New Revised MRP, 100% GST benefit passed Merex 1000mg Injection 10ml
Netmeds First Membership
Quick Links
Introduction About MEREX 1000MG INJECTION
MEREX 1000MG INJECTION contains Methotrexate, which belongs to the group of medicines called Antimetabolites. It is used to manage various cancers such as acute lymphocytic lymphoma (a type of cancer of the blood and bone marrow), meningeal leukemia (a type of cancer of white blood cells), Non-Hodgkin’s Lymphoma (a type of cancer of the lymphatic system), ovary cancer, head and neck region cancer, breast cancer, cervical cancer, lung cancer, bone cancer, cancer of the skin-originated T-cell lymphoma, bladder cancer, and various other cancers that are severe and unmanageable by conventional therapy.
MEREX 1000MG INJECTION is also used to manage psoriasis, which is severe and not manageable by other managements.
Before receiving MEREX 1000MG INJECTION, it is recommended to inform the doctor about your medical and family history, including the list of medicines (prescription, non-prescription medicines, and herbal medicines) that are being taken.
Also, MEREX 1000MG INJECTION is not recommended to be administered to pregnant and nursing women, women planning pregnancy, those who drink huge amounts of alcohol, or patients suffering from liver and kidney impairment.
Caution must be exercised by patients suffering from lung disorders, blood disorders, and gastric disorders before receiving MEREX 1000MG INJECTION.
Care must be taken to avoid taking products containing caffeine, such as black tea, coffee, and cold drinks, while receiving MEREX 1000MG INJECTION.
The common side effects that can be experienced after receiving MEREX 1000MG INJECTION are headache, nausea, vomiting, dizziness, and altered levels of blood cells. Consult a doctor if any of the above side effects worsen after receiving MEREX 1000MG INJECTION.
Uses Of MEREX 1000MG INJECTION
It is used to manage:
- acute lymphocytic lymphoma (ALL)
- meningeal leukemia
- Non-Hodgkin’s Lymphoma
- bone cancer (osteogenic sarcoma)
- advanced breast cancer
- recurrent and aggressive cancer of the head and neck region
- advanced cancer of the urinary bladder
- lung cancer (bronchogenic carcinoma)
- choriocarcinoma
- severe form of psoriasis
How MEREX 1000MG INJECTION Works
MEREX 1000MG INJECTION contains Methotrexate, which is a disease-modifying antirheumatic drug (DMARDs). It interferes with the growth of those cells in the body that reproduce quickly. As a result, the growth of those cells gets retarded, thus serving as an anti-tumour agent. MEREX 1000MG INJECTION decreases the undesired reactions of the body’s own immune-defense mechanism, thereby working as an effective immunosuppressant. In addition, it also exhibits anti-inflammatory effects, thereby reducing pain, swelling, and redness.
How to use MEREX 1000MG INJECTION
MEREX 1000MG INJECTION will be administered to you into a muscle (intramuscularly) only by a doctor or a nurse. Your doctor will administer the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of MEREX 1000MG INJECTION
Common
- nausea
- vomiting
- headache
- fever
- subacute neurotoxicity
- necrotizing demyelinating leukoencephalopathy (a condition characterized by progressive deterioration along with irritability, confusion, and an excessive desire to sleep and stay awake)
- loss of appetite
- inflammation in the mouth and throat along with the formation of ulcers
- increased levels of liver enzymes
- viral infections (herpes zoster virus)
- decrease in the level of red blood cells, white blood cells, and platelets
- drowsiness
- diarrhea
- suppression of the bone marrow
- inflammation of the mucus lining of the mouth (ulcerative stomatitis)
Uncommon
- anaphylactic reactions
- feeling confused and depressed
- convulsions
- tumour in lymph tissue
- inflammation of the pancreas
- liver disorders
- complications associated with diabetes
- reduced level of protein
- hypersensitive skin to sunlight
- brittle bones
- pain in bones and muscles
Rare
- inflammation of the sac around the heart along with the accumulation of fluid in the sac around the heart
- mood fluctuations
- affected speech
- visual disturbances
- thrombosis in the cerebrum and veins of the retina
- hypotension
- asthma (difficult breathing along with the production of wheezing sounds)
- inflammation of the gingiva and small intestine
- malabsorption
- acne
- kidney problems
- abnormal development of mammary glands
- elevated levels (creatinine and urea)
- presence of blood in the urine
Stop receiving MEREX 1000MG INJECTION and consult your doctor immediately if you experience any of the following:
- allergic reactions such as breathlessness, difficulty breathing, wheezing sound, swelling of the face, lips, tongue, rash, and itch on the skin
- weakness and/or paralysis on one side of the body
- blood clot in the leg, characterized by pain, swelling, redness, and warmth in the leg
- stoke characterized by weakness or paralysis on one side of the body or face, difficulty speaking or swallowing, headache, loss of vision, or balance
- temporary blindness
- dry, persistent, non-productive cough
- shortness of breath, wheezing, and difficulty speaking, along with pain in the chest and coughing out blood
- onset of fits
- difficulty in speaking, writing, and understanding language
- onset of fever and chill along with body ache and sore throat
- formation of ulcers and blisters in the mouth, resulting in soreness
- formation of cold sores
- severe skin rash, such as blistering of the skin, indicative of Stevens-Johnson Syndrome
- black or tar-like stools
- presence of blood in urine and stools
- painful and frequent urination
- yellowing of the skin and eyes
- unexpected bleeding, such as bleeding in the gums, faeces, or urine
How To Manage Side Effects
Diarrhea
Stick to simple meals. Avoid eating heavily rich or spicy food. Drink an oral rehydration solution to compensate for the loss of water and minerals. Stay hydrated. Consult your doctor if it persists for a long time or worsens with time.
Dizziness Or Drowsiness
Take adequate amounts of rest and sleep. Stay hydrated and replenish yourself with electrolytes. Also, do not indulge in driving or using heavy machinery, as it may prove to be dangerous.
Headache
Stay hydrated and get as much rest as possible. Stay away from bright lights and loud sounds. Apply a pain-relieving balm to the forehead. If the headache persists or worsens, consult your doctor.
Nausea And Vomiting
Stick to simple meals. Avoid eating heavily rich or spicy food. Stay hydrated. Consult your doctor if it persists for a long time or worsens with time.
Warning & Precautions
Pregnancy
ContraindicatedMEREX 1000MG INJECTION is not recommended if you are pregnant and/or are planning to become pregnant since it can be harmful to the foetus (growing baby) and lead to various malformations. Consult your doctor before receiving MEREX 1000MG INJECTION.
Breastfeeding
ContraindicatedMEREX 1000MG INJECTION is not recommended if you are a nursing mother. Consult your doctor before receiving MEREX 1000MG INJECTION.
Driving and Using Machines
ContraindicatedMEREX 1000MG INJECTION is not recommended if you feel tired and/or dizzy after receiving the medicine. Consult your doctor prior to receiving MEREX 1000MG INJECTION.
Alcohol
ContraindicatedIt is not recommended to consume alcohol while receiving MEREX 1000MG INJECTION, as it might increase the side effects. Consult your doctor before receiving MEREX 1000MG INJECTION.
Kidney
ContraindicatedMEREX 1000MG INJECTION is not recommended if you are diagnosed with a severe kidney disorder. Consult your doctor before receiving MEREX 1000MG INJECTION.
Liver
ContraindicatedMEREX 1000MG INJECTION is not recommended if you are diagnosed with a severe liver disorder. Consult your doctor before receiving MEREX 1000MG INJECTION.
Allergy
ContraindicatedMEREX 1000MG INJECTION is not recommended if you are allergic to Methotrexate and/or any other constituent of MEREX 1000MG INJECTION. Consult your doctor before receiving MEREX 1000MG INJECTION.
Lungs
Use with CautionIt is recommended to exercise caution while receiving MEREX 1000MG INJECTION if you are diagnosed with lung disorders. Consult your doctor before receiving MEREX 1000MG INJECTION.
Use In Pediatrics
Use with CautionMEREX 1000MG INJECTION is recommended to be used with caution with children. Your doctor will administer the right dose depending on your child’s age, body weight, and disease condition. Consult the doctor before receiving MEREX 1000MG INJECTION.
Use In Geriatrics
Use with CautionMEREX 1000MG INJECTION is recommended to be administered with caution and in a lower dosage to elders due to diminished function of the liver and kidneys and reduced folate levels in the blood. Consult the doctor before receiving MEREX 1000MG INJECTION.
Others
MEREX 1000MG INJECTION is not recommended for use if you:
- have bone marrow diseases
- have blood disorders
- have decreased levels of iron in the blood
- have infections and/or infectious disease
- are receiving vaccinations containing live vaccines, radiation therapy (Ex. X-rays, UV Rays)
- have stomach ulcers
- have ulcerative colitis
- have certain immunodeficiency syndromes
Before receiving MEREX 1000MG INJECTION, inform your doctor if you:
- are receiving management for the spine that may cause inflammation in the spine
- are diagnosed with the conditions that can lead to the retention of fluid in the body's organs
Interactions
A. Drug-Drug Interactions:
Before receiving MEREX 1000MG INJECTION, inform your doctor if you are taking any of the following medicines:
- medicines used to manage diabetes (Ex. sulphonylureas)
- medicines used to manage various skin and autoimmune diseases (Ex. para-aminobenzoic acid)
- medicines used to remove excess fluid and water from the body (Ex. frusemide)
- medicines used to manage epilepsy (Ex. phenytoin)
- medicines used in organ transplantation (Ex. azathioprine)
- medicines used as supplements
- medicines used to manage pain and inflammation (Ex. aspirin)
- other medicines used to manage rheumatoid arthritis and psoriasis (Ex. leflunomide, phenylbutazone, or amidopyrine)
- medicines used to manage gout (Ex. probenecid, allopurinol)
- medicines used to manage asthma (Ex. theophylline)
- medicines used to manage increased cholesterol levels (Ex. cholestyramine)
- medicines used to manage heart problems (Ex. amiodarone)
- medicines used to manage Crohn’s disease (Ex. sulfasalazine)
- medicines used to manage severe heartburn or ulcers (Ex. omeprazole)
- medicines used to manage skin conditions (Ex. acitretin)
- medicines used to manage malaria (Ex. pyrimethamine)
- medicines used to manage severe conditions such as psoriasis, along with ultraviolet light in PUVA therapy (Ex. methoxsalen)
- medicines used to manage infections (Ex. amoxicillin, ciprofloxacin)
- medicines used as vaccinations (Ex. live vaccines such as the MMR vaccine)
B. Drug-Food interactions:
It is recommended to avoid the consumption of drinks containing caffeine, such as black tea, coffee, and soft drinks, to manage dehydration.
Overdosage:
MEREX 1000MG INJECTION will be administered only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you experience any unusual reactions, contact your doctor immediately. Symptoms of overdosage with MEREX 1000MG INJECTION are nausea and vomiting, along with the development of mouth sores, black tarry or bloody stools, and severe infections.
Synopsis
| Drug | : | Methotrexate |
| Pharmacological Category | : | Anti-metabolites |
| Therapeutic Indication | : | Severe Psoriasis, Cancer |
| Dosage Forms | : | Injection, Gel, Capsule, Tablet |
More Information
- Keep MEREX 1000MG INJECTION out of the reach and sight of children
- Store MEREX 1000MG INJECTION at a temperature below 25°C
FAQs About MEREX 1000MG INJECTION
Q: What is MEREX 1000MG INJECTION used for?
A: MEREX 1000MG INJECTION is used to manage various cancers such as acute lymphocytic lymphoma (ALL), meningeal leukemia, Non-Hodgkin’s Lymphoma, cancer of the ovary, cancer of the head and neck region, breast cancer, cancer of the cervix, cancer of the lungs, cancer of the bones, cancer of skin-originated T-cell Lymphoma, cancer of the bladder, and various other cancers that are severe and unmanageable by conventional therapy. MEREX 1000MG INJECTION is also used to manage psoriasis that is not manageable by other managements and is very severe.
Q: Can I receive MEREX 1000MG INJECTION in pregnancy?
A: MEREX 1000MG INJECTION is not recommended for use in pregnant women and/or in women who are planning pregnancy because it can be harmful for the foetus (a growing baby in the womb). Consult your doctor before receiving it.
Q: Can I receive MEREX 1000MG INJECTION if I am breast-feeding a baby?
A: MEREX 1000MG INJECTION is not recommended for nursing mothers due to a lack of safety data. Consult your doctor before receiving it.
Q: Can MEREX 1000MG INJECTION be used by children?
A: MEREX 1000MG INJECTION is recommended to be used with caution in children. Consult the doctor before receiving MEREX 1000MG INJECTION.
Q: Can MEREX 1000MG INJECTION be used by the elderly?
A: MEREX 1000MG INJECTION is recommended to be administered with caution and in a lower dosage to elders due to diminished function of the liver and kidneys and reduced folate levels in the blood. Consult the doctor before receiving MEREX 1000MG INJECTION.
Q: Is there any specific food to avoid while receiving MEREX 1000MG INJECTION?
A: It is recommended to avoid the consumption of drinks containing caffeine, such as black tea, coffee, and soft drinks, along with MEREX 1000MG INJECTION, to manage dehydration.
References
1. KD Tripathi. Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 857.
2. Hao, F., Lee, R.J., Yang, C., Zhong, L., Sun, Y., Dong, S., Cheng, Z., Teng, L., Meng, Q., Lu, J. and Xie, J., 2019. Targeted Co-delivery of siRNA and methotrexate for tumor therapy via mixed micelles. Pharmaceutics. [Published on 21st February 2019] [Accessed on 5th February 2024] https://www.mdpi.com/1999-4923/11/2/92
3. Sandoz Pty Ltd. [Revised in July 2022] [Accessed on 5th February 2024] https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2012-CMI-01899-3&d=20221026172310101
4. Sandoz Pty Ltd. [Revised on 8th July 2022] [Accessed on 5th February 2024] https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2011-PI-03245-3&d=20221020172310101
5. Taj Pharmaceuticals Limited. [Revised on N.A] [Accessed on 5th February 2024] https://tajpharma.in/portfolio-item/methotrexate-injection-ip-1000mg-10ml-imutaj-taj-pharma/
6. Methotrexate. Aetos Pharma. [Accessed on 5th February 2024] https://www.aetospharma.com/product/methotrexate-injection-usp-250mg-10-ml/
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Liver Function Test (LFT)
- Kidney Function Test (KFT)
Author Details
