MET Innovfol Tablet 10'S

Introduction About MET INNOVFOL TABLET

MET INNOVFOL TABLET is a combination of D-Chiro Inositol, L-Methylfolate, Metformin, Methylcobalamin, and Myo-Inositol, which belongs to the group of medicines called Nutritional supplements. It is used in the management of diabetes mellitus and female reproductive health.

During management with MET INNOVFOL TABLET, your doctor will conduct a blood test to check your blood sugar levels and kidney function.

MET INNOVFOL TABLET is not recommended for use if you have liver disease, severely reduced kidney function, acute heart failure, a recent history of heart attack, or severe problems with blood circulation (such as shock) or have breathing difficulties. Consult your doctor before taking it.

MET INNOVFOL TABLET is not recommended for use during pregnancy or in breastfeeding women, as it may pass through the breast milk. Consult your doctor before taking it.

The most common side effects of taking MET INNOVFOL TABLET are nausea, vomiting, diarrhea, abdominal pain, bloating, flatulence, loss of appetite, and changes in taste. Consult your doctor if any of the side effects worsen.

Uses Of MET INNOVFOL TABLET

• To manage diabetes mellitus and female reproductive health

How MET INNOVFOL TABLET Works

MET INNOVFOL TABLET effectively controls blood glucose levels and manages female reproductive health, where Myo-inositol and D-chiro inositol improve insulin sensitivity and promote glucose uptake by the cells. It decreases hyperandrogenism, normalizes follicle growth and maturation, and promotes ovulation. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin. Methylcobalamin and L-methylfolate reduce hyperhomocysteinemia, improve blood flow to the ovary, and ensure follicle growth and egg health. It also helps manage brain and spinal cord birth defects.

How to use MET INNOVFOL TABLET

Take MET INNOVFOL TABLET, preferably with meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Side Effects Of MET INNOVFOL TABLET

How To Manage Side Effects

Bloating

Eat smaller and more frequent meals. Eat and drink slowly, and exercise regularly. If the bloating does not improve, contact your doctor.

Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.

Nausea And Vomiting

Take MET INNOVFOL TABLET with a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting do not improve.

Stomach Pain

Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own, consult your doctor if the symptom does not improve on its own.

Warning & Precautions

Pregnancy

Contraindicated

MET INNOVFOL TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.

Breastfeeding

Contraindicated

MET INNOVFOL TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking MET INNOVFOL TABLET.

Driving and Using Machines

Use with Caution

Do not drive or operate any machinery if you have weakness, dizziness, increased sweating, a fast heartbeat, visual problems, or difficulty in concentration after taking MET INNOVFOL TABLET.

Alcohol

Risky

Avoid excessive consumption of alcohol, as it may increase the risk of side effects.

Kidney

Contraindicated

MET INNOVFOL TABLET is not recommended for use if you have severely reduced kidney function. Consult your doctor before taking the medicine.

Liver

Contraindicated

MET INNOVFOL TABLET is not recommended for use if you have liver disease. Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take MET INNOVFOL TABLET if you are allergic to D-Chiro Inositol, L-Methylfolate, Metformin, Methylcobalamin, Myo-Inositol, or any other ingredients of this medicine.

Heart Disease

Contraindicated

MET INNOVFOL TABLET is not recommended for use if you are managed for acute heart failure, a recent history of heart attack, or severe problems with blood circulation (such as shock) or have breathing difficulties. Consult your doctor before taking MET INNOVFOL TABLET.

Use In Pediatrics

Consult your doctor

There is no proper information on the use of MET INNOVFOL TABLET by children. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

MET INNOVFOL TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking MET INNOVFOL TABLET.

Interactions

A. Drug-drug interactions:

Before taking MET INNOVFOL TABLET, inform your doctor if you are taking any of the following medicines:

• sulphonylureas, insulin, and meglitinides (other medicines used to manage diabetes) Ex. glimepiride, repaglinide
• medicines that increase urine production (diuretics) Ex. chlorothiazide
• beta-2 agonists such as salbutamol or terbutaline (used to manage asthma)
• corticosteroids (used to manage severe inflammation of the skin or asthma) Ex. dexamethasone
• verapamil (medicine used to manage blood pressure)
• rifampicin (a medicine used to manage tuberculosis)
• cimetidine (a medicine used to manage stomach problems)
• dolutegravir (a medicine used to manage viral infections)
• ranolazine (medicine used to manage chest pain)
• trimethoprim, sulfamethoxazole, neomycin, chloramphenicol, and aminosalicylic acid (medicines used to manage bacterial infections)
• vandetanib, crizotinib, fluorouracil, and olaparib (medicines used to manage cancer)
• isavuconazole (a medicine used to manage fungal infections)
• medicines used to manage pain and inflammation (NSAIDs and COX-2-inhibitors, such as ibuprofen and celecoxib)
• certain medicines for the management of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists) Ex. enalapril, candesartan
• phenytoin, phenobarbital, and primidone (medicines used to manage fits)
• antacids (used to relieve indigestion and heartburn) Ex. aluminium hydroxide or magnesium hydroxide
• preparations containing zinc, such as vitamins or food supplements
• sulfasalazine, used to manage the inflammatory bowel conditions ulcerative colitis and Crohn's disease
• cholestyramine (used to reduce cholesterol levels in the blood)
• colchicine (used to manage gout)
• oral contraceptives (medicines used to inhibit fertilization) Ex. levonorgestrel

Overdosage:

If you or anyone else accidentally took more MET INNOVFOL TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage may cause lactic acidosis, and symptoms include vomiting, abdominal pain with muscle cramps, a general feeling of not being well with severe tiredness, and difficulty breathing. Further symptoms include a reduced body temperature and heartbeat.

Synopsis

Drug                                         :   D-Chiro Inositol, L-Methylfolate, Metformin, Methylcobalamin, Myo-Inositol

Pharmacological category       :   Nutritional supplements

Therapeutic indication             :   Type II Diabetes mellitus, Female reproductive health

Dosage forms                          :   Tablet

More Information

• Keep MET INNOVFOL TABLET out of the sight and reach of children
• Store MET INNOVFOL TABLET below 30°C

FAQs About MET INNOVFOL TABLET

Q: What if I forget to take MET INNOVFOL TABLET?

A: If you forget to take a dose of MET INNOVFOL TABLET, take it as soon as you remember it, and then take the next dose at the right time. Do not take a double dose to make up for a forgotten dose.

Q: Is MET INNOVFOL TABLET safe during pregnancy?

A: MET INNOVFOL TABLET is not recommended for use during pregnancy. Inform your doctor if you are pregnant or planning to be pregnant before taking it.

Q: What are the side effects of taking MET INNOVFOL TABLET?

A: The most common side effects of taking MET INNOVFOL TABLET are nausea, vomiting, diarrhea, abdominal pain, bloating, flatulence, loss of appetite, and changes in taste. Consult your doctor if any of the side effects worsen.

Q: Who should not take MET INNOVFOL TABLET?

A: MET INNOVFOL TABLET is not recommended for use if you have liver disease, severely reduced kidney function, acute heart failure, a recent history of heart attack, or severe problems with blood circulation (such as shock), or have breathing difficulties, or have dehydration due to severe diarrhea or vomiting, severe infections, uncontrolled diabetes with lactic acidosis, ketoacidosis, or diabetic pre-coma. Consult your doctor before taking it.

Q: What precautions have to be taken while using MET INNOVFOL TABLET?

A: Before taking MET INNOVFOL TABLET, inform your doctor if you are scheduled for a lab test or have cancer or low vitamin B12 levels.

References

1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eight edition. 2019. Page – 299.

2. Merviel, P., James, P., Bouée, S. et al. Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reproductive Health. 2021. https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-021-01073-3

3. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2018] [Accessed on 9th January 2024]. https://www.medicines.org.uk/emc/files/pil.10760.pdf

4. Wockhardt UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2018] [Accessed on 9th January 2024]. https://www.medicines.org.uk/emc/files/pil.6998.pdf

5. Getz Pharma (Pvt.) Ltd. Methylcobalamin. [Accessed on 9th January 2024]. https://getzpharma.com/wp-content/uploads/2016/08/Nervon-Range-Leaflet-Export-GA.pdf

6. Myo-Inositol D-Chiro-Inositol L-Methylfolate Tablets. Ahem Health Care LLP. [Accessed on 9th January 2024]. https://www.ahemlifecare.co.in/myo-inositol-d-chiro-inositol-l-methylfolate-tablets.htm

7. Myo-Inositol, D-Chiro-Inositol, Metformin Hydrochloride, L-Methylfolate calcium, and Mecobalamin. BSA Pharma Inc. [Accessed on 9th January 2024]. https://www.pharmavends.com/product/fervum-f

8. Myo-Inositol, D-Chiro-Inositol, Metformin, L-Methylfolate calcium, and Mecobalamin. Elma Pharmaceuticals Pvt Ltd. [Accessed on 9th January 2024]. https://www.elmapharma.com/gynaecology.html

9. Myo-Inositol, D-Chiro-Inositol, Metformin Hydrochloride, L-Methylfolate calcium, and Mecobalamin. Innovcare Lifesciencies Pvt Ltd. [Accessed on 9th January 2024]. https://www.innovcare.in/womens_health/met-innovfol/

10. Folic acid. Centers for Disease Control and Prevention. [Accessed on 9th January 2024]. https://www.cdc.gov/ncbddd/folicacid/about.html 

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin – Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Narayanasetty Sai Swaroop - Pharm.D

Last updated on 10 Jan 2024 | 05:24 PM(IST)