dose.
Can MIPROGEN 100 MG PESSARIES be stopped on my own?
Continue using MIPROGEN 100 MG PESSARIES until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. Stopping MIPROGEN 100 MG PESSARIES abruptly may cause increased anxiety, moodiness and increased sensibility to fits.
What if I accidentally swallow MIPROGEN 100 MG PESSARIES?
If you accidentally swallow MIPROGEN 100 MG PESSARIES or take it by mouth, contact your doctor or go to a nearby hospital immediately. You may experience symptoms like euphoria, nausea, vomiting or menstrual cramps.
What are the common side effects of MIPROGEN 100 MG PESSARIES?
The most common side effects of using MIPROGEN 100 MG PESSARIES are headache, drowsiness, stomach discomfort or pain, bloating, breast pain, hot flushes, weight gain, irritation or itching at the insertion site and unusual tiredness or weakness, etc. Consult your doctor if any of the side effects worsen or bothers you.
Can MIPROGEN 100 MG PESSARIES be used in patients with liver problems?
MIPROGEN 100 MG PESSARIES is not recommended for use in patients who have or had severe liver problems. MIPROGEN 100 MG PESSARIES should be used with caution in patients with liver problems like jaundice (yellow skin and whites of the eyes). Consult your doctor before using it.
References
1. KD. Tripathi. Estrogens, Progestins, and Contraceptives. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 316.
2. Walter Ciampaglia, Graciela E Cognigni. Clinical Use of Progesterone in Infertility and Assisted Reproduction. Obstetrics and Gynaecology. September 2015. [Accessed on 25th July 2022] https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/aogs.12770
3. The George Washington University Biostatistics Center. A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix (PROSPECT). ClinicalTrials.gov. [Revised in June 2022] [Accessed on 18th August 2022] https://clinicaltrials.gov/ct2/show/NCT02518594
4. Accord-UK Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 18th August 2022] https://www.medicines.org.uk/emc/files/pil.5568.pdf
5. Pharmaceutics International Inc. U.S. Food & Drug Administration. [Revised in February 2008] [Accessed on 18th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022057s001lbl.pdf
6. Orion Laboratories Pty Ltd. Progesterone 100mg, 200mg pessaries. [Revised in June 2019] [Accessed on 18th August 2022] https://www.nps.org.au/assets/medicines/132757c8-f44d-4265-8c02-a53300ff892f-reduced.pdf
Useful Diagnostic Tests
- Saline-infusion sonography
- Ultrasound
- Anti-mullerian hormone
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