Metpure XL 25mg Tablet 10'S

Introduction About METPURE XL 25MG TABLET

Metpure XL 25 Tablet is a widely used prescription medicine containing Metoprolol, a beta-blocker known for supporting heart health. It is commonly used to manage high blood pressure, chest discomfort related to heart activity (angina), and irregular heartbeat (arrhythmia). In many cases, it is also recommended to aid heart function after a heart attack or to support individuals dealing with migraines or symptoms related to an overactive thyroid. Its extended-release format ensures a consistent effect throughout the day.

This medicine is generally suitable for adults who need stable blood pressure control or support with chronic cardiovascular conditions. It is often included in long-term heart care plans for individuals recovering from cardiac events or managing heart rhythm imbalances. Patients experiencing frequent migraines may also benefit, based on individualized evaluations. It may not be ideal for people with certain pre-existing health conditions, such as asthma, severe circulation issues, or very slow heart rate, unless specifically guided by a healthcare provider.

Metpure XL 25 Tablet should be taken once daily, preferably at the same time each day, with or without food. It is important to follow the dosage as instructed by your doctor and avoid abruptly discontinuing the medication, as this may have undesired effects on heart function. If a dose is missed, it should be taken as soon as possible, unless it's close to the next scheduled dosage. Regular monitoring of blood pressure and heart rate is advised throughout the treatment course to ensure safe and effective use.

Before starting this medication, always inform your doctor of any pre-existing health conditions, including liver, kidney, thyroid, or lung-related concerns. Special care should be taken if you are pregnant or breastfeeding, as the medicine may be used only under strict medical supervision. Some individuals may experience side effects such as fatigue, dizziness, slow heartbeat, nausea, headache, cold hands or feet, and mild digestive issues. These are commonly manageable but should be reported to your healthcare provider if persistent or severe.

Uses Of METPURE XL 25MG TABLET

• High blood pressure (hypertension)
• Heart-related chest pain (angina)
• Irregular heart rhythm (arrhythmia)
• Support after heart attack (myocardial infarction)
• Heart failure
• Migraine-related headache relief

Benefits of METPURE XL 25MG TABLET

Metpure XL 25 mg for high blood pressure

Metpure XL 25 mg Tablet is widely used to support the management of high blood pressure. By blocking certain natural chemicals in the body, it helps slow the heart rate and relax blood vessels. This action makes it easier for the heart to pump blood, resulting in lower blood pressure and a reduced risk of future complications such as stroke, heart attack, or kidney problems. Regular use as directed is important for optimal results.

Metpure XL 25 mg for arrhythmia

This tablet plays a key role in stabilizing abnormal heart rhythms. It helps normalize irregular heartbeats and can slow the heart rate during episodes of arrhythmia. By maintaining a steady rhythm, Metpure XL 25 mg supports overall heart health and helps reduce the risk of complications related to abnormal heart rhythms.

Metpure XL 25 mg for Chest Pain

Metpure XL 25 mg Tablet is beneficial for individuals experiencing heart-related chest pain (angina). It relaxes and widens blood vessels, ensuring the heart receives adequate oxygen. This can help decrease the frequency and intensity of chest pain episodes, allowing for improved exercise capacity and daily comfort when used consistently as prescribed.

Metpure XL 25 mg for heart health

By supporting healthy blood pressure, stabilizing heart rhythms, and improving blood flow, Metpure XL 25 mg contributes to overall heart health. Its regular use can lower the risk of serious heart-related events and promote better cardiovascular function over time

Metpure XL 25 mg for migraine

Metpure XL 25 mg Tablet may also be recommended to help relieve migraine-related headaches. It is believed to work by influencing blood flow and certain electrical activities in the brain, which can reduce the frequency and severity of migraine attacks, supporting a better quality of life for those affected.

How METPURE XL 25MG TABLET Works

How does Metpure XL 25 lower blood pressure

Metpure XL 25 Tablet lowers blood pressure by blocking the effect of stress hormones like adrenaline on the heart and blood vessels. This helps the heart beat with less force and slower pace, which reduces the pressure inside the blood vessels. As a result, blood flows more smoothly, lowering elevated blood pressure levels. Keeping blood pressure in check can reduce strain on the heart and lower the risk of conditions such as stroke, heart failure, or kidney issues.

How does Metpure XL 25 slow down the heart rate

Metpure XL 25 works by selectively blocking beta-1 receptors in the heart, which are responsible for responding to stress and increasing heart rate. By reducing this response, the medicine helps the heart beat more slowly and steadily. A slower heart rate means the heart muscle uses less oxygen and energy, easing its workload and promoting better heart performance over time.

How does Metpure XL 25 help in arrhythmia

Metpure XL 25 helps by stabilizing the heart’s electrical signals. It slows down the transmission of these signals, especially in parts of the heart responsible for rhythm control. This supports a regular heartbeat and reduces the chances of experiencing episodes of irregular heart rhythms. It is often part of a prescribed plan to maintain heart rhythm in conditions like atrial fibrillation or other cardiac rhythm disorders.

What does Metpure XL 25 do to heart vessels

Metpure XL 25 helps relax and widen the blood vessels, a process known as vasodilation. This allows blood to move more freely and reduces the effort required by the heart to pump blood throughout the body. Better blood flow also means improved oxygen supply to the heart, which can ease discomfort associated with conditions like angina and contribute to long-term heart health.

How to use METPURE XL 25MG TABLET

Metpure XL 25 recommended dosage instructions

• Take Metpure XL 25 Tablet exactly as prescribed by your doctor, based on your medical condition and response to therapy.
• The tablet is usually taken once daily. Your doctor may adjust the dose according to your needs and how you respond to the medicine.
• Do not take more than the recommended dose. Excess dosing may increase the risk of side effects such as very slow heartbeat or drastic drops in blood pressure.
• Continue taking the medicine for the duration advised, even if you feel well, as stopping abruptly may worsen your condition.
• It may take several weeks to achieve its full benefit, so regular use as advised is important.

Metpure XL 25 administration guide

• Swallow the tablet whole with a full glass of water; do not crush, break, or chew the tablet.
• Metpure XL 25 can be taken with or without food, but taking it at the same time each day helps improve adherence and effectiveness.
• If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose—do not double up.
• Avoid consuming alcohol while using this tablet, as it may intensify side effects such as dizziness or drowsiness.
• Stand up slowly from sitting or lying positions to minimize the risk of lightheadedness.

Metpure XL 25 dose adjustment

• Dose adjustments may be necessary for individuals with liver disease; consult your doctor for tailored advice.
• This medicine is generally considered safe in patients with kidney disease; dose adjustment is typically not required, but always consult your healthcare provider.
• Starting doses are often low and gradually increased to reduce the risk of side effects, such as dizziness or very slow heart rate.
• Inform your doctor about any new symptoms or side effects—your dose may need to be adjusted or tapered accordingly.
• Dose adjustments are also important in elderly patients or those taking other medications that affect blood pressure or heart rate.

What if I forgot to take METPURE XL 25MG TABLET

If you forget to take a dose of Metpure XL 25, you should take it as soon as you remember. However, if it’s almost time for your next scheduled dose, it’s best to skip the missed one and continue with your regular dosing routine. Do not take two doses at once to make up for the missed dose, as this can increase the risk of side effects such as dizziness, low heart rate, or a sudden drop in blood pressure. Taking your medicine at the same time each day helps maintain a consistent level in your body, so consider setting a daily reminder to avoid missing doses.

Overdose

Taking more than the prescribed amount of Metpure XL 25 can be dangerous and requires immediate medical attention. Symptoms of overdose may include an abnormally slow heart rate, significant decrease in blood pressure, dizziness, fainting, breathing difficulties, or even loss of consciousness. Other signs may include nausea, vomiting, confusion, and bluish lips or fingertips. In severe cases, overdose can lead to cardiac arrest or other serious complications. If an overdose is suspected, contact emergency medical services or visit the nearest hospital without delay. Bringing the medication packaging along can help healthcare professionals provide timely and accurate treatment.

Side Effects Of METPURE XL 25MG TABLET

Common side effects of METPURE XL 25MG TABLET

• tiredness, dizziness
• depression
• diarrhea
• shortness of breath, bradycardia (slow heartbeat)
• itching, rash

When to Seek Medical Attention?

Stop taking METPURE XL 25MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• difficulty breathing
• severely low heart rate
• signs of heart failure (weight gain, increasing breathlessness)

Warning & Precautions

Pregnancy

Use with Caution

METPURE XL 25MG TABLET should be used with caution in pregnant women. Consult your doctor for advice.

Breastfeeding

Use with Caution

METPURE XL 25MG TABLET should be used with caution in breastfeeding woman. Consult your doctor for advice.

Liver

Use with Caution

METPURE XL 25MG TABLET should be used with caution in patients having liver impairment. Consult your doctor for advice.

Allergy

Contraindicated

METPURE XL 25MG TABLET is not recommended for use if you are allergic to S-Metoprolol, other beta blockers like propranolol, atenolol or any of the other ingredients of this medicine.

Lungs

Contraindicated

METPURE XL 25MG TABLET is not recommended for use in patients having bronchospastic diseases (tightening of airways). Consult your doctor for advice.

Heart Disease

Contraindicated

METPURE XL 25MG TABLET is not recommended for use in patients with second- or third-degree heart block, decompensated heart failure, heart rhythm disorder (sinus bradycardia and sick sinus syndrome), cardiogenic shock, severe peripheral arterial circulatory disorder, acute myocardial infarction. Consult your doctor for advice.

Use In Pediatrics

Consult your doctor

Safety and effectiveness of METPURE XL 25MG TABLET in children (less than 6 years of age) have not been established. Consult your child’s doctor for advice. 

Use In Geriatrics

Use with Caution

METPURE XL 25MG TABLET should be used with caution in elderly patients. Consult your doctor for advice.

Other Warnings for METPURE XL 25MG TABLET

Before taking METPURE XL 25MG TABLET, inform your doctor if you:

• have diabetes and low blood sugar levels
• have pheochromocytoma (tumour of adrenal glands)
• have thyroid problem
• are going to have any surgery

Safety Advice

Risk of Masking Symptoms of Hypoglycemia in Diabetics

Metpure XL 25 Tablet, as a beta-blocker, can mask the typical symptoms of low blood sugar (hypoglycemia) in people with diabetes, especially those taking insulin or oral antidiabetic medicines. Classic warning signs—such as rapid heartbeat, tremor, or palpitations—may not be as noticeable while on this medicine, making it harder for diabetic patients to recognize and treat hypoglycemic episodes promptly. To manage this risk, regular monitoring of blood glucose levels is essential. Diabetic patients are advised to closely observe for less obvious symptoms of low blood sugar, such as sweating, confusion, or unusual fatigue. Any unexplained changes in blood sugar readings or the way you feel should be reported to your healthcare provider. Never adjust antidiabetic medication or stop Metpure XL 25 without medical consultation.

Orthostatic Hypotension: Precautions for Sudden Blood Pressure Drops

Metpure XL 25 Tablet can cause a drop in blood pressure, particularly when standing up from sitting or lying down—a condition known as orthostatic hypotension. This may lead to dizziness, lightheadedness, or even fainting, especially at the start of treatment or after dose increases. To reduce this risk, rise slowly from sitting or lying positions and avoid making sudden movements. If you feel dizzy or lightheaded, sit or lie back down immediately until the sensation passes. Elderly individuals and patients on other blood pressure-lowering medications should be especially cautious. Staying well-hydrated and following your doctor's dosage instructions closely can help manage this side effect.

Medication Use Prior to Surgery or Anesthesia

If you are scheduled for surgery or any procedure requiring general or spinal anesthesia, it is important to inform your surgeon and anesthetist in advance that you are taking Metpure XL 25 Tablet. Beta-blockers can interact with anesthetic agents, potentially leading to enhanced effects such as low heart rate (bradycardia) or drops in blood pressure during the procedure. Based on your health status and the nature of your surgery, your doctor may advise you to continue or withhold the medication before the operation. Never stop taking Metpure XL 25 Tablet abruptly on your own; always follow your healthcare provider's instructions to avoid adverse cardiovascular effects.

Diet and Lifestyle Advice

Here are diet and lifestyle tips to follow when taking Metpure XL 25 Tablet for better health outcomes and to minimize the risk of heart-related complications:

• Limit Sodium Intake
  Reduce the use of table salt in your meals and avoid high-sodium processed or packaged foods. Lowering sodium helps the tablet control your blood pressure more effectively.
• Choose a Heart-Healthy Diet
  Eat plenty of whole grains, fresh fruits, vegetables, and low-fat dairy products. Include sources of omega-3 fatty acids like fatty fish, walnuts, and flaxseeds. Use healthier cooking oils such as olive or canola oil instead of saturated fats.
• Avoid Alcohol
  Refrain from drinking alcohol while on Metpure XL 25 Tablet, as it may increase dizziness and the risk of side effects by enhancing the medicine’s impact on blood pressure and alertness.
• Maintain Consistent Medication Timing
  Take your medication at the same time every day, with or without food, to keep your blood pressure steady and improve adherence to treatment.
• Stay Physically Active
  Participate in regular, moderate-intensity activities like brisk walking, cycling, or swimming, as recommended by your doctor. Physical activity supports heart health and better blood pressure control.
• Quit Smoking
  If you smoke, try to stop. Smoking significantly raises the risk of heart disease, and quitting will enhance the protective effects of your medication.
• Manage Stress
  Practice relaxation techniques such as mindfulness, breathing exercises, or yoga. Adequate sleep and spending time with loved ones can also help reduce stress and its negative effects on blood pressure.
• Rise Slowly from Seated or Lying Position
  Stand up gradually to prevent dizziness or fainting, especially when starting the medication or if you occasionally feel lightheaded.
• Monitor Side Effects and Keep Regular Check-Ups
  Be watchful for potential side effects like fatigue, dizziness, cold hands or feet, or stomach discomfort. Report any persistent or severe symptoms to your doctor and do not stop or adjust the dose on your own.

How Does Metpure XL 25 Compare to Other Beta-Blockers Like Bisoprolol or Atenolol for Heart Conditions?

How Does Metpure XL 25 Tablet Compare to Telmisartan in Reducing Blood Pressure and Arterial Stiffness?

Drug - Drug interaction

Metpure XL 25 Tablet (metoprolol succinate) may interact with a variety of other medications, potentially influencing its effectiveness or causing unwanted side effects. Understanding these interactions and their management is crucial for patient safety. Below are some of the most notable drug-drug interactions and practical management strategies:

1. Calcium Channel Blockers (e.g., verapamil, diltiazem)
Interaction: Using Metpure XL 25 Tablet with these medicines can have additive effects in slowing the heart rate and atrioventricular (AV) conduction, increasing the risk of bradycardia or even heart block.
Management: Avoid intravenous administration of both drugs together; if combined oral use is necessary, monitor heart rate and ECG regularly. Seek medical advice if you experience palpitations, dizziness, or chest discomfort.

2. Digoxin and Other Drugs Slowing AV Conduction
Interaction: The risk of bradycardia and heart block increases due to the additive effect on heart conduction.
Management: Monitor heart rate and ECG, and consult your doctor if symptoms like severe dizziness or fainting develop

3. Antidiabetic Agents (Insulin, Oral Hypoglycemics, Sulfonylureas)
Interaction: Metpure XL 25 may mask typical symptoms of low blood sugar (hypoglycemia), making it harder to recognize warning signs like rapid heart rate.
Management: Monitor blood sugar levels more frequently, especially if you have diabetes, and consult your doctor for possible dose adjustments of antidiabetic medicines

4. Clonidine
Interaction: Stopping clonidine suddenly while on Metpure XL 25 can trigger a dangerous rise in blood pressure (hypertensive crisis).
Management: If discontinuing clonidine, stop Metpure XL 25 first and under strict medical supervision

5. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Interaction: NSAIDs can decrease the blood pressure-lowering effect of Metpure XL 25.
Management: Use NSAIDs cautiously; monitor blood pressure more frequently and inform your healthcare provider if you notice reduced effectiveness

6. Other Antihypertensive Agents (Amlodipine, Hydralazine, etc.)
Interaction: May cause excessive lowering of blood pressure or additive heart rate effects.
Management: Monitor blood pressure and heart rate regularly. Dose adjustments may be required if pronounced hypotension or bradycardia occurs

7. CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine)
Interaction: These medicines can increase blood levels of metoprolol, raising the risk of side effects such as low heart rate or fatigue.
Management: The dose of Metpure XL 25 may need to be lowered; monitor for enhanced side effects

8. Oral Contraceptives
Interaction: May increase the blood levels of metoprolol.
Management: May require close monitoring for side effects or dose adjustment

9. Glucagon
Interaction: Metpure XL 25 can reduce the effectiveness of glucagon in raising blood sugar.
Management: Be cautious in diabetic management and consult with your healthcare provider if needed

Drug - Food interaction

1. Alcohol Interaction
Interaction: Alcohol can significantly amplify the blood pressure-lowering effect of Metpure XL 25, leading to an increased risk of side effects such as dizziness, drowsiness, impaired coordination, and the possibility of fainting due to a sudden drop in blood pressure. This combination can also hamper activities requiring mental alertness, such as driving or operating machinery.
Management: You should avoid consuming alcohol while taking Metpure XL 25 Tablet. If you accidentally consume alcohol and experience dizziness or excessive drowsiness, avoid activities that require focus and seek medical advice if symptoms persist or become severe

Synopsis

More Information

FAQs About METPURE XL 25MG TABLET

References

1. KD. Tripathi. Drugs Acting in ANS. Essentials of medical pharmacology. Eighth edition. 2019. Page – 163.

2. Dasbiswas, Arup, Suresh Shinde and Debasri Dasbiswas. S-metoprolol: the 2008 clinical review. Europe PMC. April 2008. [Accessed on 15th July 2025]. 

3. Mohan, Jagdish C., et al. Rediscovering Chirality-Role of S-Metoprolol in Cardiovascular Disease Management. Europe PMC. June 2017. [Accessed on 15th July 2025]. 

4. Zuventus healthcare limited. KIMET-XL 12.5/25/50 TAB (S-metoprolol). [Accessed on 15th July 2025]. 

5. Aralez Pharmaceuticals US Inc. metoprolol succinate. Dailymed.com. [Revised in July 2022] [Accessed on 15th July 2025]. 

6. Central Drugs Standard Control Organization (CDSCO). [Accessed on 15th July 2025]. 

Useful Diagnostic Tests

• ECG at Home
• ECG + BP Check at Home
• Full Body Checkup with ECG & BP at Home
• Comprehensive Cardiac Risk Screening with 12 Lead ECG and BP
• Cardiac Risk Profile
• Kidney Package Basic

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Thamada Manikanta Praveen - MBBS, MD (General Medicine)

Last updated on 17 Jul 2025 | 11:04 AM(IST)