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Introduction About MEGATAS S 50 TABLET
MEGATAS S 50 TABLET is a combination of Mirabegron and Solifenacin which belongs to the group of medicines called Urinary Antispasmodics. It is used to manage the signs of overactive bladder (such as sudden urge to pass urine, increased frequency of passing urine, unable to control urine or wetting yourself because you couldn’t go the bathroom). MEGATAS S 50 TABLET reduces the activity of an overactive bladder and enables you to wait longer before having to go to the bathroom. Try to take MEGATAS S 50 TABLET at the same time each day to achieve maximum benefits. It can be taken with or without meals.
Before taking MEGATAS S 50 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any other problems in the bladder that obstructs urine flow or if you have glaucoma, constipation, stomach problems (such as tear or block in the gut), muscle weakness or urinary tract infections as a precaution. MEGATAS S 50 TABLET is not recommended for use in patients who are not able to pass urine (urinary retention) and in patients with severe bowel problems (such as toxic megacolon).
It is not suitable for use in pregnant or breastfeeding women and in children aged below 18 years. The most common side effects of taking MEGATAS S 50 TABLET are dry mouth, blurred vision, constipation, nausea, abdominal fullness, stomach pain, burping, heartburn, headache and dizziness. Consult your doctor if any of these side effect worsens.
Uses Of MEGATAS S 50 TABLET
- Used to manage signs of overactive bladder (such as sudden urge to pass urine, increased urine frequency, unable to control urine or wetting yourself)
How MEGATAS S 50 TABLET Works
MEGATAS S 50 TABLET is a urinary muscle relaxant medicine which relaxes the smooth muscles surrounding the bladder. This helps your bladder to hold more volume of urine and can control urine flow. As a result, it reduces signs of overactive bladder and enables you to wait longer before having to go to the bathroom.
How to use MEGATAS S 50 TABLET
Take MEGATAS S 50 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. MEGATAS S 50 TABLET can be taken with or without food. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of MEGATAS S 50 TABLET
Common
- dry mouth
- blurred vision
- nausea
- constipation
- indigestion
- stomach pain
- diarrhea
- sense of fullness in the stomach
- burping, heartburn
- fast heart rate
- urinary tract infection
- headache
- dizziness
Uncommon
- bladder infections
- vaginal infections
- vaginal itching
- sleepiness
- changes in taste
- dry eyes, nose or throat
- dry skin
- difficulty in passing urine
- tiredness
- fluid build-up in the lower legs
- stomach infections
- increased blood pressure
- skin rash, itching
Rare
- accumulation of a large amount of hardened stool in the large intestine (faecal impaction)
Stop taking MEGATAS S 50 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, itching and swelling of the face, lips, mouth, tongue or throat causing difficulty in swallowing or breathing)
- severe skin rash with blistering and peeling of the skin
- severe migraine headache
- irregular heart rhythm
Warning & Precautions
Pregnancy
Monitoring requiredMEGATAS S 50 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Breastfeeding
ContraindicatedMEGATAS S 50 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience sleepiness, tiredness or blurred vision after taking MEGATAS S 50 TABLET.
Kidney
Consult your doctorMEGATAS S 50 TABLET is not recommended for use in patients with moderate to severe kidney problems (including in those who undergo dialysis). It should be used with caution in patients with other mild kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorMEGATAS S 50 TABLET is not recommended for use in patients with moderate to severe liver problems. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take MEGATAS S 50 TABLET if you are allergic to Solifenacin or Mirabegron or any other ingredients of this disease.
Heart Disease
Consult your doctorMEGATAS S 50 TABLET is not recommended for use in patients with uncontrolled high blood pressure. It should be used with caution in patients with heart problems (such as heart failure or abnormal heart rhythm). Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedMEGATAS S 50 TABLET is not recommended for use in children and adolescents (aged below 18 years of age). Therefore, consult your doctor before giving the medicine.
Use In Geriatrics
Use with CautionMEGATAS S 50 TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
Others
MEGATAS S 50 TABLET is not recommended for use if you:
- have urinary retention
- have a severe stomach or bowel condition
- have severe muscle weakness
- have glaucoma
Before taking MEGATAS S 50 TABLET, inform your doctor if you:
- have any bladder obstruction
- have difficulty in passing urine or a weak urine stream
- have constipation or any obstruction in the gut
- have a stomach tear
- have heartburn
- have nerve pain
- have urinary tract infection
Interactions
A. Drug-Drug Interaction:
Before taking MEGATAS S 50 TABLET, inform your doctor if you are taking any of the following medicines such as:
- medicines used to manage fungal infections (Ex. ketoconazole, itraconazole)
- medicines used to manage viral infections (Ex. ritonavir, nelfinavir)
- medicines used to manage high blood pressure (Ex. verapamil, diltiazem)
- other anticholinergic medicines (used to increased heart rate, reduce body secretions and increase body movements) Ex. ipratropium, atropine
- medicines used to manage reflux disease (Ex. metoclopramide, cisapride)
- medicines such as bisphosphonates used to manage bone loss
- rifampicin (a medicine used to manage tuberculosis)
- medicines used to manage fits (Ex. phenytoin, carbamazepine)
- medicines used for mental illness (such as thioridazine, mesoridazine, haloperidol and chlorpromazine)
- medicines used to manage abnormal heart rhythm (such as digoxin, propafenone or flecainide, quinidine, sotalol, procainamide, ibutilide, dofetilide and amiodarone)
- medicines used for depression (Ex. imipramine or desipramine)
- dabigatran (used to reduce the risk of blood clots)
- medicines used to manage allergic rhinitis (Ex. cetirizine, levocetirizine, montelukast)
- medicines used to manage bacterial infections (Ex. pentamidine, moxifloxacin, erythromycin, clarithromycin)
B. Drug-Food Interactions:
MEGATAS S 50 TABLET can be taken with or without food. Consult your doctor for advice.
Overdosage:
If you or anyone else accidentally took more of MEGATAS S 50 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are headache, dry mouth, dizziness, drowsiness, blurred vision, hallucinations, over-excitability, seizures, difficulty in breathing, increased heart rate, increased blood pressure, accumulation of urine in the bladder and dilated pupils.
Synopsis
| Drug | : | Mirabegron, Solifenacin |
| Pharmacological Category | : | Beta 3-adrenoceptor agonist, Muscarinic Receptor Antagonists |
| Therapeutic Indication | : | Overactive bladder |
| Dosage Forms | : | Tablet, Combi pack, Combi kit |
More Information
Storage
- Keep MEGATAS S 50 TABLET out of reach of children
- Store MEGATAS S 50 TABLET at room temperature
FAQs About MEGATAS S 50 TABLET
Q: What is the use of MEGATAS S 50 TABLET?
A: MEGATAS S 50 TABLET is used to manage the signs of overactive bladder (such as sudden urge to pass urine, increased frequency of passing urine, unable to control urine and wetting yourself because you could not go the bathroom).
Q: Will the use of MEGATAS S 50 TABLET controls urination?
A: Yes. MEGATAS S 50 TABLET helps the bladder to hold more volume of urine and controls urine flow. It reduces the activity of an overactive bladder and enables you to wait longer before having to go to the bathroom.
Q: What are the side effects of MEGATAS S 50 TABLET?
A: The most common side effects of taking MEGATAS S 50 TABLET are dry mouth, blurred vision, headache, dizziness, constipation, nausea, abdominal fullness, stomach pain, burping, heartburn and stomach discomfort. Inform your doctor if any of the above side effects worsen.
Q: Can MEGATAS S 50 TABLET affect blood pressure?
A: Yes. MEGATAS S 50 TABLET may raise blood pressure in some individuals. Therefore, it should be used with caution in patients with history of hypertension.
Q: What happens if you stop taking MEGATAS S 50 TABLET?
A: Do not stop taking MEGATAS S 50 TABLET without consulting your doctor as it may make your symptoms reappear. Take MEGATAS S 50 TABLET for the stipulated duration advised by your doctor to achieve maximum benefits.
Q: How does MEGATAS S 50 TABLET help in overactive bladder?
A: MEGATAS S 50 TABLET helps your bladder to hold more volume of urine and controls urine flow. It reduces the activity of an overactive bladder and enables you to wait longer before having to go to the bathroom.
Q: Can you take MEGATAS S 50 TABLET every day?
A: Yes. MEGATAS S 50 TABLET is prescribed once a day. However, your doctor will evaluate your health condition and suggest you whether you can take MEGATAS S 50 TABLET or not.
Q: Who should not take MEGATAS S 50 TABLET?
A: MEGATAS S 50 TABLET is not recommended for use in patients having severe liver or kidney diseases, severe stomach or bowel condition (ulcerative colitis), myasthenia gravis or glaucoma. Therefore, consult your doctor for advice.
Q: How MEGATAS S 50 TABLET works in my body?
A: MEGATAS S 50 TABLET is a muscle relaxant which relaxes the smooth muscles surrounding the bladder. This helps your bladder to hold more volume of urine and controls urine flow. As a result, it reduces the activity of an overactive bladder and enables you to wait longer before having to go to the bathroom.
Q: Can MEGATAS S 50 TABLET cause dry mouth?
A: MEGATAS S 50 TABLET may cause dry mouth in some individuals. To manage this, drink plenty of water to keep yourself hydrated. However, inform your doctor if this side effect troubles you.
Q: Can MEGATAS S 50 TABLET be used during pregnancy?
A: MEGATAS S 50 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Q: What is the best time to take MEGATAS S 50 TABLET?
A: MEGATAS S 50 TABLET can be taken at any time of the day. However, consult your doctor for advice.
Q: Can MEGATAS S 50 TABLET cause dizziness?
A: Yes. MEGATAS S 50 TABLET rarely causes dizziness in some individuals. If you experience dizziness, try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Q: How and when should I take MEGATAS S 50 TABLET?
A: Take MEGATAS S 50 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. [GBNKEYEORD] can be taken with or without food. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: Will MEGATAS S 50 TABLET affect fertility?
A: No. MEGATAS S 50 TABLET does not affect fertility. It only improves urinary symptoms associated with overactive bladder by relaxing the smooth muscles surrounding the bladder.
Q: How long will MEGATAS S 50 TABLET take to manage my disease?
A: It may take up to 4 weeks for MEGATAS S 50 TABLET to show the results. However, this period varies from person to person based on their disease condition. Consult your doctor if your symptoms are not relived even after taking MEGATAS S 50 TABLET for a prolonged period.
Q: What to do if I forgot to take MEGATAS S 50 TABLET?
A: If you forgot to take a dose of MEGATAS S 50 TABLET take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next dose at regular times. Do not take a double dose to compensate a missed dose.
Q: Will taking a higher dose of MEGATAS S 50 TABLET be more effective?
A: No. Do not take a higher dose of MEGATAS S 50 TABLET than the prescribed one without consulting your doctor. Taking a higher dose of MEGATAS S 50 TABLET may not be beneficial. Instead, it can cause serious side effects. If the prescribed dose is not effective for you, consult your doctor. Your doctor may prescribe a suitable higher dose or suggest an alternative therapy after evaluating your disease condition.
References
1. KD. Tripathi. Drugs Acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page-118.
2. Paul Abrams, Con Kelleher, David Staskin, Tomasz Rechberger, Richard Kay, Reynaldo Martina, Donald Newgreen, Asha Paireddy, Rob van Maanen, Arwin Ridder. Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study (Symphony). NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. February 2014. [Accessed on 1st February 2023] https://pubmed.ncbi.nlm.nih.gov/24612659/
3. Betmiga 25 mg prolonged-release tablets Betmiga 50 mg prolonged-release tablets mirabegron. Electronic Medicines Compendium. [Revised in December 2022] [Accessed on 1st February 2023] https://www.medicines.org.uk/emc/files/pil.7540.pdf
4. Zentiva, k.s. Electronic Medicines Compendium (EMC) [Revised in May 2020] [Accessed on 1st February 2023] https://www.medicines.org.uk/emc/files/pil.10403.pdf
5. Cipla Ltd. Vesibeta – S Tablet. Ciplamed.com. [Revised in August 2021] [Accessed on 1st February 2023] https://ciplamed-library.com/content/vesibeta-s-tablets
6. Leeford Healthcare Pvt Ltd. Begroease-S 50. [Accessed on 1st February 2023] https://www.leeford.in/product/1542/begroease-s-50
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